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大量的临床和实验研究证实,人和实验动物的痛阈都具有明显的昼夜节律。与针刺镇痛各环节相关的神经递质、激素分泌水平、神经元活动也同样具有昼夜节律,针刺在发挥镇痛功效的同时,也具有整复节律的作用。从时间节律特征来探索针刺镇痛机制提供了崭新的视角和思路,可望取得新的重要进展。 相似文献
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基于结缔组织探讨针刺镇痛的机制 总被引:1,自引:0,他引:1
疼痛主要是由神经介导的,因此,针刺镇痛机制的研究相对集中在神经系统方面。不少研究认为,神经反应在针刺镇痛中起主要作用,但是以神经系统为主导的学说,不能解释一些临床现象。例如,很多患者在接受针刺治疗过程中感觉是轻松的、舒适的,并非一定要感受到剧痛才有效; 相似文献
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针刺镇痛机制的研究进展 总被引:9,自引:0,他引:9
针灸在我国有着2000多年的历史,早在《黄帝内经》中就有详细的记载,是祖国医学的重要组成部分。上世纪50年代末,我国医学家在针灸可以缓解疼痛的临床基础上,发展了一种新的麻醉方法一针刺麻醉(acupuncture anesthesia),从而推动了针刺镇痛(acupuncture analgesia)机制的研究。50多年来,我 相似文献
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催眠和针刺均可缓解实验性疼痛,但二者的镇痛机制尚不清楚,对8名男性志愿受试者,用冷加压试验引起实验性疼痛。在用双盲交叉法施也安慰剂和催眠镇痛和针刺镇痛的效应进行测定。结论:1、催眠和针刺均能显著减弱冷加压试验引起的疼痛,前者经后者的作用更强;2、催眼镇痛和针刺镇痛主要不是由阿片内啡肽系统传递的;3、无论催眠或针刺,给纳洛酮或安慰剂对血浆β-内啡素水平均无明显影响。 相似文献
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针刺镇痛机制研究的过去与未来 总被引:1,自引:1,他引:0
<正> Acupuncture is known as an age-old healing art originated and developedin China,It has constituted one of the major means to protect the health ofthe people for many years,and it is regarded as important as as herb medicinein combating diseases in china,However,acupuncture suffered a serious set-back during the Ching Dynasty when acupuncture was denounced as beingharmful to the human body and was p(?)ohibited by the Manchu rulers,Althoughwidely used privately among the general population,acupuncture was not acce- 相似文献
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脑室注射γ 氨基丁酸 (GABA)A受体的拮抗剂荷包牡丹碱 (Bicuculline,Bic)未能阻断针刺镇痛效应 ,说明脑内GABA不参与或不通过激活A受体参与针刺镇痛效应。为阐明脑内GABA在针刺镇痛中的作用及其受体机制 ,本文比较观察了脑室注射 (icv)和蛛网膜下腔注射 (ith)GABAB受体的拮抗剂CGP 55845对针刺镇痛效应的影响。以辐射热照射大鼠尾部引起甩尾反射潜伏期作为痛阈的指标 ,以脑室注射 5μL、蛛网膜下腔注射 1 0 μL药液加 5μL生理盐水后、或电针“次”穴后痛阈变化百分率的最大值判断镇痛效应 … 相似文献
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The mechanism of acupuncture analgesia (AA) has been widely explored since the 1970s. Early studies investigated the relationship between acupuncture and endogenous opiates (beta-endorphin, enkephalin, endomorphin and dynorphin). Before the 1990s, most experts agreed on the concept that in normal animal models, lower frequency electroacupuncture (EA) stimulates the release of beta-endorphin, enkephalin and endomorphin, which in turn activates the mu- and delta-opioid receptors, and that higher frequency EA stimulates dynorphin which activates the kappa-opioid receptor. Besides endogenous opiates, our studies have focused on serotonin. The serotoninergic descending inhibitory pathway is suggested to be an important mechanism of acupuncture analgesic, collaborating with endogenous opiates. Many efforts have been made to clarify these mechanisms, but to date no satisfactory consensus has been reached. In the late 1990s, researchers began to focus on the different analgesic effects of EA between normal and hyperalgesic animal models. Published data from these studies imply that normal and hyperalgesic animals respond differently to EA. Results from experiments on the anti-hyperalgesia effect of EA have raised a new issue about the influences of EA on receptors to excitatory amino acid in the spinal cord level. Results from various studies have shown that these receptors play a role in the mechanism of AA. Recently, research on the autonomic nervous system (ANS) seem to indicate its connection with acupuncture. The inflammatory reflex (via the ANS) might be a crucial part of anti-hyperalgesia elicited by acupuncture, and this reflex, which regulates the immune system in the organism, can elucidate not only the mechanism of AA but also the mechanism of acupuncture applied to other inflammatory conditions. Innovation of functional image study enables us to analyze the responses of cortex on living human body to acupuncture. However, results of these experiments are still controversial. After 30 years of acupuncture research, there are still many puzzles left to be solved regarding the mechanism of AA. 相似文献
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Acupuncture, as a healing art in traditional Chinese medicine, has been widely used to treat various diseases. In the history of acupuncture
anesthesia, in the past decades, mechanisms of acupuncture analgesia has been widely investigated, and in recent years, acupuncture protection
on organ functions has attracted great interest. This review summarized the research progress on mechanisms of acupuncture for analgesia and
of its protection against organ function injury in anesthesia, and its perspective of analgesia, immunomodulation, neuroendocrine regulation
and multiple organ protection. The current evidence supports that acupuncture analgesia and its organ protection in anesthesia is associated
with the integration of neuroendocrine-immune networks in the level of neurotransmitters, cytokines, hormones, neuronal ensembles,
lymphocytes, and endocrine cells. Although the mechanisms of acupuncture analgesia and its organ protection are still not completely
understood, basic as well as clinic researches on the mechanisms and applications of acupuncture and related techniques are being carried out. 相似文献
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Objective
To analyze and review the clinical efficacy of acupuncture (including electroacupuncture) alone for allergic rhinitis (AR) and to compare its efficacy with antihistamines and Chinese patent medicine Bi Yan Kang Tablet.Methods
The search strategy, inclusion and exclusion criteria were made according to the principle of evidence-based medicine. We performed a systematic search on China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang), Chongqing VIP Database (CQVIP), Chinese Biomedical Literature Database (CBM), PubMed, Excerpta Medica Database (EMBASE), Web of Science, Cochrane Library, and Cochrane Central Register of Controlled Trials (CENTRAL) for randomized controlled trials (RCTs) of acupuncture for allergic rhinitis between January 1990 and December 2015. The quality was evaluated by Cochrane Handbook for Systematic Reviews of Interventions Version 5.1, and the meta-analysis was conducted by RevMan 5.3 version.Results
Twenty eligible RCTs were included into the meta-analysis after selection. Compared with antihistamines, the meta-analysis showed RR=1.24>1, 95%CI[1.15, 1.33], P<0.00001, indicating that acupuncture achieved a better total effective rate for AR than antihistamines; MD = –0.93<0, 95%CI[–1.22,–0.63], P<0.00001, indicating that acupuncture is better than antihistamines in decreasing the total nasal symptom score (TNSS) in AR patients; and MD = 1.46>0, 95%CI[–10.84, 13.75], P = 0.82, indicating that there was no statistical difference between acupuncture and antihistamines in regulating immunoglobulin E (IgE) in AR patients. Compared with Bi Yan Kang Tablet, the meta-analysis has shown RR = 1.50>1, 95%CI[1.30, 1.73], P<0.00001, indicating that acupuncture achieved a better total effective rate for AR than Chinese patent medicine Bi Yan Kang Tablet.Conclusion
Acupuncture alone can achieve a better total effective rate for AR than antihistamines and Bi Yan Kang Tablet. It is also better than antihistamines in improving clinical symptom scores; however, whether acupuncture is better than Bi Yan Kang Tablet needs further proof. As far as current data are concerned, there was no statistical difference between acupuncture and antihistamines in improving serum IgE; further study is needed in this regard. The risk of bias due to absent randomization methods or blinding implementation decreased the evidence level of the overall conclusion.17.
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针灸辨证治疗偏头痛的效果分析 总被引:1,自引:0,他引:1
目的观察针灸辨证治疗偏头痛的效果。方法对我院收治的80例偏头痛患者采用针灸辨证治疗。结果经过治疗,肝阳上亢型总有效率为95.2%,痰浊上扰型总有效率为94.1%,瘀血阻络型总有效率为100.0%,气血亏虚型总有效率为85.7%,肝肾阴虚型总有效率为90.0%,总有效率为93.7%。结论采用针刺辨证治疗偏头痛标本兼治,内外齐施,从而达到“通则不痛”、“荣则不痛”的目的。 相似文献
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Pro. HUA had practiced traditional Chinese medicine and acupuncture for about 50 years, borne excellent medical skills and was then highly respected by his colleagues and patients. In his large amount of practice, he combined syndrome differentiation in Chinese medicine and disease differentiation in western medicine in order to work hard on acupuncture indications and some stubborn diseases. With the time going on and medical cases accumulating, some unique treatment styles had been formed, such as Jiaji (paravertebral) acupuncture, sacroiliac acupuncture and sacral acupuncture. They are briefly introduced as follows. 相似文献
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目的:腹腔镜手术术后采用喷他佐辛进行镇痛效果评价.方法:随机抽取我院2008-2010年经腹腔镜手术患者52例,随机分为28人观察组和24人对照组;观察组按照术前8-12h给药喷他佐辛1-2粒,200mg/粒,手术结束后待患者可以正常进食后6h给喷他佐辛1例,之后连续两日早晚个给药1例,注意观察用药期间患者镇痛效果、不良反应、体征、和睡眠状况.结果:对比两组镇痛效果,观察组与对照组比较疼痛明显减轻;待清醒后观察组VAS值为1.43±0.26VS对照组VAS值为2.79±1.44(P〈0.05),但术后6h,12h,24h两组VAS值无显著差异.结论:喷他佐辛用于术后镇痛疗效和安全性均值的肯定适于经腹腔镜手术后镇痛使用. 相似文献