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1.
Objective
To observe the clinical efficacy difference between electroacupuncture at B?ihuì (百会 GV 20) and Yìntáng (印堂 EX-HN 3) and oral administration of sertraline hydrochloride for treatment of post-schizophrenic depression.Methods
Sixty patients with post-schizophrenic depression were randomly divided into electroacupuncture group and western medicine group in the proportion of 1:1, with 30 patients in each group. The patients in the two groups were all given antipsychotics as the basic treatment. Electroacupuncture at GV 20 and EX-HN 3 was performed additionally in electroacupuncture group with 30?min/time and once every other day. The treatment was given for 3 times a week, lasting for 6 weeks. Oral administration of sertraline hydrochloride was given in western medicine group additionally for once a day, lasting for 6 weeks. The comprehensive conditions of patients in the two groups were evaluated before and after treatment by adopting Global Assessment Scale (GAS). The degree of depression of patients in the two groups was assessed before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit by adopting Hamilton Depression Scale-17 (HAMD-17).Results
GAS: GAS scores of the patients in the two groups after treatment were higher than those before treatment (both P?<?0.05), but the difference of GAS scores of the patients in the two groups after treatment was not statistically significant. HAMD-17: The HAMD-17 scores of patients in electroacupuncture group reduced gradually in the six time points of before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit, and the differences of scores between the two adjacent time points were statistically significant (all P?<?0.05). The HAMD-17 scores of patients in western medicine group reduced gradually in the 6 time points, and the differences of scores between the two adjacent time points among after treatment for 2 weeks and 4 weeks, and after treatment were statistically significant (all P?<?0.05). The HAMD-17 scores of patients in electroacupuncture group were lower than that in western medicine group after treatment for 1 week, 2 weeks and 4 weeks, and the differences were statistically significant (all P?<?0.05).Conclusion
According to the comparison of the clinical efficacies of electroacupuncture at GV 20 and EX-HN 3 and oral administration of sertraline hydrochloride for treatment of post-schizophrenic depression, the overall conditions were improved effectively and the difference was not statistically significant. Electroacupuncture takes effect more rapidly in treatment of depression, and its effect can last for a longer time. 相似文献2.
Objective
To compare the clinical efficacy difference between comprehensive ying needling therapy and intramuscular injection with ribavirin for mumps.Methods
One hundred patients with mumps were randomly divided into comprehensive ying needling therapy group (group A, 52 cases) and western medicine group (group B, 48 cases), then 8 cases were eliminated and drop out from group A and 4 cases were eliminated and drop out from group B respectively, actual inclusion 44 cases in group A 44 cases in group B. Point bloodletting was performed at parotid gland (腮腺Sāixiàn) and Threeshang acupoints of the patients in group A for once every other day, treatment for 7 days was considered as 1 course of treatment, and 2 courses were needed. Intramuscular injection with ribavirin was given to the patients in group B for twice a day, treatment for 7 days was considered as 1 course, and 2 courses were needed. The parotid gland swelling score, fever score, orifice parotid duct swelling score, score of difficulty in opening mouth and the clinical efficacy of the patients in the two groups were compared before and after treatment.Results
The cured and markedly effective rate in group A was 90.9% (40/44), which was superior to 68.2% in group B (30/44) (P?<?0.05). The symptom scores were all improved significantly in the two groups after treatment (all P?<?0.05), and the improvement in group A was superior to that in group B (all P?<?0.05).Conclusion
The curative effect of comprehensive ying needling therapy for treatment of mumps was superior to that of conventional western medicine therapy. 相似文献3.
WANG Lihua LI Jia HUANG Wei RAN Guoping ZHANG Yanji ZHUO Yue JIN Yiting ZHOU Zhongyu 《世界针灸杂志》2018,28(2):97-102
Objective
To explore the effect of peroxisome proliferators-activated receptor γ coactivator-1α (PGC-1α) and uncoupling protein-1 (UCP-1) in the brown adipose tissue (BAT) of obese rats in the process of acupuncture treatment for obesity.Methods
Fifty clean-grade male Wistar rats with the age of 3 months were randomly divided into high-fat diet group (n?=?40) and normal diet group (control group, n?=?10). Nutritional obesity animal models were established through feeding with high-fat diet. Twenty-four animal models in the high-fat diet group were established successfully, and then they were randomly divided into model group, acupuncture group and non-acupoint group, with 8 rats in each group. In acupuncture group, Zúsānl? (足三里ST 36) and Tiānshū (天枢ST 25) were selected. In non-acupoint group, the non-acupoints located on 5?mm beside ST 36 and ST 25 were selected as acupuncture points, and electroacupuncture intervention was adopted for 5 times/week for 8 weeks. The body mass of obese rats was measured, the body fat ratio in BAT of rats was calculated, and the expression levels of PGC-1α and UCP-1 in BAT of rats were detected by immunohistochemical method.Results
① After treatment, the body mass of rats in acupuncture group reduced significantly, which increased in the other three groups. The changing value of body mass of rats in acupuncture group was higher than that in model group (P < 0.05), the changing value of body mass of rats in acupuncture group was higher than that in non-acupoint group (P < 0.05) and the difference in body mass changing value of rats between non-acupoint group and model group was not statistically significant (P > 0.05), the body fat ratio in BAT of rats in non-acupoint group was lower than that in acupuncture group, and the differences were statistically significant (P?<?0.05). ② Compared with model group, the body fat ratio in BAT of rats in acupuncture group increased significantly (P < 0.05), and the difference in body fat ratio in BAT of rats between non-acupoint group and model group was not statistically significant (P > 0.05). ③ Compared with model group, the PGC-1α and UCP-1 levels in BAT of obese rats in acupuncture group increased (P < 0.05), and the difference in expression levels of PGC-1α and UCP-1 in BAT of rats between non-acupoint group and model group was not statistically significant (P > 0.05), the expression levels in non-acupoint group were lower than that in acupuncture group, and the differences were statistically significant (P < 0.05).Conclusion
Electroacupuncture at “ST 36” and “ST 25” can effectively up-regulate the expression levels of PGC-1α and UCP-1 of diet induced obesity rats, it indicates that “ST 36” and “ST 25” have close relationship with obesity and it is may be one of the effect mechanisms of electroacupuncture in losing weight through facilitating the “browning reaction” of white adipose tissue. 相似文献4.
Objective
To observe the clinical efficacy of electroacupuncture combined with intermittent pneumatic compression therapeutic apparatus for treatment of diabetic peripheral neuropathy, and the effect on serum VEGF and HIF-1α levels of patients.Methods
Ninety-six patients were randomly divided into electroacupuncture treatment group (EA group), intermittent pneumatic compression treatment group (IPC group), electroacupuncture combined with intermittent pneumatic compression treatment group (EA?+?IPC group) and cobamamide group (CM group), with 24 cases in each group. Electroacupuncture treatment (once a day), intermittent pneumatic compression treatment (twice a day) and intramuscular injection with cobamamide (1 mg, once a day) were carried out in EA group, IPC group and CM group, respectively, and intermittent pneumatic compression treatment (twice a day) was conducted on the basis of electroacupuncture treatment (once a day) in EA?+?IPC group. After treatment for 2 consecutive weeks, the differences in subjective symptoms, motor nerve conduction velocity, sensory nerve conduction velocity and serum HIF-1α and VEGF levels of patients in the four groups before and after treatment were observed and compared.Results
After treatment for 2 weeks, the differences in total effective rate between EA group and CM group, IPC group and CM group, as well as EA?+?IPC group and CM group were all significant (all P < 0.05), and the total effective rate in EA?+?IPC group was significantly higher than that in EA group and IPC group (both P < 0.05). After treatment for 2 weeks, the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve of patients in EA group, IPC group and EA?+?IPC group were all higher than that before treatment (all P < 0.05); the motor nerve conduction velocity of median nerve and the sensory nerve conduction velocity of common peroneal nerve in EA group were all higher than that in CM group (both P < 0.05); the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve in IPC group were also all higher than that in CM group (both P < 0.05); the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve in EA?+?IPC group were all higher than that in CM group (both P < 0.05); the sensory nerve conduction velocity of common peroneal nerve in EA?+?IPC group was higher than that in EA group and IPC group (both P < 0.05), and the motor nerve conduction velocity of median nerve in EA?+?IPC group was higher than that in IPC group (P < 0.05). The serum HIF-1α and VEGF levels of patients in EA group, IPC group and EA?+?IPC group after treatment significantly reduced (all P < 0.05), and were lower than that in CM group after treatment (all P < 0.05); the serum HIF-1α and VEGF levels of patients in EA?+?IPC group after treatment were lower than that in EA group and IPC group, and the difference in serum HIF-1α level was statistically significant (both P < 0.05).Conclusion
Electroacupuncture combined with intermittent pneumatic compression therapeutic apparatus can effectively improve the clinical symptoms of patients with diabetic peripheral neuropathy, the efficacy were better than electroacupuncture, intermittent pneumatic compression treatment and cobamamide. 相似文献5.
Ping SHAO Zhen DU Zhiping XIN Xiao ZHENG Minlei QIU Zheng ZHU Xuming YANG 《世界针灸杂志》2018,28(3):167-173
Objective
To compare the effect differences of electroacupuncture (EA) at Jiāj? (夹脊 EX-B2) and conventional acupoints for lumbar intervertebral disc herniation (LIDH) and the factors influenced the effect during the way of data mining.Methods
A total of 160 patients of LIDH were randomly assigned into the EX-B2 group and the conventional acupoints group, 80 cases in each one. The patients in the EX-B2 group received EA at the symmetrical 2 acupoints of the bilateral EX-B2 on the lesion part. The patients in the conventional acupoints group received EA at the tender point of the lesion part, Zhìbiān( 秩边BL54), Huántiào(环跳 GB30), Weǐzhōng(委中BL40), Chéngshān(承山BL57) and Fúyáng (跗阳BL59) on the affected side. The retain time of the needles is both 45?min. The treatment of the two groups is 3 times a week and for a connective 20 times. The modified Assessment Criteria for Low Lumbar Pain of Japanese Orthopedic Association (JOA), Visual Analogue Scale (VAS) were evaluated before and after the treatment and at the 6-month follow up.Results
(1) Effective outcomes. JOA score: The JOA score of the patients in the EX-B2 group after treatment was (20.89?±?3.43), and was (19.35?±?4.02) on the follow-up. Compared with the JOA score (12.35?±?4.42) in the same group before the treatment, there were statistical significant higher (both P<0.05). The JOA score in the EX-B2 group after treatment and on the follow-up were both higher than that of the conventional acupoints group at the same time point (both P<0.05). VAS score: The VAS score of the patients in the EX-B2 group on the 24?h after the first treatment was (4.09?±?1.81), and was (2.11?±?1.30) after the treatment. Compared with the VAS score (4.09?±?1.81) in the same group before the treatment, there were statistical significant lower (both P<0.05). The VAS score in the EX-B2 group on the 24?h after the first treatment and after treatment showed no statistical differences than that of the conventional acupoints group at the same time point (both P>0.05). (2)Related results from data mining: The middle-aged people and disease duration less than six months, their effect of the immediate treatment was the best. According to JOA score, EA at EX-B2 was better than EA conventional acupoints, either in the process of treatment effect, or in pertinence of the treatment, which were superior to EA conventional acupoints therapy; The best curative effect time of EA at EX-B2 was the first treatment after 24?h, and the best curative effect of the conventional acupoints was after the first treatment. The age and disease duration also affected curative effect.Conclusion
The effect of EA at EX-B2 was superior to the conventional acupoints in treating LIDH. 相似文献6.
Ze-qin REN Xu YUAN Rong ZHAO Jin-long XU Ze-guan YANG Jian AI Zhi-xiong ZUO Ding-jun CAI 《世界针灸杂志》2018,28(3):161-166
Objective
To test the neural electrophysiological basis of acupuncture treatment on attention deficit of insomnia patients.Methods
Thirty insomnia attention deficit patients were enrolled as the patient group in this study, and 30 normal people were collected as the normal group as the compare. In patient group, acupuncture was adopted and the acupoints were Bǎihuì (百会 GV20), Shéntíng (神庭 GV24), Sìshéncōng (四神聪 EX-HN1), Shénmén(神门 HT7) and Sānyīnjiāo(三阴交 SP6), even reinforcing and reducing method, once a day, 10 times as a course and totally 2 courses. There was no intervention for the normal group. Pittsburg Sleep Quality Index (PSQI) for assessing the sleep quality, Schulte grid scale and the event-related potential (ERP) for assessing the attention deficit were evaluated before the treatment, 10 days after the treatment and after the treatment. The normal group were taken evaluation at the same time point.Results
1. PSQI. The PSQI score in the patient group before the treatment was (16.20?±?2.02) and was (4.20?±?1.64) after the treatment. The difference was statistically significant (P?<?0.05). The normal group was (4.00?±?1.52) at the same point after the treatment, and the differences was not statistically significant (P > 0.05). 2. Schulte grid scale. The Schulte grid scale rating score was decrease from (32.87?±?6.71) s before the treatment to (12.82?±?3.40) s after the treatment, and the difference was statistically significant (P?<?0.05). The normal group was (12.29?±?3.47) s at the same point after the treatment, and the differences was not statistically significant (P > 0.05). 3. ERP. (1) P300: in the patient group, the latency of P3a decreased from (316.60?±?18.42) ms before the treatment to (300.10?±?12.03) ms after the treatment; the latency of P3b decreased from(328.32?±?16.32) ms before the treatment to (304.63?±?13.248) ms after the treatment; the amplitude of P3a increased from (5.501.16) μV before the treatment to (15.20?±?2.12) μV after the treatment; the amplitude of P3b increased from(5.76?±?1.87) μV before the treatment to (16.76?±?2.37) μV after the treatment, and the differences were statistically significant (all P?<?0.05). (2) CNV: in the patient group, the latency of point A decreased from (404?±?129) ms before the treatment to (369?±?105) ms after the treatment; the latency of point C decreased from (2584?±?563) ms before the treatment to (2308?±?369) ms after the treatment; the amplitude of A-B increased from (10.3?±?17.4) μV before the treatment to (13.7?±?24.8) μV after the treatment, and the differences were statistically significant (all P?<?0.05).Conclusion
Acupuncture can improve the sleep quality and the attention deficit condition of insomnia attention deficit patients by regulating the nerve electrophysiology of the brain. 相似文献7.
Objective
To explore the short and long-term efficacy of combining electroacupuncture (EA) and Qibei mixture in the treatment of irritable bowel syndrome (IBSD).Methods
Six hundred and forty-four patients with confirmed IBSD from the Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical University in China, recruited from July 2012 to June 2016, were randomly divided into four groups, the EA group, Qibei mixture group, combination group and medication group with 161 patients in each group. The patients in the EA group were treated with EA at zúsānlǐ (足三里ST36), Gān shù (肝俞BL18), Pǐshù (脾俞BL20), Tàichōng (太冲LR36) and Qízhōngsìbiān (脐中四边) once daily for 4 weeks, while the patients in the Qibei mixture group were treated with 50?mL of Qibei mixture twice daily, the combination group with the above-mentioned EA and Qibei mixture, and the medication group with 1 tablet compound diphenoxylate twice, 3?g montmorillonite powder three times and 25?mg amitriptyline twice daily. The defecation frequencies, stool properties, accompanying symptom score, life quality score and adverse reactions were recorded pre-treatment, at the end of treatment and 6 weeks post-treatment for the four groups.Results
Compared with pre-treatment, the defecation frequencies, stool property score and accompanying symptom score were all decreased significantly at the end of treatment in each group (all P?<?0.01), while the scores of nine dimensions of quality of life were all increased significantly (all P?<?0.01). The above-mentioned indices were better in the combination group than in the other groups (all P?<?0.05). Compared with the end of treatment, no significant recurrences of the above-mentioned indices had occurred in the combination group or the EA group at 6 weeks post-treatment (both P?>?0.05), but these indices all recurred significantly in the group given Qibei mixture and the medication group (P?<?0.05). The short- and long-term total effective rates in the combination group both showed significant differences from those in the other groups (P?<?0.05, P?<?0.01). No serious adverse reactions occurred in the four groups.Conclusion
EA and Qibei mixture can decrease defecation frequencies, improve stool properties, and alleviate accompanying symptoms to increase life quality, but the therapeutic effect of combination therapy is greater, with better reliability and long-term efficacy. 相似文献8.
Objective
To compare differences of acupotomy loosing combined with medication treatment, electroacupuncture combined with medication treatment and simple medication treatment in effects on rheumatoid arthritis patients with elbow joint stiffness and investigate the anti-inflammatory mechanism of the acupotomy loosing.Methods
A total of 60 cases of rheumatoid arthritis (RA) patients with elbow joint stiffness were randomly assigned into the group receiving acupotomy loosing (group A), group with electroacupuncture (group B) and the one undergoing medication treatment (group C) with 20 cases for each group. Based on the medication treatment, all patients underwent continuous oral administration with Methotrexate (MTX), Leflunomide (LEF) and Bitongding capsules for 3 weeks. And no other treatments were given to group C. In addition to medications treatment, the electroacupuncture was performed in group B. The acupoints of Tiānzhù (天柱 BL 10), Dàzhuī (大椎 GV 14); Fēngchí (风池 GB 20), Qūchí (曲池 LI 11), Qūzé (曲泽 PC 3), Ch?zé (尺泽 LU 5), Sh?usānl? (手三里 LI 10), Xi?oh?i (小海 SI 8), Shàoh?i (少海 HT 3), Tiānj?ng (天井 TE 10), Qīngl?ngyuān (清冷渊 TE 11) and Hég? (合谷 LI 4) in the affected side were selected. A pair of electrodes were connected to LI 11 and LI 10, and another pair of electrodes were connected to PC 3 and LU 5, and the continuous wave with frequency of 2?Hz was designed, the needle retention for 30?min was performed, and the acupuncture was performed for 6 times per week with 3 weeks for one course, and there was one course totally. Besides the medication treatment, group A underwent the acupotomy loosing therapy. The tender point in lateral elbow joint, etc. were taken as the treatment point, and 6–8 treatment points being taken for each time, and longitudinal dredging and transverse exfoliation were conducted for 2–3 times with the acupotomy. The treatment was given for one time per week with three weeks for one course, and there was one course totally. The changes of maximum angle of active extension position, maximum angle of active flexion position and range of motion were observed, and levels of IL-6, IL-10 and TNF-α in affected synovial fluid of elbow joint were tested before the treatment and 2 weeks after the treatment in the groups.Results
① Compared with those before treatment, the maximum angle of active extension position were smaller, the maximum angle of active flexion position were larger and the range of motion were wider of the affected elbow joints of the patients in the 3 groups on the 2 weeks after the treatment. There were statistical significances for the differences (All P < 0.05). Two weeks after the treatment, as compared with those in group C, the affected elbow joint for patients in the group B and group A was smaller in maximum angle of active extension position, larger in maximum angle of active flexion position and wider in range of motion and there were statistical significances for the differences (All P < 0.05). Comparing with those in the group B, the affected elbow joint for patients in the group A was smaller in maximum angle of active extension position, larger in maximum angle of active flexion position and wider in range of motion and there were the statistical significances for the differences (All P < 0.05). ② Compared with those before treatment, the levels of TNF-α and IL-6 were lower and the level of IL-10 was higher of the 3 groups on the 2 weeks after the treatment. There were the statistical significances for the differences (All P <0.05). For 2 weeks after the treatment, compared with those in the group C, group B and group A were lower in levels of TNF-α and IL-6 and higher in level of IL-10 and there were the statistical significances for the differences (All P < 0.05). As compared with those in the group B, group A was lower in levels of TNF-α and IL-6 and higher in level of IL-10 and there were the statistical significances for the differences (All P < 0.05).Conclusions
The combination of acupotomy loosing can improve the maximum angle of active extension position, maximum angle of active flexion position and range of motion in affected elbow joint for RA patients with elbow joint stiffness, whose efficacy was superior to single basic treatment and electroacupuncture combined with basic treatment. Meanwhile, the levels of proinflammatory cytokines, such as TNF-α and IL-6 can be decreased, and the level of anti-inflammatory cytokines, such as IL-10 can be increased, playing a role in regulating the imbalance between proinflammatory cytokines and anti-inflammatory cytokines in RA patients, which may be one of mechanisms regarding treating RA and improving the range of motion for stiff joints. 相似文献9.
Objective
To compare the clinical efficacy between electroacupuncture combined with heat-sensitive moxibustion and western medicine for treatment of premature ovarian failure.Methods
Eighty patients were randomly divided into an electroacupuncture combined with heat-sensitive moxibustion group (group A, n=40) and a western medicine group (group B, n=40). Zîgōng (Results
The cured and markedly effective rate of group A was 72.5% (29/40), which was superior to that of group B (37.5%, 15/40) (P<0.05). The symptom scores were improved significantly in the two groups after treatment (all P<0.05), and the improvement in group A was superior to that in group B (all P<0.05).Conclusion
The efficacy of electroacupuncture combined with heat-sensitive moxibustion is superior to that of conventional western medicine in treatment of premature ovarian failure. 相似文献10.
Bo CHEN Mu-yang LI Li-ying XING Xue-mao ZHUO Ze-lin CHEN Yi GUO Ming-yue LI 《世界针灸杂志》2018,28(4):263-267
Objective
To investigate the local initiation role of local exosomes of acupoints in acupuncture analgesic effect.Methods
Thirty-two rats with adjuvant arthritis were randomly divided into model group (Group CFA), model?+?electroacupuncture group (Group EA), model?+?antagonist?+?electroacupuncture group (Group GW4869?+?EA), and model?+?dimethyl sulfoxide?+?electroacupuncture group (Group DMSO?+?EA), with 8 rats in each group. The model rat s of adjuvant arthritis were prepared by intradermal injection of 0.1?mL of Freund's adjuvant complete into the metatarsal of the right posterior foot to induce inflammation. No intervention was given in Group CFA, while electroacupuncture was performed in the other three groups at “Zúsānl? (足三里 ST 36, bilaterally)” and “Huántiào (环跳 GB 30, bilaterally)” of the rats with the following electroacupuncture parameters: dilatational wave with a frequency of 2/10?Hz, an intensity of 5/10/15 (0.76/1.53/2.3?mA), a duration of 30?min, and an intensity increasing every 10?min. In Group DMSO?+?EA, DMSO (with a concentration of 0.2%, 50µL/acupoint) was injected at bilateral “ST 36” of the model rats one hour before electroacupuncture, while GW4869 (with a concentration of 3?mg/mL, 50µL/acupoint) was injected at bilateral ST 36 of the model rats one hour before electroacupuncture in Group GW4869?+?EA. The paw withdrawal latency (PWL) was used as the therapeutic effect index.Results
The PWL of rats in each group at Hour 24 after modeling was significantly lower than that before modeling, indicating that the models were successfully established. After the electroacupuncture treatment, the PWL of rats showed an increasing trend in all groups. The PWL of Group GW4869?+?EA (6.74?±?1.09)s was lower than that of Group EA (7.72?±?1.54)s on Day 1 after injection, but the difference was not statistically significant (P?>?0.05). The PWL values of Group GW4869?+?EA (7.72?±?0.70)s, (7.87?±?0.58)s were significantly lower than those of Group EA (9.96?±?0.94)s, (9.66?±?0.96)s (both P?<?0.05) on Days 2 and 3 after injection, and the differences were statistically significant.Conclusion
It was preliminarily found that acupuncture analgesic effect was significantly reduced after local exosomes of acupoints were blocked, indicating that local exosomes of acupoints may be involved in the initiation process of acupuncture effect. 相似文献11.
Objective
To investigate the effect and mechanism of electroacupuncture (EA) in the intervention of neurogenic bladder (NB) caused by suprasacral spinal cord injury (SCI).Methods
The total 60 female Sprague-Dawley (SD) rats were divided into blank group, sham operation group by adopting random number table method, with 12 rats in each group. The remaining rats were made into models through operation, and 24 successful model rats were randomly divided into model group and EA group, with 12 rats in each group. Since the 19th day after modeling, EA was conducted at “Cìliáo” (次髎BL 32), “Zhōngjí” (中极CV 3), “Sānyīnjiāo” (三阴交SP 6) and “Dàzhuī” (大椎GV 14) in EA group, remaining the needle for 20?min every time. The intervention was performed for once a day, and 7 consecutive days were needed. The rest of the three groups were only tied up for the same time. Urodynamics test was conducted after the intervention. The contents of PACAP-38 and PAC1R of the spinal cord of the injury site were detected by Western blot.Results
Compared with the blank group, there were no significant differences in the bladder capacity, leak point pressure, bladder compliance and PACAP-38 and PAC1R contents in spinal cord in sham operation group; compared with the sham operation group, the maximum bladder capacity and the bladder compliance in the model group were lower (both P<0.05), the leak point pressure was higher (P<0.05), the contents of PACAP-38 and PAC1R were lower (both P<0.05); compared with the model group, the maximum bladder capacity and the bladder compliance in the EA group were higher (both P<0.05), the leak point pressure was lower (P<0.05), the contents of PACAP-38 and PAC1R were higher (both P<0.05).Conclusion
EA at BL 32, CV 3, SP 6 and GV 14 can improve the bladder function of NB rats of suprasacral SCI, and its mechanism may be related to the increase expression of PACAP-38 and PAC1R protein in the injured spinal cord tissue. 相似文献12.
Qiong LIU Wei ZHU Mailan LIU Xia LIU Jianan CAO Shuning HU Xiaorong CHANG Xianghong JING 《世界针灸杂志》2018,28(4):257-262
Objective
To observe the influence of acupuncture stimulus and thermal stimulus on the expression of mast cells (MCs) and 5-hydroxytryptamine (5-HT) in local acupoint area of Guānyuan (关元 CV 4) and serum 5-HT in rats.Methods
Thirty-nine male C57BL/6 rats were randomly divided into blank control group, acupuncture stimulus group and thermal stimulus group, with 13 rats in each group. The rats were stimulated by manual acupuncture at CV 4 for 5?min in acupuncture stimulus group, while those in thermal stimulus group were stimulated by adopting a thermal moxibustion apparatus on CV 4 for 30?min. The expression of MC and 5-HT in the skin in the acupoint area of CV 4 before and after acupuncture stimulus and thermal stimulus was observed and analyzed via adopting toluidine blue staining method and immunofluorescence histochemical method (5 rats were selected from each group), and the 5-HT content in serum before and after stimulus was determined through enzyme-linked immunosorbent assay (ELISA) (8 rats were selected from each group). The influence of acupuncture stimulus and thermal stimulus on the contents of MC and 5-HT in the skin and serum 5-HT in rats was analyzed and compared.Results
① After acupuncture stimulus or thermal stimulus on CV 4 of C57BL/6 rats, the number of MC in the acupoint area significantly increased when compared with that in blank group (the acupuncture stimulus group 12.40?±?2.07 vs. the blank group 3.00?±?5.96; thermal stimulus group 26.20?±?10.85 vs. the blank group 12.40?±?2.07, both P?<?0.05), and MC aggregation and degranulation were observed (the acupuncture stimulus group 17.80?±?4.55 vs. the blank group 8.00?±?3.16; the thermal stimulus group 24.00?±?9.05 vs. the blank group 8.00?±?3.16, P?<?0.05, P?<?0.01). ② After acupuncture stimulus or thermal stimulus, 5-HT was released by MCs in the acupoint area, which aggregated around the blood vessels, and the number of 5-HT in the acupoint area significantly increased when compared with that in blank group (the blank group 3.00?±?1.28 vs. the acupuncture stimulus group 10.02?±?3.21; the blank group 3.00?±?1.28 vs. the thermal stimulus group 14.00?±?3.94, both P?<?0.01). ③ Compared with blank group, both acupuncture stimulus and thermal stimulus could reduce the 5-HT content in serum (the blank group 0.72?±?0.2372 vs. acupuncture stimulus group 0.43?±?0.21; the blank group 0.72?±?0.24 vs. thermal stimulus group 0.32?±?0.18, both P?<?0.01), and the effect in thermal stimulus group was slightly superior to that in acupuncture stimulus group (P?<?0.05).Conclusion
Both acupuncture stimulus and thermal stimulus can cause the aggregation and degranulation of MCs and high expression of 5-HT in the acupoint area. The effect of thermal stimulus was superior to that of acupuncture stimulus in degranulation. 相似文献13.
Objective
To observe the comprehensive curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain for post stroke depression associated with anxiety.Methods
Sixty-four patients with post stroke depression associated with anxiety were randomly divided into 2 groups according to the random numbers generated by spss16.0 software, the group of acupuncture manipulation of regulating governor vessel and unblocking brain (group A) and medication group (group B), with 32 patients in each group. Acupuncture manipulation of regulating governor vessel and unblocking brain was performed in group A, B?ihuì (百会GV 20), Shéntíng (神庭GV 24), Y?mén (哑门GV 15) and Dànzhōng (膻中CV 17), Gānshū (肝俞BL 18), Xīnshū (心俞BL 15), Shènshū (肾俞BL 23), Tàichōng (太冲LR 3), Tàixī (太溪KI 3), Shénmén (神门HT 7) and Nèiguān (内关PC 6) were selected. The treatment was conducted for once a day, and 5 times a week. Escitalopram oxalate tablets were given orally to the patients in group B for once a day. The treatment was conducted for 8 consecutive weeks in each group. The scores of Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), Barthel index (BI) and Fugl–Meyer assessment (FMA) in the two groups before and after treatment were compared.Results
Comparison with the same group before treatment, HAMD score and HAMA sore in the two groups after treatment for 4 weeks and 8 weeks were all obviously lower than that in the same group before treatment (all P?<?0.01); after treatment for 8 weeks, BI score and FMA score in the two groups were all significantly higher than that in the same group before treatment (all P?<?0.01). Comparison between two groups after treatment, HAMD score and HAMA sore in group A after treatment for 4 weeks were significantly lower than that in group B (both P?<?0.05); only the HAMA sore in group A after treatment for 8 weeks was lower than that in group B (P?<?0.05), and there was no significant difference in HAMD score in the two groups (P?>?0.05); after treatment for 8 weeks, FMA score in group A was obviously higher than that in group B (P?<?0.05), and there was no significant difference in BI score in the two groups (P?>?0.05).Conclusion
The curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the anxiety state and motor function of the patients with post stroke depression is superior to that of escitalopram. With regard to the improvement of depression, this acupuncture manipulation was provided with the characteristic of rapid onset, and its long-term efficacy is equivalent to that of escitalopram. In terms of the improvement of activities of daily living, the curative effect of the two methods is equally well. 相似文献14.
Objective
To observe the effect of acupuncture at Jǐngjiājǐ (颈夹脊) on the repair and regeneration of cochlear hair cells of guinea pigs with sensorineural deafness.Methods
Sixty healthy guinea pigs were selected, 20 guinea pigs were randomly assigned to the normal control group (group A), and other guinea pigs were randomly divided into model control group (group B) and acupuncture treatment group (group C) after injection with gentamicin sulfate in order to induce deafness. No intervention was given to the guinea pigs in group A and group B, and acupuncture at Jǐngjiājǐ was given to the guinea pigs in group C for 30 days. ABR threshold, DPOAE amplitudes and hair cells counting of guinea pigs in each group were recorded after intervention for 30 days.Results
After intervention for 30 days, ABR threshold in group C was significantly lower than that in group B (38.46?±?7.36?vs 82.94?±?6.47, P<0.01), and the DPOAE amplitudes in group C were obviously higher than that in group B (28.06?±?5.64?vs 25.23?±?5.38, P<0.01). The number of cochlear hair cells in group C increased significantly, over 50% of the hair cells survived, accounting for 66.67% of the observation cases. The number of cochlear hair cells in the 3rd and 4th gyri was close to the normal level, and plenty of proliferous sustentacular cells can be seen. Compared with group B, the number of cochlear outer hair cells in each gyrus in group C significantly increased (36.76?±?1.97?vs 28.59?±?2.24, P<0.01), indicating that acupuncture at Jǐngjiājǐ can promote the repair and regeneration of cochlear hair cells.Conclusion
Acupuncture at Jǐngjiājǐ can promote the repair and regeneration of cochlear hair cells, thus improving the hearing of guinea pigs with deafness. 相似文献15.
Objective
To observe the clinical efficacy of acupuncture–moxibustion therapy of "banking up original qi and consolidating the foundation" for prevention and treatment of seasonal allergic rhinitis.Methods
Sixty included patients were divided into two groups according to the random number table method with 30 patients in each group. In acupuncture group, warming-needle moxibustion was carried out at Zúsānl? (足三里ST 36), and cone moxibustion on Fùz? (附子Radix Aconiti Lateralis Praeparata) cake was conducted at Guānyuán (关元CV 4), Qìh?i (气海CV 6) and Dàzhuī (大椎GV 14). The treatment was conducted in May or June (2 months before the onset of rhinitis in this area). The treatment was carried out for once every other day and three times per week. Treatment for 24 times was considered as 1 course of treatment. No intervention treatment was conducted in control group. The score of rhinitis symptom, the visual analogue scale (VAS) score changes of total nasal symptom score (TNSS) and total non-nasal symptom score (TNNSS) of patients in 2015 and in 2016 were observed, and the clinical efficacy of the two groups was compared.Results
(1) The score of rhinitis symptom, the VAS score changes of TNSS and TNNSS in acupuncture group in 2016 declined when compared with the results in 2015, which were 4.57?±?0.82?vs 9.40?±?1.89, 13.37?±?4.01?vs 30.80?±?4.77 and 15.93?±?6.30?vs 46.13?±?9.79 (P?<?0.001), the results in acupuncture group after treatment were lower than that in control group at same time, which were 4.57?±?0.82?vs 7.53?±?2.06, 13.37?±?4.01?vs 27.17?±?6.84,15.93?±?6.30?vs 35.53?±?11.69(all P?<?0.001). According to comparison, there was no obvious difference in the results in control group at the two time points, which were 8.60?±?2.39?vs 7.53?±?2.06, 29.63?±?6.30?vs 27.17?±?6.84 and 40.90?±?12.31?vs 35.53?±?11.69 (all P?>?0.05). (2) The total effective rate was 96.7% (29/30) in acupuncture group and 10% (3/30) in control group, and the difference was statistically significant (P?<?0.001).Conclusion
Acupuncture–moxibustion therapy of "banking up original qi and consolidating the foundation" was effective on prevention and treatment of seasonal allergic rhinitis. 相似文献16.
Pei WANG Cai-rong ZHANG De-chun CHEN Ke-qing ZHUANG Zhi-lan HUANG Can DONG Han-qing HONG Zhi-zhong RUAN 《世界针灸杂志》2018,28(4):246-250
Objective
To compare the clinical efficacy differences of acupotomy therapy guided by the meridian sinew theory and acupotomy therapy guided by the anatomy theory of western medicine in the treatment of knee osteoarthritis.Methods
Sixty-three patients were randomly divided into the acupotomy group of the meridian sinew theory (Group A, n?=?32) and the acupotomy group of the anatomy theory (Group B, n?=?31). For Group A, with positive reaction points such as the tenderness points of three yang meridians and three yin meridians of the foot, and funicular nodules as the points of needle insertion, the needle-knife, after disinfection and anesthesia, gives priority to longitudinal dissection after insertion, and then carries out subcutaneous sweeping maniplation. For Group B, with 8 points for needle insertion, including the origins and terminations of the medial and lateral collateral ligaments, the origins and terminations of the patellar ligament, the terminations of the quadriceps femoris tendon, and pes anserinus bursa point, the treatment was performed in strict accordance with the four-step procedures of acupotomy (positioning, orientating, pressurizing to separate, and puncturing) after disinfection and anesthesia. The treatment was conducted once a week and three times in total. Statistical analysis was conducted with the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index and Visual Analogue Scale (VAS) for overall pain before treatment and at week 2 and 4 during treatment, and the adverse reactions of patients were observed and recorded to evaluate the curative effect.Results
During the treatment period, the overall response rates (ORRs, that is markedly effective?+?effective) were compared between the two groups. The ORR of Group A was 90.63% and that of Group B was 87.09%. There was no statistical significant difference between the two groups (P?>?0.05). After treatment, the WOMAC function score of Group A was significantly lower than that before treatment (17.28?±?10.22?vs 32.75?±?14.88, P?<?0.001), and that of Group B was lower than that before treatment (24.87?±?16.48?vs 30.90?±?16.64, P?<?0.05), there was a statistical significant difference between the two groups (P?<?0.05). As for the comparison of VAS pain scores, in Group A, there was statistical significant difference (4.48?±?1.60?vs 5.05?±?1.60, P?<?0.05) between at Week 2 and before treatment, and statistically significant difference (1.88?±?1.03?vs 5.05?±?1.60, P<0.001) between at Week 4 and before treatment. In Group B, there was no significant difference (P>0.05) between at Week 2 and before treatment, and there was statistically significant difference (3.31?±?1.56?vs 4.77?±?1.68, P<0.001) between at Week 4 and before treatment. The VAS pain score of Group A was significantly lower than that of Group B (P?<?0.001), and 2 cases of mild adverse reactions occurred in Group A and 3 in Group B.Conclusion
Both acupotomy therapies guided by the meridian sinew theory and by the anatomy theory of Western medicine have good curative effect on knee osteoarthritis, but acupotomy guided by the meridian sinew theory has more superiorities in operability, safety and effectiveness, which is easy to be generalized in grass-roots and community hospitals. 相似文献17.
Objective
To observe the clinical therapeutic effects of acupuncture on chemotherapy-induced hand-foot syndrome (HFS).Methods
A total of 60 patients treated with chemotherapy of capecitabine and suffering from the chemotherapy-induced HFS were divided into an acupuncture group and a Vitamin B6 group according to the random number table, 30 cases in each one. In the acupuncture group, after chemotherapy, acupuncture was given at B?ihuì (百会 GV 20), Hég? (合谷 LI 4), Wàiguān (外关 TE 5), Zúsānl? (足三里 ST 36) and Ashi points. The needles were retained for 30?min in each treatment, once a day, totally for 2 weeks. In the Vitamin B6 group, after chemotherapy, Vitamin B6 was taken orally, 300?mg a day, totally for 2 weeks. Separately, on the day of enrollment and after 2 weeks of treatment, the scores of Karnofsky performance scale (KPS) and the quality of life (QLQ-C30) were evaluated in the acupuncture group and the Vitamin B6 group. After 2 weeks of treatment, the therapeutic effects were evaluated.Results
The effective rate of chemotherapy-induced HFS was 70.0% in the acupuncture group and was 36.7% in the Vitamin B6 group. The result in the acupuncture group was higher than the Vitamin B6 group, indicating the significant difference (P?<?0.05). After treatment, the KPS scores (84.23?±?10.49) in the acupuncture group were higher obviously than the Vitamin B6 group (77.84?±?10.33), indicating the significant difference (P?<?0.05). Regarding QLQ-C30 evaluation, after 2-week treatment, the scores in the items of physical function, role function, emotional function, cognitive function and social function were all reduced remarkably as compared with those before treatment in the two groups, indicating the significant differences (all P?<?0.05). After treatment, the scores of physical function (7.13?±?1.56?vs 16.72?±?4.29), emotional function (4.89?±?0.87?vs 11.76?±?1.29) and cognitive function (6.32?±?1.23?vs 18.17?±?4.1) in the acupuncture group were all lower obviously than those in the Vitamin B6 group, indicating the significant differences (all P?<?0.05); and the scores of role function and social function were not different significantly as compared with the VB6 group (all P?>?0.05).Conclusion
Acupuncture is effective for HFS induced by the chemotherapy with capecitabine and its effects are better than the oral administration of Vitamin B 6 in terms of physical function, emotional function and cognitive function. 相似文献18.
Wei-ting Wang Chun-hua Hao Shao-xiang Zhang Xiang-hua Zhang Feng Guo Shuang-yong Sun Rui Zhang Zhuan-you Zhaoa 《中草药(英文版)》2019,11(1):45-51
Objective: To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets(SQTS) on sequelae post-stroke in rats.Methods: The rat cerebral ischemia sequelae post-stroke models were successfully induced by blocking the middle cerebral artery with electric coagulator after the seventh week and balance beam test ≤ 4. The rats were then received with SQTS(0.5, 1, and 2 g/kg) and Naodesheng(NDS, 1.24 g/kg), Vinpocetine(VP,1.55 mg/kg) for 30 d. The beam-walking test and shuttle test were performed before and after 10, 20, and 30 d of administration. In addition, histopathology changes and GAP-43, GFAP were measured by HE staining and immunohistochemisty.Results: The model displayed signs of brain damage on motor function, learning and memory function and histopathology. After 30 d of treatment, SQTS at different doses(0.5, 1.0, and 2.0 g/kg) restored the beam-walking scores by 21.7%(P 0.05), 30.4%(P 0.05), and 39.1%(P 0.05); Decreased electric shock by 35.0%(P 0.05), 50.0%(P 0.05), and 75.0%(P 0.05), respectively. On the other hand, the histological changes were less severe and the GAP-43 expression increased in hippocampal CA1 and cortical region.Conclusion: SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity. 相似文献
19.
Objective
To explore the effect of acupuncture on the endoplasmic reticulum stress IRE 1-CHOP signal pathway and the expression levels of related apoptosis genes in pancreatic tissue of rats with STZ-induced diabetes mellitus.Methods
Eighty SD rats were selected, among which, 10 were fed with normal diet and taken as blank control group (“blank group” for short), the other 70 rats were fed with high fat and high glucose food and injected with small dosage of STZ intraperitoneally, and 30 models were established successfully. The models were randomly divided into acupuncture treatment group (“acupuncture group” for short), model control group (“model group” for short) and western medicine group (metformin) with 10 rats in each group. After treatment for 4 weeks, RBG, and the expression levels of CHOP, IRE 1, Bax, Bcl-2 protein and mRNA in pancreatic tissue of rats were determined.Result
Compared with the conditions before treatment, RBG reduced obviously in the acupuncture group and western medicine group (P<0.05), and there was no statistical difference in RBG in the model group and blank group (P>0.05); the expression levels of CHOP, IRE 1 and Bax proteins in pancreatic tissue of rats in the model group were significantly higher than those in the blank group (P<0.05), the expression results in the acupuncture group and western medicine group were significantly lower than those in model group (P<0.05); the expression levels of CHOP, IRE 1 and Bax mRNAs in pancreatic tissue of rats in the model group were significantly higher than those in the blank group (P<0.01), the expression results in the acupuncture group and western medicine group were significantly lower than those in the model group (P<0.01); the expression level of Bcl-2 protein in the model group was significantly lower than that in the blank group (P<0.05), the expression results in the acupuncture group and western medicine group were significantly higher than that in the model group (P<0.01); there was no statistical difference between the acupuncture group and western medicine group (P>0.05); the expression level of Bcl-2 mRNA in the model group was significantly lower than that in the blank group (P<0.01), the expression results in the acupuncture group and western medicine group were significantly higher than that in the model group (P<0.01); there was no statistical difference between the acupuncture group and western medicine group (P>0.05).Conclusion
There was endoplasmic reticulum stress in the pancreatic tissue of rats with STZ-induced diabetes mellitus, and IRE 1-CHOP signal pathway was the main pathway for inhibiting the endoplasmic reticulum stress in the pancreatic tissue. Acupuncture can improve the endoplasmic reticulum stress in pancreatic tissue, inhibit apoptosis genes, and protect the pancreatic tissue through IRE 1-CHOP signal pathway. 相似文献20.