共查询到20条相似文献,搜索用时 121 毫秒
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Shanhui Zhang Fei Zhou Donghai Liang Hongying Lv Hongsheng Yu 《Oncology and Translational Medicine》2020,(2):72-80
Objective This study aimed to compare the effectiveness of adjuvant chemoradiotherapy(CRT)and adjuvant chemotherapy(ChT)for T3–4/N+gastric cancer(GC)following D2/R0 dissection,and identify the specific subgroups that could benefit from adjuvant CRT.Methods All eligible patients were divided into the CRT group and ChT group.We assessed the survival outcomes and patterns of recurrence for each group,and determined the prognostic factors for survival by performing Cox proportional risk regression analyses.Results A total of 192 gastric cancer patients were included in the study.The estimated 3-year and 5-year disease-free survival(DFS)probabilities in the CRT and ChT groups were 52.9%vs.36.7%(P=0.024)and 41.2%vs.31.1%(P=0.148),respectively,and the estimated 3-year and 5-year overall survival(OS)probabilities were 82.4%vs.70.0%(P=0.044)and 52.0%vs.35.6%(P=0.022).Patients in the CRT group had a lower risk of locoregional recurrence than those in the ChT group(20.6%vs.34.4%;P=0.031).The subset analyses revealed that patients with stage N1–2 disease were more likely to benefit from adjuvant CRT than from adjuvant ChT(DFS:53.1%vs.36.4%;P=0.039;OS:53.1%vs.38.6%;P=0.036).Conclusion For locally advanced gastric cancer patients with LN+,adjuvant CRT showed superior survival benefits compared with adjuvant ChT alone.Patients with N1–2 achieved better survival from adjuvant CRT. 相似文献
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Xiangdong Cheng Yian Du Ling Huang Zhiming Jing Zhiguo Zheng 《中德临床肿瘤学杂志》2008,7(4):213-216
Objective:To investigate the death mode of human hepatoma cells exposed to matrine and the role of glutathione (GSH) and cytochrome c.Methods:The MTT test and Cell Death Detection ELISA were used to identify cell death mode and viability of cells exposed to matrine.The volume of intracellular GSH was detected by GSH reductase.Finally Western blotting was chosen to analyze the expression of cytochrome c and Caspase-9 in HepG2 cells treated by matrine.Results:The apoptotic cell death induced by matrine in Hep G2 cells dramatically increased in the time-,dose-dependent manner.Matrine can exhaust intracellular GSH effectively to change the redox state in cells.Furthermore it affect the cytotoxicity of matrine.Results of Western blotting showed that matrine induced the release of cytochrome c from mitochondria to cytoplasm,and then stimulate the cleavage of Cespese-9 in a time-dependent manner.Conclusion:Matrine induced apoptosis in Hep G2 cells through the mitochondrial pathway,and oxidative stress via depletion of GSH is directly involved in the apoptotic process. 相似文献
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Daniel J. Brat Timothy Charles Ryken Steven N. Kalkanis Jeffrey J. Olson 《Journal of neuro-oncology》2014,118(3):461-478
Question
1. What are the most important diagnostic considerations in reporting progressive glioblastoma?Target population
These recommendations apply to adults with progressive glioblastomaRecommendations
Level III
For patients who undergo biopsy or neurosurgical resection at the time of radiologic or clinical progression, it is recommended that the pathologist report the presence and extent of progressive neoplasm as well as the presence and extent of necrosis within the pathologic material examined. Furthermore, to ensure the proper interpretation of progressive glioblastoma, it is recommended that the pathologist take into account the patient’s previous diagnosis and treatment, as well as the current clinical and neuroimaging features that have led to a second biopsy or resection.Question
2. What techniques and ancillary studies are most useful in separating malignant progression from treatment effect?Target population
These recommendations apply to adults with progressive glioblastomaRecommendations
Level III
In the setting of prior radiation and chemotherapy, it is recommended to adhere to strict histologic criteria for microvascular proliferation and necrosis in order to establish a diagnosis of a glioblastoma. Immunohistochemistry and genetic studies are selectively recommended for distinguishing neoplastic cells from atypical reactive cells in progressive glioblastoma. 相似文献12.
Background
Nasal eosinophilia is one of the potential tests for substantiating the diagnosis of allergic rhinitis.Objective
The aim was to establish the validity of nasal eosinophilia in allergic rhinitis, to study it's various clinical correlates and interpret it in context of skin sensitivity pattern.Study Design
Prospective cased study.Setting
Hospital based.Patients
The patients were selected on the basis of history and clinical examination and were from the Himalayan region.Intervention
Diagnostic.Methods
The patients and the equal number of controls, were subjected to nasal smear for eosinophilia and intra-dermal skin tests to various allergeus.Results
Overall, eighty percent of nasal smears were positive in various degrees among the cases. Around eighty-eight percent of cases showed both smear and skin test positivity, thereby signifying a high degree of harmony among them and further validating and confirming the diagnosis of allergic rhinitis.Conclusion
Nasal eosinophilia was found to be a useful diagnostic test in allergic rhinitis, with a moderately high sensitivity and a high specificity. 相似文献13.
Monther Ali Alajmi Khalid A. Al-Abdulhadi Hamoud Saud Al-noumas Gopalan Kavitha 《Indian journal of otolaryngology and head and neck surgery》2009,61(4):266-269
Objective
To determine the efficacy of intravenous dexamethasone in reducing postrhinoplasty edema.Design
A prospective, randomized clinical trial with placebo control.Setting
Department of Otorhinolaryngology, Al-Sabah and Zain Hospital, Kuwait.Subject
Eighty-four patients (male = 28; female = 56) aged between 20 and 40 years, undergoing open rhinoplasty with hump removal and bilateral lateral osteotomies were enrolled in this study.Intervention
Patients were randomized to receive two doses of 10 mg of dexamethasone intravenously or placebo, first dose during surgery and second dose 12 hours after surgery.Main outcome measures
Patients were evaluated postoperatively at 24 hours, days 2, 5, 7 and 10 for periorbital edema.Results
10 mg of dexamethasone given intravenously during rhinoplasty and a second dose 12 hours after surgery, reduced postoperative periorbital edema significantly.Conclusion
This study showed a statistically significant benefit of dexamethasone over placebo in reducing periorbital edema after rhinoplasty. No complications were attributed to the administration of dexamethasone. 相似文献14.
D. S. Robertson 《Cellular oncology (Dordrecht)》2018,41(1):103-106
Purpose
Purpose of the work is to highlight a possible connection between metabolic iodine and natural tumour control.Method
Method adopted is to use information available in the literature.Result
Result indicated a means of the purpose being attained.Conclusion
Conclusion drawn is that a tumour control method derives from the relationship studied.15.
Samuel Ryu John M. Buatti Ann Morris Steven N. Kalkanis Timothy Charles Ryken Jeffrey J. Olson 《Journal of neuro-oncology》2014,118(3):489-499
Question
Can re-irradiation (by using conventional radiotherapy, fractionated radiosurgery, or single fraction radiosurgery) be used in patients with progressive glioblastoma multiforme after the first adjuvant combined multimodality treatment with radiation and chemotherapy?Target population
These recommendations apply to adult patients with progressive glioblastoma after first line combined multimodality treatment with chemotherapy and radiation.Recommendations
Level III
When the target tumor is amenable for additional radiation, re-irradiation is recommended as it provides improved local tumor control, as measured by best imaging response. Such re-irradiation can take the form of conventional fractionation radiotherapy, fractionated radiosurgery, or single fraction radiosurgery.Level III
Re-irradiation is recommended in order to maintain or improve a patient’s neurological status and quality of life prior to any further tumor progression. 相似文献16.
Urvashi Razdan R. M. Raizada V. N. Chaturvedi 《Indian journal of otolaryngology and head and neck surgery》2004,56(1):20-22
Objective
To assess the efficacy of conservative modalities in the management of epistaxis.Study design
Prospective case studies.Setting
Rural medical college hospital.Patients
Indoor and outdoor patients with epistaxis.lntervention
Conservative(non surgical) management techniques in epistaxis.Results
Chemical cauterization was successful in 72.07% cases, anterior nasal packing in 84.5% and posterior nasal packing in 95.6% cases.Conclusion
Out of 300 cases of epistaxis included in the study (except for one case that required internal maxillary artery ligation). all cases were treated successfully with conservative treatment alongwith treating the underlying pathology causing epistaxis. 相似文献17.
Intratympanic dexamethasone application in Meniere's disease—Is it superior to conventional therapy?
Gilbert Paragache Naresh K. Panda Meena Ragunathan Sridhara 《Indian journal of otolaryngology and head and neck surgery》2005,57(1):21-23
Objective
To compare the efficacy of conventional medical treatment versus transtympanic dexamethasone application into middle ear as treatment modality in Meniere's disease.Study Design
Prospective randomized study.Setting
Tertiary referral centre.Method
Forty patients of Meniere's disease were treated, 20 by conventional method and 20 by transtympanic dexamethasone applications.Intervention
Theraputic.Results
Vertigo control of 85% achieved in study group when compared to 80% in control group, 15% of patients had hearing improvement in study group while 10% had hearing improvement in control group. Aural fullness and tinnitus control were identical in both groups.Conclusions
Both modalities of therapy were found to have almost equal efficacy, with Intra tympanic steroid (ITS) therapy having an edge over conventional therapy in cases with severe attacks and shorter duration of symptoms. 相似文献18.
L Costas C Infante-Rivard J-P Zock M Van Tongeren P Boffetta A Cusson C Robles D Casabonne Y Benavente N Becker P Brennan L Foretova M Maynadié A Staines A Nieters P Cocco S de Sanjosé 《British journal of cancer》2015,112(7):1251-1256
Background:
Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.Methods:
We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.Results:
Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.Conclusions:
Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes. 相似文献19.
Judith S. Kaur MD Kathryn Coe PhD Julia Rowland PhD Kathryn L. Braun DrPH Francisco A. Conde PhD ARPN Linda Burhansstipanov DrPH MPH Sue Heiney PhD RN Marjorie Kagawa‐Singer PhD MA MN RN Qian Lu MD PhD Catherine Witte RPh MDiv 《Cancer》2012,118(21):5366-5373
BACKGROUND:
Although large numbers of cancer survivors exist in every community, including minority communities, there is a significant gap in knowledge about best practices for these patients.METHODS:
The Community Networks Program, funded by the National Cancer Institute Center to Reduce Cancer Health Disparities, has developed and tested unique services for these communities. These programs have used community‐based participatory research techniques under a framework of diffusion of innovation and communications theory.RESULTS:
This article describes some specifically tailored interventions that may be useful to a wide range of providers working with the underserved.CONCLUSIONS:
Enhancing life after cancer can be achieved in underserved communities by supplementing local resources. Cancer 2012. © 2012 American Cancer Society. 相似文献20.
H. Vijayendra C. J. Ittop R. Sangeetha 《Indian journal of otolaryngology and head and neck surgery》2008,60(4):341-344