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1.
The effects of sex steroid hormones on the level of plasma lipid peroxidation are studiedin vitro. Estradiol shows pronounced antioxidative activity; progesterone and testosterone slightly suppress lipid peroxidation only
when used in high concentrations.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 73–76, July, 1997 相似文献
2.
Effects of sex steroid hormones on lipid peroxidation and glutathione antioxidant system in rat skin
P. V. Sergeev T. V. Ukhina N. L. Shimanovskii 《Bulletin of experimental biology and medicine》1999,128(6):1235-1238
Effects of estradiol and testosterone on the intensity of lipid peroxidation and contents of glutathione redox system components
in the dermis and epidermis of rat skin were studied. Only estradiol induced considerable dose-dependent and tissue-specific
biphasic antioxidant effects on the skin.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 12, pp. 663–666, December, 1999 相似文献
3.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(2):126-131
The relationship between the intensity of lipid peroxidation and the activity of the antioxidant system in the heart, liver,
and brain is studied in male Wistar rats with low and high resistance to hypoxia tested by being “raised” to an altitude of
11.5 km and in intact outbred rats. It is found that in all groups of rats the content of lipid peroxidation products is highest
in the liver, lower in the heart, and lowest in the brain. In all groups, the rate of the ascorbate-induced lipid peroxidation
is highest in the brain, lower in the liver, and lowest in the heart. The activity of the antioxidant system is highest in
the brain, lower in the liver, and lowest in the heart of low-resistance and outbred rats, while in high-resistance rats it
is the same in all the organs. Thus, the difference in the parameters of lipid peroxidation and, particularly, of the antioxidant
system in the studied organs is most pronounced in rats with a low resistance to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 138–143, February, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
4.
I. E. Zimakova R. R. Salikhova T. S. Tagirova R. S. Garaev R. A. Kamburg O. B. Ibragimov M. B. Kondrat'eva 《Bulletin of experimental biology and medicine》1996,121(5):484-486
Daily 18-hour hypokinesia induces atherogenic shifts in the blood lipid spectrum and activates lipid peroxidation in rats.
Mebicar is shown to have a correcting effect on lipid metabolism and on the intensity of lipid peroxidation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 535–537, May, 1996 相似文献
5.
Thermal ischemia of rat kidneys for 30 min induces lipid peroxidation with simultaneous activation of Ca-dependent ATPase
in microsomes. In the presence of the channel-forming antibiotic alamethicin this activity decreases, indicating an increased
passive permeability of the membrane vesicles for Ca2+ and ATP with a decrease in the true activity of the enzyme after ischemia. α-Tocopherol reduces the intensity of lipid peroxidation
in the microsome fraction isolated from kidneys after thermal ischemia and protects ATPase activity in the presence and absence
of alamethicin in the incubation medium. It is suggested that peroxidation of membrane phospholipids activated by thermal
ischemia is one of the causes of decreased true activity of Ca-dependent ATPase and increased passive permeability of the
kidney membranes for Ca2+ and ATP.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 9, pp. 289–291, September, 1997 相似文献
6.
G. L. Ignatova I. A. Volchegorskii E. G. Volkova O. L. Kolesnikov 《Bulletin of experimental biology and medicine》1997,124(2):800-801
The content of products of lipid peroxidation and antioxidative activity were measured in exhaled air condensate and blood
sera of patients with chronic bronchitis. Exacerbation of purulent bronchitis was found to be associated with an increase
of heptane-soluble products of lipid peroxidation in serum and condensate, which was not observed in patients with catarrhal
bronchitis. In catarrhal bronchitis, the content of heptane-soluble products is increased only in the serum; antioxidative
activity increased in exhaled air condensate in catarrhal bronchitis and decreased in serum and condensate in purulent bronchitis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 202–204, August, 1997 相似文献
7.
K. T. Momynaliev V. M. Govorum O. M. Panasenko V. I. Sergienko 《Bulletin of experimental biology and medicine》1996,121(5):468-470
The effect of cholesterol on hypochlorite-induced lipid peroxidation is studied in cholesterol-phosphatidylcholine liposomes.
Cholesterol is shown to promote the accumulation of lipid peroxidation products in the presence of 0.1–3 mM hypochlorite anion
in the incubation medium. The content of 2-thiobarbituric acid-reactive products is maximal at a cholesterol: phosphatidylcholine
molar ratio of 1∶1. On the other hand, in the presence of low hypochlorite concentrations (10–100 μM) cholesterol is found
to inhibit lipid peroxidation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 516–519, May, 1996 相似文献
8.
K. N. Kontorshchikova T. I. Solov'eva 《Bulletin of experimental biology and medicine》1996,121(2):148-150
Clinical death of outbred albino rats ensues after rapid blood loss due to a cut in the coronary coronary artery. Five minutes
later, the isolated heart is perfused with ozonized Krebs-Henseleit solution. The activity of the antioxidant system in the
heart is increased compared with that during routine oxygenation. The intensity of lipid peroxidation assessed by the intensity
of chemiluminescence and the amount of lipid peroxidation products is significantly decreased during ozonization.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, № 2, pp. 161–163, February, 1996
Presented by B. A. Korolev, Member of the Russian Academy of Medical sciences 相似文献
9.
A. D. Nozdrachev A. N. Zhekalov R. I. Kovalenko V. P. Galantsev A. A. Molchanov A. E. Sosyukin E. A. Popov V. V. Malinin 《Bulletin of experimental biology and medicine》1997,124(6):1225-1228
Changes in the intensity of lipid peroxidation and serum activities of superoxide dismutase and catalase were similar after
18-month adaptation to new ecological conditions of soldiers serving in two different regions. All values increased and reached
the maximum by the 6th month, after which they stabilized; catalase activity decreased after 6 months.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 678–682, December, 1997 相似文献
10.
T. G. Sazontova Yu. V. Arkhipenko F. Z. Meerson 《Bulletin of experimental biology and medicine》1995,120(1):687-690
The relationship between the level of accumulation of lipid peroxidation products and the status of the Ca2+-transporting system in the sarcoplasmic reticulum of the rat myocardium is studied against the background of two cardioprotective
factors, namely adaptation to periodic hypoxia and a diet enriched in polyunsaturated fatty acids of the ω-3 class. It is
shown that the diet leads to an increase of level of lipid peroxidation products by 1.8 times in the heart and by 19 times
in the liver, whereas a adaptation has no effect on the level of lipid peroxidation products in either of these organs. At
the same time, the combined action of both factors considerably enhances the resistance of the myocardial Ca2+-transporting system to free radical-induced oxidation. Inin vitro experiments it is shown that adaptation to periodic hypoxia results in a more than twofold deceleration of Ca2+ transport inhibition during the oxidation induction by the Fe2+/ascorbate system; the diet causes a 3.5-fold deceleration of such inhibition. The results show that the accumulation of a
high level of lipid peroxidation products is not always followed by damage to the Ca2+-transporting system in the myocardial sarcoplasmic reticulum.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
7, pp. 42–45, July, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
11.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(1):22-25
Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high
and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are
found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products
is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance
to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming
that oxidation plays a major role in the damaging and lethal effects of acute hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp 26–29, January, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
12.
A. P. Vlasov V. A. Trofimov T. V. Tarasova G. Yu. Sudakova V. N. Poderov I. V. Saushev O. Yu. Rubtsov T. N. Dubovskaya S. V. Aksenova 《Bulletin of experimental biology and medicine》2000,129(1):24-26
The severity of endotoxemia in peritonitis depends on morphofunctional state of the intestine determined by the intensity
of free-radical lipid peroxidation and phospholipase A2 activity, which are the highest on day 1 postoperation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 31–33, January, 2000 相似文献
13.
V. D. Slepushkin N. N. Mikhailova I. V. Egorov A. V. Kiseleva 《Bulletin of experimental biology and medicine》1999,127(4):350-354
Effect of melatonin on antioxidant activity and lipid peroxidation in blood, heart, liver, and brain was studied in rats exposed
to traumatic shock. Melatonin exerted a potent modulatory effect on antioxidant enzyme activity. Its efficacy depended on
organ sensitivity to oxygen deficiency under conditions of traumatic shock.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 387–391, April, 1999. 相似文献
14.
Repeated (5-fold) intraperitoneal injections of 5×10−9 mol/kg endothelin-1 inhibited DNA synthesis in tracheal epitheliocytes and activated lipid peroxidation in the lungs of newborn
rats. Endothelin-1 in a dose of 5×10−8 mol/kg stimulated proliferative activity of tracheal smooth muscle cells and intensified lipid peroxidation in the blood,
which aggravated observed changes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 3, pp. 294–296, March. 2000 相似文献
15.
V. A. Myshkin Z. G. Khaibullina S. A. Bashkatov V. P. Krivonogov D. A. Enikeev 《Bulletin of experimental biology and medicine》1995,120(2):785-788
Three pyrimidine derivatives — methyluracil, hydroxymethacil (a new compound), and its lithium salt — were tested in model
systems of differing complexity for antioxidant properties in comparison with the well-known antioxidant ionol. Tests for
antiradical activity and for effects on spontaneous and Fe2+-ascorbate- or NADPH-dependent lipid peroxidation revealed high antioxidant activity (comparable to that of ionol) of the
hydroxymethacil lithium salt.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
8, pp. 142–144, August, 1995
Presented by G.N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
16.
A. P. Shepelev A. V. Shestopalov A. A. Ryndich I. M. Staviskii 《Bulletin of experimental biology and medicine》1996,122(1):712-713
The content of lipid peroxidation products increases in lipids isolated fromShigella sonnei after heating. Thermoresistant strains are characterized by higher activity of superoxide dismutase and catalase and by stable
activity of glutathione reductase and glutathione transferase compared with thermolabile strains. Thermoresistant strains
are also resistant to some antibiotics and hydrogen peroxide.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 69–71, July, 1996 相似文献
17.
G. I. Bisharova L. I. Kolesnikova V. V. Malyshev 《Bulletin of experimental biology and medicine》1998,126(3):947-949
A comparative study of the parameters of free-radical lipid peroxidation and antioxidant system was performed in children
living in the North for various time periods. Intense lipid peroxidation was shown to be the key factor in the pathogeneses
of several diseases caused by disturbances in the cellular membrane. Decreased resistance of red blood cells to peroxidative
hemolysis is a phenomenon characterizing the adaptation-violating processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 342–344, September, 1998 相似文献
18.
S. K. Soodaeva E. A. Ostrakhovich A. V. Kozlov B. T. Velichkovskii 《Bulletin of experimental biology and medicine》1994,118(2):834-836
The iron content, the state of the serum antioxidant system, and their relationship with the changes in lipid peroxidation
in rat liver and lungs at the early stages of chrysotile-asbestos action, and the effect of the naturally occurring flavonoid
rutin are studied. Intensification of lipid peroxidation in the liver and lungs and an increase in the oxyproline content,
which correlates with the rise in serum antioxidant activity, are observed four weeks after a single intratracheal administration
of 50 mg asbestos. The total serum iron content remains unchanged. Rutin has a pronounced anti-asbestos effect, inhibits the
early stages of fibrosis, and facilitates normalization of the antioxidant system imbalance induced by asbestos.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
8 pp. 145–147, August, 1994 相似文献
19.
U. R. Farkhutdinov R. R. Farkhutdinov 《Bulletin of experimental biology and medicine》2000,129(3):219-222
Lipid peroxidation in the lungs and plasma of albino rats was studied under normal conditions and during experimental pneumonia.
In intact rats the content of lipid peroxidation products and the rate of their accumulation in lung homogenate is lower than
in homogenates of other organs. Bivalent iron ions added to blood plasma did not induce chemiluminescence characteristic of
lipid peroxidation. Experimental pneumonia intensifies production of active oxygen forms by alveolar macrophages and blood
neutrophils and increases the content of lipid peroxidation products in lung homogenate. Combined application of antibiotics
and antioxidant (vitamin E) during experimental pneumonia promotes normalization of free-radical oxidation and diminishes
morphological alterations in the lungs.
Translated fromByulleten' Eksperimental'noi Biologii i Medistiny, Vol. 129, No. 3, pp. 260–264, March, 2000 相似文献
20.
A. A. Vishnevskii G. A. Zakhrov V. M. Yakovlev G. I. Gorokhova L. S. Kostyuchenko 《Bulletin of experimental biology and medicine》1995,120(2):779-781
Vascular spasm, hypertrophy of cardiac muscle cells, and necrotic changes in the myocardial tissue of rats administered norepinephrine
in incremental doses over 14 days were accompanied by a considerable activation of lipid peroxidation and a weakening of antioxidant
defense during the first 7 days of exposure to this injurious agent. On day 14, despite the greatly increased load of norepinephrine,
the concentrations of lipid peroxidation products and the activity of antioxidant enzymes deviated from their control values
to a lesser extent than on day 7. A similar change was shown by the concentration of brain tissue phosphatidylinositol-4,5-diphosphate,
a source of second messengers, suggesting that the phosphoinositide system of second messengers is involved in the mechanisms
whereby the destructive effects of norepinephrine are mitigated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
8, pp. 137–139, August, 1995
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献