良性急性胃十二指肠溃疡穿孔两种手术方式的疗效比较

目的探讨良性急性胃十二指肠溃疡穿孔两种不同手术方式治疗的临床效果。方法对本院132例良性急性胃十二指肠溃疡穿孔病例,A组90例为单纯穿孔修补术加抑酸、根除幽门螺杆菌;B组42例胃大部切除进行疗效比较。结果所有病例治愈出院,随访3-120个月．两组的疗效按改良Visick分级评分标准I、II级分别为84．4％、76．1％,溃疡复发率分别为5．5％、7．1％,术后再次穿}L率均为零,两组比较差异均无统计学意义（P〈0．05）。B组切口感染发生率高于A组,差异有统计学意义（P〉O．05）。结论消化性溃疡穿孔修补加抑酸、根除幽门螺杆菌治疗,操作简单、创伤小、并发症少、远期疗效好,可作为良性急性胃十二指肠溃疡穿孔治疗的首选方式。     

良性胃十二指肠溃疡急性穿孔不同手术方法的疗效比较

目的探讨良性胃十二指肠溃疡急性穿孔不同手术方式治疗的临床价值。方法对我院1993年1月～2007年6月收治的128例胃十二指肠溃疡急性穿孔分为单纯穿孔修补术加抑酸、根除幽门螺杆菌（第一组）、穿孔修补加扩大壁细胞迷走神经切断术（第二组）、胃大部切除（第三组）进行疗效比较。结果所有病例治愈出院，随访6～120个月。三组的疗效按改良Visick分级评分标准Ⅰ、Ⅱ级分别为84．4％、88．1％、74％，溃疡复发率分别为6．7％、4．8％、7．4％，术后再次穿孔率均为零。χ^2均〈χ^2 0.05（1）），P〉0．05，三组差异无显著性。结论消化性溃疡穿孔修补加抑酸、根除幽门螺杆菌治疗，操作简单、创伤小、并发症少、远期疗效好，可以作为胃十二指肠溃疡穿孔治疗的首选方式。     

消除幽门螺杆菌对十二指肠溃疡穿孔单纯修补术后的临床意义

目的 评估消除幽门螺杆菌(HP)对十二指肠溃疡穿孔单纯修补术后复发的影响和临床意义。方法 将123例十二指肠溃疡穿孔单纯修补术中的HP阳性110例随机分成抗HP组和非抗HP组各55例,进行随访及内镜检查,比较溃疡的初步愈合及1年后溃疡复发请况。结果 抗HP组和非抗HP组HP消除分别为53例及9例(P<0.001),溃疡早期完全愈合分别为52例及51例(P>0.5),1年后溃疡复发分别为2例及18例(P<0.01),有显著差异。结论 消除幽门螺杆菌可减少十二指肠溃疡穿孔单纯修补术后的溃疡复发,减少并发症出现。对于十二指肠溃疡穿孔的患者,除非有并发幽门梗阻、大出血或恶变等,否则一般可予单纯修补术,加以抗HP治疗,而不必予彻底性手术。     

消化性溃疡穿孔单纯修补术后疗效观察

目的　观察胃、十二指肠溃疡穿孔行单纯缝合修补术后继以内科治疗的效果。方法　对168例胃、十二指肠溃疡穿孔患者行单纯修补术后 ,再行抗幽门螺杆菌等内科治疗 ,并跟踪随访观察。结果　本组 1年总复发率和胃、十二指肠溃疡复发率分别是 :术后正规内科治疗组为 5 .8% ,8.3 % ,3 .6% ;术后非正规内科治疗组 62 .9% ,66.7% ,5 8.8% ;术后未治疗组为 88.9% ,10 0 % ,80 .0 %。后 2组与正规治疗组间差异显著 (P <0 .0 5 )。术后采用正规内科治疗组 ,未出现出血、穿孔、幽门梗阻等并发症 ,无再手术者。出现并发症及再手术者 ,在非正规内科治疗组分别为 4.5 %和2 .4% ;在未接受内科治疗组为 42 .9%和 3 0 .0 %。吸烟者胃和十二指肠溃疡复发率分别为 80 .6%和 68.8% ,与不吸烟者差异有显著性 (P <0 .0 5 )。结论　溃疡穿孔单纯缝合修补操作简单、安全、并发症少 ,术后结合正规的内科治疗 ,效果满意。吸烟是影响溃疡愈合及复发的重要因素之一。     

单纯修补或加PCV后清除Hp治疗十二指肠溃疡穿孔

目的：评估十二指肠溃疡穿孔行单纯修补或加行壁细胞迷切（ＰＣＶ）术后常规清除幽门螺杆菌（Ｈｐ）的疗效。方法：１９９４年来,我院收治十二指肠溃疡穿孔５１例,其中单纯修补４１例,修补加ＰＣＶ１０例。术后均常规予清除Ｈｐ治疗,并对术后恢复及溃疡复发情况作一回顾性分析。结果：经２年以上随访,单纯修补或加ＰＣＶ术后再常规清除Ｈｐ,溃疡复发率和再手术率均明显降低。修补加ＰＣＶ组疗效显著优于单纯修补组（Ｐ＜０．０５）;单纯修补组中,急性溃疡穿孔病例的疗效显著优于慢性溃疡穿孔（Ｐ＜０．０５）。结论：单纯修补术后再清除Ｈｐ可作为急性溃疡穿孔的理想治疗方案;修补加ＰＣＶ术后再清除Ｈｐ治疗慢性溃疡穿孔可获良好根治溃疡效果。     

基层医院58例胃十二指肠溃疡急性穿孔的诊治体会

目的:探讨胃十二括肠溃疡急性穿孔的治疗方案.方法:对我院6年来收治的58例胃十二指肠溃疡急性穿孔进行回顾性分析.结果:7例内科保守治疗,外科单纯修补38例,胃大部切除11例,死亡2例.其中切口感染3例,胃排空障碍1例.术后结合药物治疗,疗效满意.结论:胃十二指肠溃疡急性穿孔缝合修补术操作简单、安全而有效,患者负担轻,是基层医院治疗胃十二指肠溃疡急性穿孔的可行方法.     

消化性溃疡穿孔治疗方法的选择

目的探讨损伤控制在胃十二指肠溃疡穿孔手术治疗中的应用。根据损伤控制理论合理选择胃十二指肠溃疡穿孔的手术方式。方法回顾性分析我院1996年1月-2006年12月收治的胃十二指肠溃疡穿孔98例的临床资料。结果行单纯溃疡修补术84例,治愈81例,死亡3例;行胃大部切除术12例,治愈11例,死亡1例;保守治疗2例,均治愈。结论胃十二指肠溃疡穿孔病人诊断一旦明确,在损伤控制理论的指导下,在进行体液复苏,抗感染,纠正水、电解质和酸碱平衡紊乱的前提下,以抢救生命为首要治疗目的,选择损伤小、简单、快捷且能阻断病情发展的穿孔修补手术,术后进行规范的抗溃疡及根除幽门螺杆菌治疗,能有效治愈溃疡,预防复发。     

老年人胃十二指肠溃疡穿孔诊治分析

目的探讨胃十二指肠穿孔的外科治疗。方法回顾性分析10年来82例老年人胃十二指肠穿孔的治疗效果及影响预后的因素。结果良性溃疡穿孔79例,其中62例行单纯修补,9例行单纯修补加高选择性迷走神经切断术,5例行穿孔修补加胃空肠吻合,6例行毕Ⅱ式胃大部切除术,其中有3例为胃窦部恶性溃疡穿孔。本组院内死亡3例,2例死于多器官功能衰竭（MOF）,1例死于大面积脑梗死,术后患者家属放弃治疗5例。结论对老年人胃十二指肠溃疡穿孔应以单纯修补为主,胃癌穿孔应行胃大部切除或胃癌根治术,尽量缩短手术时间。     

十二指肠溃疡急性穿孔218例治疗分析

目的探讨十二指肠溃疡急性穿孔行单纯修补及术后药物治疗的效果。方法对我院2001年1月~2005年12月收治的十二指肠球部溃疡急性穿孔218例实施单纯修补术208例,术后给予抗溃疡药物及根除幽门螺杆菌(helicobacetr pylori,HP)治疗;保守治疗10例。结果本组近期效果良好。术后随访190例,随访半年~4年,溃疡复发13例,复发率为6%。失访28例。结论十二指肠溃疡急性穿孔行单纯修补术疗效确切。术后行正规抗溃疡及根除HP治疗能有效降低溃疡的复发率和并发症的发生率。     

腹腔镜胃十二指肠溃疡修补术治疗急性胃十二指肠溃疡穿孔

目的:总结腹腔镜胃十二指肠溃疡修补术治疗急性胃、十二指肠溃疡穿孔的临床经验。方法:1997年6月至2007年12月35例急性胃十二指肠溃疡穿孔患者施行腹腔镜消化性溃疡穿孔修补术。结果:35例中十二指肠球部溃疡穿孔28例,胃窦部溃疡穿孔7例,穿孔直径0.5～0.8cm,手术时间80～180min,手术均获成功,术后患者疼痛轻微,均未使用止痛剂。术后康复顺利,术后住院5～10d,平均6.5d,切口均甲级愈合,痊愈出院。出院后予以内科根除幽门螺杆菌、口服H2受体拮抗剂治疗。结论:腹腔镜手术治疗急性胃、十二指肠溃疡穿孔,与开腹手术同样安全有效。胃溃疡穿孔患者术中需快速病理检查,若为恶性病变应中转开腹。     

Diagnostic and therapeutic treatment policy in ulcerous gastroduodenal bleedings

Results of treatment of 796 patients with ulcerous gastroduodenal bleedings (UGDB) are analyzed. The study group consisted of 676 patients who have undergone endoscopic hemostasis. The control group consisted of 120 patients treated with traditional therapy. Endoscopic hemostasis in the study group was effective in 628 (92.8%) patients, recurrence of bleeding was seen in 21 (3.3%) patients. Effective hemostasis in the control group was achieved in 92 (76.6%) patients, recurrence of bleeding occurred in 13 (14.1%) patients. Positive result of Helicobacter pylori detection was in 600 (88.7%) patients. It is concluded that local treatment of ulcer with glue applications reduces 3 times number of bleeding recurrences.     

Effect of Helicobacter pylori eradication on the ulcer recurrence rate after simple closure of perforated duodenal ulcer: retrospective and prospective randomized controlled studies

BACKGROUND: The possible advantage of eradication of Helicobacter pylori in patients with perforated duodenal ulcer is unknown. This study was planned to assess the prevalence of H. pylori after simple closure of a perforated duodenal ulcer and to study the effect of H. pylori eradication on ulcer persistence and recurrence. METHODS: Some 202 patients were followed prospectively for 2 years after simple closure of a perforated duodenal ulcer (prospective group). A second group of 60 patients was reviewed 5 years or more after perforation closure (retrospective group). The prevalence of H. pylori in patients with perforated duodenal ulcer was compared with that in controls. Patients in the prospective group were randomized to receive either ranitidine alone or quadruple therapy (ranitidine, colloidal bismuth subcitrate, metronidazole and tetracycline) after operation. The incidence of H. pylori infection after the two treatments and the association with residual or recurrent ulcer were studied. In the retrospective group long-term ulcer recurrence was correlated with H. pylori status. RESULTS: The prevalence of H. pylori in patients with perforated duodenal ulcer was not significantly different from that in controls. At every interval of follow-up in the prospective group and in the retrospective group the H. pylori infection rate was significantly higher in patients who had recurrent or residual ulcers. CONCLUSION: Eradication of H. pylori after simple closure of a perforated duodenal ulcer should reduce the incidence of residual and recurrent ulcers.     

抗幽门螺杆菌治疗对寻常型银屑病患者疗效及血清IL-17的影响

目的 探讨抗幽门螺杆菌（Hp）治疗对Hp阳性寻常型银屑病患者疗效的影响及Hp感染与寻常型银 屑病发病的可能机制。方法 选取2019年12月-2021年9月重庆三峡医药高等专科学校附属医院皮肤科确诊 的50例Hp阳性寻常型银屑病患者,采用随机数字表法分成试验组与对照组,每组25例。试验组予以外用卤 米松乳膏、卡泊三醇软膏联合四联抗Hp治疗,对照组予以外用卤米松乳膏、卡泊三醇软膏治疗,比较两组 治疗前、治疗后1个月PASI评分以及血清IL-17水平。结果 两组治疗后PASI评分低于治疗前,且试验组低 于对照组,差异有统计学意义（P＜0.05）;两组治疗后IL-17水平低于治疗前,且试验组低于对照组,差 异有统计学意义（P＜0.05）。结论 对Hp阳性寻常型银屑病患者进行抗Hp治疗有利于提高患者临床疗效, Hp感染可能通过诱导血清IL-17水平升高而参与银屑病的发生与发展。     

腹腔镜与开腹对胃十二指肠溃疡急性穿孔治疗的临床疗效分析

目的探讨腹腔镜与开腹手术治疗胃十二指肠溃疡急性穿孔的疗效。方法将2015年1月至2016年9月我院收治的80例胃十二指肠溃疡急性穿孔患者作为研究对象进行前瞻性研究。根据随机数字法分为腹腔镜组和开腹组,各40例患者,开腹组采取传统的开腹手术修补穿孔治疗,腹腔镜组采取腹腔镜手术修补穿孔治疗,应用SPSS 22.0统计学软件进行统计学处理,术中及术后相关指标以均数±标准差(x珋±s)表示,组间比较采用独立t检验;术后并发症的发生率及复发率采用卡方(χ2)检验,以P0.05表示差异具有统计学意义。结果与开腹组相比,腹腔镜组的手术时间、切口长度、术后下床活动时间、肛门排气时间和住院时间均显著缩短,术中出血量显著降低,差异具有统计学意义(P0.05);腹腔镜组术后并发症的发生率和复发率分别为5例(12.5%)和1例(2.5%),开腹组分别为13例(32.5%)和6例(15.0%),差异具有统计学意义(P0.05)。结论腹腔镜手术治疗胃十二指肠溃疡急性穿孔患者具有损伤小、手术时间短、恢复快、安全性高等特点,临床上应大力推广应用。     

Should Helicobacter pylori infection be treated before kidney transplantation?

BACKGROUND: Before the introduction of modern medication for ulcer disease, gastroduodenal complications were often fatal in recipients of kidney transplants. Helicobacter pylori causes gastritis and is an important risk factor for peptic ulcer disease and gastric malignancies. The aim of this study was to evaluate whether H. pylori infection influences the outcomes of kidney transplantation. METHODS: Between 1991 and 1994, serum H. pylori antibodies were determined in samples taken just before transplantation from 500 consecutive recipients of kidney transplants. Clinical data were collected retrospectively by means of questionnaires sent to the patients and from the national kidney transplantation registry. RESULTS: The prevalence of seropositivity of H. pylori was 31% in the 500 renal transplant subjects, and the seropositivity increased with age. There were no differences in patient or graft survival between the seronegative and seropositive patients. During the first 3 months after transplantation, five seronegative and one seropositive patient had gastroduodenal ulcers, with bleeding complications in three of the seronegative ones. After 3 months, there were more ulcers in the seropositive group (6 vs 3%) and more oesophagitis in the seronegative group (9 vs 7%). During the 6-year follow-up, two cases of gastroduodenal malignancies were found in the helicobacter-positive group and none in the seronegative group. CONCLUSIONS: Helicobacter pylori infections did not result in significant postoperative gastric complications. Two of the 155 seropositive patients developed gastroduodenal malignancies.     

序贯疗法与标准三联疗法根除幽门螺杆菌疗效随机对照研究

目的比较国产质子泵抑制剂（PPI）、阿莫西林、克拉霉素、替硝唑组成的序贯疗法与标准三联疗法根除幽门螺杆菌（Hp）的疗效、不良反应、药物费用。方法将经胃镜检查确诊为有明显异常的慢性胃炎、慢性胃炎伴消化不良症状和消化性溃疡且Hp阳性的患者86例随机分组,试验组（45例）方案为前5d兰索拉唑、阿莫西林,后5d兰索拉唑、克拉霉素、替硝唑;对照组（41例）三联疗法为兰索拉唑、阿莫西林、克拉霉素,疗程10d。结果试验组Hp根除率按意图治疗分析和按试验方案分析分别为88．89％（40／45,95％CI76．00％-96．00％）和93．33％（42／45,95％CI82．00％-98．00％）;对照组为78．05％（32／41,95％CI78．04％～90．72％）和85．37％（35／41,95％CI85．37％～96．19％）。两组比较差异有统计学意义（P〈0．05）。试验组有2例（4．44％）,对照组有6例（14．63％）自诉服药后有不良反应。试验组的药物费用比对照组低廉。结论以国产兰索拉唑、阿莫西林、克拉霉素、替硝唑组成的10d序贯疗法治疗Hp感染,具有疗效高、不良反应低、相对价廉的特点。     

Perforated Peptic Ulcer Treated by Simple Closure and Helicobacter Pylori Eradication

Simple closure followed by Helicobacter pylori (Hp) eradication has become the most used procedure in perforated ulcer treatment. However, its efficacy and safety are still to be determined. To assess recurrence and re-perforation rates, and as a secondary objective, to analyze Hp infection rates in perforated ulcer patients and controls, we conducted a prospective study. Ninety-two consecutive patients (ages: 19–96 years) were operated on between 1996 and 2002, and treated by simple closure followed by Hp eradication and NSAID avoidance. The data were prospectively collected in a database. Hp infection was diagnosed in 68 patients (73.9%). Thirty-four patients (37%) consumed nonsteroidal anti-inflammatory drugs (NSAIDs), and 23 (25%) had both Hp infection and NSAID antecedents. The perforation was gastric in 4 cases and pre-pyloric, pyloric or duodenal in 88. There were postoperative complications in 24 patients (26%) and 4 patients died (4.3%). Hp eradication was shown in 46 patients. There was clinical ulcer recurrence in 4 (4.3%); in 3 of them recurrence manifested as re-perforation, all in gastric locations. Overall relapse and re-perforation 1-year crude rates were 6.1% and 4.1%, respectively. Crude rates for non-gastric ulcer recurrence were 0 at 1 year and 2.6% at 2 years and for non-gastric ulcer re-perforation rates were 0 at 1 and 2 years. This therapeutic strategy is associated with a low rate of recurrence and no re-perforations in case of duodenal, pyloric, or pre-pyloric perforated ulcers, but it is not acceptable for perforated gastric ulcers.     

胃十二指肠溃疡患者的微创手术修补效果研究

目的探讨胃十二指肠溃疡患者的微创手术修补效果。 方法前瞻性研究2014年3月至2017年3月106例胃十二指肠溃疡患者不同手术方法效果,根据数字表法随机将患者分为开腹组和腹腔镜组,每组53例。采用SPSS 15.0软件进行统计分析,两组患者术中术后各项指标及疼痛评分的比较采用( ±s)表示,组间比较采用独立t检验;两组的近远期并发症发生率、复发率比较采用χ²检验,P<0.05表示差异有统计学意义。 结果腹腔镜组患者的手术时间、术中出血量、术后1天、术后3天的疼痛评分及术中芬太尼用量均低于开腹组,差异具有统计学意义;腹腔镜组患者的术后近期并发症发生率3.8%低于开腹组18.9%(χ²＝5.957, P＝0.015),术后1年远期并发症发生率3.8%也低于开腹组24.5%(χ²＝9.308, P＝0.002),差异均具有统计学意义;开腹组1年内胃十二指肠溃疡复发7例,复发率为13.2%,腹腔镜组1年内胃十二指肠溃疡复发1例,复发率1.9%,两组患者的胃十二指肠溃疡复发率的差异具有统计学意义(χ²＝4.821, P＝0.028)。 结论微创腹腔镜疗法应用于胃十二指肠溃疡患者的治疗可以缩短手术时间,减少术中出血量,降低术后和远期并发症,减少术后疼痛,值得临床推广。