儿童涎腺上皮性肿瘤的临床研究

目的：探讨儿童涎腺上皮性肿瘤的发病特点及诊疗要点。方法：对４５例经病理证实的１６ 岁以下儿童涎腺上皮性肿瘤患者的临床资料进行统计分析。结果：儿童涎腺上皮性肿瘤,男女之比为１．１４：１;发病平均年龄为１０．３４岁,随着年龄的增大,患病比随之增高,但年龄越小患恶性肿瘤的可能性愈大,且恶性程度愈高;发病部位以腮腺、颌下腺及腭部多见,大小涎腺间良恶性肿瘤患病比无明显差别;良性肿瘤以多形性腺瘤常见,恶性肿瘤以粘液表皮样癌最常见。良性肿瘤术后少有复发,恶性肿瘤复发率约占被随访者的５０％ 。结论：对儿童涎腺上皮性肿瘤,尤其是患儿年龄愈小时,患恶性肿瘤的可能性更大,应引起高度警惕。恶性肿瘤手术应彻底,不可因患儿年龄小过分强调保留面神经而增加复发的机会。     

涎腺疾病

腭部涎腺肿瘤116例临床分析,XAGE-1b基因在唾液腺腺样囊性转移中的作用,微量元素与儿童复发性腮腺炎关系的研究，^125I放射性粒子组织间植入治疗面神经受侵的腮腺恶性肿瘤初步临床观察,短发夹状RNA沉默H-ras基因对人涎腺腺样囊性癌细胞增殖的影响，功能性腮腺切除术治疗腮腺浅叶良性肿瘤的临床研究.     

腭部肿瘤302例临床分析

目的：本文的目的是分析腭部肿瘤的病原特征、诊断方法和处理原则。材料和方法：收集我院３０２例腭部肿瘤并行临床病理分析。结果：本组腭部肿瘤３０２例，其中男性１４９例，女性１５３例，男：女约为１：１；发病年龄３～８５岁，平均年龄４３．９，３０～４９岁占４０．４％。原发部位多位于硬软腭交界处（４６％）。混合瘤、鳞状细胞癌、粘液表皮样癌、腺样囊肿癌发病率明显高于其他病种，占本组病全的６８．５％，其中腺样性肿瘤良性多见于恶性，良：恶约为１４９：１。结论：资料分析提示腭部良性肿瘤多于恶性肿瘤。     

615例小涎腺上皮性肿瘤的临床病理分析

目的　探讨小涎腺上皮性肿瘤的临床病理特点。方法　对615例小涎腺上皮性肿瘤的部位分布、发病年龄、性别及组织学类型进行回顾性分析。结果　615例小涎腺上皮性肿瘤中腺瘤265例,癌350例,良恶性肿瘤之比为1∶1·3。良性肿瘤中以多形性腺瘤最为常见(81·1%),其次为肌上皮瘤(14·7%)。恶性肿瘤中以腺样囊性癌最常见(32·9%),其次为粘液表皮样癌(21·4%),腺癌(11·7%)。小涎腺上皮性肿瘤以腭部最为好发,分别占良、恶性肿瘤的77·0%和60.0%。腺瘤中女性患者(51·3%)稍多于男性(48·7%);小涎腺癌患者中男性(56·3%)多于女性 (43·7%)。小涎腺腺瘤患者平均发病年龄40·9岁,小涎腺癌平均发病年龄49·1岁,恶性肿瘤的发病年龄显著高于良性肿瘤(P<0·05)。结论　小涎腺上皮性肿瘤在病理类型构成比、部位、年龄、性别分布上具有其独到的特点。     

儿童涎腺上皮性肿瘤的临床研究

目的：探讨儿童涎腺上皮性肿瘤的发病特点及诊疗要点,方法：对４５例病理证实的１６岁以下儿童涎腺上皮性肿瘤患者的临床资料进行统计分析。结果：儿童涎腺上皮性肿瘤,男女之比为１．１４：１,发病平均年龄为１０．３４岁,随着年龄的增大,患病比随之增高,但年龄越小患病性肿瘤的可能性愈大,且恶性程度愈高;发病部位以腮腺、颌下腺及腭部多见,大小涎腺间良恶性肿瘤患病比无明显差别：良性肿瘤以多形性腺瘤常见,恶性肿瘤以粘     

528例老年人涎腺肿瘤的构成比分析

目的 了解目前老年人涎腺肿瘤的构成现状,为早期诊断和治疗提供帮助。方法 对本科90年代老年人涎腺肿瘤住院患者的临床资料进行总结分析。结果 老年人涎腺肿瘤患者总数呈增长趋势,且多发于60－74岁;良恶性之比为1．7：1;良性肿瘤中腺淋巴瘤的构成比接近多形性腺瘤,恶性肿瘤中腺样囊性癌的构成比居首;腮腺区发病最多,其次为腭部;女性患病率有增高趋势。结论 老年人涎腺肿瘤的构成与80年代有所不同,在临床工作中须引起重视。     

腭部涎腺肿瘤不同手术方式效果的追踪观察

本文就８６例腭部涎腺肿瘤的没手术方式的效果进行了３年以上的追踪，结果显示：６４例良性肿瘤绝大多数以单纯切除为主，春复发率为１９％，均菜性腺瘤，２２例恶性肿瘤，单纯切除者７例，扩大切除者９例，上颌骨次全切除者６例，６例行舌骨上淋巴清扫，３便行颈淋巴清白，１２例术后放疗。其复发率为４１％，恶性肿瘤复发率明显主于良性肿瘤。２２例恶性肿瘤不同手术方式效果的比较亦有明显的差别。单纯切除得和扩大切除者的复发率     

唾液腺上皮性肿瘤1209例临床分析

目的：了解1990-2005年间唾液腺上皮性肿瘤的临床流行病学特点。方法：对南京大学医学院附属口腔医院1990年2月至2005年2月15年间收治的1209例唾液腺上皮性肿瘤患者进行回顾研究，对其病理类型、好发部位、年龄和性别等进行统汁分析。结果：1209例患者中，良性肿瘤与恶性肿瘤之比为1．96：1，男女之比为1：1。良性肿瘤以多形性腺瘤最多见（76．75％）．其次为Warthin瘤（14．75％）；恶性肿瘤以黏液表皮样癌最常见（34．2％），其次为腺样囊性癌（26．2％）。良性肿瘤和恶性肿瘤的好发部位相同，均以腮腺最多，腭部小唾液腺和下颌下腺分列第2位和第3位；发病年龄主要集中于20-70岁之间．结论：唾液腺上皮性肿瘤可发生于任何年龄，良性多于恶性，多形性腺瘤是其最常见的病理类型．     

腭部腺样囊性癌的手术及综合治疗(附30例临床分析)

腭部涎腺之恶性肿瘤,在涎腺恶性肿瘤中居于首位。好发于腭部小涎腺的腺样囊性癌,在腭部腺性上皮癌中居于第一或第二位。我们自1970年至1987年底以前,曾收治腭部涎腺之腺样囊性癌35例,其中资料较全并取得随访结果的有30例,现就其临床资料进行总结,着重谈谈我们对这一肿瘤进行手术及综合治疗的方法以及治疗效果的分析。     

涎腺肿瘤的发生与诊断治疗问题

涎腺可发生多种类型的肿瘤，其中以腮腺发生最多，占６７．１％；发生于舌下腺者最少，仅有１．６％，但其中２／３是恶性肿瘤．涎腺肿瘤发生的年龄以３０～３９岁为高峰期，５９％发生于３９岁以下．如在发现包块之前，先出现神经症状或功能障碍，则易引起误诊误治．涎腺肿瘤中以多形性腺癌发生最多，占５６．６％；在良性肿瘤中占８０．７％；其包膜常不完整，还有多中心的问题．恶性肿瘤中以粘液表皮样癌为最多，占２５．７％；其次是腺样囊性癌与腺癌．恶性肿瘤中有１６．７％发生淋巴结转移，有０．８％发生肺部转移．关键词     

Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population

Minor salivary gland carcinomas are uncommon but most often occur in the oral cavity, particularly the hard palate. Dental examination may provide an opportunity for early detection. During the period of 1977-2000 a group of 75 patients (31 males and 44 females, median age 44.2 years and range 15-86 years) with minor salivary gland tumors were diagnosed, based on the 1991 WHO classification. The peak occurrence of the tumors was in the fifth decade for males and sixth decade for females. The frequency of benign tumors was 38.6% (n = 29) and malignant tumors 61.3% (n = 46). Pleomorphic adenoma was the most common histological type of benign tumor identified whereas mucoepidermoid carcinoma and adenoid cystic carcinoma were the most common malignant tumors. The most common primary location of the tumors was the palate followed by the cheek. A benign tumor usually presented as an asymptomatic swelling and ulceration, pain being more frequently associated with the malignant tumors. This study shows that intraoral tumors of minor salivary glands vary widely in presentation, and should be taking into account by medical and dental practitioners in any differential diagnosis when assessing intraoral pathology. Any lesion arising from the hard palate (the most common site in this series) should be considered as a possible minor salivary gland tumor. Referral to a multidisciplinary head and neck clinic following diagnosis is strongly recommended.     

2456例唾液腺肿瘤临床病理分析

目的探讨唾液腺肿瘤的发病、病理类型等临床特点。方法收集中山大学孙逸仙纪念医院口腔颌面外科1973年1月至2018年12月间确诊的唾液腺肿瘤病例2456例患者的相关资料,回顾分析其性别、年龄、病理类型、发病部位、良恶性构成比等特点。结果46年间收治的唾液腺肿瘤患者2456例,女性比例占41.9%,男性占58.1%,40~60岁年龄段为发病高峰,其中良性肿瘤1863例(75.9%),恶性肿瘤593例(24.1%),良恶性之比为3.1∶1。良性肿瘤构成比前2位是多形性腺瘤(58.7%)、Warthin瘤(33.6%),恶性肿瘤构成比前2位是黏液表皮样癌(27.7%)、腺样囊性癌(26.1%)。最常见的良性肿瘤多形性腺瘤的好发部位是腮腺、腭部、颌下腺,而恶性肿瘤中粘液表皮样癌则常见于腮腺和腭部的小唾液腺。本组资料中唾液腺肿瘤发病呈逐年递增的趋势,近10年病例占总病例数的53.3%。结论唾液腺肿瘤病人数量逐年增加;唾液腺肿瘤的总发生率男性高于女性;大唾液腺以良性肿瘤为主,小唾液腺恶性肿瘤多见;多形性腺瘤、Warthin瘤、黏液表皮样癌最常见;40~60岁是唾液腺良、恶性肿瘤高发年龄段。     

Intraoral minor salivary gland neoplasms: review of 213 cases.

PURPOSE: Minor salivary gland tumors (MSGTs) constitute a heterogeneous group of neoplasms with great histomorphologic variation. This study reviews a large series of benign and malignant salivary gland tumors of the oral region and determines the incidence and the correlation of the histopathologic features with the clinical characteristics. MATERIALS AND METHODS: Two hundred thirteen cases of MSGT were retrospectively studied. Hematoxylin-eosin-stained slides were examined in all cases. Special stains and immunohistochemical stains were used in selected cases. Clinical characteristics of the neoplasms were also noted. RESULTS: One hundred nineteen tumors were benign (56%), and 94 tumors were malignant (44%). Pleomorphic adenoma was the most common benign tumor (93 of 119). Canalicular adenoma was the second most common benign MSGT in our series (25 of 119). Of the 94 malignant MSGTs, mucoepidermoid carcinoma (MEC) (45 of 94), adenoid cystic carcinoma (22 of 94), and polymorphous low-grade adenocarcinoma (18 of 94) were the most common. Most MECs (34 of 45) were low-grade lesions. Of 5 central MECs, 3 cases occurred in the maxilla and 2 cases arose in the mandible. CONCLUSIONS: Benign intraoral MSGTs are slightly more common than malignant MSGTs. Pleomorphic adenoma is the most common MSGT, and MEC is the most common malignant variety. The palate is the most common site for minor gland neoplasms. Benign labial salivary gland neoplasms are more common in the upper lip, and malignant labial tumors are more common in the lower lip.     

A retrospective study of 60 cases of salivary gland tumors in a Thai population.

Sixty cases of salivary gland tumors were diagnosed in the Oral Pathology Department, Faculty of Dentistry, Mahidol University, Bangkok, Thailand, from 1973 to 2002. Fifty-two cases (86.7%) involved the intraoral minor salivary glands, six cases (10%) were found in the major glands, and two cases (3.3%) were intrabony. The predominance of malignant over benign tumors was evident with 68.3% being malignant and 31.7% benign. Patients ranged in age from 9 to 75 years. The female to male ratio of benign intraoral salivary gland tumors was 1.4 to 1 and of malignant types was 1.1 to 1. The principle site of occurrence was the palate (65.4%), followed by buccal mucosa (13.5%). Pleomorphic adenoma (30%) was the most common benign tumor, and mucoepidermoid carcinoma (44.3%) was the most common malignant tumor. Comparing the data from the present study with other series, some discrepancies exist.     

Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases

In a demographic and histologic study of 426 oral minor salivary gland tumors, 57.5% were classified as benign and 42.5% were classified as malignant or potentially malignant. There was an overall female preponderance (1.59/1). The mean age for females was 53.1 years and for males was 50.6 years. The mean age for patients with malignant tumors was 5.4 years greater than for patients with benign tumors and was statistically significant. The palate was the most common site for oral minor salivary gland tumors followed by the upper lip and the buccal mucosa. These three sites accounted for 76.1% of all cases. Pleomorphic adenoma was the most common benign tumor (41% of all cases and 71% of benign tumors) followed by monomorphic adenoma of the canalicular and basal cell subtypes (10% of all tumors and 18.9% of benign lesions). Mucoepidermoid carcinoma was the most commonly encountered malignant tumor, accounting for 15.2% of all tumors and 35.9% of malignant lesions. Low-grade (terminal duct, lobular, polymorphous) adenocarcinoma was the most second most common type, making up 11% of all tumors and 26.4% of all malignant tumors. The results of this study are compared with other recent studies.     

Analysis of the proportion of salivary gland tumors in 528 elder patients]

OBJECTIVE: To analyse the clinical characteristic, evolution and prognosis of undifferentiated carcinoma with lymphoid stroma(malignant lymphoepithelial The purpose of this study was to investigate the present proportional ratio of salivary gland tumors in elder patients, to provide references for early diagnosis and treatment clinically. METHODS: The medical data of 528 elder patients with salivary gland tumors treated in our department in 1990s were reviewed and analyzed. RESULTS: The number of salivary gland tumors in elder patients had increased in recent years. These tumors were frequently found in patients of 60-74 years. The ratio of benign to malignant was 1.7:1. In benign tumors, the proportion of adenolymphoma approached pleomorphic adenoma. While in malignant tumors, adenoid cystic carcinoma accounted the most. These tumors were most commonly found in the parotid gland, followed by the palate. The prevalence of female had an increase trend. CONCLUSION: The proportion of salivary gland tumor in elder patients in 1990s was different from that in 1980s. This change should attract enough attention form the surgeons.     

A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais

Background:  There have been several epidemiologic studies on intra-oral salivary gland tumors in several countries, but little is known of these tumors in Thailand.
Objectives:  To determine the relative frequency and distribution of various types of intra-oral salivary gland tumors in the Thai population.
Methods:  The files of the Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, from 1969 to 2007 were searched for intra-oral salivary gland tumors. Histopathologic slides were reviewed and reclassified according to the 2005 WHO Classification of Head and Neck Tumors. The age, gender, race, and anatomical distribution of the tumors were collected from the patients' records.
Results:  Of the 16,358 accessioned cases, 311 cases (1.90%) were diagnosed as intra-oral salivary gland tumors. One hundred and forty-seven cases (47.27%) were benign tumors, while 164 cases (52.73%) were malignant tumors. The mean age of the patient ± SD = 41.57 ± 16.65 years. Females outnumbered male patients by a ratio of M:F = 1:1.38. Almost all except one patient were Thais. Pleomorphic adenoma was the most common intra-oral salivary gland tumor. The majority of cases occurred at the palate.
Conclusions:  Pleomorphic adenoma is the most common intra-oral salivary gland tumor and the most common benign intra-oral salivary gland tumor, while mucoepidermoid carcinoma is the most common malignant intra-oral salivary gland tumor. Intra-oral salivary gland tumors in Thailand elicit similar trend as in previous studies, with only minor differences such as the ranking of some tumors, the higher incidence of intra-bony location, and the lower incidence of polymorphous low-grade adenocarcinoma.     

Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases

Objective:  Determine the clinical and histopathologic features of epithelial salivary gland tumors of children and adolescents.
Methods:  A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files. Information about demographic, clinical, histopathologic characteristics, and follow-up status were analyzed.
Results:  Sixty tumors (75.9%) were benign and 19 (24.1%) malignant. The most common tumor overall was pleomorphic adenoma (PA). The parotid was the most frequently involved site (43.0%). PA was the most common type of benign tumor. The most common malignant tumor was mucoepidermoid carcinoma. Five patients with parotid PA and two cases with palate myoepithelioma showed local recurrences. One patient with mucoepidermoid carcinoma showed local recurrences and died from the tumor 3 years after the initial treatment. One patient with adenocarcinoma presented local and neck recurrences, and died 4 years after initial treatment.
Conclusions:  Our data showed that the salivary gland tumors in children and adolescents may be the higher incidence of benign tumors, especially of PA; the slightly higher tendency for female predominance; the higher incidence of parotid glands. Mucoepidermoid carcinoma was the most common malignant tumor, with majority of low grade. Initial treatment should be planned to excise the tumor completely with satisfactory margins. The neck dissections or postoperative radiotherapy were performed in patients with low differentiation malignancies, or patients who present nodal metastasis or with clinically suspicious regional metastasis.     

大涎腺上皮性肿瘤212例临床分析

目的 总结大涎腺上皮性肿瘤的临床特点,指导临床实践。方法 按照WHO 1991年涎腺肿瘤组织学分类标准,对212例经病理确诊的大涎腺上皮性肿瘤进行回顾性临床分析,讨论良、恶性肿瘤的不同临床特征。结果 212例肿瘤中,腺瘤166例(78.3％),以多形性腺瘤为主;涎腺癌46例(21.7％),以腺样囊性癌最多见。腮腺是最主要发病部位。涎腺腺瘤临床多表现为无痛性肿块,涎腺癌常伴有疼痛和(或)神经麻痹等症状。结论 大涎腺良、恶性肿瘤具有不同的临床特征,有助于临床正确诊断。