腭部涎腺上皮性肿瘤43例临床分析

腭部涎腺上皮性肿瘤４３例临床分析ＣＬＩＮＩＣＡＬＡＮＡＬＹＳＩＳＯＦ４３ＣＡＳＥＳＳＡＬＩＶＡＲＹＥＰＩＴＨＥＬＩＡＬＴＵＭＯＲＩＮＰＡＬＡＴＥ王益华周东升郑家伟近年来，有关大涎腺肿瘤的临床资料报道较多，对于小涎腺肿瘤的研究报道则比较少。我科自１９８...     

腭部涎腺肿瘤不同手术方式效果的追踪观察

本文就８６例腭部涎腺肿瘤的没手术方式的效果进行了３年以上的追踪,结果显示：６４例良性肿瘤绝大多数以单纯切除为主,春复发率为１９％,均菜性腺瘤,２２例恶性肿瘤,单纯切除者７例,扩大切除者９例,上颌骨次全切除者６例,６例行舌骨上淋巴清扫,３便行颈淋巴清白,１２例术后放疗。其复发率为４１％,恶性肿瘤复发率明显主于良性肿瘤。２２例恶性肿瘤不同手术方式效果的比较亦有明显的差别。单纯切除得和扩大切除者的复发率     

376例涎腺肿瘤临床分析

自１９８１年６月～１９９６年６月我们共收治涎腺肿瘤３７６例，占同期颌面颈部肿瘤的１７．４％，现分析讨论如下：临床资料１临床分组：３７６例分为二组。儿童组１１８例，男５３例，女６５例，年龄２３天～１４岁；成人组２５８例，男１４０例，女１１８例，年龄１５...     

涎腺肿瘤256例临床病理分析

涎腺肿瘤２５６例临床病理分析湖北医科大学附属口腔医院外科（４３００７０）许丽萍钟林生王秀丽我科１９８５年－１９９０年共收治涎腺肿瘤２５６例，其诊断均经病理证实，本文就其临床及病理资料分析如下。临床资料１、性别和年龄：男性１３５例，女性１２１例，男女之...     

涎腺肿瘤100例临床分析

本文介绍了100例涎腺肿瘤的临床分析,其中多形性腺瘤占多数,经1～5年随访只有1例复发。     

265例涎腺肿瘤临床分析

目的:总结分析近10多年来涎腺肿瘤临床及发病特点的一些变化.方法:对265例涎腺肿瘤进行临床分析.结果及结论:涎腺肿瘤近10多年来发病逐渐增多,其占口腔颌面部肿瘤的构成比在增加,尤其是腮腺Warthin瘤发病增多最为明显;多形性腺瘤仍是涎腺肿瘤中发病最多的肿瘤,但其构成比在降低,在腮腺肿瘤中,Warthin瘤的构成比已超过多形性腺瘤而居第一位.     

涎腺肿瘤524例临床分析

涎腺肿瘤的发病与治疗,各家资料从不同侧面正在作深入的探讨。我们自1966.2～1986.12共收治涎腺肿瘤581例。其中资料较完整者524例。本文就524例,特别对已观察满3年以上的193例恶性肿瘤进行分析讨论。 临床及病理资料 性别及年龄:本组524例中,男316例,女208例,年龄9～76岁,其中40～59岁发病率     

儿少期大涎腺肿瘤

儿少期大涎腺部位的肿块,易被误诊为炎性肿块而延误治疗。本文报告了２６例儿少期大涎腺肿瘤,文中地其临床诊断及治疗进行了分析讨论。     

168例涎腺肿瘤临床分析

目的:对涎腺肿瘤的临床和病理特点进行分析,探索涎腺肿瘤诊断治疗中存在的问题.方法:对1985～2005年间收治的经组织学确诊的168例涎腺肿瘤的临床和病理特点进行回顾性分析.结果:168例涎腺肿瘤男性多于女性.年龄在11～80岁.多发生于腮腺(67.3%),少发生于舌下腺(2.4%).良性肿瘤124例占73.8%,恶性肿瘤44例占26.2%.应用针吸细胞学检查,活检、B超、CT、MRI以及临床检查是诊断的重要措施.结论:涎腺肿瘤术前穿刺细胞学检查对诊断和治疗方案有指导意义.小的腮腺良性肿瘤,实施瘤周正常腺体切除的腮腺部分切除术,不增加复发率,并具有很多优点.     

儿童涎腺上皮性肿瘤的临床研究

目的：探讨儿童涎腺上皮性肿瘤的发病特点及诊疗要点。方法：对４５例经病理证实的１６ 岁以下儿童涎腺上皮性肿瘤患者的临床资料进行统计分析。结果：儿童涎腺上皮性肿瘤,男女之比为１．１４：１;发病平均年龄为１０．３４岁,随着年龄的增大,患病比随之增高,但年龄越小患恶性肿瘤的可能性愈大,且恶性程度愈高;发病部位以腮腺、颌下腺及腭部多见,大小涎腺间良恶性肿瘤患病比无明显差别;良性肿瘤以多形性腺瘤常见,恶性肿瘤以粘液表皮样癌最常见。良性肿瘤术后少有复发,恶性肿瘤复发率约占被随访者的５０％ 。结论：对儿童涎腺上皮性肿瘤,尤其是患儿年龄愈小时,患恶性肿瘤的可能性更大,应引起高度警惕。恶性肿瘤手术应彻底,不可因患儿年龄小过分强调保留面神经而增加复发的机会。     

涎腺肿瘤3461例临床病例分析

目的 :了解涎腺肿瘤发病情况、构成特点及发展趋势。方法 :对四川大学华西口腔医院 195 5～ 2 0 0 2年间收治的 3 461例涎腺肿瘤临床资料进行回顾性分析。结果 :良恶性的平均发病年龄分别是 41.3 8岁和 45 .2 0岁 ,良恶性的男女之比分别是 0 .99∶1和 1.3 4∶1。腮腺、腭部的小涎腺和颌下腺分别列为涎腺肿瘤原发部位前3位 ;多形性腺瘤、腺淋巴瘤、基底细胞腺瘤与粘液表皮样癌、腺样囊性癌、腺癌分别列为良、恶性肿瘤前三位。结论 :涎腺肿瘤发病有增加的趋势 ;男性患者的构成比恶性肿瘤高于良性 ;女性患者构成比有增加趋势 ;腮腺和腭部分别是大、小涎腺肿瘤的高发部位 ;多形性腺瘤和粘液表皮样癌是最常见的涎腺良、恶性肿瘤。     

Hyaluronan and CD44 expression in minor salivary gland tumors

OBJECTIVES: Hyaluronan (HA) and CD44 are most likely associated with tumor invasion and metastasis. Malignancies with different degrees of aggressiveness may express different levels and patterns of HA and CD44. The aim of this project was to examine the distribution of HA and CD44 in minor salivary gland tumors to determine if staining could be correlated with biologic behavior or tumor type. MATERIALS AND METHODS: Biotinylated hyaluronan binding protein as a probe for HA and monoclonal antibodies specific for CD44 were used to stain classic examples of the five most commonly encountered minor salivary gland tumors: monomorphic adenomas, pleomorphic adenomas, polymorphous low grade adenocarcinomas, mucoepidermoid carcinomas, and adenoid cystic carcinomas. RESULTS: Tumor cells of monomorphic adenomas were negative for both HA and CD44, and tumor capsules were intensely HA-positive. Pleomorphic adenomas exhibited HA and CD44 positivity in both mesenchymal and epithelial components, and HA in capsular tissues. All malignant salivary gland tumors expressed similar intense HA in tumor stroma. HA staining was more intense in stroma than in parenchymal cells. Tumor cells of most adenoid cystic carcinomas were HA-positive, while most polymorphous low grade adenocarcinomas were HA-negative. HA was uniformly distributed throughout supporting stroma of high and low grade malignancies, except for two polymorphous low grade adenocarcinomas (PLGAs) in which HA was more intense at the invading edge of the tumors. CD44 expression was seen only in tumor cells (not stroma) of malignancies, and was of similar intensity in both low and high grade tumors. CONCLUSIONS: Differences in the expression of HA and CD44 among different types of salivary gland tumors were noted. These findings, however, could not be correlated with known biologic behaviors of the tumor groups studied. Immunohistochemical staining of salivary gland tumors for HA and CD44 may be useful in separating monomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma, lesions that may be difficult to distinguish with routine light microscopy.     

MMP－9在涎腺肿瘤和炎症中的表达及意义

目的：研究MMP－9在涎腺良、恶性肿瘤组织和涎腺炎症疾病中的表达特征及临床指导意义。方法：免疫组化和明胶酶谱法检测MMP－9在涎腺良、恶性肿瘤组织、炎症组织和正常涎腺组织中的表达。结果：MMP－9在涎腺良、恶性肿瘤组织、炎症组织和正常涎腺组织中均有表达,并且在恶性肿瘤中的表达显著高于其它3组（P＜0．05）;涎腺炎症组表达又显著高于良性肿瘤组（P＜0．05）,良性肿瘤组表达显著高于正常组织（P＜0．05）。结论：MMP－9蛋白表达强度与涎腺肿瘤的恶性程度呈正相关;并且涎腺炎症组织中MMP－9表达高于涎腺良性肿瘤,说明MMP－9不仅与肿瘤的侵袭和转移相关,还有可能与肿瘤的发生存在一定的联系。     

腭部巨大基底细胞腺癌1例报告及文献复习

基底细胞腺癌以腮腺为好发部位,也可累及唇、腭等,临床较为少见。由于其临床特点不显著,常常易误诊误治。治疗方法包括手术、放疗、化疗等,治疗后有局部复发和远处转移的可能。本文报告1例腭部基底细胞腺癌病例,并结合文献对其诊断和治疗进行了讨论。     

Chromosomal aberrations in adenomatoid hyperplasia of palatal minor salivary gland

Adenomatoid hyperplasia of minor salivary glands is rare, idiopathic, and benign, and typically presents as a tumour-like mass in the hard or soft palate. Its exact nature is not clear and histological examination usually shows an excess of normal-appearing minor salivary glands. To our knowledge, cytogenetic analysis of it in a minor salivary gland of the palate has not previously been reported. We present the cytogenetic analysis of adenomatoid hyperplasia in the hard palate of a 52-year-old woman.     

星形细胞上调基因1在唾液腺肿瘤中的表达和意义

目的: 探讨星形细胞上调基因1(astrocyte elevated gene-1,AEG-1)在唾液腺肿瘤中的表达和意义。方法：免疫组化检测唾液腺良性肿瘤(多形性腺瘤)、恶性肿瘤(黏液表皮样癌和腺样囊性癌)组织中AEG-1的表达,探讨AEG-1的表达与唾液腺肿瘤临床病理特征的相关性。选取同期15例非肿瘤手术切除的正常唾液腺组织作为对照。采用SPSS10.0软件包对数据进行统计学分析。结果：肿瘤组织中AEG-1阳性率显著高于正常唾液腺组织(P=0.001),恶性肿瘤组AEG-1的阳性率显著高于良性肿瘤组织(P=0.033),晚期恶性肿瘤(T3+T4)AEG-1阳性率显著高于早期肿瘤(T1+T2)(P=0.035)。结论：AEG-1可能在唾液腺肿瘤的发生和恶变过程中起着一定作用。     

Evaluation of the nucleolar organizer region associated proteins in minor salivary gland tumors

Forty-three intraoral salivary gland tumors were studied to determine the value of the AgNOR technique in the assessment of these neoplasms. Well defined black dots were visible in the nucleii of all the specimens studied. The mean AgNOR count per nucleus for each tumor was calculated as follows: pleomorphic adenoma (n = 15) 1.52; Polymorphous low-grade adenocarcinoma (n = 12) 1.90; adenoid cystic carcinoma (n = 6) 2.92; mucoepidermoid carcinoma (n = 4) 1.93; carcinoma ex mixed tumor (n = 4) 2.05; undifferentiated carcinoma (n = 1) 3.13 and epithelial-myoepithelial carcinoma (n = 1) 2.23. The difference between the means of benign and malignant tumors (P less than 0.01) and polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma (P less than 0.01) were highly significant. The overlapping of the AgNOR count between various tumors prohibited the use of this technique as an absolute criterion in establishing a final diagnosis. It could however be used as a diagnostic aid in differentiating between salivary gland neoplasms.     

�������������

涎腺肿瘤是口腔颌面部较为常见的肿瘤,约占全部口腔颌面肿瘤疾患的1/5,其中上皮源性肿瘤占多数,其他组织来源(如间叶组织)肿瘤则比较少见.如同卵巢肿瘤,涎腺肿瘤的病理类型十分复杂,生物学行为也大相径庭.     

涎腺肿瘤C-erbB-2癌基因mRNA表达的研究

目的 探讨Ｃ－ｅｒｂＢ２－ｍＲＮＡ表达水平同涎腺肿瘤组织类型、发生和生物学性质的关系。方法 采用ｄｏｔ ｂｌｏｔ杂交,以＾３２Ｐ标记的寡核苷酸探针,以正常涎腺为对照,对涎腺肿瘤Ｃ－ｅｒｂＢ－２ｍＲＮＡ表达进行研究。结果 正常涎腺和涎腺肿瘤中惺峭同程度Ｃ－ｅｒｂＢ－２ｍＲＮＡ的表达,以正常涎腺组织的表达水平为基准,在腺淋巴瘤、基底细胞腺瘤呈现低表达、无表达或正常涎腺组织表达水平相似,多形性腺瘤、粘液