A型肉毒毒素治疗鼻唇沟纹的临床应用

目的研究A型肉毒毒素治疗鼻唇沟纹的方法,以期达到较佳的除皱效果.方法采用A型肉毒毒素行面部肌肉多点注射,3～6个月可重复注射.结果本组28例患者,治疗后48～72 h起效,随访3～6个月,鼻唇沟纹去除效果满意.结论 A型肉毒毒素稀释后定点、定量注射用于治疗鼻唇沟纹,安全有效,操作方法简单,并发症少.     

医用羟丙基甲基纤维素-透明质酸钠溶液联合A型肉毒毒素在面部年轻化治疗中的应用

目的 观察填充材料医用羟丙基甲基纤维素-透明质酸钠溶液联合A型肉毒毒素在面部年轻化治疗中的临床应用效果.方法 首先将A型肉毒毒素注射于鱼尾纹、额纹、眉间纹等部位,而后在鼻唇沟、泪槽、眉间纹以及口角处注射医用羟丙基甲基纤维素-透明质酸钠溶液.结果 本组共56例患者,术后随访1～6个月,满意率达98.2%.结论 医用羟丙基甲基纤维素-透明质酸钠溶液联合A型肉毒毒素应用于面部年轻化的治疗,疗效确切,值得临床推广应用.     

A型肉毒毒素联合填充剂治疗鼻唇沟

目的 观察A型肉毒毒素联合软组织填充剂治疗鼻唇沟皱褶的临床疗效.方法 针对鼻唇沟上端近鼻翼侧最隆起处,采用A型肉毒毒素小剂量单点浅层注射,同时联合填充剂在真皮深层和皮下浅层行双层次扇形注射填充,3～6个月后可重复注射.结果 本组56例患者,随访3～6个月,有效随访51例患者,其中显效者46例(90.2%),有效者5例(9.8%).所有患者注射后均无面部表情僵硬、局部臃肿等并发症发生.结论 A型肉毒毒素联合填充剂注射用于治疗鼻唇沟,疗效确切,降低了使用单一药物的不良反应发生率,是一种安全有效的方法.     

应用A型肉毒毒素注射治疗腋臭30例

目的:观察A型肉毒毒素治疗腋臭的临床效果.方法:采用A型肉毒毒素行腋部真皮深层和皮下浅层注射.结果:本组30例患者,注射后随访3～6个月,出汗量明显减少,异味消除,平均有效期5个月.结论:局部注射A型肉毒毒素治疗腋臭,安全有效,操作简单,并发症少.     

A型肉毒毒素改善面部动力性皱纹的近期效果观察

目的探讨应用A型肉毒毒素治疗面部动力性皱纹的特点及效果评价。方法 2012年11月至2013年6月,78例面部皱纹患者,均为女性,年龄27~46岁,应用A型肉毒毒素进行面部除皱,包括额纹48例,鱼尾纹30例。注射前及注射后1、3、6、9个月分别照相,比较面部皱纹变化情况,结合患者自我感觉等指标,综合分析A型肉毒毒素注射除皱的近期效果。结果所有78例患者术后随访9个月,医患双方就术后效果共同进行评价,注射部位皱纹消除明显,患者对治疗效果满意。结论应用A型肉毒毒素治疗面部动力性皱纹,疗效良好,安全方便,副作用少,术后满意度高。     

小剂量A型肉毒毒素矫治单侧面瘫的疗效与安全性评价

目的：探讨小剂量A型肉毒毒素重复注射矫治单侧面瘫的疗效及安全性,以期达到较佳的外观效果,为单侧面瘫的治疗寻找更加理想的方法。方法：测估定位后,采用小剂量A型肉毒毒素行健侧面部颊肌处多点注射。3～6个月后重复注射。结果：本组18例患者,治疗后48～72h起效,3～6个月后需重复注射,随访6～18个月,面部外观改善效果较满意。结论：小剂量A型肉毒毒素稀释后定点、定量注射用于矫治单侧面瘫,安全有效,操作方法简单,并发症少,能够成为矫治单侧面瘫的一种理想方法。     

透明质酸与肉毒毒素联合注射治疗重度眉间纹

目的探讨透明质酸与肉毒毒素联合注射治疗眉间纹的适应证、注射方法和临床效果。方法选择67例严重眉间纹患者,联合应用透明质酸（0．3～0．8m1）和肉毒毒素（9～14U）注射治疗,观察注射后的临床效果、疗效时间和不良反应等。结果透明质酸与肉毒毒素联合注射后,静态眉间纹即刻得到明显改善;注射后2、3d,动态皱眉纹开始逐渐减轻;约1个月时,效果明显改善。随访3～12个月,术后皱纹改善满意,最长可达18个月。结论对重度眉间纹（同时具有静态和动态皱眉纹）的患者,应用透明质酸行皱纹内填充,并结合肉毒毒素对眉间复合体肌肉进行注射,可达到更好的治疗效果。     

A型肉毒毒素治疗面部皱纹300例

目的：观察A型肉毒毒素治疗面部皱纹的运用效果。方法：对以面部美容为目的的300例患者应用A型肉毒毒素定点、定量注射治疗,注射点均匀、对称分布于面部肌肉层。其中包括额部皱纹、鱼尾纹、眉间皱纹、下睑纹、鼻唇沟纹。结果：300例患者行A型肉毒毒素治疗后显效者234例（占78％）,有效者66例（占22％）,无效者为0例。结论：A型肉毒毒素在治疗面部皱纹确切有效,操作简便、易行,无痛苦,不影响工作,易于推广。     

局部注射少量A型肉毒毒素治疗上半面部皱纹的临床研究

目的：观察局部注射少量A型肉毒毒素（BTXA）去除上半面部皱纹的临床疗效。方法：应用A型肉毒毒素的198例患者,其中眉间纹65例,鱼尾纹80例,额纹20例,鼻背部皱纹33例。所有患者行局部多点注射A型肉毒毒素,浓度为4U/0.1ml,并根据不同的患者调整剂量和浓度。记录患者疗效、维持时间与不良反应。结果：A型肉毒毒素治疗面部上三分之一皱纹有效率为100%,显效率94.4%。肌肉麻痹的效果通常持续3～6个月不等,不良反应主要为4例上睑下垂,3例局部水肿和4例青紫,各占2.0%、1.5%和2.0%。上述症状于3～10内自行完全消失。结论：A型肉毒毒素局部注射治疗面部上三分之一皱纹起效迅速、无创伤、简便易行。     

联合应用A型肉毒毒素与软组织填充剂治疗眉间纹的临床观察

目的 观察A型肉毒毒素与注射用透明质酸钠凝胶联合应用在眉间纹治疗中的临床应用效果.方法 自2008年6月至2010年1月,对62例求美者的眉间纹进行联合治疗,首先根据眉间纹深浅程度及长短不同,在皮下及真皮深层均匀注射适量的透明质酸钠凝胶,按摩平整后,将A型肉毒毒素注射于眉间纹相关肌肉肌腹处.结果 术后对62例求美者随访1～8个月,满意率达98.8%,无严重不良反应发生.结论 A型肉毒毒素与软组织填充剂联合应用治疗眉间纹疗效确切,安全性高,值得临床推广应用.     

自体脂肪移植联合A型肉毒毒素注射改善鼻唇沟凹陷的效果

目的 探究对鼻唇沟凹陷患者应用自体脂肪移植联合A型肉毒毒素注射治疗的效果。方法 选择 2020年8月-2023年8月我院收治的120例鼻唇沟凹陷患者,以随机数字表法分为研究组和对照组,每组 60例。对照组采用自体脂肪移植治疗,研究组采用自体脂肪移植联合A型肉毒毒素注射治疗,比较两组 临床疗效、皱纹严重程度、面部美观恢复情况、生活质量、不良反应发生情况及治疗满意度。结果 研究 组治疗总有效率为96.67%,高于对照组的85.00%（P ＜0.05）;研究组治疗后6个月WSRS评分低于对照组 （P ＜0.05）;研究组GAIS评分高于对照组（P ＜0.05）;研究组治疗后6个月生活质量各维度评分均高于 对照组（P ＜0.05）;两组不良反应发生率比较,差异无统计学意义（P ＞0.05）;研究组治疗总满意度为 95.00%,高于对照组的76.67%（P＜0.05）。结论 自体脂肪移植联合A型肉毒毒素注射改善鼻唇沟凹陷的效 果良好,能够有效减轻患者的鼻唇沟皱纹,促进面部美观恢复,有利于提高其生活质量,且治疗后不良反 应发生几率较低,治疗满意度较高。     

Treatment of Nasal Wrinkles with Botulinum Toxin

BACKGROUND: Nasal wrinkles on the dorsum of the nose can frequently be treated with botulinum toxin type A by injecting a few units into the nasalis muscle. Between 2 and 5 U of botulinum toxin have commonly been used. However, clinicians have observed that some nasal wrinkles persist following nasalis treatment. OBJECTIVE: To detail remaining nasal and perinasal rhytids and further injection sites, which can lead to improvement. METHODS: Two hundred fifty patients with nasal rhytids were treated between 1997 and 2004. Three units of botulinum toxin type A were injected bilaterally into the nasalis muscle. Patients were seen at 1 month for follow-up, and the remaining rhytids were documented. RESULTS: Forty percent of patients had satisfactory treatment of nasal wrinkles with the initial bilateral 3 U injections. Sixty percent of subjects had remaining nasal rhytids following the nasalis muscle injections. Thirty percent o f subjects hadpersistent wrinkles at the root of the nose (nasal orbicular wrinkles), and 30% had wrinkles at the nasal root and between the eyes (nasociliary wrinkles). The injection of botulinum toxin into additional locations according to the anatomic differences of each person showed excellent resolution of the rhytids without complications. CONCLUSION: Understanding nasal wrinkle patterns allows for complete wrinkle treatment of the nose beyond simple bilateral treatment of the nasalis. New points of botulinum toxin application improve not only wrinkles at the root of the nose but also wrinkles in the nasoalar area.     

A型肉毒毒素治疗面部皱纹效果观察

目的:探讨A型肉毒毒素行面部老化治疗中的最佳注射点位,探讨A型肉毒毒素应用的特点,适应证及并发症等。方法:分析2009年8月至2012年12月之间198例面部老化患者行A型肉毒毒素注射治疗的临床资料,根据注射点位的不同,术后随访观察额纹、鱼尾纹、眉间纹等处皱纹的改变情况。结果:按实验中的点位注射,198例患者中180例效果显著,18例自觉效果不够理想,无患者出现眉下垂、睑外翻等并发症,也无晕厥休克等严重过敏性反应。结论:应用A型肉毒毒素治疗面部老化,治疗效果肯定,治疗过程安全,可扩大A型肉毒毒素应用于面部老化治疗的范围,也可采用多点位、小剂量注射可起到个性化去皱的效果。     

单用A型肉毒毒素与联合颞部除皱术在面部除皱中的效果比较

目的:探讨单纯应用A型肉毒毒素与颞部除皱术联合应用A型肉毒毒素在治疗面部皱纹的临床应用效果。方法:以本院2009年1月至2012年1月共88例面部皱纹整容的患者作为研究对像,接受颞部除皱术联合A型肉毒毒素治疗的40例患者为A组,以单纯应用A型肉毒毒素治疗的48例患者为B组。比较两组疗效与术后并发症情况。结果:A组术后皱纹消失保持时间(23.50±6.50)个月,B组为(5.20±1.40)个月,A组明显高于B组(P0.05)。A组38例患者(95.0%)双眼均出现猫眼样年轻化改变,B组患者均无该变化;A组患者眼睑闭合困难及面部肿胀发生率均高于B组,面部僵硬发生率低于B组,差异具有统计学意义(P0.05)。结论:颞部除皱术联合A型肉毒毒素治疗面部皱纹的手术效果令人满意,除皱保持时间较单纯应用A型肉毒毒素大大延长,且手术具有微调眉眼形态的作用,术后患者年轻化明显。     

Effect of Botulinum Toxin Type A on Movement-Associated Rhytides Following CO2 Laser Resurfacing

BACKGROUND: Many patients who undergo CO2 laser resurfacing for correction of rhytides experience recurrence of movement-associated wrinkles within 6 to 12 months following the laser procedure. OBJECTIVE: The purpose of this study was to evaluate the effect of botulinum toxin type A (Botox) injections on movement-associated rhytides following cutaneous laser resurfacing. METHODS: Forty patients who had received full face CO2 laser resurfacing for the treatment of facial rhytides were randomized to receive Botox injections to the glabella, forehead or lateral canthal regions or to receive no additional treatment (control group). Clinical and photographic assessments were performed at baseline and at 3, 6 and 9 months. RESULTS: Enhanced and more prolonged correction of forehead, glabellar and/or lateral canthal rhytides was observed in patients treated with Botox injections postoperatively compared to non-Botox treated control patients. CONCLUSION: The use of botulinum toxin type A following cutaneous CO2 laser resurfacing results in prolonged correction of movement-associated rhytides. It is advised that patients receive information regarding the benefits of maintenance therapy with botulinum toxin as part of their routine preoperative education.     

A 型肉毒素治疗面部皱纹的美容效果

为探究A型肉毒素治疗面部皱纹的美容效果，本研究选取2021年1月-2023年1月于我院行面部 皱纹修复的50例患者为研究对象，所有患者均采用A型肉毒素进行治疗，观察临床治疗效果和不良反应发 生情况。结果显示，治疗总有效率高达98.00%，不良反应发生率较低，仅为4.00%。可见，在面部皱纹治疗 中，应用A型肉毒素治疗效果肯定，治疗过程安全，值得临床应用。     

Dose-Ranging Study of Botulinum Toxin Type A in the Treatment of Glabellar Rhytids in Females

OBJECTIVE: To compare the efficacy, safety, and duration of effect of four doses of botulinum toxin type A in the treatment of glabellar rhytids in females. DESIGN: Double-blind, randomized, parallel-group, dose-ranging trial followed by an open-label extension. SETTING: Private dermatologic clinic. SUBJECTS: Eighty female subjects with moderate to severe wrinkles at maximum frown entered the study. The first 40 subjects completing the double-blind phase entered the open-label extension. INTERVENTION: Random administration of 10, 20, 30, or 40 U botulinum toxin type A in divided doses. Open-label trial: 30 U botulinum toxin type A at the same sites in divided doses. MAIN OUTCOME MEASUREMENTS: Trained observer and subject assessments of wrinkle severity at maximum frown and repose using the Facial Wrinkle Scale (0 = none to 3 = severe), subject satisfaction, and adverse events. Follow-up monthly for up to 1 year postinjection. RESULTS: Relapse rates and responder rates revealed benefits lasting 3 to 6 months or longer. Objectively, 10 U of botulinum toxin type A was significantly less effective than 20, 30, or 40 U. The relapse rate at 4 months was significantly higher in the 10 U group (83%) versus 40, 30, or 20 U (28%, 30%, and 33%, respectively). Subject satisfaction was high in all groups. Duration of effect and response rates were sustained during the open-label extension. Adverse effects were mild and infrequent. CONCLUSION: Twenty to 40 U botulinum toxin type A doses were significantly more effective at reducing glabellar lines than 10 U. Most subjects experienced benefits for 3 to 4 months; some subjects demonstrated effect for up to 12 months.     

Botulinum Toxin A: Successful Décolleté Rejuvenation

BACKGROUND: Décolleté wrinkles develop with age. In women more than 35 years of age these wrinkles are still transient, but become permanent at about age 50. In a substantial number of women décolleté wrinkles, seem to be associated with an insertion of platysma exceeding the second intercostal space. We report botulinum A toxin therapy of these wrinkles in five patients. OBJECTIVE: To show the effect of botulinum A toxin on décolleté wrinkles. METHODS: All five women with décolleté lines treated with botulinum A had different varieties of the platysma muscle inserting deep down beneath the fourth intercostal space. During platysma contraction injection points were marked and a certain dosage of toxin was applied. RESULTS: Two weeks after therapy a significant improvement of the treated décolleté region was observed. CONCLUSION: These observations indicated that botulinum A toxin can be an effective and safe method in the temporary management of décolleté wrinkles. It should therefore be considered as a new adjuvant treatment in cosmetic décolleté rejuvenation.