药物流产不同用药途径的临床比较分析

目的:探讨药物流产的临床用药途径.方法:选择60例要求药物终止早期妊娠的患者作为观察对象,按照不同临床给药途径,分为甲组和乙组,甲组为米非司酮100g 24h内米索前列醇阴道给药;乙组为米非司酮200g 48h内米索前列醇阴道给药.分别观察两组的用药效果.结果:两组均实现完全流产,且在流产率、副作用、术后出血等方面基本一致.结论:从减少病人花费、缩短药物流产时间的角度考虑,米非司酮100mg配伍米索前列醇24h用药终止早期妊娠的方案更容易为患者所接受.     

药物流产加量终止早期妊娠4～5周600例临床效果观察

目的探讨加量米非司酮、米索前列醇用于早期流产的临床效果。方法对600例孕4～5周并要求终止妊娠的妇女,口服加量米非司酮、米索前列醇行药物流产,结果完全流产率为99．9％,妊娠物排出时间明显缩短,排出时间小于3h者占93％。结果米非司酮加量至200mg,米索前列醇0．6—1．6mg,用于终止早期妊娠4～5周。结论加量米非司酮、米索前列醇可提高完全流产率,缩短妊娠物排出时间,减少阴道流血量及流血时间,提高药物流产的安全性,是一种有效的方法。     

米非司酮配伍米索前列醇终止中期妊娠的临床观察

目的观察米非司配伍米索前列醇用于终止中期妊娠的效果及安全性。方法对于487例孕12～18周的妊娠妇女,用米非司酮配伍米索前列醇终止妊娠,每天早、晚9时空腹口服米非司酮25mg,首次加倍,连服两天,第三天早晨6时空腹服用米非司酮25mg,第三天早晨8时阴道置入米索前列醇0.6mg,在使用米索前列醇6小时后无宫缩则重复用药一次,进行药物流产观察。结果 487例患者中,392例完全流产（80.5%）,79例不完全流产（16.2%）,16例失败（3.3%）。结论米非司酮配伍米索前列醇可成功终止12～18周的中期妊娠,有效率高,安全性好。     

米索前列醇2种给药途径终止10～16周妊娠效果比较

目的观察米非司酮配伍米索前列醇不同用药途径对10～16周妊娠的流产效果。方法将168名妊娠10～16周的健康妇女随机分配给以米非司酮150mg后,83例米索前列醇阴道给药、85例米索前列醇空腹口服终止妊娠。结果2组在流产时间、出血量差异无统计学意义(χ2=0.075,P>0.05),口服米索前列醇比阴道给药的不良反应增加(χ2=11.53,P<0.05)。结论米非司酮配伍米索前列醇2种用药途径对10～16周妊娠的终止是有效安全简便方法,在减少不良反应方面米索前列醇用药途径阴道给药组优于口服组。     

米非司酮配伍米索前列醇终止中期妊娠的临床观察

目的观察米非司配伍米索前列醇用于终止中期妊娠的效果及安全性。方法对于487例孕12～18周的妊娠妇女,用米非司酮配伍米索前列醇终止妊娠,每天早、晚9时空腹口服米非司酮25mg,首次加倍,连服两天,第三天早晨6时空腹服用米非司酮25mg,第三天早晨8时阴道置入米索前列醇0.6mg,在使用米索前列醇6小时后无宫缩则重复用药一次,进行药物流产观察。结果 487例患者中,392例完全流产(80.5%),79例不完全流产(16.2%),16例失败(3.3%)。结论米非司酮配伍米索前列醇可成功终止12～18周的中期妊娠,有效率高,安全性好。     

小剂量米非司酮配伍米索前列醇终止早期妊娠的临床观察

<正>米非司酮配伍米索前列醇终止早期宫内妊娠,已在全球大多数国家应用[1-3]。常规剂量米非司酮配伍米索前列醇终止早期妊娠完全流产率达90%以上[4],但小剂量米非司酮终止≤7周妊娠的研究少见报道。在临床工作中笔者发现,因有不同程度早孕反应,部分服用常规剂量米非司酮消化道反应加重,或米非司酮漏服者服用米索前列醇后仍能成功流产,而且以较小剂量药物达到同样治疗效果,也是临床治疗的目标。本研究旨在探讨小剂量米非司     

药物流产的临床观察

药物流产是非手术措施终止早期妊娠的一种方法，苏尼特左旗妇幼保健所用米非司酮配伍米索前列醇终止早期妊娠，得到较为满意的临床效果，完全流产率达92％，与年龄、孕周、孕次有关，年龄越小、孕次越少、孕周越小完全流产率越高。米非司酮阻止孕酮对子宫内膜或蜕膜作用，导致出廊和流产，米索前列醇促进宫缩与宫颈软化，有利于胚胎排出。药物流产痛苦小，服药简便，成功率高，是终止早期妊娠的有效措施.     

米非司酮米索前列醇联合中药在终止早期妊娠中的应用

目的探讨米非司酮、米索前列醇联合中药在终止早期妊娠中的临床效果。方法选择2012年1—12月在我服务站诊断为宫内妊娠、要求终止妊娠且无明显药物流产禁忌证的患者120例作为研究对象。将患者随机分为治疗组（应用米非司酮、米索前列醇联合中药）60例和对照组（应用米非司酮、米索前列醇）60例,对两组的总有效率、不全流产率、产时、产后出血量进行比较。结果两组总有效率差异无统计学意义;排胎时间、不全流产率、产后出血量差异有统计学意义。结论米非司酮、米索前列醇联合中药在早期妊娠引产中应用能减少排胎时间,降低不全流产率及减少产后出血量。     

米非司酮配伍米索前列醇终止妊娠的研究进展

<正>米非司酮配伍米索前列醇用于终止早孕的方法在全世界范围内得到了广泛的应用,获得了很好的临床效果,近几年来被逐渐应用于妊娠时间更长的妇女流产。本文就米非司酮配伍米索前列醇用于终止早期及中期妊娠的作用机制、临床有效性及安全性等加以综述。     

米非司酮配伍米索前列醇终止10～15周末妊娠的临床观察

目的:讨论米非司酮配伍米索前列醇终止10～15周末早中期妊娠的安全性和有效性。方法:选择妊娠10～15周末自愿行药物流产的健康孕妇50例运用米非司酮顿服200mg,48h后顿服米索前列醇0.6mg,结合米索前列醇根据孕周大小阴道后穹窿给药终止妊娠的方法,观察流产的有效性和安全性。结果:50例中,47例无需手术,占94.0%,3例仅需做清宫术,占6.0%,并且50例经随访无宫腔粘连、闭经、月经稀发等并发症。结论:米非司酮配伍米索前列醇终止10～15周末妊娠是安全有效易行的。     

Investigation and Control of Anthrax Outbreak at the Human–Animal Interface,Bhutan, 2010

In 2010, we investigated anthrax outbreak in Bhutan. A total of 43 domestic animals died, and cutaneous anthrax developed in 9 persons, and 1 died. All affected persons had contact with the carcasses of infected animals. Comprehensive preparedness and response guidelines are needed to increase public awareness of anthrax in Bhutan.     

Risk for Travel-associated Legionnaires’ Disease,Europe, 2009

Legionnaires’ disease is underreported in Europe; notification rates differ substantially among countries. Approximately 20% of reported cases are travel-associated. To assess the risk for travel-associated Legionnaires’ disease (TALD) associated with travel patterns in European countries, we retrieved TALD surveillance data for 2009 from the European Surveillance System, and tourism denominator data from the Statistical Office of the European Union. Risk (number cases reported/number nights spent) was calculated by travel country. In 2009, the network reported 607 cases among European travelers, possibly associated with 825 accommodation sites in European Union countries. The overall risk associated with travel abroad was 0.3 cases/million nights. We observed an increasing trend in risk from northwestern to southeastern Europe; Greece had the highest risk (1.7). Our findings underscore the need for countries with high TALD risks to improve prevention and control of legionellosis; and for countries with high TALD risks, but low notification rates of Legionnaires’ disease to improve diagnostics and reporting.     

Travel-associated Diseases,Indian Ocean Islands, 1997–2010

Data collected by the GeoSentinel Surveillance Network for 1,415 ill travelers returning from Indian Ocean islands during 1997–2010 were analyzed. Malaria (from Comoros and Madagascar), acute nonparasitic diarrhea, and parasitoses were the most frequently diagnosed infectious diseases. An increase in arboviral diseases reflected the 2005 outbreak of chikungunya fever.     

Haemophilus ducreyi Associated with Skin Ulcers among Children,Solomon Islands

During a survey of yaws prevalence in the Solomon Islands, we collected samples from skin ulcers of 41 children. Using PCR, we identified Haemophilus ducreyi infection in 13 (32%) children. PCR-positive and PCR-negative ulcers were phenotypically indistinguishable. Emergence of H. ducreyi as a cause of nongenital ulcers may affect the World Health Organization’s yaws eradication program.     

Dengue Virus Transmission by Blood Stem Cell Donor after Travel to Sri Lanka; Germany, 2013

Three days after donation of peripheral blood stem cells to a recipient with acute myeloblastic leukemia, dengue virus was detected in the donor, who had recently traveled to Sri Lanka. Transmission to the recipient, who died 9 days after transplant, was confirmed.     

Long-Term Survival Among Histological Subtypes in Advanced Epithelial Ovarian Cancer: Population-Based Study Using the Surveillance,Epidemiology, and End Results Database

BackgroundActual long-term survival rates for advanced epithelial ovarian cancer (EOC) are rarely reported.ObjectiveThis study aimed to assess the role of histological subtypes in predicting the prognosis among long-term survivors (≥5 years) of advanced EOC.MethodsWe performed a retrospective analysis of data among patients with stage III-IV EOC diagnosed from 2000 to 2014 using the Surveillance, Epidemiology, and End Results cancer data of the United States. We used the chi-square test, Kaplan–Meier analysis, and multivariate Cox proportional hazards model for the analyses.ResultsWe included 8050 patients in this study, including 6929 (86.1%), 743 (9.2%), 237 (2.9%), and 141 (1.8%) patients with serous, endometrioid, clear cell, and mucinous tumors, respectively. With a median follow-up of 91 months, the most common cause of death was primary ovarian cancer (80.3%), followed by other cancers (8.1%), other causes of death (7.3%), cardiac-related death (3.2%), and nonmalignant pulmonary disease (3.2%). Patients with the serous subtype were more likely to die from primary ovarian cancer, and patients with the mucinous subtype were more likely to die from other cancers and cardiac-related disease. Multivariate Cox analysis showed that patients with endometrioid (hazard ratio [HR] 0.534, P<.001), mucinous (HR 0.454, P<.001), and clear cell (HR 0.563, P<.001) subtypes showed better ovarian cancer-specific survival than those with the serous subtype. Similar results were found regarding overall survival. However, ovarian cancer–specific survival and overall survival were comparable among those with endometrioid, clear cell, and mucinous tumors.ConclusionsOvarian cancer remains the primary cause of death in long-term ovarian cancer survivors. Moreover, the probability of death was significantly different among those with different histological subtypes. It is important for clinicians to individualize the surveillance program for long-term ovarian cancer survivors.     

Outbreak of Panton-Valentine Leukocidin–Associated Methicillin-Susceptible Staphylococcus aureus Infection in a Rugby Team,France, 2010–2011

Staphylococcus aureus strains that produce Panton-Valentine leukocidin are known to cause community infections. We describe an outbreak of skin abscesses caused by Panton-Valentine leukocidin–producing methicillin-susceptible S. aureus (clonal complex 121) in a professional rugby team in France during July 2010–February 2011. Eight team members were carriers; 7 had skin abscesses.     

大龄单身女性寻求生育力保存的伦理问题探析

近年来,在肿瘤和卵巢相关疾病发生率逐年增加、不少大龄单身女性渴望为自己购买一份“生殖保险”等社会及个人因素催化下,人类对于生育力保存的需求急剧增加,满足这一需求正在或将成为重大挑战。对于寻求进行生育力保存的大龄单身女性来说,在合适的年龄应用玻璃化冷冻技术将其卵母细胞冻存是目前可采用的最佳生育力保存手段。而单身女性卵子冷冻将面临来自伦理道德、社会乃至法律的巨大挑战。本文概述国内外大龄单身女性卵子冷冻的现状,并对其可能涉及的相关伦理问题及解决途径进行综述,以促进理性正视单身女性卵子冷冻问题。     

Reemergence and Autochthonous Transmission of Dengue Virus,Eastern China, 2014

In 2014, 20 dengue cases were reported in the cities of Wenzhou (5 cases) and Wuhan (15 cases), China, where dengue has rarely been reported. Dengue virus 1 was detected in 4 patients. Although most of these cases were likely imported, epidemiologic analysis provided evidence for autochthonous transmission.