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Ramesh S 《Clinical reviews in allergy & immunology》2008,34(2):217-230
Food allergies have increased significantly in the past decade. An accurate history is crucial in approaching the management.
At the outset, food intolerance must be distinguished from food allergies and, furthermore, these allergies should be classified
into either an IgE, Non-IgE, or a mixed response. The clinical features vary from life-threatening anaphylaxis to milder IgE-mediated
responses, atopic dermatitis, and gastrointestinal symptoms. The severity of the reaction and the potential risk for anaphylaxis
on reexposure should be assessed. Milk, soy, egg, wheat, and peanut allergies are common in children, whereas peanut, tree
nut, fish, shell fish allergies, and allergies to fruits and vegetables are common in adults. Structural proteins are important
determinants of the severity of the reactions and may often predict the natural history and cross reactivity. Diagnostic work
up must be guided by the clinical history. Skin testing and food-specific IgE done by standard methods are very useful, whereas
oral challenges may be indicated in some situations. Majority of the patients outgrow their allergies to milk, soy, egg, and
wheat, and some to peanut also, therefore, patients should be periodically reassessed. Novel diagnostic techniques which detect
specific allergenic epitopes have been developed. Several newer therapies are promising. 相似文献
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Aneta Krogulska Jaros?aw Dynowski Marzena Funkowicz Beata Ma?achowska Krystyna W?sowska-Królikowska 《Allergy, asthma & immunology research》2015,7(6):547-556