共查询到14条相似文献,搜索用时 15 毫秒
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Genetic diversity of HIV‐1 and transmitted drug resistance among newly diagnosed individuals with HIV infection in Hangzhou,China
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Jiafeng Zhang Zhihong Guo Jiezhe Yang Xiaohong Pan Jun Jiang Xiaobei Ding Wenjun Zhang Yan Xia Yun Xu Jingjing Huang 《Journal of medical virology》2015,87(10):1668-1676
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HIV‐1 transmitted drug resistance and genetic diversity among patients from Piauí State,Northeast Brazil
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Maria Edileuza Soares Moura Mônica Nogueira da Guarda Reis Yanna Andressa Ramos Lima Kelsen Dantas Eulálio Ludimila Paula Vaz Cardoso Mariane Martins Araújo Stefani 《Journal of medical virology》2015,87(5):798-806
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Mattia C.F. Prosperi Maurizio Zazzi Grazia Punzi Laura Monno Grazia Colao Paola Corsi Simona Di Giambenedetto Genny Meini Valeria Ghisetti Stefano Bonora Monica Pecorari Maria Rita Gismondo Patrizia Bagnarelli Tiziana Carli Andrea De Luca for the ARCA Collaborative Group 《Journal of medical virology》2010,82(12):1996-2003
Protease inhibitor (PI)‐resistant HIV‐1 has hardly ever been detected at failed boosted PI‐based first‐line antiretroviral regimens in clinical trials. However, this phenomenon has not been investigated in clinical practice. To address this gap, data from patients starting a first‐line lopinavir/ritonavir (LPV/rtv)‐based therapy with available baseline HIV‐1 RNA load, a viral genotype and follow‐up viral load after 3 and 6 months of treatment were extracted from the Italian Antiretroviral Resistance Cohort Analysis (ARCA) observational database. Based on survival analysis, 39 (7.1%) and 43 (7.8%) of the 548 examined patient cases had an HIV‐1 RNA >500 and >50 copies/ml, respectively, after 6 months of treatment. Cox proportional hazard models detected baseline HIV‐1 RNA (RH 1.79, 95%CI 1.10–2.92 per 1 ? log10 increase, P = 0.02) and resistance to the nucleoside backbone (RH 1.04, 95%CI 1.02–1.06 per 10‐point increase using the Stanford HIVdb algorithm, P < 0.001) as independent predictors of HIV‐1 RNA at >500 copies/ml, but not at the >50 copies/ml cutoff criteria. Higher baseline viral load, older patient age, heterosexual route of infection and use of tenofovir/emtricitabine were predictors of failure at month 3 using the 50‐copy and/or 500‐copy threshold. Resistance to LPV/rtv did not occur or increase in any of the available 36 follow‐up HIV‐1 genotypes. Resistance to the nucleoside backbone (M184V) developed in four cases. Despite the likely differences in patient population and adherence, both the low rate of virological failure and the lack of development of LPV/rtv resistance documented in clinical trials are thus confirmed in clinical practice. J. Med. Virol. 82:1996–2003, 2010. © 2010 Wiley‐Liss, Inc. 相似文献
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L. Skoura S. Metallidis D. Pilalas A. Kourelis A. Margariti E. Papadimitriou Z.A. Antoniadou T. Chrysanthidis O. Tsachouridou P. Kollaras P. Nikolaidis N. Malisiovas 《Clinical microbiology and infection》2013,19(3):E169-E172
We conducted a retrospective study on the prevalence and correlates of transmitted drug resistance among newly-diagnosed antiretroviral naive human immunodeficiency virus (HIV) patients in Northern Greece, during the period 2009–11. Transmitted drug resistance was documented in 21.8% of patients enrolled, affecting approximately 40% of subtype A HIV-1-infected individuals. Overcoming challenges due to the ongoing financial crisis, effective preventive measures should be implemented to control further dissemination of resistant HIV strains. 相似文献
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Ebot Ojong Bassey Iya Jules Djeufouata Forwah Ndeh Augusta nsonwu Vigny Njongang Maisie Etukudo Chinyere Usoro Julie Ekpo 《African health sciences》2022,22(1):410
BackgroundAlthough an increasing access to ART in sub-Saharan Africa has made it possible for HIV/AIDS patients to live longer, clinicians managing such patients are faced with the challenge of drug-related metabolic complications.MethodsA cross -sectional study was carried out at the University of Calabar Teaching Hospital, Nigeria, on three groups of participants; namely HIV patients on ART, ART-naïve patients and HIV negative subjects (n =75). Demographic and anthropometric data were collected using a well-structured questionnaire while biochemical parameters were measured using colorimetric methods.ResultsThe highest prevalence of MS was associated with the HIV/AIDS patients on ART (i.e. 32.0 %, and 50.3% for NCEP-ATP III and IDF criteria respectively). Patients on ART had significant increases (p< 0.05) in waist to hip ratio, FPG, serum TG and LDL-c; and a significantly higher (p< 0.05) prevalence of hypertension, diabetes, low HDL-c and hypertriglyceridaemia compared to the ART-naïve patients. Low serum HDL-c was the most prevalent form of dyslipidaemia in all three groups and the most prevalent component of MS in HIV patients.ConclusionART increases the risk of MS and CVD. HIV/AIDS patients on ART should be advised on lifestyle modifications and undertake regular assessment of their cardiovascular risk factors. 相似文献
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Emergence of uncommon HIV‐1 non‐B subtypes and circulating recombinant forms and trends in transmission of antiretroviral drug resistance in patients with primary infection during the 2013‐2015 period in Marseille,Southeastern France
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Catherine Tamalet Hervé Tissot‐Dupont Anne Motte Christian Tourrès Catherine Dhiver Isabelle Ravaux Isabelle Poizot‐Martin Thérèse Dieng Christelle Tomei Sylvie Bregigeon Olivia Zaegel‐Faucher Hélène Laroche Sarah Aherfi Saadia Mokhtari Hervé Chaudet Amelie Ménard Philippe Brouqui Andreas Stein Philippe Colson 《Journal of medical virology》2018,90(10):1559-1567
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L. Kolte J. C. Gaardbo K. Skogstrand L. P. Ryder A. K. Ersbll S. D. Nielsen 《Clinical and experimental immunology》2009,155(1):44-52
This study determines levels of regulatory T cells (Tregs), naive Tregs, immune activation and cytokine patterns in 15 adult human immunodeficiency virus (HIV)‐infected patients receiving prolonged highly active anti‐retroviral therapy (HAART) who have known thymic output, and explores if naive Tregs may represent recent thymic emigrant Tregs. HIV‐infected patients treated with HAART with a median of 1 and 5 years were compared with healthy controls. Percentages of Tregs (CD3+CD4+CD25+CD127low), naive Tregs (CD3+CD4+CD25+CD45RA+) and activation markers (CD38+human leucocyte antigen D‐related) were determined by flow cytometry. Forkhead box P3 mRNA expression and T cell receptor excision circles (TREC) content in CD4+ cells were determined by polymerase chain reaction and cytokines analysed with Luminex technology. Levels of Tregs were significantly higher in HIV‐infected patients compared with controls, both after 1 and 5 years of HAART (P < 0·001), despite fully suppressed HIV‐RNA and normalization of both CD4 counts, immune activation and cytokine patterns. Furthermore, levels of naive Tregs were elevated significantly in HIV‐infected patients (P < 0·001) and were associated with thymic output measured as the TREC frequency in CD4+ cells (P = 0·038). In summary, Treg levels in HIV‐infected patients are elevated even after 5 years of HAART. Increased thymic production of naive Tregs may contribute to higher Treg levels in HIV‐infection. 相似文献
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Molecular characterization of hepatitis C virus for determination of subtypes and detection of resistance mutations to protease inhibitors in a group of intravenous drug users co‐infected with HIV
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Tânia Silva Helena Cortes Martins Rodrigo Coutinho Emília Leitão Rui Silva Elizabeth Pádua 《Journal of medical virology》2015,87(9):1549-1557