CDK4与Ki-67在非小细胞肺癌中的表达及其意义

目的:探讨CDK4和Ki-67在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及其意义。方法:收集胸腔外科手术切除的NSCLC组织及相应正常肺组织标本271例,应用免疫组织化学法检测CDK4和Ki-67在NSCLC中的表达并进行统计学分析。结果:CDK4和Ki-67主要表达于细胞核中,在NSCLC、腺癌、鳞癌组织中的总阳性表达率高于相应正常组织(均P<0.001);在腺癌、鳞癌组间CDK4与Ki-67表达差异均无统计学意义;在分化程度、TNM分期及淋巴结是否转移组间,CDK4与Ki-67表达差异显著(均P<0.01);且在总NSCLC、腺癌、鳞癌中CDK4与Ki-67表达呈正相关,相关系数r分别是0.520,0.544,0.501,均P<0.001;CDK4和Ki-67表达强度为-/+的NSCLC患者较表达强度为++/+++的NSCLC患者中位生存时间长,差异有统计学意义(分别P=0.0019,P=0.0227)。Cox单因素回归分析显示分化程度、TNM分期、淋巴结是否转移及CDK4与Ki-67的表达是影响NSCLC临床预后的因素(均P<0.01);而Cox多因素回归分析显示TNM分期和CDK4表达是影响NSCLC预后的风险因素(分别P=0.001,P=0.033)。结论:CDK4的过表达可能与NSCLC的发生、发展和转移具有一定的关系,联合检测CDK4与Ki-67的表达可能有助于NSCLC的早期诊断和预后判断。     

颈部转移性淋巴结的超声造影表现分析

目的 探讨颈部转移性淋巴结的超声造影表现特征.方法 对23例患者的52个颈部转移性淋巴结进行灰阶超声造影,观察造影图像表现.结果 52个转移性淋巴结中,36个(69%)淋巴结造影表现为显著增强的实质内有局灶性低或无灌注区;14个(27%)淋巴结造影表现为整个淋巴结微弱增强,灌注均匀或不均匀,其中的9个淋巴结造影同时表现为边界不清,与不均匀增强的周围软组织混合成一片,造影图像上无法辨认淋巴结的轮廓;2个(4%)淋巴结造影表现为整个淋巴结显著而均匀的增强.结论 超声造影能反映转移性淋巴结的灌注情况,对诊断有一定价值.     

单、双指数模型扩散加权成像对非小细胞肺癌Ki-67表达的预测价值

目的评估双指数扩散模型体素内不相干运动扩散加权成像(intravoxel incoherent motion diffusion weighted imaging,IVIM)各参数(灌注分数、假扩散系数及真扩散系数)及单指数扩散模型扩散加权成像(diffusion weighted imaging,DWI)表观扩散系数(apparent diffusion coefficient,ADC)对非小细胞肺癌Ki-67表达的预测价值。材料与方法共60例患者(41例男性,19例女性,年龄35～81岁)使用3.0 T MR扫描仪行IVIM (b=0、50、100、150、200、400、600、800 s/mm2)、DWI (b=50、800 s/mm2)检查。所有患者均通过外科手术或CT引导下穿刺活检或支气管镜检查获得病理结果。使用body diffusion toolbox软件测量ADC、D、f and D*值,2名有经验的放射科医师分别对各参数值进行测量,每个病灶测量三次取平均值。使用组内相关系数(the intraclass correlation coefficient,ICC)计算2名医师测量各参数的一致性,进而使用Spearman相关计算ADC,D,f and D*值与Ki-67的相关性。结果 ADC及D值与Ki-67呈负相关关系(ADC:r=-0.335,P=0.009)(D:r=-0.330,P=0.01),f、D*值与Ki-67无显著相关关系;肺腺癌ADC值与Ki-67呈负相关关系(r=-0.424,P=0.008)。结论单指数扩散模型参数ADC、双指数扩散模型参数D值有望成为无创性的在体预测非小细胞肺癌Ki-67表达程度的指标,这为使用影像学方法预测非小细胞肺癌的预后提供客观依据。     

非小细胞肺癌CT影像特征与Ki-67、血管内皮生长因子表达的关系

目的  分析非小细胞肺癌（NSCLC）CT影像特征与Ki-67、血管内皮生长因子（VEGF）的表达关系,为NSCLC的临床诊治及判断预后提供理论依据。方法  回顾性收集我院2018年1月~2023年1月112例确诊为NSCLC的患者,采用Philips Brilliance 256iCT检查患者CT影像特征,检测NSCLC组织中Ki-67、VEGF的表达,分析影像特征、临床资料（病理类型、性别、年龄、吸烟史）与Ki-67、VEGF表达水平的关系。结果  CT特征与Ki-67表达关系中,出现毛刺征、深分叶征、动脉期强化CT值≥ 20 Hu、静脉期强化CT值≥20 Hu、肺门淋巴结肿大、直径≥3 cm,Ki-67阳性表达率高（P < 0.05）;出现钙化、胸膜牵拉征,Ki-67阳性表达率低（P < 0.05）;其余指标差异无统计学意义(P>0.05)。CT特征与VERF表达关系中, 出现血管集束征、动脉期明显强化≥20 Hu、直径≥3 cm、肺门淋巴结肿大,VEGF阳性表达率高(P < 0.05);出现空泡征、深分叶征、直径 < 3 cm,VEGF阳性表达率低（P＜0.05）。临床资料与Ki-67、VEGF表达关系中,男性、有吸烟史、患者中Ki-67阳性表达率高,病理类型为鳞癌Ki-67阳性表达率低,差异有统计学意义（P < 0.05）;VEGF表达与临床资料组间差异均无统计学意义（P>0.05）。结论  NSCLC患者的CT影像特征与Ki-67、VEGF中的表达状态密切相关,一定程度上可推测免疫组化指标表达情况。     

基于超声造影参数的Logistic回归模型预测浸润性 乳腺癌Ki-67表达水平的临床价值

目的 探讨超声造影参数与浸润性乳腺癌Ki-67高低表达的相关性。方法 回顾性分析2019年10月～2022年10月我院行手术治疗的66例浸润性乳腺癌患者二维超声及造影信息。根据肿瘤手术病理 Ki-67表达情况分为Ki-67高表达组和Ki-67低表达组。比较两组病灶二维特点、超声造影剂到达时间(AT)、达峰时间(TTP)、峰值强度(PI)、上升支斜率(AS)、峰值减半时间( DT/2)、平均通过时间(MTT)、曲线下面积(AUC)的差异。对差异有统计学意义的超声指标采用logistic回归分析,建立Ki-67高表达的预测模型并分析其预测性能。结果 Ki-67高表达组病灶内血流分级(BFG)II-III占比高于Ki-67低表达组(P＜0.05);造影参数AT、PI、AS在Ki-67高低表达组中比较具有统计学意义(P＜0.05)。多因素分析结果显示：AT、PI是影响Ki-67的独立危险因素。以此为基础构建了预测Ki-67高表达组的模型：Logistic(P)=1.335- 0.937*AT+0.281*PI+2.834*BFG(Ⅱ-Ⅲ),该模型对判断Ki-67是否高表达具有较高参考价值,灵敏度、特异度分别为87.18%、88.89%。结论 超声造影参数联合血流分级模型可为无创评估浸润性乳腺癌的肿瘤细胞增殖程度及肿瘤血管生成提供一定的影像学依据。     

非小细胞肺癌磁共振扩散加权成像表观扩散系数、肿瘤标记物及Ki-67表达的相关性研究

目的探讨非小细胞肺癌(NSCLC)磁共振扩散加权成像(DWI)表观扩散系数(ADC)与肿瘤标记物及Ki-67表达的相关性。方法选取2018年8月至2019年6月就诊于陕西省核工业215医院肿瘤科的NSCLC患者37例,均使用3.0T磁共振扫描仪行DWI(b=50、800s/mm~2)检查。由2名有经验的放射科医生测量ADC,每个病灶测量3次,取平均值。使用组内相关系数(ICC)计算2名医生测量结果的一致性。使用电化学发光法在治疗前对所有患者行血清肿瘤标记物[包括糖类抗原(CEA)、鳞状细胞癌抗原(SCC)及细胞角蛋白19片段(CYFRA21-1)]检测。所有患者均通过外科手术或CT引导下穿刺活检或支气管镜检查获得病理结果,进而使用Spearman相关计算ADC与血清肿瘤标记物(CEA、SCC及CYFRA21-1)水平、Ki-67表达水平间的相关性。结果腺癌与鳞癌各项参数中,仅SCC在腺癌与鳞癌组差异有统计学意义(P=0.003),其余各项参数差异均无统计学意义(P0.05)。Ki-67与CYFRA21-1呈正相关(r=0.359,P=0.029),ADC与SCC呈负相关趋势(r=-0.307,P=0.065),ADC与Ki-67无显著相关性(r=-0.089,P=0.599)。结论肿瘤标记物CYFRA21-1对预测NSCLC Ki-67表达水平有一定价值,有助于术前无创地评估肿瘤细胞的异常增殖状态;SCC可在一定程度上用来预测肿瘤组织的ADC,对判断肿瘤组织的恶性程度有潜在价值。     

基于胸部CT平扫纹理特征预测肺癌Ki-67表达水平的可行性研究

目的:探讨基于胸部CT平扫纹理特征预测肺癌Ki-67表达水平的可行性。方法:回顾性收集2021年1月—2022年10月在济宁市第三人民医院病理诊断为肺癌的患者,将肺癌患者进行Ki-67表达水平检查的患者纳入研究。将Ki-67高表达分为A组(n=47),Ki-67低表达分为B组(n=30),比较2组患者CT图像纹理特征值、临床数据,采用二元logistics回归分析,筛选出预测Ki-67高低表达的独立风险因素并建立模型。对独立风险因素与logistics预测模型进行受试者工作特征(ROC)曲线分析诊断效能。结果:两组患者年龄、性别、癌胚抗原差异均无统计学意义(P>0.05)。使用MaZda中内置的最小分类误差与最小平均相关系数法降为后获得4个纹理特征。二元logistics回归方程示FrequencySize (频率大小)Compactness (致密度)、HaraEntroy (原始熵)为预测非小细胞肺癌Ki-67表达高低的独立分析因素,Logit (P)=1.713+HaraEntroy×4.253+FrequencySize×0.124+Compactness×1.356,L...     

超声造影对颈部淋巴结结核与鼻咽癌转移性淋巴结的鉴别诊断

目的分析颈部淋巴结结核（CTBL）与鼻咽癌转移性淋巴结的超声造影（CEUS）增强模式表现,评价CEUS在两者鉴别诊断中的应用价值。 方法回顾性分析2013年7月至2017年8月在杭州市红十字会医院行颈部淋巴结常规超声及CEUS检查,并经病理证实的61例CTBL患者和48例鼻咽癌转移性淋巴结患者的超声资料,观察淋巴结的分区,长径（L）/短径（S）值、淋巴门、钙化、内部坏死、血流、阻力指数（RI）及CEUS的增强模式,采用χ²检验比较各组间的统计学差异。 结果CTBL常规超声表现的钙化多呈粗钙化（≥0.5 mm）,鼻咽癌转移性淋巴结的钙化多呈微钙化（<0.5 mm）,两者比较差异有统计学意义（P<0.05）;两组淋巴结的L/S、淋巴门、内部坏死、血流比较,差异均无统计学意义（P均>0.05）;61例CTBL分区以Ⅲ、Ⅳ、Ⅱ区常见（39.3%、31.1%、14.8%）,48例鼻咽癌转移性淋巴结分区以Ⅱ、Ⅴ、Ⅲ区常见（45.8%、29.2%、12.5%）,两组间不同分区的构成差异有统计学意义（χ²=32.125,P<0.05）;根据CEUS环形增强的厚度分为厚环、薄环及无环形增强。其中CTBL以厚环多见（39/54,72.2%）,鼻咽癌转移性淋巴结以薄环多见（26/38,68.4%）,两组之间差异有统计学意义（χ²=25.171,P<0.05）。 结论结合常规超声,CEUS能够在淋巴结增强特征上进一步提供信息,有助于鉴别CTBL及鼻咽癌转移性淋巴结。     

前列腺癌超声造影参数与其Ki-67蛋白表达的相关性研究

目的探讨前列腺癌超声造影参数与其Ki-67蛋白表达的相关性。方法收集经直肠前列腺穿刺活检确诊的前列腺癌患者95例,术前均行超声造影检查,观察超声造影模式,确定异常增强区域。免疫组化法检测异常增强区域组织Ki-67蛋白的表达情况,并根据其检测结果分为:阴性组40例、低表达组40例和高表达组15例。应用QLAB软件分析异常增强区域的时间-强度曲线,记录并比较各组超声造影定量参数。分析各超声造影参数与Ki-67蛋白表达的相关性。绘制受试者工作特征(ROC)曲线评价超声造影参数对Ki-67蛋白表达的诊断价值。结果超声造影模式以不均质增强为主,异常增强区域的时间-强度曲线形态以速升速降及速升缓降为主。各组超声造影时间-强度曲线的曲线下面积(AUC)、峰值强度(PI)、强度降半时间(HT)、平均通过时间(MTT)、上升支斜率比较,差异均有统计学意义(均P<0.05),其中AUC、PI、HT、MTT与Ki-67蛋白表达均呈正相关(r=0.657、0.537、0.503、0.407,均P<0.05)。ROC曲线显示AUC、PI、HT对Ki-67蛋白表达有较高的诊断价值,当截断值分别为479.44 dBs、7.71 dB、49.48 s,其ROC曲线下面积分别为0.848、0.793、0.752,以AUC的诊断特异性和敏感性最高(83.64%、73.24%)。结论超声造影时间-强度曲线定量参数AUC、PI、HT与Ki-67蛋白表达均有相关性,可为无创评估前列腺癌的肿瘤细胞增殖程度及肿瘤血管生成提供一定依据,可为预测肿瘤恶性程度及预后提供影像学参考。     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.     

鼻咽癌颈部转移性淋巴结的超声造影特征及时间强度曲线分析

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.