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W D Tigertt 《Annals of internal medicine》1971,74(6):1017-1018
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Granel B Swiader L Serratrice J Disdier P Weiller PJ 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2000,21(5):421-427
INTRODUCTION: Heat shock proteins (HSP) are molecular chaperones which facilitate the biosynthesis and maturation of proteins within cells (protein folding). They promote assembly and disassembly of polypeptides and play a major role in cellular function, not only during the stress response but also at basal state. CURRENT KNOWLEDGE AND KEY POINTS: As HSP are immunogenic molecules and can be expressed on cellular membranes, their role in auto-immune and inflammatory diseases, particularly in systemic lupus erythematosus, Beh?et's disease and rheumatoid arthritis, has been studied. Cellular immune response of T cells and humoral response with antibodies production against HSP occurring in the course of those diseases have been observed. FUTURE PROSPECTS AND PROJECTS: Anti-HSP immune response might provide better understanding of the pathogenic mechanisms involved in those diseases. At present it is not known whether HSP can trigger them. Indeed, anti-HSP immunity could be induced by the immunological process or be part of a normal immunoregulatory response. 相似文献
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"Permanent" or complex dyskinesias in the aged 总被引:1,自引:0,他引:1
G W Paulson 《Geriatrics》1968,23(9):105-110