共查询到20条相似文献,搜索用时 46 毫秒
1.
Background
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in survival signaling. FAK has been shown to be overexpressed in breast cancer tumors at early stages of tumorigenesis. 相似文献2.
Introduction
Research has been limited in circadian activity rhythms and their relationship with health status in early-stage breast cancer survivors. Maintaining strong circadian parameters may reduce symptoms and improve physical functioning and disease-free survival. 相似文献3.
K.L. Prenzel A.H. Hölscher U. Drebber M. Agavonova C.A. Gutschow E. Bollschweiler 《European journal of surgical oncology》2012
Introduction
Nodal micrometastasis is a negative prognosticator for esophageal cancer. There is a trend toward endoscopic resection for early cancer of the esophagus without lymphadenectomy. Frequency and prognostic impact of nodal micrometastasis in early cancer of the esophagus have not been investigated so far.Patients and methods
This study includes 69 patients with a pT1-stage cancer of the esophagus (SCC: n = 26, AC: n = 43), who underwent transthoracic en-bloc esophagectomy with D2-lympadenectomy between 1996 and 2004. On routine histopathological analysis 48 patients were diagnosed as pN0. Lymph nodes (n = 1344) of these patients were further examined for the presence of isolated tumor cells with the monoclonal anti-epithelial antibody AE1/AE3.Results
In lymph nodes of 7 (14.6%) out of 48 pN0-patients a positive staining for AE1/AE3 as a sign for nodal micrometastasis was found. In these patients the tumor has infiltrated the submucosal layer. In patients with tumors restricted to mucosal layer (n = 20) no nodal micrometastasis was present. 5-year survival of pN0-patients with nodal micrometastasis was inferior compared to pN0-patients (57% vs. 82%; p = 0.002).Conclusion
Almost 15% of patients with pT1 N0 M0 carcinoma of the esophagus and only those with submucosal infiltration show nodal micrometastasis. It has a significant negative impact on survival already in early esophageal cancer. 相似文献4.
Fabio Parisi Ana M González Yasmine Nadler Robert L Camp David L Rimm Harriet M Kluger Yuval Kluger 《Breast cancer research : BCR》2010,12(5):R66
Introduction
Multi-marker molecular assays have impacted management of early stage breast cancer, facilitating adjuvant chemotherapy decisions. We generated prognostic models that incorporate protein-based molecular markers and clinico-pathological variables to improve survival prediction. 相似文献5.
Ying Gao Nan Hu XiaoYou Han Carol Giffen Ti Ding Alisa Goldstein Philip Taylor 《BMC cancer》2009,9(1):269
Background
Family history (FH) by different relative types and risk of upper gastrointestinal (UGI) cancers has been only rarely reported; the data on UGI cancer survival are sparse. 相似文献6.
Jochim S Terhaar sive Droste Frank A Oort René WM van der Hulst Veerle MH Coupé Mike E Craanen Gerrit A Meijer Linde M Morsink Otto Visser Roy LJ van Wanrooij Chris JJ Mulder 《BMC cancer》2010,10(1):332
Background
Diagnosing colorectal cancer (CRC) at an early stage improves survival. To what extent any delay affects outcome once patients are symptomatic is still unclear. 相似文献7.
Background
We evaluated if the survival benefit of adding rituximab to standard chemotherapy for non-Hodgkin lymphoma (NHL) observed in clinical trials has been experienced by an Australian NHL patient population. 相似文献8.
Gordon C Wishart Elizabeth M Azzato David C Greenberg Jem Rashbass Olive Kearins Gill Lawrence Carlos Caldas Paul DP Pharoah 《Breast cancer research : BCR》2010,12(1):R1
Introduction
The aim of this study was to develop and validate a prognostication model to predict overall and breast cancer specific survival for women treated for early breast cancer in the UK. 相似文献9.
Roos DE Smith JG Stephens SW 《Clinical oncology (Royal College of Radiologists (Great Britain))》2011,23(9):646-651
Aims
This randomised non-inferiority trial was designed to assess whether radiosurgery plus adjuvant whole brain radiotherapy (RS + WBRT) is as effective as surgery plus whole brain radiotherapy (S + WBRT) for cancer patients with a solitary brain metastasis, with respect to overall survival and quality of life.Materials and methods
Major inclusion criteria were a history of systemic cancer within 5 years and enhanced magnetic resonance imaging-confirmed solitary brain metastasis suitable for both radiosurgery and surgery. All patients were to receive WBRT (30 Gy in 10 fractions). Between February 2003 and April 2009, 40 patients were considered eligible, 22 consented to randomisation and 21 were analysed (11 RS + WBRT, 10 S + WBRT). The trial was closed early due to slow accrual.Results
The estimated median overall survival times for RS + WBRT and S + WBRT patients were 6.2 and 2.8 months, respectively (hazard ratio 0.53, 95% confidence interval 0.20–1.43, P = 0.20). Corresponding median failure-free survival times were 3.1 and 1.7 months (P = 0.20). For 19 ‘per protocol’ patients, 2/10 in the RS + WBRT arm had distant intracranial failure (one also had local failure) and 3/9 S + WBRT patients had distant intracranial failure (no local failures). There were no grade 3–4 late radiation toxicities. Two months after starting treatment there were no significant differences in quality of life between the arms.Conclusion
This randomised trial encountered the accrual difficulties and consequent low statistical power commonly associated with interdisciplinary studies drawing from a small eligible population, but can contribute to future overviews on the management of solitary brain metastases. 相似文献10.
Introduction
Much recent work has focused on hypotheses that very early life exposures influence adult cancer risk. For breast cancer it has been hypothesized that high in utero estrogen exposure may increase risk. 相似文献11.
Peter Stadler Kurt Putnik Thore Kreimeyer Lisa D Sprague Oliver Koelbl Christof Sch?fer 《BMC cancer》2006,6(1):279
Background
The advantage of hyperfractionated accelerated radiation therapy for advanced head and neck cancer has been reported. Furthermore, randomized trials and meta-analyses have confirmed the survival benefit of additional chemotherapy to radiotherapy. We retrospectively analyzed the efficiency and toxicity of the Regensburg standard therapy protocol "SCHARC" and the overall survival of our patients. 相似文献12.
Objective
The aim of this study was to compare the serum CA125 regression in advanced ovarian carcinoma patients treated with paclitaxel/platinum (TP) and platinum/epirubicin/ifosfamide (PAC) during early chemotherapy. The relationship between survival and CA125 regression during first line chemotherapy was evaluated. 相似文献13.
Erin E. Kent Leonard S. Sender Joan A. Largent Hoda Anton-Culver 《Cancer causes & control : CCC》2009,20(8):1409-1420
Objective
In California, leukemia represents ~35, 5, and 2% of all cancers in children (aged 0–14), adolescents (15–29), and young adults (30–39), respectively. Poorer survival has been previously noted in individuals residing in lower socioeconomic status (SES) neighborhoods. We explored the relationship between SES and survival as modified by age and race/ethnicity using data from the California Cancer Registry. 相似文献14.
Background
Validation of the use of the lognormal model for predicting long-term survival rates using short-term follow-up data. 相似文献15.
Jørgen Aarøe Torbjørn Lindahl Vanessa Dumeaux Solve Sæbø Derek Tobin Nina Hagen Per Skaane Anders Lönneborg Praveen Sharma Anne-Lise Børresen-Dale 《Breast cancer research : BCR》2010,12(1):R7
Introduction
Early detection of breast cancer is key to successful treatment and patient survival. We have previously reported the potential use of gene expression profiling of peripheral blood cells for early detection of breast cancer. The aim of the present study was to refine these findings using a larger sample size and a commercially available microarray platform. 相似文献16.
17.
Stephanie E Combs Steffen Heeger Renate Haselmann Lutz Edler Jürgen Debus Daniela Schulz-Ertner 《BMC cancer》2006,6(1):133
Background
The implementation of combined radiochemotherapy (RCHT) with temozolomide (TMZ) has lead to a significant increase in overall survival times in patients with Glioblastoma multiforme (GBM), however, outcome still remains unsatisfactory. 相似文献18.
Maryam Zare Ferdous Rastgar Jazii Mohammad Reza Alivand Negin Karimi Nasseri Reza Malekzadeh Mansour Yazdanbod 《BMC cancer》2009,9(1):24
Background
Squamous cell carcinoma of esophagus (SCCE) occurs at a high incidence rate in certain parts of the world. This feature necessitates that different aspects of the disease and in particular genetic characteristics be investigated in such regions. In addition, such investigations might lead to achievement of molecular markers helpful for early detection, successful treatment and follow up of the disease. Adenomatous Polyposis Coli (APC) promoter hypermethylation has been shown to be a suitable marker for both serum and solid tumors of adenocarcinoma of esophagus. We investigated the status of APC promoter hypermethylation in Iranian patients, compared the results with the former studies, and evaluated its applicability as a candidate molecular marker by examining association between survival of SCCE patients and APC promoter methylation. 相似文献19.
Yu GP Mehta V Branovan D Huang Q Hashibe M Zhang ZF Schantz SP 《Cancer causes & control : CCC》2012,23(1):153-164
Objective
To examine if survival has changed over the last 20 years in patients with base of tongue and tonsil cancers in the United States. 相似文献20.