Making the most of research

The results of research are worthless if they are not used. Efficient two-way communication between the producers and users of scientific studies helps to prevent this from happening.     

Making the most of a translator

Anaheim Memorial Hospital in California is a trailblazer. It's one of the first hospitals in the nation to use translation software for both supply procurement and claims-related transactions. Initially, it acquired the software to streamline the ordering of supplies by shifting to standard electronic formats. Today, the hospital is using the software to receive electronic remittance advice, and it has plans for other labor-saving applications.     

对数线性模型在病例-父母/对照-母亲混合设计中的应用

以唇腭裂与亚甲基四氢叶酸还原酶(MTHFR)基因A1298C多样性的关系为例,基于似然比检验(LRT)的对数线性模型分析母亲、子代基因型与唇腭裂的关系,介绍应用对数线性模型分析病例-父母/对照-母亲混合设计资料的方法应用。发现母亲基因型为CC时,相对于基因型为AA的母亲,其子代唇腭裂发病风险降低,S₂=0.45(95%CI:0.26~0.79);子代基因型为AC时,相对于AA其发病风险降低,R₁=0.69(95%CI:0.48~0.97),其余未见关联。混合设计的效力要大于病例-父母对照研究(0.86>0.78)。表明MTHFR A1298C可能在唇腭裂的病因学机制中起重要作用。应用对数线性模型对这类混合设计资料的分析可以同时探讨母亲、子代基因型对疾病的影响,且相对病例-父母对照研究效力更高,适用于出生缺陷等生命早期疾病的病因学研究。     

Making the most of data for disease management

Managed care organizations have a wealth of administrative, claims and clinical data available to them--data that could pinpoint patients who could benefit from cost-effective disease management programs. Health plans that have such efforts offer advice on how to home in on the best data.