芒果致小儿接触性皮炎1例

1临床资料，患儿女，4岁，口周红斑，伴瘙痒2天。2天前患儿食用芒果，约3h后，发现口周皮肤略红，伴轻度瘙痒。     

吉非替尼引起丘疹脓疱样疹3例

1临床资料例1女,51岁,头皮红斑、丘疹、脓疱伴瘙痒及脱发5个月,加重1周。患者半年前在外院确诊为非小细胞肺癌脑部转移,予口服人类表皮生长因子受体抑制剂吉非替尼(Gefitinib),250 mg/d治疗。用药20 d后,枕部出现大小不一的红斑,其上散在针尖大小的丘疹及脓疱,伴瘙痒,后逐渐增多加重,红斑融合成片伴脱发及黄色渗液,瘙痒明显。     

度普利尤单抗治疗儿童特应性皮炎

报告1例度普利尤单抗治疗6岁儿童特应性皮炎。患儿女，6岁。因躯干和四肢红斑、丘疹伴渗出及瘙痒7个月，加重2个月就诊。皮肤科检查：躯干、四肢可见弥漫性红斑、丘疹、鳞屑及苔藓样斑块，伴渗出及结痂；双手掌可见红斑、水疱及大疱；足底、足跟部可见红斑、丘疹及斑块，伴渗出及结痂。予度普利尤单抗皮下注射治疗（首剂量300 mg，后每3周1次，每次300 mg治疗，治疗12周后改为每4周1次，每次300 mg），治疗后患儿躯干及四肢皮损大部分消退，无明显新发皮损，自觉瘙痒明显减轻。入院期间，患儿共接受度普利尤单抗治疗28周，治疗过程中无明显不良反应。后随访患儿2年，一直予度普利尤单抗维持治疗（每4周1次，每次300 mg），随访期间患儿全身无大面积皮损反复的情况，且无明显不良反应。     

误诊为阴囊湿疹的二期梅毒1例

患者男,23岁。阴囊红斑、鳞屑伴瘙痒1个月。初发皮损为阴囊暗红色浸润性红斑和片状鳞屑,自觉瘙痒,按阴囊湿疹治疗后皮疹增多,蔓延至阴茎,且瘙痒加剧。梅毒血清学试验:TPPA(+);RPR 1:64(+)。诊断:二期梅毒。予苄星青霉素驱梅治疗1周后皮损明显消退,瘙痒缓解。     

度普利尤单抗治疗难治性大疱性类天疱疮1例

患者男,62岁,全身红斑水疱伴瘙痒1年,伴背痛、无法行走2周.患者全身反复出现红斑伴瘙痒6年,曾诊断为湿疹,长期门诊治疗.1年前部分皮疹表面出现水疱,外院经组织病理和免疫病理确诊为大疱性类天疱疮,经糖皮质激素、免疫抑制剂、静脉注射免疫球蛋白多次治疗后皮疹仍时有反复,伴明显瘙痒.随后,尝试使用度普利尤单抗600 mg皮下...     

嗜酸性粒细胞增多性皮炎5例

1 临床资料例1女,48岁.全身反复出现红斑丘疹,伴瘙痒半年,加重1周.6月前患者躯干部出现较多红斑丘疹,伴瘙痒,约2周后皮损累及四肢,瘙痒加剧,夜不能眠.外院查外周血EOS 1.58×109/L,以"过敏性皮炎"收入院治疗,无效.有左眼视网膜出血黄斑病变史,否认食物、药物过敏史,家族无类似病史.体检:T 37℃,系统检查未见异常.     

单发于肛周的家族性良性天疱疮一例并家系调查

先证者女,36岁,因反复肛周红斑、糜烂、渗出伴瘙痒10余年就诊.10余年前患者肛周皮肤开始出现红斑伴瘙痒,搔抓后出现糜烂、渗出和结痂,无明显疼痛和水疱.长期反复发作,时轻时重.     

单发于肛周的家族性良性天疱疮一例并家系调查

先证者女,36岁,因反复肛周红斑、糜烂、渗出伴瘙痒10余年就诊.10余年前患者肛周皮肤开始出现红斑伴瘙痒,搔抓后出现糜烂、渗出和结痂,无明显疼痛和水疱.长期反复发作,时轻时重.     

红花油致接触性皮炎1例

患者男,45岁。因右腿红斑,血疱伴瘙痒,疼痛1周。于2004年9月来我科就诊。患者1周前因车祸导致右腿扭伤。自行外用红花油治疗（以前未外用过红花油）。外用后次日在接触部位出现牌状红斑,伴瘙痒,并很快在红斑上出现黑色血疱。部分为大血疱,伴疼痛,患者既往有血小板减不症病史40年（病因不明,未经系统诊治）发病以来无发势及其他全身症状,一般情况良好。     

妊娠期IgA天疱疮1例

临床资料患者女,27岁.因停经27周,全身反复起红斑、水疱,伴瘙痒2个月就诊.皮疹初起为前胸后背的小片状红斑,中央水疱,水疱破后可结痂,结痂脱落后遗留色素沉着,伴明显瘙痒.后红斑、水疱、结痂反复发作,呈环状向外扩展.     

红皮病性大疱性类天疱疮1例

 患者女,78岁。因“躯干、四肢红斑、鳞屑伴瘙痒5年,加重3年余”入院,入院后1周大腿及腹部出现紧张性水疱。住院第6天、第9天血清抗BP180抗体均阳性,IgE>2 500 U/mL。皮损组织病理可见表皮下水疱,真皮浅层大量淋巴细胞为主的浸润。直接免疫荧光示:基底膜带IgG和C3线状沉积,IgA阴性。诊断：红皮病性大疱性类天疱疮。给予甲泼尼龙40 mg静脉滴注1天1次,治疗1周,病情好转出院。1年后随访,患者泼尼松片减量至15 mg口服1天1次,躯干四肢可见轻度红斑,无水疱、糜烂和瘙痒     

Efficacy of itraconazole in the treatment of tinea versicolor

Twenty adult patients (15 males and 5 females) with extensive, clinically diagnosed tinea versicolor (TV.) resistant to topical agents, of long duration were selected. Laboratory investigations like KOH smear, routine haemogram, LFT, and RFT were done. They were given itraconazole (100 mg) orally twice daily for 5-7 days and followed up at the end of 1 week and again three weeks later. After one week itching, erythema and scaling subsided in 80% of cases. There was no recurrence during one year follow up.     

DERMATOMYOSITIS AND CARCINOMA

SUMMARY. A man aged 56 complained of itching, and subsequently erythema of the face, orbits and other areas exposed to light. Six weeks later, he developed haematuria, and in the following week, a rapidly progressive weakness of the shoulder girdle muscles.
He was found to have a rising titre of complement fixing antibody in his serum to an extract of his own bladder tumour. Immunofluorescent tests showed deposits of γ-globulin around muscle bundles and in the upper cutis.     

An open-label pilot study to evaluate the safety and efficacy of topically applied pimecrolimus cream for the treatment of steroid-induced rosacea-like eruption

BACKGROUND: Steroid-induced rosacea-like eruption is characterized by facial rosacea-like dermatitis in patients that have been treated with topical steroids for relatively long periods. OBJECTIVE: To evaluate the efficacy and tolerability of 1% pimecrolimus topical cream for steroid-induced rosacea-like eruption. METHODS: In an open-label pilot study, 40 patients were enrolled and instructed to apply 1% pimecrolimus cream twice daily for 6 weeks. Patients were evaluated by a rosacea clinical score, investigator's global assessment, overall erythema severity, and tolerability at weeks 0, 2, and 6. RESULTS: In 35 patients, the rosacea clinical score decreased significantly from 16.0+/-4.3 at baseline to 8.1+/-3.3 at week 2 and 4.2+/-2.5 at week 6 (P<0.0001). Investigator's global assessment was 4.1+/-1.1 (baseline), then decreased to 1.4+/-0.8 (week 2) and 0.5+/-0.6 (week 6) (P<0.0001). By week 6, 48.6% of the patients were clear. Overall erythema severity was 2.4+/-0.7 (baseline), 0.9+/-0.4 (week 2), and 0.3+/-0.4 (week 6) (P<0.0001). Cutaneous adverse events (local burning, stinging, and itching) occurred in 17.5%. CONCLUSION: Pimecrolimus cream might be efficacious, safe, and well tolerated for steroid-induced rosacea-like eruption. The small sample size and open label nature of this study is its limitation. Further double-blind, vehicle-controlled studies are needed.     

AN INTERROGATIVE STUDY OF PATTERN OF URTICARIA IN CHILDREN

Of the 44 patients of urticaria in children in 52.3 percent, the etiologic agents were defined with food as the major cause. The clinical features were characterized by itching, erythema, wheals and oedema of different configuration. The urticaria lesions were commonly seen on the extremities and the trunk. Largely the patients applied for treatment in the course of a week. Majority of the patients were in the age group of 5–9 years. The acute urticaria was most frequent, while the other variants were rare. The laboratory investigations were largely equivocal. The parasitic infestations in particular as etiologic factors were inconclusive.     

The clinical importance of demodex folliculorum presenting with nonspecific facial signs and symptoms

Demodex folliculorum (D. folliculorum), found in the pilosebaceous unit, is the most common ectoparasite of humans. Various clinical forms such as pustular folliculitis, papulopustular scalp eruptions, perioral dermatitis, and blepharitis have been defined, although in general, the disease has been classified into three main groups as "pityriasis folliculitis", "rosacea-like demodicidosis", and granulomatous rosacea-like "demodicidosis gravis". Our aim was to test for the presence of D. folliculorum in pathogenic numbers in patients who came to our clinic with non-specific symptoms such as facial itching with or without erythema, seborrheic dermatitis-like or perioral dermatitis-like lesions, papulopustular lesions, and an acneiform clinical appearance without telengiectasia or flushing. Twenty-eight (87.5%) female and 4 male (12.5%), patients and 33 age-and-sex matched healthy subjects enrolled in this study. D. folliculorum was sought in the lesion sites using the non-invasive method known as the Standardised Skin Surface Biopsy (SSSB). The discovery of more than five parasites in an area of 1 cm2, was evaluated as pathogenic. For treatment, 5% permethrine cream was applied twice daily for 15 to 30 days. The clinical symptoms of the patients were classified into clinical groups and evaluated as facial itching in 2 (6.3%), nonspecific erythema and itching in 21 (65.6%), erythema and pityriasiform squamous lesions in 3 (9.4%), acneiform in 3 (9.4%), papulopustular lesions in 1 (3.1%), granulomatous rosacea-like in 1 (3.1%), and perioral dermatitis-like symptoms in 1 (3.3%), D. folliculorum density was determined as 5>D/cm2 in all clinical lesions. A significant clinical healing and density of D. folliculorum at <=5 D/cm2 was determined in all but two patients after treatment. We consider that D. folliculorum presentation with different symptoms and signs than classical forms is not rare. For this reason, we suggest that it is useful to test for D. folliculorum in patients with non-classical presentations like facial itching, itching accompanied by non-specific erythema, itching and non-specific pityriasiform squamous lesions, and acneiform lesions.     

胰高血糖素瘤伴坏死松解性游走性红斑1例

49岁女性，全身广泛红斑伴痒痛10个月，病理变化为表皮上层的松解、坏死。血胰高血糖素增高，CT检查发现胰尾及肝脏肿瘤，手术切除肿瘤后，皮疹消退。     

Skin metastasis of breast cancer clinically undistinguished from amyopathic dermatomyositis

We report a 65-year-old woman who consulted us on May 25, 1998, showing pruritic, partially flagellate erythema on the back and upper extremities, livedo lesions with erythema on the loins, and erythematous papules on the dorsal finger joints for 2 months. Histopathological findings of erythema on the back showed mononuclear cell infiltration around capillaries and marked edema in the dermis. Laboratory data were within normal range except for positive anti-nuclear antibody. She had undergone total left mastectomy on June 2, 1997 for breast cancer. Supraclavicular lymph node metastasis was found at the beginning of May, 1998. A diagnosis of amyopathic dermatomyositis associated with breast cancer was made. Erythema with itching gradually subsided from the end of August, 1998. Treatment with radiation and chemotherapy reduced lymph node swelling, but complete remission was not obtained. Erythema similar to the previous lesion but without itching re-appeared on the back from January, 2000. Histological findings of erythema showed many carcinoma cells similar to the primary lesion of left breast cancer in the whole dermis. A diagnosis of skin metastasis of breast cancer was made. These findings suggest that skin metastasis should be taken into account for patients with erythema on the trunk similar to dermatomyositis.     

Allergic contact response to vitamin A acid

Three patients treated daily with vitamin A acid cream experienced after one week, seven weeks and 14 weeks respectively sudden redness and itching at the treated sites. Patch testing with the cream (containing 0.05% vitamin A acid) and with vitamin A acid 0.05% in absolute alcohol produced strongly positive reactions in the patients but only slight erythema in some of the controls. Since patch testing with vitamin A acid 0.005% in absolute alcohol elicited no response in controls but positive reactions in the three patients, it is probable that these latter reactions were due to contact allergy. Histologically the test reaction showed intact epidermis and dense dermal infiltration by mononuclear cells, and thus resembled a response of the tuberculin type.     

妊振股臀红斑：一种新的妊娠皮肤病？

报告3例发生于妊娠期的特征性皮肤病。其特点为妊振中后期发病,皮疹为大片状明显隆起的浸润性地图状红斑,形态单一,无自觉症状,主要分布于股殿部,在产前或产后自行消退。组织学改变为真皮中上部水肿和稀疏的血管周围淋巴细胞浸润。作者就本病的鉴别诊断进行了讨论,并建议命名为妊娠股臀红斑。