腹腔镜子宫内膜癌分期手术的临床效果观察

目的探讨腹腔镜子宫内膜癌分期手术的临床疗效及预后。方法 2005年1月～2011年3月243例子宫内膜癌行分期手术,其中腹腔镜分期手术75例,开腹分期手术168例,比较2组手术时间、术中出血量、并发症、术后胃肠功能恢复时间、术后住院时间、生存情况。结果腹腔镜组清扫淋巴结总数显著多于开腹组[(27.1±11.2)枚vs.(22.6±9.7)枚(t=3.182,P=0.002)];腹腔镜组术中出血量(315.1±108.0)ml显著少于开腹组(851.6±246.9)ml(t=-18.047,P=0.000);腹腔镜组排气时间(1.8±0.7)d显著早于开腹组(2.6±0.8)d(t=-7.475,P=0.000);腹腔镜组尿管拔除时间(8.5±5.3)d明显早于开腹组(12.5±6.0)d(t=-4.971,P=0.000);腹腔镜组术后住院时间(13.7±7.1)d与开腹组(14.9±6.5)d无统计学差异(t=-1.292,P=0.198);2组生存率和无瘤生存率无统计学差异(χ2=0.351,P=0.553;χ2=0.000,P=0.998)。结论腹腔镜子宫内膜癌分期手术的疗效与开腹手术相当,但腹腔镜手术淋巴结切除数量多,出血量少,排气时间短,更具微创价值。     

腹腔镜辅助阴式子宫切除术临床研究

目的探讨腹腔镜辅助阴式子宫切除术的临床价值。方法子宫良性病变须行子宫全切术125例随意分为2组。研究组65例采用腹腔镜辅助阴式子宫切除术(laparoscop ic assisted vaginal hysterectomy,LAVH);对照组60例采用传统开腹全子宫切除术(TAH)。结果手术时间LAVH(127.0±4.1)m in,TAH(70.2±1.7)m in(t=99.669,P=0.000)。术中出血量LAVH(80.1±23.1)m l,TAH(190.8±53.0)m l(t=-15.339,P=0.000)。术后并发症发生率研究组30.8%(20/65),对照组58.3%(35/60),2组比较差异有显著性(2χ=9.621,P=0.002)。结论腹腔镜辅助阴式子宫切除术具有损伤小、出血量少、恢复快等优点,是一种较为理想的手术方式。     

改进腹腔镜与开腹大子宫全切术的比较

目的 探讨双极联合超声刀腹腔镜下大子宫全切除术的安全性和可行性.方法 2009年2月～2012年7月145例因子宫良性病变行大子宫(子宫12～ 20孕周大小)切除术,按患者意愿分为腹腔镜组(n=78)和开腹组(n=67),比较2组患者手术情况、术后恢复、住院时间、并发症及随访情况.结果 腹腔镜组术中出血少[(102.7 ±35.6)ml vs.(125.4±23.7)ml,t=-4.441,P=0.000],术后肠道恢复快[(45.6±6.8)h vs.(67.4±8.5)h,t=-17.149,P=0.000],住院时间短[(5.5±0.5)d vs.(7.7±0.6)d,t=-24.083,P=0.000],切口非甲级愈合率低[0 vs.7.5％ (5/67),P=0.019].2组并发症发生率比较无统计学差异[2.6％ (2/78) vs.4.5％(3/67),x2=0.030,P=0.863].腹腔镜组随访74例,随访时间5～32个月,(28.7±6.2)月,术后1～3个月左下腹最大穿刺孔轻微疼痛2例,3个月后无不适;开腹组随访64例,随访时间5～ 36个月,(30.5±5.8)月,术后1～6个月腹部切口疼痛4例,6个月后无不适.结论 腹腔镜下大子宫全切术是安全、可行的,较开腹手术具有出血少、恢复快、住院时间短的优势.     

腹腔镜辅助阴式大子宫切除术与开腹全子宫切除术临床效果的比较

目的探讨对大子宫行腹腔镜辅助阴式子宫切除术(laparoscopic-assisted vaginal hysterectomy,LAVH)的临床应用价值. 方法 2004年9月～2007年9月,根据患者对手术方式的自愿选择,对60例因子宫良性病变致子宫增大超过12孕周的患者行LAVH,将同期的开腹全子宫切除(total abdominal hysterectomy,TAH)患者随意选取60例作为对照组进行回顾性对比研究.2组年龄、子宫大小、病种、腹部手术史、合并卵巢囊肿情况无统计学差异. 结果 2组手术均顺利完成.与TAH组相比,LAVH组术中出血量少[(125.7±46.1) ml vs (148.5±56.0) ml, t=-2.435,P=0.016],术后住院时间短[(3 5±1.2) d vs (6.3±1.2) d, t=-12.324,P=0.000],需术后镇痛者少(5 vs 23, χ2=15.093,P=0.000),2组手术时间无统计学差异[(111.9±26.5) min vs (104.4±21.3) min, t=1.375,P=0.172]. 结论对超过12孕周的子宫行LAVH是安全可行的,但必须熟练地掌握手术技巧.     

腹腔镜辅助下阴式大子宫切除术与开腹大子宫切除术的比较研究

目的探讨腹腔镜辅助下阴式子宫切除术(laparoscopic assisted transvaginal hysterectomy,LAVH)在大子宫切除中的临床价值。方法 2009年1～12月62例LAVH,与同期35例开腹大子宫切除术(transabdominal hysterectomy,TAH)进行比较,比较2组手术时间、术中出血量、术后排气时间、术后住院时间及术后病率。结果 LAVH组术中出血量(114.3±53.5)ml明显少于TAH组(193.3±58.4)ml(t=-6.756,P=0.000),术后排气时间(32.6±13.7)h早于TAH组(43.7±13.9)h(t=-3.812,P=0.000),术后住院(5.6±1.8)d明显短于TAH组(7.2±1.8)d(t=-4.204,P=0.000),术后病率5例显著少于TAH组9例(χ2=5.643,P=0.018)。2组手术时间分别为(106.1±33.6)min和(104.3±23.8)min,无统计学差异(t=0.280,P=0.780)。2组患者术后第1、3、6、12个月随访,恢复良好,无术后严重并发症发生。结论与TAH相比,采用LAVH切除大子宫术中出血少,术后恢复快。     

宫腔镜在宫内妊娠物残留诊治中的应用

目的探讨宫腔镜在宫内妊娠物残留的诊断与治疗中的价值。方法2005年8月～2008年8月对66例(宫腔镜组)宫腔镜检查明确诊断宫内妊娠物残留后,38例宫腔镜下定位后行清宫术、18例宫腔镜下直视清宫术、10例宫腔镜下电切术,并与同期的68例妊娠残留物(对照组)采用传统的清宫方法比较。比较2组治愈率、手术时间、术后出血时间、出血量等。结果宫腔镜组治愈率100%(66/66)明显高于对照组75.0%(51/68)(χ2=18.897,P=0.000);宫腔镜组术后出血时间(4.1±0.8)d明显少于对照组(15.3±3.6)d(t=-24.688,P=0.000);宫腔镜组出血量(16.2±4.8)ml明显少于对照组(92.1±9.6)ml(t=-57.616,P=0.000)。宫腔镜组手术时间(43.2±6.5)min与对照组(41.8±5.9)min相比无明显差异(t=1.306,P=0.194)。结论宫腔镜是诊断及治疗宫内妊娠物残留的一种有效方法。     

子宫动脉阻断术在腹腔镜子宫手术中的应用

目的探讨腹腔镜下子宫动脉阻断术(uterine artery blockage,UAB)这种预处理方法在子宫切除术中的价值。方法回顾性分析2005年2月~2007年12月我院161例腹腔镜子宫切除术共的手术时间、术中出血量、术后排气时间、术后病率情况。82例(UAB组)腹腔镜下先钛夹闭合双侧子宫动脉,再行子宫切除术,79例对照组(非UAB组)直接行腹腔镜下子宫切除术。结果UAB组手术时间为(117±28)min,与非UAB组(121±31)min无统计学差别(t=-0.645,P=0.520);UAB组术中出血量(55±27)ml,显著少于非UAB组(124±46)ml(t=-11.658,P=0.000);UAB组术后排气时间(31±6)h,与非UAB组(33±8)h无统计学差别(t=-1.799,P=0.074);UAB组术后病率13.4%(11/82),与非UAB组19.0%(15/79)无统计学差别(χ2=0.923,P=0.337)。结论腹腔镜下先阻断子宫动脉后切除子宫,操作容易,需要器械简单,术中出血明显减少,手术野清晰,术后恢复快,值得临床推广应用。     

不同子宫动脉处理方法在腹腔镜下子宫次全切除术中的比较

目的比较不同子宫动脉处理方法在腹腔镜下子宫次全切除术中的临床意义。方法 2010年5月～2011年5月,行腹腔镜下子宫次全切除术124例,按手术组的不同,其中63例双极电凝、剪刀切断双侧子宫动脉（研究组）,61例单纯套扎双侧子宫动脉（对照组）。对两组手术时间、出血量、体温恢复时间、肛门排气时间、住院时间及术后并发症等情况进行比较。结果与对照组相比,研究组手术时间短[（78.2±14.3）min vs.（87.5±11.7）min,t=-3.956,P=0.000],术后住院时间短[（4.1±0.9）d vs.（4.8±1.1）d,t=-3.884,P=0.000]。2组出血量、体温恢复时间、肛门排气时间差异无显著性（P〉0.05）。结论腹腔镜下子宫次全切除术中行双侧子宫动脉双极电凝、剪刀切断的方法安全、有效,明显缩短手术时间。     

腹腔镜与开腹全子宫切除术的临床效果比较

目的比较腹腔镜全子宫切除术(total laparoscopic hysterectomy,TLH)与开腹全子宫切除术的临床效果。方法对我院2004年3月～2006年5月有全子宫切除指征的TLH100例(腹腔镜组)和TAH100例(开腹组)的临床资料进行回顾分析,比较2种术式的手术时间、术中出血量、排气时间、住院时间、术后疼痛剂使用等情况。结果腹腔镜组排气时间(34.9±12.6)h显著短于开腹组的(52.6±11.7)h(t=-10.294,P=0.000);腹腔镜组住院时间(4.5±1.2)d显著短于开腹组(6.3±1.2)d(t=-10.607,P=0.000);腹腔镜组术后镇痛5例,显著少于开腹组58例(χ2=38.752,P=0.000)。2组在术中出血量和手术时间无统计学差异(P>0.05)。腹腔镜组1例输尿管阴道瘘;开腹组1例膀胱损伤,6例切口脂肪液化,2组手术并发症发生率无统计学差异(χ2=3.255,P=0.071)。结论TLH具有创伤小、腹腔内环境干扰小、恢复快等优点。     

宫腔镜微剪与电切治疗纵隔子宫的比较

目的比较宫腔镜微剪法与电切法治疗纵隔子宫的效果. 方法宫腔镜治疗纵隔子宫25例,其中11例微型剪刀剪开(微剪组),14例电切割(电切组). 结果 2组一次性手术成功率分别为81.8%(9/11)、 100%(14/14), 无显著性差异(P=0.183);手术时间分别为(71.8±25.2)min、(32.7±9.5)min, 有显著性差异(t=5.364,P=0.000).除电切组1例完全纵隔术后1个月宫颈部分粘连,经Hegar扩宫治愈外,2组均无严重并发症.随访8～31个月,2组妊娠成功率分别为 72.7%(8/11)、 71.4%(10/14),无显著性差异(P=1.000). 结论 B超或腹腔镜监护下宫腔镜微剪与电切治疗纵隔子宫效果满意、无差别,电切法手术时间较短.     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.     

Systemic analgesia adapted to the children's condition

A concept of balanced analgesia using nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen), opioids, and corticosteroids can also be used in patients with pre-existing illnesses. NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e.g. patients with renal impairment, bleeding tendency, or extreme prematurity. NSAIDs can be given with minimal risks to the younger child with mild to moderate asthma, and, in these patients, the use of steroids can be encouraged; in addition to their antiemetic and analgesic action, a beneficial effect on asthma symptoms can be expected. In the non-intubated child with cerebral trauma, exaggerated sedation caused by opioids and increased bleeding tendency caused by NSAIDs must be avoided. In neonates and small infants, the oral administration of sucrose or glucose is helpful to minimize pain reaction during short uncomfortable interventions.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.