直肠癌手术对男性性功能和排尿功能的影响

目的 研究直肠癌患术后性功能和排尿功能的变化。方法 对我院79例直肠癌患通过凋查的方式调查术后性功能和排尿功能情况，并按年龄、术式进行回顾性分析。结果 性功能障碍小于40岁患为37．5%，40-59岁为60．4％，大于60岁为95．7％。Miles术后并发性功能障碍为80．5％，近期排尿困难为46．3％(19／41)，远期排尿困难为4．9％(2／41)；Dixon术后并发性功能障碍55．3％，近期排尿困难为28．9%(11／38)，无远期排尿困难。结论 男性直肠癌患术后性功能和排尿功能障碍发生率高。手术时患的年龄和手术方式对其发生率有直接影响。保留植物神经的直肠癌根治术可有效地减少患术后忡功能和排尿功能暗碍。     

腹腔镜中低位直肠癌根治术对男性患者性功能及排尿功能的影响

目的 探讨腹腔镜中低位直肠癌根治术对男性患者性功能及排尿功能的影响.方法 回顾性分析2006年5月至2009年3月解放军总医院收治的150例男性中低位直肠癌患者的临床资料,其中腹腔镜组68例,开腹组82例.比较两组患者术后6、12个月勃起功能障碍和射精功能障碍发生率及近、远期排尿功能障碍发生率,计数资料采用x2检验.结果 腹腔镜组与开腹组患者术后6个月勃起功能障碍、术后6个月射精功能障碍、术后12个月射精功能障碍、远期排尿功能障碍发生率分别为15%(10/68)、16%(11/68)、10%(7/68)、0和22%(18/82)、23%(19/82)、21%(17/82)、2%(2/82),两组比较,差异无统计学意义(x2=1.285,1.137,3.013,1.681,P>0.05).腹腔镜组与开腹组患者术后12个月勃起功能障碍、近期排尿功能障碍发生率分别为7%(5/68)、4%(3/68)和17%(14/82)、20%(16/82),两组比较,差异有统计学意义(x=4.565,5.930,P<0.05).结论 腹腔镜中低位直肠癌根治术能减少男性患者盆自主神经损伤,提高患者术后生命质量.

Abstract：

Objective To evaluate the effects of laparoscopic radical resection of mid-low rectal cancer on sexual and urinary functions of male patients. Methods The clinical data of 150 patients with mid-low rectal cancer who were admitted to the PLA General Hospital from May 2006 to March 2009 were retrospectively analyzed. Sixty-eight patients were allocated to laparoscopic group and 82 to open group. The incidences of erectile and ejaculatory dysfunction and the short- and long-term urinary dysfunction of patients in the 2 groups were compared seperately at 6 and 12 months after the operation. All data were analyzed using the chi-square test. Results The incidences of erectile and ejaculation dysfunction at 6 months after operation, incidence of ejaculation dysfunction at 12 months after operation, and long-term urinary dysfunction were 15% (10/68), 16% (11/68), 10% (7/68) and 0 in the laparoscopic group, and 22% (18/82), 23% (19/82), 21% (17/82) and 2% (2/82) in the open group, respectively, no significant difference between the two groups was found (x2 = 1. 285, 1. 137, 3. 013, 1.681, P>0. 05). The incidences of erectile dysfunction at 12 months after operation and short-term urinary dysfunction were 7% (5/68) and 4% (3/68) in the laparoscopic group, and 17% (14/82) and 20% (16/82) in the open group, respectively, a significant difference between the two groups was observed (x = 4. 565, 5.930, P <0.05). Conclusion Laparoscopic radical resection of mid-low rectal cancer can reduce the injury of pelvic autonomic nerve and improve the life quality of patients.     

直肠癌根治术中保留盆腔自主神经对男性性功能和排尿功能的影响

目的探讨直肠癌根治术中保留盆腔自主神经对男性性功能和排尿功能的影响。方法110例男性直肠癌患者行保留盆腔自主神经的直肠癌根治术,Dukes A期48例完全保留自主神经(Ⅰ型),Dukes B期53例保留双侧盆神经丛(Ⅱ型),Dukes C期9例保留一侧盆神经丛(Ⅲ型)。结果Ⅰ、Ⅱ和Ⅲ型患者在性功能和排尿功能方面的差异有统计学意义(P<0.05),局部复发率分别为2.08%,11.32%和22.22%,其差异有统计学意义(P<0.05),总的5年生存率为60.91%。结论直肠癌根治术中保留盆腔自主神经,可降低病人术后性功能障碍和排尿功能障碍发生率,提高病人生存质量。     

直肠癌根治术中保留盆腔自主神经对男性性功能、排尿功能及局部复发率的影响

排尿功能及性功能障碍是直肠癌根治术后较常见的并发症,近年来国内外一些研究发现,在直肠癌根治术中实施全直肠系膜切除(TME)时,完全或部分保留盆腔自主神经(Pelyic autonomic nerve preservation,PANP),可以降低术后排尿和性功能障碍的发生率.但PANP是否会影响手术的根治性,是否会增加患者术后的局部复发率,存在争议.本文回顾分析我院2000年1月～2003年6月在直肠根治术中实施和未实施PANP各46例病人术后排尿及性功能障碍的发生率及局部复发率,研究PANP在直肠癌根治术的应用价值.     

保存植物神经的直肠癌根治术对排尿和性功能的影响

目的 探讨中下段直肠癌患者行保存植物神经的肿瘤根治术对排尿和性机能的影响。方法 根据不同病情实施不同保存植物性神经的直肠癌根治术１８８例：Ｄｕｋｅｓ Ａ期９８例,完全保存神经;Ｂ期７８例,保存一侧或两侧神经;Ｃ期１２例,只保存Ｓ３、４神经。结果 术后自行排尿时间平均为：Ａ期８．５ｄ,Ｂ期９．０ｄ,Ｃ期１６．８ｄ。保存勃起和射精机能者：Ｄｕｋｅｓ Ａ期分别是９６．９％和１００％;Ｂ期是４７．４％和５０％;Ｃ期均为０。术后肿瘤局部复发者占１２．８％（２４／１８８）,其中Ｄｕｋｅｓ Ａ、Ｂ、Ｃ期分别为４．１％、２０．５％和３３．３％。５年生存率Ｄｕｋｅｓ Ａ、Ｂ、Ｃ期分别是７７．６％、５２．６％、３３．３％。结论 保存植物神经的直肠癌根治术,在不增加局部复发率和减少５年生存率的同时,可明显提高患者的生存质量。     

男性直肠癌直肠系膜切除术中保留盆腔自主神经对排尿及性功能影响的研究

目的 探讨男性直肠癌直肠系膜切除术(TME)保留盆腔自主神经(PANP)对排尿功能及性功能的影响.方法 男性直肠癌患者240例,分为PANP组120例,行TME术并保留盆腔自主神经;对照组120例,不保留盆腔自主神经.统计学比较2组患者术后排尿功能及性功能、3年生存率和局部复发率. 结果PANP组术后排尿功能障碍发生率为30.8%、术后勃起功能障碍发生率为28.3%、术后射精功能障碍发生率为34.2%,对照组分别为55.0%、60.0%、62.5%,2组比较差异均有统计学意义(P<0.05);PANP组术后3年局部复发率和生存率分别为9.4%、75.0%,对照组为9.0%、65.0%,2组比较差异无统计学意义(P>0.05).结论 男性直肠癌TME术中PANP可以明显改善患者的排尿功能和性功能,提高患者的术后生活质量,且不影响治疗效果.     

男性患者直肠癌术后性功能的变化

目的 研究男性直肠癌患者术后性功能障碍发生率、年龄、术式及肿瘤侵犯程度对术后性功能的影响。方法 通过调查表的方式调查了７２例７０岁以下男性直肠癌术后患者的性功能情况并进行回顾性分析。结果 术后性功能障碍总发生率为６３．９％。手术时年龄５９岁以下组和６０岁以上组发生率分别为６２．２％,６６．７％。两组差异无显著性。前切除术及Ｍｉｌｅｓ术后发生率分别为６０．７％,６５．９％,ＤｕｋｅｓＡ,Ｂ,Ｃ期患者     

腹腔镜和开腹直肠癌手术对男性性功能的影响

目的 探讨腹腔镜和开腹直肠癌根治术对男性性功能的影响.方法 将2001年5月至2008年11月间行完全腹腔镜下直肠癌根治术的17例65岁以下的男性病人作为研究对象,另选择同期施行开腹手术的21例男性直肠癌病人作为对照组.对两组病例术后性功能情况进行回顾分析.结果 两组之间术前及术后6个月、12个月IIEF-5评分无明显差异,无论腹腔镜组还是开腹组术后IIEF.5评分均较术前有下降,差异有统计学意义(P<0.05).两组与手术有关的射精功能障碍发生率,术后6月时为37.50%和42.11%(P>0.05),术后12月时为37.50%和36.84%(P>0.05),两组比较差异均无统计学意义.结论 腹腔镜直肠癌根治术后性功能障碍的发生率与开腹手术相比没有差异.     

男性直肠癌切除术后性功能障碍分析

对25例男性直肠癌切除后性功能进行调查。平均年龄为42．5岁，Miles手术18例，性欲减退8例（44．4％），勃起障碍11例（61.1％），射精障碍13例（72．2％）。Dixon手术7例，性欲减退1例（14.3％），勃起障碍1例（14.3％），射精障碍2例（28．6％）。认为手术损伤盆腔神经是造成术后病人性功能障碍的直接和主要因素。防治关键在于术中完整地保护植物神经，注意剥离层次和切除范围。     

腹腔镜与开腹直肠癌根治术后排尿功能和性功能的比较

目的 比较腹腔镜与开腹直肠癌根治术后排尿功能和性功能的差异.方法 前瞻性非随机对比2008年6月至2009年7月122例腹腔镜直肠癌根治术（LS组）和74例开腹直肠癌根治术（OS组）后排尿功能和性功能的差异.结果 LS组和OS组术后排尿功能障碍发生率分别为5.7%（7/122）和8.1%（6/74）,男性术后勃起功能障碍发生率分别为16.7%（8/48）和20.7%（6/29）,男性术后射精功能障碍发生率分别为20.8%（10/48）和20.7%（6/29）,女性术后性功能障碍发生率分别为37.5%（12/32）和42.9%（9/21）,差异均无统计学意义（P＞0.05）.结论 腹腔镜直肠癌根治术不会增加患者术后排尿功能和性功能障碍的发生率.     

直肠癌手术对男性患者术后排尿功能和性功能的影响

排尿功能和性功能障碍是直肠癌手术治疗后的常见并发症,有许多研究对这一问题进行了探讨,现就这一问题的现状做一综述.     

套入式结肠直肠黏膜吻合保肛术对青年男性低位直肠癌术后性功能的影响

目的 探讨套入式结肠直肠黏膜吻合保肛术对青年男性低位直肠癌患者术后性功能的影响.方法 对68例低位直肠癌青年男性患者行套入式结肠直肠黏膜吻合术,分别于术前及术后调查其性功能.结果 68例患者中术后性功能障碍共发生22例,发生率32.35%,其中勃起障碍15例,射精障碍7例.6例Dukes A期患者均未发生性功能障碍,Dukes B期及C期患者术后性功能障碍发生率分别为26.67%及38.30%,两者差异有统计学意义(P＜0.05).结论 套入式结肠直肠黏膜吻合术可以很好地保护青年男性低位直肠癌患者的性功能,是一安全、有效的保肛术式.     

The long-term voiding function and sexual function after pelvic nerve-sparing radical surgery for rectal cancer

BACKGROUND: The aim of the present study is to symptomatically analyze the extent to which pelvic nerve-sparing radical surgery for rectal cancer impacts on long-term voiding and male sexual function. METHODS: A self-administered questionnaire was mailed to 68 patients who underwent pelvic nerve-sparing radical surgery for invasive rectal cancer with 52 responses (28 men and 24 women; 27 complete and 25 incomplete preservation; response rate 76.5%). Each patient was asked to record if there had been any changes in lower urinary tract symptoms after surgery. Sexual function was also investigated in men. RESULTS: Of the 52 patients, 48 (92%) maintained voluntary voiding without catheterization in the long term. Clean intermittent self-catheterization was performed in only four patients with incomplete preservation because of persistent voiding dysfunction. Subjectively, approximately 60% of the patients remained unchanged in lower urinary tract symptoms after surgery. The satisfaction rate regarding the current voiding status was significantly higher in women than in men (83% versus 61%, P = 0.0294), but was not significantly different between those with complete (76%) and incomplete preservation (64%). Despite the acceptable urinary status, 88% of men had some deterioration in the erectile function, regardless of the types of surgical procedures. Overall, 64% of men were unsatisfied with the current sexual function. CONCLUSIONS: Pelvic nerve-sparing radical surgery for rectal cancer preserved the long-term voiding function in the majority of patients. In completely preserved patients and in women, symptomatic outcomes were more satisfactory. Postoperative erectile dysfunction was found to be a serious problem, even in complete nerve-sparing procedure.     

Quality of life after surgery for rectal cancer with special reference to pelvic floor dysfunction

Aim Conventional outcomes such as survival, tumour recurrence and complication rates after surgery for rectal cancer have been rigorously assessed, but the importance of maintaining quality of life (QOL) after surgery for rectal cancer has received less attention. The aim of the current study was to analyse QOL and the occurrence of pelvic dysfunction after the surgical treatment of rectal cancer. Method Between May 2005 and May 2008, 150 patients with rectal cancer underwent abdominoperineal resection (APR) or anterior resection (AR). Seventy‐four answered two preoperative questionnaires. At a follow up of 1 year, 65 were alive without sign of recurrence and answered the same questionnaires: (a) validated RAND 36‐item health survey QOL questionnaire; and (b) self‐administered disease‐related questionnaire with special reference to anorectal and urogenital function. Results The postoperative general QOL was similar after surgery, and mental functioning was better (P < 0.001). Problems with physical functions were associated with anal dysfunction after AR (P < 0.001) and problems with social functioning were associated with urinary dysfunction (P = 0.038). At 1 year after surgery, urinary incontinence was worse (P = 0.026) after all operations, and the incidence of dysuria was higher after APR than AR (P = 0.001). Male sexual function also worsened (P = 0.060). Anorectal dysfunction caused more inconvenience among patients who underwent AR (P = 0.028). Preoperative radiation was associated with postoperative ejaculation problems (P = 0.028) and anal incontinence (P = 0.012). Conclusion Factors affecting QOL and pelvic floor function should be taken into account when making treatment decisions in rectal cancer.