板层状鱼鳞病1例

1　临床资料　患儿男 ,3岁。因全身皮肤反复红斑、脱屑 2年就诊。其母诉患儿出生后 ,全身皮肤干燥 ,但无红斑鳞屑。半岁时全身皮肤出现红斑 ,有少量细薄干燥鳞屑 ,无丘疹水疱 ,无糜烂渗液 ,继而红斑逐渐融合成片 ,鳞屑变大呈多角形或四方形 ,反复发作至今。 1岁半时 ,患儿出现双下眼睑外翻 ,十指指甲增厚。患儿系足月顺产 ,母孕期无上感及特殊用药史。父母非近亲婚配 ,家族中无类似皮肤病史。体检 :发育较差 ,体重 12kg。皮肤科情况 :头发较黄 ,头皮上覆细薄干燥鳞屑 ,全身皮肤除生殖器外弥漫性潮红、干燥 ,上覆大片多角形或方形淡黄色疏松…     

斑驳病

患儿女,10个月. 主诉:额部白斑10个月. 现病史:患儿于出生时额部出现白斑,呈菱形,边界清楚,无明显鳞屑,皮损中央可见2 处正常皮岛,受累区部分头发、眉毛变白.躯干四肢未见白斑或色素沉着斑.额部白斑的面积随患儿长大而扩大.未见患儿摩擦或搔抓皮损.患儿发育正常.     

毛发管型一例

<正>临床资料患儿,女,7岁。因头发附着物2个月,于2013年6月10日就诊。2个月前家长发现其头发上有白色附着物,不易去除,无瘙痒等不适。患儿平素扎马尾。既往体健。体格检查:发育正常,发黑,疏密可,有光泽,头皮无红斑、丘疹、鳞屑。距头皮2~3cm处头发上可见2 mm长的白色附着物紧密包绕发     

儿童泛发性环状扁平苔藓1例及皮肤CT影像特征

正1病历摘要患儿男,9岁。全身红褐色环状斑丘疹1年,于2014年12月29日就诊。患儿1年前无明显诱因腹部出现黄豆大红色鳞屑性丘疹,不断增多,并向背部及四肢扩展,之后丘疹呈离心性向外扩大,部分皮损中央皮肤正常,部分皮损遗留色素沉着斑,无自觉症状。曾外用药膏(不详)治疗,皮损无明显消退。既往体健,家族中无类似疾病患者。     

无汗性外胚叶发育不良伴巨大型环状肉芽肿1例

报告1例无汗性外胚叶发育不良伴巨人型环状肉芽肿,患儿男,8岁,出生后从未出过汗,头部,面部,躯干,四肢散在直径2～20cm淡红色环状斑块1年,体格检查可见头发稀疏,鞍状鼻,臼状门齿,锥状尖牙,组织病理诊断,环状肉芽肿。     

婴儿花斑癣1例

患儿男， 54天。因额部淡褐色斑 34天，于 1999年 7月 9日就诊。患儿生后 20天其母发现患儿额部呈粟粒大小圆形点状斑疹，表面有细薄鳞屑，渐发展为黄豆大淡褐色圆形斑，数目增多，未作治疗。家族史：患儿祖母胸背部有类似损害，并与患儿有接触史。皮肤科情况：患儿前额、眉间、眉毛中、鼻梁部均可见密集分布的粟粒至黄豆大圆形淡褐色斑，边缘清楚，表面覆以少许糠秕样鳞屑。实验室检查：刮取患儿皮损鳞屑涂片镜检，见典型的弧形菌丝和成簇圆形厚壁孢子。沙堡氏琼脂培养基培养阳性。同时刮取其祖母胸部皮损鳞屑涂片镜检和培养，结果与患儿相…     

伴有自身免疫异常的环状红斑

环状红斑(Annular Erythema,AE)是临床常见的皮疹,可出现于多种疾病。近年来人们注意到有些AE伴有明显自身免疫异常。这类AE的基本表现是,初为小片界限清楚、轻度浸润的水肿性红斑,逐渐扩大,中央趋于消退而成环状;并可融合呈多环状和回状。表面平滑,或附有少许鳞屑。皮疹数量多少不等,分布于面颈、胸背和四肢。通     

猪小孢子菌所致婴儿脓癣并体癣一例

患儿男,２．５个月,因头顶部斑块,颈部圆形皮疹１个月就诊。其母诉１９９７年１月患儿头顶部出现蚕豆大斑块,渐增大、变软并毛发脱落。颈部黄豆大红色斑疹逐渐扩大呈环状。在当地诊所给中药粉外用及青霉素注射均无效,遂来我院就诊。体检：一般情况好,患儿肥胖,多汗,各系统检查无异常。皮肤科情况：左侧额顶部１２cm×１０cm边界尚清之圆形斑片,周边稍高起,其上散在约蚕豆大斑块数块,边缘有波动感,部分已破溃,上覆黄色粘稠脓性分泌物及痂皮,并可见断发、脱发,毛发极易拔掉（图１）。右侧颈部１cm×１cm大小环状鳞屑斑,色红,…     

落叶型天疱疮1例

正1临床资料患者男,47岁。全身红斑、水疱、鳞屑2月,加重伴发热、畏寒1月。患者2月前无明显诱因首先在双耳皮肤出现散在水疱伴轻微瘙痒,未予重视,皮损逐渐增多,泛发全身,水疱很快破裂,破裂后出现糜烂面、鳞屑,渗出较多,并发出恶臭味,1月前病情加重,并伴有发热畏寒,为中低度热,水疱基本干涸,出现弥漫性红斑、暗红斑。鳞屑不断片状脱落,头皮见厚层鳞屑,头发呈束状。既往体健,家族中无类似患者。体检:系统     

播散性浅表汗孔角化病并发寻常性银屑病

报告2例播散性浅表汗孔角化病并发寻常性银屑病.例1.男,53岁.头部、下肢红斑鳞屑3年,环形斑块1年.皮肤科检查:头皮鳞屑性红斑,面部、臀部散在边缘堤状隆起而中央轻度萎缩的褐色环状斑块.例2.男,37岁.全身红斑、鳞屑8年,环形斑块2年.皮肤科检查:头皮鳞屑性红斑,躯干、四肢鳞屑性红斑与边缘堤状隆起而中央轻度萎缩的褐色环状斑块混杂分布,两例患者红斑鳞屑性皮损经组织病理检查均符合寻常性银屑病,褐色环状斑块改变均见下方颗粒层消失的柱状角化不全,符合播散性浅表汗孔角化病.诊断:播散性浅表汗孔角化病并发寻常性银屑病.文中对银屑病并发汗孔角化病的可能原因进行了讨论.     

以红皮病为首发症状的艾滋病一例

患者，男，40岁。全身皮肤潮红、脱屑伴瘙痒1个月。患者既往无湿疹、银屑病病史。查体：全身弥漫性潮红，表面覆盖黄白色细碎鳞屑，口周、眼周可见裂隙伴渗出，双足背覆盖袜套样黄色、褐色样鳞屑，可见痂样结构。HIV抗体初筛及确诊试验阳性。诊断为艾滋病、红皮病。     

Depigmented haloes associated with the involution of flat warts

Depigmented haloes developed around involuting flat warts in two patients whose warts were treated with a 6% salicylic acid-propylene glycol gel formulation. The clinical picture was indistinguishable from that seen in halo naevus.     

Oval cells and cystic structures in multiplication of M leprae

Ten preserved biopsy suspensions from leprosy patients were inoculated in biphasic medium and incubated alternatively in refrigerator and at 37 °C. The cultures were observed every week for 3 months. The typical actinomycetoid growth appeared within 3-5 days. Microscopically, two types of cysts (unstained and dark) were seen along with oval cells. Dark cysts showed developement of irregular septae or cracks breaking the mass into irregular quadrangular pieces. Granular acid-fast material could be made out inside the cracks and around the cysts. Oval cells were seen either independently or organised around pink homogeneous material. The oval cells were stained blue or pink. Some of them showed both blue and pink shades.     

Treponema pallidum in peripheral nerve tissue of syphilitic chancres

Biopsies for electron microscopy were obtained from syphilitic chancres of 7 patients, 6 males and one female. In 4 of the patients, Treponemata pallida were seen gathering around peripheral nerves and invading the spaces between Schwann cells and their basal lamina. No definite degenerative changes were seen in the axons. In all patients, Treponemata pallida were gathering around the small blood vessels. The fine structure of Treponema pallidum in the lesions included a twined cytoplasmic cylinder with an inner and an outer lamina, an axial fibril consisting of three to five parallel filaments, each consisting of six microtubules, and a covering, outpouching periplastic membrane.     

增生性外毛根鞘瘤

报告1例增生性外毛根鞘瘤.患者女,58岁.头皮出现红色结节,不痛不痒,逐渐增大30年.皮损组织病理检查:真皮内可见大小不等由鳞状细胞组成的瘤细胞团块,部分瘤细胞胞质淡染,周围呈栅栏状排列;部分瘤细胞周围可见增厚的基膜,瘤细胞周嗣有角化不良及角囊肿形成,外毛根鞘角化,肿瘤内及间质中可见钙化灶.     

Ultrastructuctural Characterization of the Extramammary Paget Cell Plasma Membrane: A Freeze – Fracture Study

The plasma membrane ultrastructure of the extramammary Paget cells was characterized by freeze-fracture electron microscopy, which was first employed for the study of Paget cells. The Paget cell plasma membrane revealed a flat fractured plane with much fewer and smaller desmosome-particle aggregations than those of the keratinocyte. No gap junctions were detected. Many intramembranous particle-free vesicles were seen in the intercellular spaces. Particle-free blebs projecting from the plasma membranes were seen on some cell surfaces. These features greatly differed from those of keratinocytes. On the other hand, an increase of gap junctions was noticed o the keratinocytes around or in the Paget's disease lesions.     

Ultrastructural study of iron deposition in the eccrine sweat glands of patients with iron overload

An ultrastructural study of eccrine sweat glands was carried out on three patients with iron overload (two with idiopathic haemochromatosis and one with transfusional haemosiderosis). In all three patients small electron-dense particles were seen in both eccrine sweat glands and macrophages. They appeared primarily in the clear cells of the eccrine sweat glands as membrane-bound irregularly shaped bodies, and were shown to contain iron by energy dispersive X-ray microanalysis. Iron aggregates in and around sweat glands were also seen on light microscopy.     

Immunohistochemical characterization of cellular infiltrates in epidermal tumors induced by two-stage and complete chemical carcinogenesis in mouse skin.

We investigated the population and pattern of the infiltrated cells in both benign and malignant epidermal tumors which were induced chemically with benzo(a)pyrene (B(a)P) in murine skin. In benign papillomas, which were evolved by a two stage carcinogenesis regimen, a slight to mild inflammatory infiltration around the tumors was observed, and cells infiltrating into the tumor nests were rarely seen. In carcinomas, which were produced by a complete carcinogenesis regimen, a dense inflammatory infiltration was observed around the tumor nests. The infiltrated cells were characterized as T-lymphocytes, macrophages, and neutrophils. Natural killer (NK) cells were found around and in the tumor nests, but their number was small. Both T-lymphocytes and macrophages were found to invade the tumor nests in squamous cell carcinoma whose duration was more than four weeks. This experimental carcinogenesis animal model allows the detailed quantitative and functional analysis of the infiltration of immunocompetent cells into epidermal tumors.     

Vulvar vestibulitis syndrome: a clinicopathological study of 14 cases

BACKGROUND: Vulvar vestibulitis syndrome (VVS) is one of the most frequent causes of superficial dyspareunia in young women. VVS has a pronounced psychological impact. The results of pathological studies published thus far are controversial. PATIENTS AND METHODS: Fourteen women with VVS were included in this study and underwent vestibular biopsy. Vulvar biopsies were taken from the orifice of Bartholin's gland. The biopsy samples were stained with a standard stain and PAS and 25 serial sections were prepared for each specimen. RESULTS: The mean patient age was 26 years and VVS had been present for a mean 30 months. Extensive inflammation of mononuclear cells was observed in the vulvar chorionic epithelium. This inflammation was seen mainly around the minor vestibular glands. Mild exocytosis of lymphocytes was noted in the vestibular glands and ducts. DISCUSSION: Most studies concerning this disease report chronic inflammation of the vulvar vestibular mucosa. This inflammation is seen mainly around the minor vestibular glands. We report the same pattern in our study. Moreover, we observed some exocytosis into the epithelium of minor vestibular glands and the excretory duct. This aspect has not been reported to date, further supporting the individual nature of this entity.     

Dissemination in Cutaneous Leishmaniasis

In a field study of cutaneous leishmaniasis (CL) due to Leishmania major, zymodeme Lon-4, in an endemic focus in Saudi Arabia, 80 patients in a group of 643 patients (12.44%) were found to have multiple, inflammatory, satellite papules (SP) around one or more CL lesions. The SP often appeared to erupt after commencement of antileishmanial treatment. They showed a range of morphology and pathology, and comparisons with corresponding CL lesions showed important differences. Amastigotes were seen in only one of seven biopsy specimens. Another morphologic feature, subcutaneous induration (SCI), was noted on routine palpation in 20 patients in the same patient group (3.11%). The SCI either was radiating all around the lesion and appeared as an "iceberg nodule" or was present as a "tonguelike" process proximal to the CL lesion. Amastigotes were seen in four of nine biopsy specimens of SCI. SP and SCI represent reactions to local dissemination of the parasite or its antigenic products, and as morphologic features aid in the clinical diagnosis of CL.