共查询到20条相似文献,搜索用时 31 毫秒
1.
Kastner S DeSimone K Konen CS Szczepanski SM Weiner KS Schneider KA 《Journal of neurophysiology》2007,97(5):3494-3507
We used fMRI at 3 Tesla and improved spatial resolution (2 x 2 x 2 mm(3)) to investigate topographic organization in human frontal cortex using memory-guided response tasks performed at 8 or 12 peripheral locations arranged clockwise around a central fixation point. The tasks required the location of a peripheral target to be remembered for several seconds after which the subjects either made a saccade to the remembered location (memory-guided saccade task) or judged whether a test stimulus appeared in the same or a slightly different location by button press (spatial working-memory task). With these tasks, we found two topographic maps in each hemisphere, one in the superior branch of precentral cortex and caudalmost part of the superior frontal sulcus, in the region of the human frontal eye field, and a second in the inferior branch of precentral cortex and caudalmost part of the inferior frontal sulcus, both of which greatly overlapped with activations evoked by visually guided saccades. In each map, activated voxels coded for saccade directions and memorized locations predominantly in the contralateral hemifield with neighboring saccade directions and memorized locations represented in adjacent locations of the map. Particular saccade directions or memorized locations were often represented in multiple locations of the map. The topographic activation patterns showed individual variability from subject to subject but were reproducible within subjects. Notably, only saccade-related activation, but no topographic organization, was found in the region of the human supplementary eye field in dorsomedial prefrontal cortex. Together these results show that topographic organization can be revealed outside sensory cortical areas using more complex behavioral tasks. 相似文献
2.
Y. Takikawa Reiko Kawagoe Nobuo Miyashita Okihide Hikosaka 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,121(4):442-450
We recorded saccade-related neurons in the vicinity of the dentate nucleus of the cerebellum in two monkeys trained to perform
visually guided saccades and memory-guided saccades. Among 76 saccade-related neurons, 38 showed presaccadic bursts in all
directions. More than 80% of such burst neurons were located in the area ventral to, not inside, the dentate nucleus, which
corresponded to the basal interstitial nucleus (BIN as previously described). We found that the activity of the BIN neurons
was correlated with saccade duration but not with saccade amplitude or velocity. Thus, when tested with visually guided saccades,
the burst started about 16 ms before saccade onset and ended about 33 ms before saccade offset, regardless of saccade amplitude.
The characteristic timing of the BIN cell activity was maintained for different types of saccades (visually guided, memory-guided
and spontaneous saccades), which had different dynamics. Although the number of spikes in a burst for each neuron was linearly
correlated with saccade amplitude for a given type of saccade, the slope varied depending on the type of saccade. Peak burst
frequency was uncorrelated with saccadic peak velocity. In contrast, burst duration was highly correlated with saccade duration
regardless of the type of saccade. These results suggest that BIN neurons may carry information to determine the timing of
saccades.
Received: 14 August 1997 / Accepted: 17 February 1998 相似文献
3.
In a series of now classic experiments, an output structure of the basal ganglia (BG)--the substantia nigra pars reticulata (SNr)--was shown to be involved in the generation of saccades made in particular behavioral contexts, such as when memory was required for guidance. Recent electrophysiological experiments, however, call this original hypothesis into question. Here we test the hypothesis that the SNr is involved preferentially in nonvisually guided saccades using electrical stimulation. Monkeys performed visually guided and memory-guided saccades to locations throughout the visual field. On 50% of the trials, electrical stimulation of the SNr occurred. Stimulation of the SNr altered the direction, amplitude, latency, and probability of saccades. Visually guided saccades tended to be rotated toward the field contralateral to the side of stimulation, whereas memory-guided saccades tended to be rotated toward the hemifield ipsilateral to the side of stimulation. Overall, the changes in saccade vector direction were larger for memory-guided than for visually guided saccades. Both memory- and visually guided saccades were hypometric during stimulation trials, but the stimulation preferentially affected the length of memory-guided saccades. Electrical stimulation of the SNr produced decreases in visually guided saccades bilaterally. In contrast, memory-guided saccades often had increases in saccade latency bilaterally. Finally, we found approximately 10% reduction in the probability of memory-guided saccades bilaterally. Visually guided saccade probability was unaltered. Taken together the results are consistent with the hypothesis that SNr primarily influences nonvisually guided saccades. The pattern of stimulation effects suggests that SNr influence is widespread, altering the pattern of activity bilaterally across the superior colliculus map of saccades. 相似文献
4.
M. V. Slavutskaya V. V. Moiseeva V. V. Shulgovskii 《Neuroscience and behavioral physiology》2012,42(3):244-252
Increases in the latent periods of memory-guided saccades as compared with those of visually guided saccades were observed,
providing evidence of slowing in saccade programming based on extraction of information from working memory. Comparison of
the parameters and topography of the N1 and P1 components of evoked potentials induced by a signal to perform a memory-guided
saccade and a visual stimulus-guided saccade suggested that the early stages of saccade programming, associated with the processing
of spatial information, are mediated mainly by the descending mechanism of attention for memory-guided saccades and the ascending
mechanism for saccades in response to a visual stimulus. These data may indicate that the increase in the latent period of
memory-guided saccades is associated with lengthening of the central stage of saccade programming – the decision-taking stage,
a correlate of which is the N2 wave developing in the middle of the latent period of the memory-guided saccade. The temporospatial
dynamics of the N1, P1, and N2 components provide evidence that memory-guided saccade programming is controlled by the fronto-medio-thalamic
system of selective attention, as well as by left-hemisphere motor attention mechanisms. 相似文献
5.
Cortical control of saccades 总被引:8,自引:0,他引:8
B. Gaymard C. J. Ploner S. Rivaud A. I. Vermersch C. Pierrot-Deseilligny 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,123(1-2):159-163
Saccadic eye movements are controlled by a cortical network composed of several oculomotor areas that are now accurately localized.
Clinical and experimental studies have enabled us to understand their specific roles better. These areas are: (1) the parietal
eye field (PEF) located in the intraparietal sulcus involved in visuospatial integration and in reflexive saccade triggering;
(2) the frontal eye field (FEF), located in the precentral gyrus, involved in the preparation and the triggering of purposive
saccades; and (3) the supplementary eye field (SEF) on the medial wall of the frontal lobe, probably involved in the temporal
control of sequences of visually guided saccades and in eye-hand coordination. A putative cingulate eye field (CEF), located
in the anterior cingulate cortex, would be involved in motivational modulation of voluntary saccades. Besides these motor
areas, the dorsolateral prefrontal cortex (dlPFC) in the midfrontal gyrus is involved in reflexive saccade inhibition and
visual shortterm memory. 相似文献
6.
Frontoparietal activation with preparation for antisaccades 总被引:2,自引:0,他引:2
Several current models hold that frontoparietal areas exert cognitive control by biasing task-relevant processing in other brain areas. Previous event-related functional magnetic resonance imaging (fMRI) studies have compared prosaccades and antisaccades, which require subjects to look toward or away from a flashed peripheral stimulus, respectively. These studies found greater activation for antisaccades in frontal and parietal regions at the ends of long (>or=6 s) preparatory periods preceding peripheral stimulus presentation. Event-related fMRI studies using short preparatory periods (相似文献
7.
When a saccade occurs to an interesting object, visual fixation holds its image on the fovea and suppresses saccades to other objects. Electrical stimulation of the frontal eye field (FEF) has been reported to elicit saccades, and recently also to suppress saccades. This study was performed to characterize properties of the suppression of visually guided (Vsacs) and memory-guided saccades (Msacs) induced by electrical stimulation of the FEF in trained monkeys. For any given stimulation site, we determined the threshold for electrically evoked saccades (Esacs) at < or =50 microA and then examined suppressive effects of stimulation at the same site on Vsacs and Msacs. FEF stimulation suppressed the initiation of both Vsacs and Msacs during and about 50 ms after stimulation at stimulus intensities lower than those for eliciting Esacs, but did not affect the vector of these saccades. Suppression occurred for ipsiversive but not contraversive saccades, and more strongly for saccades with larger amplitudes and those with initial eye positions shifted more in the saccadic direction. The most effective stimulation timing for suppression was about 50 ms before saccade onset, which suggests that suppression occurred in the efferent pathway for generating Vsacs at the premotor rather than the motoneuronal level, most probably in the superior colliculus and/or the paramedian pontine reticular formation. Suppression sites of ipsilateral saccades were distributed over the classical FEF where saccade-related movement neurons were observed. The results suggest that the FEF may play roles in not only generating contraversive saccades but also maintaining visual fixation by suppressing ipsiversive saccades. 相似文献
8.
Gaze-evoked blinks are contractions of the orbicularis oculi (OO)-the lid closing muscle-occurring during rapid movements of the head and eyes and result from a common drive to the gaze and blink motor systems. However, blinks occurring during shifts of gaze are often suppressed when the gaze shift is made to an important visual stimulus, suggesting that the visual system can modulate the occurrence of these blinks. In head-stabilized, human subjects, we tested the hypothesis that the presence of a visual stimulus was sufficient, but not necessary, to modulate OO EMG (OOemg) activity during saccadic eye movements. Rapid, reorienting movements of the eyes (saccades) were made to visual targets that remained illuminated (visually guided trials) or were briefly flashed (memory-guided trials) at different amplitudes along the horizontal meridian. We measured OOemg activity and found that the magnitude and probability of OOemg activity occurrence was reduced when a saccade was made to the memory of the spatial location as well as to the actual visual stimulus. The reduced OOemg activity occurred only when the location of the target was previously cued. OOemg activity occurred reliably with spontaneous saccades that were made to locations with no explicit visual stimulus, generally, back to the fixation location. Thus the modulation of gaze-evoked OOemg activity does not depend on the presence of visual information per se, but rather, results from an extraretinal signal. 相似文献
9.
Tzelepi A Lutz A Kapoula Z 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2004,155(4):439-449
Eight normal subjects made visually guided eye movements to four LED targets placed at two different distances (20 and 70 cm) and on either side (±10°) at 70 cm. Four types of eye movements were elicited: pure saccades, convergence, divergence, and combined (divergent saccades). EEG activity was recorded from 62 electrodes and was aligned to stimulus onset. A negativity peaked after 140 ms and was modulated according to the location of the stimulus in space and the type of movement prepared, mainly in central and posterior cortex. For saccade targets, we confirmed a stimulus-related negativity in the posterior and central cortical area, contralateral to target direction. For convergence and divergence targets, this negativity was bilaterally distributed; convergence targets activated a rather extended cortical network in the central and posterior area, while divergence targets activated a more confined posterior area, spreading ventrally from the occipital cortex. Cortical activity for combined targets was lateralised contralaterally to stimulus direction but its topography resembled more closely that after the divergence stimulus. When observers suppressed the relevant eye movement to the stimulus, EEG activity was enhanced on the right hemisphere, showing the more pronounced effect on the right occipital-temporal and central-parietal electrode sites. 相似文献
10.
Spatial memory following shifts of gaze. I. Saccades to memorized world-fixed and gaze-fixed targets
During a shift of gaze, an object can move along with gaze or stay fixed in the world. To examine the effect of an object's reference frame on spatial working memory, we trained monkeys to memorize locations of visual stimuli as either fixed in the world or fixed to gaze. Each trial consisted of an initial reference frame instruction, followed by a peripheral visual flash, a memory-period gaze shift, and finally a memory-guided saccade to the location consistent with the instructed reference frame. The memory-period gaze shift was either rapid (a saccade) or slow (smooth pursuit or whole body rotation). This design allowed a comparison of memory-guided saccade performance under various conditions. Our data indicate that after a rotation or smooth-pursuit eye movement, saccades to memorized world-fixed targets are more variable than saccades to memorized gaze-fixed targets. In contrast, memory-guided saccades to world- and gaze-fixed targets are equally variable following a visually guided saccade. Across all conditions, accuracy, latency, and main sequence characteristics of memory-guided saccades are not influenced by the target's reference frame. Memory-guided saccades are, however, more accurate after fast compared with slow gaze shifts. These results are most consistent with an eye-centered representational system for storing the spatial locations of memorized objects but suggest that the visual system may engage different mechanisms to update the stored signal depending on how gaze is shifted. 相似文献
11.
Muscimol-induced inactivation of monkey frontal eye field: effects on visually and memory-guided saccades. 总被引:3,自引:0,他引:3
Muscimol-induced inactivation of the monkey frontal eye field: effects on visually and memory-guided saccades. Although neurophysiological, anatomic, and imaging evidence suggest that the frontal eye field (FEF) participates in the generation of eye movements, chronic lesions of the FEF in both humans and monkeys appear to cause only minor deficits in visually guided saccade generation. Stronger effects are observed when subjects are tested in tasks with more cognitive requirements. We tested oculomotor function after acutely inactivating regions of the FEF to minimize the effects of plasticity and reallocation of function after the loss of the FEF and gain more insight into the FEF contribution to the guidance of eye movements in the intact brain. Inactivation was induced by microinjecting muscimol directly into physiologically defined sites in the FEF of three monkeys. FEF inactivation severely impaired the monkeys' performance of both visually guided and memory-guided saccades. The monkeys initiated fewer saccades to the retinotopic representation of the inactivated FEF site than to any other location in the visual field. The saccades that were initiated had longer latencies, slower velocities, and larger targeting errors than controls. These effects were present both for visually guided and for memory-guided saccades, although the memory-guided saccades were more disrupted. Initially, the effects were restricted spatially, concentrating around the retinotopic representation at the center of the inactivated site, but, during the course of several hours, these effects spread to flanking representations. Predictability of target location and motivation of the monkey also affected saccadic performance. For memory-guided saccades, increases in the time during which the monkey had to remember the spatial location of a target resulted in further decreases in the accuracy of the saccades and in smaller peak velocities, suggesting a progressive loss of the capacity to maintain a representation of target location in relation to the fovea after FEF inactivation. In addition, the monkeys frequently made premature saccades to targets in the hemifield ipsilateral to the injection site when performing the memory task, indicating a deficit in the control of fixation that could be a consequence of an imbalance between ipsilateral and contralateral FEF activity after the injection. There was also a progressive loss of fixation accuracy, and the monkeys tended to restrict spontaneous visual scanning to the ipsilateral hemifield. These results emphasize the strong role of the FEF in the intact monkey in the generation of all voluntary saccadic eye movements, as well as in the control of fixation. 相似文献
12.
Bucci MP Kapoula Z Bernotas M Zamfirescu F 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2000,134(1):133-138
Memory-guided saccades to disparate targets (i.e., more eccentric for one eye) flashed 1 s earlier become disconjugate (i.e., of different amplitude for the two eyes) after only about 30 trials. After about 225 trials the disconjugacy persists even when the target to remember is no longer disparate. This suggests fast learning based on short-term memorization of disparity. Learning, however, fails to occur if during the training the memory delay for each trial is increased to 2 s. The purpose of the present study was to test the importance of the frequency of stimulus presentation and thereby the rate of saccades. The same memory-guided saccade paradigm was used as in the prior study and a short training period of 225 trials was applied. For each training trial, the memory delay was again 2 s, but the time allocated for fixation of the central dot and the time allocated for fixation of the remembered target in the dark was reduced to increase the frequency of saccades made. Saccades became rapidly disconjugate and their disconjugacy was retained in a subsequent neutral condition using non-disparate targets. These findings indicate that stimulus frequency and thereby saccade frequency is important for disconjugate oculomotor learning based on disparity memorization. Nevertheless, additional experiments using longer memory delays of 3 s or 4 s show a definite failure of memorization and disconjugate learning. 相似文献
13.
Dynamic dissociation of visual selection from saccade programming in frontal eye field. 总被引:7,自引:0,他引:7
Previous studies of visually responsive neurons in the frontal eye fields have identified a selection process preceding saccades during visual search. The goal of this experiment was to determine whether the selection process corresponds to the selection of a conspicuous stimulus or to preparation of the next saccade. This was accomplished with the use of a novel task, called search-step, in which the target of a singleton visual search array switches location with a distracter on random trials. The target step trials created a condition in which the same stimulus yielded saccades either toward or away from the target. Visually responsive neurons in frontal eye field selected the current location of the conspicuous target even when gaze shifted to the location of a distractor. This dissociation demonstrates that the selection process manifest in visual neurons in the frontal eye field may be an explicit interpretation of the image and not an obligatory saccade command. 相似文献
14.
Bayer HM Handel A Glimcher PW 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2004,154(4):428-441
The substantia nigra pars reticulata (SNr), a major output nucleus of the basal ganglia, has been implicated anatomically, pharmacologically and physiologically in the generation of saccadic eye movements. However, the unique contribution of the SNr to saccade generation remains elusive. We studied the activity of SNr neurons while rhesus monkeys made saccades from different initial orbital positions, to determine what effects, if any, eye position had on SNr neuronal activity. We found that there was no effect of eye position on SNr neuronal responses. We also examined the responses of SNr neurons during memory-guided saccades to determine whether SNr discharges were affected by whether the target of the upcoming saccade was visible. We found that there was no change in response properties during memory saccade trials as compared to otherwise identical visually guided trials. SNr neurons appear to carry no information about either eye position or whether a movement is guided by a visible or remembered target. These results suggest that nigral signals are encoded in the same coordinate frame as those in the SC and FEF, but that unlike neuronal responses in these areas, SNr activity is not influenced by whether the saccade target remains visible until the movement is executed. 相似文献
15.
Eye movement disorders after frontal eye field lesions in humans 总被引:10,自引:0,他引:10
S. Rivaud R. M. Müri B. Gaymard A. I. Vermersch C. Pierrot-Deseilligny 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1994,102(1):110-120
Eye movements were recorded electro-oculographically in three patients with a small ischemic lesion affecting the left frontal eye field (FEF) and in 12 control subjects. Reflexive visually guided saccades (gap and overlap tasks), antisaccades, predictive saccades, memory-guided saccades, smooth pursuit and optokinetic nystagmus (OKN) were studied in the three patients. Staircase saccades and double step saccades were also studied in one of the three patients. For both leftward and rightward saccades, latency in the overlap task (but not in the gap task) and that of correct antisaccades and of memory-guided saccades was significantly increased, compared with the results of controls. There was a significant decrease in the amplitude gain of all rightward saccades programmed using retinotopic coordinates (gap and overlap tasks, predictive and memory-guided saccades), whereas the amplitude gain of corresponding leftward saccades was preserved. Such an asymmetry between leftward and rightward saccades was significant. In the staircase paradigm as well as for the first saccade in the double step paradigm (with the use of retinotopic coordinates in both cases), the amplitude gain of rightward saccades was also significantly lower than that of leftward saccades. Moreover, in the double step paradigm, the amplitude gain of the first rightward saccade was significantly lower than that of the second rightward saccade (programmed using extraretinal signals), which was preserved. The percentage of errors in the antisaccade task did not differ significantly from that of normal subjects. In the predictive saccade paradigm, the percentage of predictive rightward saccades was significantly decreased. The left smooth pursuit gain for all tested velocities, the right smooth pursuit gain for higher velocities, and the left OKN gain were significantly decreased. The results show, for the first time in humans, that the FEF plays an important role in (1) the disengagement from central fixation, (2) the control of contralateral saccades programmed using retinotopic coordinates, (3) saccade prediction and (4) the control of smooth pursuit and OKN, mainly ipsilaterally. In contrast, the left FEF did not appear to be crucial for the control of the only type of saccades programmed using extraretinal signals studied here. 相似文献
16.
Response of neurons in the lateral intraparietal area to a distractor flashed during the delay period of a memory-guided saccade 总被引:8,自引:0,他引:8
Recent experiments raised the possibility that the lateral intraparietal area (LIP) might be specialized for saccade planning. If this was true, one would expect a decreased sensitivity to irrelevant visual stimuli appearing late in the delay period of a memory-guided delayed-saccade task to a target outside the neurons' receptive fields. We trained two monkeys to perform a standard memory-guided delayed-saccade task and a distractor task in which a stimulus flashed for 200 ms at a predictable time 300-100 ms before the end of the delay period. We used two locations, one in the most active part of the receptive field and another well outside the receptive field. We used six kinds of trials randomly intermixed: simple delayed-saccade trials into or away from the receptive field and distractor trials with saccade target and distractor both in the receptive field, both out of the receptive field, or one at each location. This enabled us to study the response to the distractor as a function of the monkey's preparation of a memory-guided delayed-saccade task. We had assumed that the preparation of a saccade away from the receptive field would result in an attenuation of the response to the distractor, i.e., a distractor at the location of the saccade goal would evoke a greater response than when it appeared at a location far from the saccade goal. Instead we found that neurons exhibited either a normal or an enhanced visual response to the distractor during the memory period when the target flashed outside the receptive field. When the distractor flashed at the location of the saccade target, the response to the distractor was either unchanged or diminished. The response to a distractor away from the target location of a memory-guided saccade was even greater than the response to the same target when it was the target for the memory-guided saccade task. Immediate presaccadic activity did not distinguish between a saccade to the receptive field when there was no distractor and a distractor in the receptive field when the monkey made a saccade elsewhere. Nonetheless the distractor had no significant effect on the saccade latency, accuracy, or velocity despite the brisk response it evoked immediately before the saccade. We suggest that these results are inconsistent with a role for LIP in the specific generation of saccades, but they are consistent with a role for LIP in the generation of visual attention. 相似文献
17.
B. Gaymard S. Rivaud C. Pierrot-Deseilligny 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1994,102(1):1-9
Accuracy of four different types of memory-guided saccades was studied in two patients with a small central thalamic lesion, probably involving the region of the internal medullary lamina (IML), and in a control group. In the first paradigm, the eyes and head remained immobile between the time of the presentation of the visual target to be remembered and the memory-guided saccade. In the other three paradigms, the eyes were displaced during the same period (before the memory-guided saccade) by either visually-guided saccades, a smooth pursuit eye movement or a body movement (with vestibulo-ocular reflex suppression). Therefore, in these three paradigms, the initial eye displacement required the use of extraretinal eye position to produce accurate memory-guided saccades. Compared with the control group, the two patients had normal accuracy in the first memory-guided saccade paradigm, in which there was no initial eye displacement, but markedly impaired saccade accuracy in the other three paradigms. These results suggest that the cortical areas triggering saccades did not receive correct extraretinal eye position signals. They are consistent with an impairment of the efference copy, which could be distributed to the cortical ocular motor areas by the IML. 相似文献
18.
N. Mano Y. Ito H. Shibutani 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1991,84(3):465-470
Summary Extracellular single unit discharges of cerebellar Purkinje cells (P-cells) were recorded from the cerebellar hemispheres of two Japanese monkeys (Macaca fuscata) during spontaneous and visually guided eye movements. We found that saccade-related P-cells, whose simple-spike (SS) discharge rates were modulated in close correlation with saccadic eye movements, were localized in fairly restricted areas in the hemisphere, mostly in Crus IIa with some in the deep folia of Crus I. P-cells located in simple lobules, superficial folia of Crus I or in Crus IIp did not change their discharge rate during voluntary eye movements. Fifty-five saccade-related P-cells recorded from Crus I and II showed modulation of SS discharge rate related to both spontaneous and visually triggered saccades, with the modulation closely time-locked to the saccades. Two thirds (37/55) of saccade-related P-cells began to change their SS discharge rate 20–100 ms prior to the onset of saccades. The remaining one third (18/55) changed their activity approximately at the same time as the saccade onset. These saccade-related P-cells did not show changes in activity during smooth pursuit eye movements, and we did not find any P-cells in the cerebellar hemisphere which showed changes of activity preferentially during smooth pursuit eye movements. In about half (26/55) of the saccade-related P-cells, the pattern of modulation prior to and during saccades was biphasic: increase-decrease or decrease-increase. The other half (29/55) showed monophasic increases or decreases. For a given P-cell, the discharge pattern during saccades was similar for saccades of all directions, though there was a preferred direction in the amount of discharge rate modulation. The present findings suggest that the cerebellar hemisphere (Crus I and IIa) plays an important role in the control of voluntary saccadic eye movements, in addition to other cerebellar cortical areas (flocculus and posterior vermis) which are known to participate in the control of saccades. 相似文献
19.
M. V. Slavutskaya V. V. Moiseeva N. A. Fonsova V. V. Shulgovskii 《Neuroscience and behavioral physiology》2011,41(4):408-415
Differences in the parameters of memory-guided saccades and saccades to visual stimuli were demonstrated. Increases in the
latent periods of memory-guided saccades as compared with saccades to visual stimuli provided evidence of slowing of saccade
programming based on the extraction of information from working memory. Differently directed lateral differences were seen
in the latent periods and durations of saccades to visual targets and memory-guided saccades, reflecting the leading role
of the left hemisphere in the programming of saccades to visual stimuli and the right hemisphere in the programming of memory-
guided saccades. Comparison of parameters of the temporospatial dynamics of initiation potentials P-1 and N-1, which develop in the last 100 msec of the latent periods of saccades, suggest that there are different mechanisms for
the final step of programming saccades to visual stimuli and memory-guided saccades. Decreases in the latent period of the
P-1 and N-1 peak potentials before memory-guided saccades may be evidence showing acceleration of the initiation processes for memory-guided
saccades as compared with visually evoked saccades. This provides grounds for suggesting that the slowing of the programming
of memory-guided saccades occurs at steps preceding saccade initiation. 相似文献
20.
Claudio de’Sperati 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1999,126(4):563-577
In order to investigate the role of mental rotation in the directional control of eye movements, we instructed subjects to
make saccades in directions different from that of a visual stimulus (rotated saccades). Saccadic latency increased linearly
with the amount of directional transformation imposed between the stimulus and the response. This supports the hypothesis
that reorienting a saccade is accomplished through a mental rotation process. No differences were found in amplitude, duration,
velocity, and curvature between rotated and visually guided saccades. Analogous to mental rotation tasks involving reaching
arm movements, it is surmised that frontal/prefrontal cortical structures participate in rotated saccades by reorienting the
intended saccadic direction. A linear increase in response time with the imposed directional transformation was also found
in an analogous mental task not requiring a directed motor response, namely, mentally localizing a point in space at a certain
angle from a stimulus direction. However, the speed of mental rotation was systematically lower than in the rotated saccade
task. These findings indicate that mental rotation is a rather general mechanism through which directional transformations
are achieved.
Received: 11 May 1998 / Accepted: 27 February 1999 相似文献