Primary choriocarcinoma of the ovary.

Eight patients with choriocarcinoma of the ovary treated at the Choriocarcinoma Research and Treatment Center are presented and the previously reported cases reviewed. A more optimistic prognosis can be offered for these tumors than previously. Four of the 8 patients are in remission and 4 have died. Triple therapy should be used for these tumors despite the increase in toxicity.     

Primary pure choriocarcinoma of the ovary.

The authors report a case of pure primary choriocarcinoma of the ovary (FIGO stage III A) in a young patient with 24-month follow-up. The patient, an advanced case of choriocarcinoma, was treated with combination chemotherapy comprising vincristine, bleomycin and cisplatinum. It is stressed that at that stage of the disease it is of prime importance to initiate combination chemotherapy for improvement in survival and prognosis of such cases rather than to distinguish the gestational or nongestational origin of the tumor.     

Primary choriocarcinoma of the ovary: a case report

A case of primary choriocarcinoma of the ovary in a 32-year-old woman, 1 month after a voluntary interruption of pregnancy, is reported. A review of the literature shows that this tumour is rare and the distinction between a gestational and a non-gestational choriocarcinoma is difficult. The distinction between these two diagnoses and specific treatment are discussed.     

Gestational choriocarcinoma of the ovary

A case of gestational choriocarcinoma of the ovary in which Spiegelberg's criteria are met is presented. The primacy of such a lesion is discussed. The distinction between nongestational and gestational ovarian choriocarcinoma is described.     

Pure nongestational choriocarcinoma of ovary

Introduction Primary ovarian choriocarcinoma arising presumably from a germ cell is extremely rare. Besides arising gestationally or nongestationally, it may be pure or mixed with other germ cell tumors like immature teratoma, dysgerminoma, polyembryoma.Case report and discussion We present a case of a 22-year-old woman diagnosed with pure nongestational choriocarcinoma of the ovary with a review of the literature and discussion of its origin.     

Primary choriocarcinoma of the vulva

Abstract. Weiss S, Amit A, Schwartz MR, Kaplan AL. Primary choriocarcinoma of the vulva.
Primary extrauterine choriocarcinoma is very rare, found mostly in the genital tract (tube, cervix, ovary, vagina). Other sites such as lungs, gastrointestinal tract, heart, brain and submentum also have been reported.   A 31-year-old woman presented with abnormal uterine bleeding 6 weeks after her last menstrual cycle. Her HCG titer level was 900 mIu/ml. She underwent dilation and curettage (D & C). Pathology failed to reveal any chorionic villi. Further evaluation was done, including a second D & C, laparoscopy, exploratory laparotomy, CT, MRI and ultrasound which all failed to define a source for the elevated HCG titer which subsequently rose to 95,000 mIu/ml 130 days after her last menstrual cycle. At that time a vulvar mass was observed. Fine needle aspiration (FNA) was positive for choriocarcinoma. The patient was treated with one course of methotrexate 60 mg intramuscularly every other day for 5 days. Actinomycin-D 0.5 mg given intravenously daily for 5 days was added to courses 2–7. Radiotherapy (4000 rads) was applied concomitant with the chemotherapy. The remainder of the mass was subsequently excised. The patient has remained with no evidence of disease for 10 years. This is the first case report of primary vulvar choriocarcinoma.     

Primary tubal choriocarcinoma

Choriocarcinoma is one of the most serious forms of gestational trophoblastic tumor. It is a malignant tumor from the epithelium of the chorionic villi. The most frequent location site is the uterus. Associated with ectopic pregnancy, it is extremely rare and in general, very aggressive. In 75% of the cases, it items from distant metastasis; therefore, a histological examination of the tubes must be performed in all ectopic pregnancies. Our patient was a 33-year-old woman who was admitted to emergency room (ER) with an intense pain in the right, iliac cavity, and limited genital bleeding. During the exploration, there was abdominal pain, with doubtful signs of peritoneal irritation. The vaginal ultrasound offered an image that was compatible with an extra uterine pregnancy in the left appendages. At emergency, right salpingectomy was performed via laparotomy. The patient was treated with polychemotherapy and contraceptives for a year, with no recurrence of the disease. Control follow-up was performed using beta-human chorionic gonadotropin (HCG) testing on a weekly basis during the first month and then bi-monthly during the first year of follow-up.     

Primary cervical choriocarcinoma

A case of choriocarcinoma in the uterine cervix, which developed 3 years after elective abortion, is presented. Colposcopic and pelvic angiographic findings are described. Review of the literature suggests a favorable prognosis of this particular type of ectopic choriocarcinoma.     

Primary ovarian choriocarcinoma

This rare tumour was evidenced in a 14-year-old girl. She died two and a half months following the operation, with the symptoms of respiratory insufficiency. The Metotrexate therapy did not produce the disappearance of the chorionic gonadotropin in the urine.     

Primary mediastinal choriocarcinoma.

Although mediastinal choriocarcinoma is very rare, the possibility of choriocarcinoma should be considered in fertile women who have unexplained abnormal chest radiographic findings.     

Primary choriocarcinoma of the ovary--a case report]

A report is given on a rare case of nongestational primary chorionepithelioma of the ovary. A 30 years old woman was treated by salpingo-oophorectomy and methotrexate-monotherapy. She is showing long-term remission.