The effect of GABA-ergic agents on the blood electrolyte balance in acute craniocerebral trauma]

A study was made of the balance of potassium and sodium ions in red blood cells and blood plasma of rats with acute craniocerebral injury seen over time. It has been established that phenibut (50 mg/kg) and sodium hydroxybutyrate (0.2 g/kg) prevent electrolytic changes in blood at different periods of injury. The K+/Na+ ratio of red blood cells can be used as an objective indicator to characterize the time course of changes in craniocerebral injury and to evaluate the efficiency of its pharmacological correction.     

The effect of adrenergic agents on the level of extracellular potassium normally and in myocardial ischemia (infarct)

Adrenergic drugs exert effects on the processes of potassium ions transmembrane distribution between the intra- and extracellular spaces. Drug-induced hypokalemia is the result of beta (predominantly beta-2) adrenergic stimulation. Arrhythmias in myocardial ischemia occur at the combination of hypercatecholaminemia and rapid transmembrane distribution of potassium ions between the intra- and extracellular spaces. The distribution results in the association of the increased local extracellular potassium concentration in the myocardium and rapidly developing hypokalemia.     

Therapeutic-preventive effect of sodium selenite on the course of experimental myocardial infarct]

An occlusion of the left coronary artery in rats tends to signally raise the intensity of free radical oxidation of myocardial-lipids, which is revealed by the chemofluorescent method. A direct correlational link between the intensity of the lipids peroxidation and the extent of the myocardial damage was established. Subcutaneous injection of sodium selenite in a dose of 30 gamma/kg 2 hours prior to ligation and once daily for a space of 7 days produces a distincly reduced intensity of free-radical processes in the myocardium, decreases the extent of infarction and prevents the appearance of gross changes on the ECG.     

Characteristics of liver circulation and the outflow of bile and lymph in acute carbon tetrachloride poisoning]

In acute tests set up on 13 dogs the pressure and blood flow in the portal vein and hepatic artery, the pressure in the inferior vena cava along with lymph- and bile currents were registered following intraportal introduction of CCI4. Subject to determination were also the resistance of venous and arterial hepatic vessels and of the splachnic zone, as well as the summary blood flow. The rising pressure and diminished blood flow in the portal vein were found to be the result of the growing resistance of venous vessels in the liver. Falling pressure and reduced blood flow in the hepatic artery bore witness to the general toxic effect of CCl4 on the animal organism. Increased portal pressure and disturbed permeability of biological membranes was attended by a greater lymph outflow. The inhibition of bile secretion came as a result of hypoxic and toxic damage of the liver.     

小剂量β—受体阻滞剂对急性心肌梗死患者心率变异的影响

目的 研究小剂量β－受体阻滞剂对急性心肌梗患者心率变异的影响。方法 ４４例急性心肌梗死患者入院后随机分为β－ 体阻滞剂治疗组（１８例）和对照组（２６例）。治疗组于即刻给予氨酰心安（１２．５～２５ｍｇ／ｄ）或美多心安（２５～５０ｍｇ／ｄ），余治疗相同。１０～１４ｄ后行２４ｈ动态心电图检查，分析心率变异的时域指标ＳＤＮＮ ＳＤＡＮＮ ｒＭＳＳＤ ＰＮＮ５０、散点图指标ＶＬＩ ＶＡＩ的变化。用配对ｔ检验     

水蛭冻干粉的急性毒性及对急性血淤证大鼠的治疗作用

目的 评价水蛭冻干粉的急性毒性,比较水蛭冻干粉及水蛭饮片对急性血淤证大鼠的作用.方法 采用最大给药量实验评价水蛭冻干粉的急性毒性;将SD大鼠随机分为空白组、模型组、阿司匹林组(31.25 mg·kg-1)、宽体金线蛭冻干粉和日本医蛭冻干粉高、中、低剂量组(0.3125、0.2083、0.1042 g·kg-1)、宽体金...     

The effect of bonnecor on blood coagulability and thrombocyte aggregation in transient myocardial ischemia]

The experiments on conscious rabbits have indicated that bonnecor given in doses of 0.05 mg/kg and 0.5 mg/kg accelerates clot formation and platelet aggregation, without changing the density of a thrombus. In experimental transient myocardial ischemia, the agent decreases the hypercoagulative change associated with the damaging effect of occlusion and reperfusion.     

血糖代谢对急性心肌梗死临床特征及预后的影响

目的探讨糖尿病、应激性高血糖对急性ST段抬高型心肌梗死冠脉病变及预后的影响。方法收集2014年7月～2016年6月就诊于厦门大学附属第一医院的急性心肌梗死并行直接PCI的患者共128例。共分为三组。糖尿病患者40例,为A组。非糖尿病应激性高血糖患者39例,为B组。非糖尿病无应激性高血糖患者49例,为C组。随访1年。比较三组基线资料(包括DTB Door To Balloo时间、入院GRACE评分)、冠脉病变、SYNTAXⅡ评分及出院GRACE评分、主要不良心脑血管事件(major adverse cardiac and cerebrovascular event,MACCE)发生率。结果基线特征显示A组与C组相比合并高血压的患者更多,差异有统计学意义(P<0.05)。A与C组相比、B与C组相比合并高脂血症的患者更多,差异有统计学意义(P<0.05)。A组入院GRACE评分高于C组,差异有统计学意义(P<0.05)。A组糖化血红蛋白高于B组及C组,A组、B组入院时随机血糖均高于C组,差异有统计学意义(P<0.05)。C组冠脉单支病变显著多于A组及B组。A组及B组冠脉三支病变显著多于C组。A与B组相比、A与C组相比、B与C组比较,SYNTAXⅡ评分的差异均有统计学意义(P<0.05)。A组出院GRACE评分明显高于C组,差异有统计学意义(P<0.05)。A与C组相比,1年后全因死亡增多,差异有统计学意义(P<0.05)。A组因心力衰竭入院明显多于C组,差异有统计学意义(P<0.05)。结论糖尿病患者三支病变更常见。SYNTAXⅡ评分结果提示糖尿病患者冠脉病变程度重于非糖尿病应激性高血糖患者,非糖尿病应激性高血糖患者冠脉病变程度重于非糖尿病无应激性高血糖患者。1年随访显示糖尿病患者因心力衰竭入院的风险更高,全因死亡率更高。     

经皮冠状动脉介入治疗对急性心肌梗死患者窦性心率震荡及心率变异性的影响观察

目的探讨对急性心肌梗死患者予以经皮冠状动脉介入治疗后,对其心率变异性和窦性心率震荡的影响情况。方法 2015年8月~2017年3月期间选取我院收治的急性心肌梗死患者72例,按照不同的治疗方法将其均分两组,各36例。将实施药物治疗的患者作为参照组,将实施经皮冠状动脉介入治疗的患者作为实验组。对比两组急性心肌梗死患者的震荡斜率TS、24小时内R-R之间的标准差SDNN和5min之内R-R之间的平均标准差SDANN情况。结果经皮冠状动脉介入治疗后,实验组急性心肌梗死患者的TS、SDANN、SDNN相比于参照组,均明显较高,差异有统计学意义(P<0.05)。结论对急性心肌梗死患者予以经皮冠状动脉介入治疗,其心肌缺血情况予以改善,对其心律失常和心性猝死情况予以有效的预防,证明其效果较优。     

Effect of nootropil on the conditioned reflex activity in acute myocardial infarct

At the acute stage of myocardial infarction the higher functions of the brain such as fixation and reproduction of temporary connections were shown to be markedly depressed. The use of nootropil in experimental myocardial infarction was followed by the improvement of conditioned-reflex activity.     

The effect of potential beta-adrenolytic agents on oxidation and phosphorylation processes in myocardial muscle mitochondria in vitro]

Concentrations ranging from 1-9 x 10(-7) mol.dm-3 were employed for in vitro studies. Under the selected experimental conditions, both agents markedly decreased the stimulated consumption of oxygen by the cardiac muscle mitochondria in the condition S3, the rate of the formation of energy by mitochondria as well as the respiratory control index. The coefficient of oxidative phosphorylation was not markedly changed due to the effect of the added agents. The results of the present paper suggest possible integration of the cardiac muscle mitochondria in the oxidative metabolism of the potential beta-adrenolytic agents FA33 and FP33, which requires further in vivo studies.     

Effect of ether-oxygen anesthesia and of the premedication agents on the toxicity and cardiotonic effect of strophanthin]

Experiments conducted with mice, rats and cats demonstrated ether-oxygen anesthesia to reduce the tolerance of the animals to strophanthin in the LD50 and MDL tests. The premedication agents (atropine, promedol, diprazine) increased, according to observations on mice and rats, the resistance of the animals to strophanthin. In tests on dogs involving determination of the cardiac ejection by thermodilution strophanthin in a dose of 44 gamma/kg and under ether-oxygen anesthesia with premedication produced a statistically significant increase of the systolic cardiac index and well-marked bradycardia. Exclusion of thepremedicationagents drastically lowered the effect of strophanthin.     

The effect of the thromboxane A2/prostaglandin endoperoxide receptor antagonist SQ 30,741 on myocardial infarct size and blood flow during myocardial ischemia and reperfusion

The effect of the thromboxane A2 (TXA2) receptor antagonist SQ 30,741 on infarct size and myocardial blood flow during coronary occlusion and reperfusion was determined. In anesthetized dogs, the left circumflex coronary artery (LCX) was occluded and after 10 min a continuous infusion of SQ 30,741 (1 mg/kg + 1 mg/kg/h, i.v.) or saline was begun. After 90 min of LCX occlusion, the LCX was reperfused for 5 h and infarct size was then determined. Myocardial blood flows before, during, and after occlusion were determined using radioactive microspheres. SQ 30,741 resulted in a significant decrease in infarct size (34% +/- 6% of left ventricular area at risk) compared to controls (60% +/- 9%). Cardioprotection was also found with SQ 30,741 when infarct size was normalized for both area at risk and predrug collateral flow. The protective effect of SQ 30,741 occurred without an increase in collateral flow. At 1 h postreperfusion, subendocardial flow was significantly higher in SQ 30,741-treated animals (109 +/- 15 ml/min/100 g) compared to controls (71 +/- 16 ml/min/100 g). SQ 30,741, in the dose resulting in infarct size reduction, produced a 95% inhibition of platelet TXA2 receptors throughout the experiment as measured by dose-dependent inhibition of the ex vivo platelet shape change response to U-46,619, a TXA2 mimetic. Thus, a dose of SQ 30,741 that results in TXA2 blockade also results in myocardial salvage without changes in collateral flow.     

乐果对培养乳鼠心肌细胞的毒作用

（目的）探讨乐果对培养乳鼠心肌细胞细胞收缩功能、乳酶脱氢酶（ＬＤＨ）、天冬氨酸转氨酶（ＡＳＴ）和细胞骨架的影响。（方法）体外乳鼠心肌细胞细胞培养。（结果）乐果可使心肌细胞收缩力减弱;１３.2umol/L染毒３h后心肌搏动频率明显降低,而５２.8umol/L和２１１.2umol/L染毒１h后即降低;２１１.2umol/L染毒心肌细胞,ＬＤＨ和ＡＳＴ漏出达最大值的时间分别为１h和３h,而１３.2或５２.8umol/L染毒分别为３h和８h,另外,乐果还可使心肌细胞骨架着色谱浅,排列不规则,上述改变破例有明显的剂量－效应和时程依赖性关系。（结论） 乐果树对乳鼠心肌细胞有明显的毒作用。其机制可能涉及心肌细胞膜和线粒体膜通透性增加,刺激肌质网的钙泵系统摄取Ｃa^2 ,引起细胞骨架构型改变,从而影响心肌的收缩功能。     

The effect of anti-arrhythmia agents on ventricular arrhythmias arising as a consequence of disorders in the myocardial blood supply

The protective and therapeutic effects of some antiarrhythmic drugs of classes I-IV were studied in the experiments on 103 cats and 75 dogs. The antiarrhythmic drugs of classes 1a (N-propylaimaline bromide, aimaline, ethacizine), 1b (trimecaine) and IV (finoptine) were shown to prevent with various effectiveness the occurrence of early occlusion and reperfusion ventricular arrhythmias. The antiarrhythmic drugs of classes II (anapriline) and III (cordaron) proved to be ineffective in these cases. Ventricular arrhythmia in dogs occurring at the late stage of experimental infarction is reliably relieved in all cases with the antiarrhythmic drugs of class 1a, in most cases--those of classes 1b and III. The antiarrhythmic drugs of classes II and III are ineffective on this model. The experimental results analysed with regard to modern concepts of the genesis of modelled arrhythmias may be used as the experimental basis for a rational choice of antiarrhythmic drugs.     

急性心肌梗死范围影响因素分析

目的 探讨急性心肌梗死(AMI)梗死范围的影响因素.方法 前瞻性地观察92例行急诊PCI术的AMI患者临床资料,应用统计学方法分析AMI梗死范围的影响因素.结果 AMI梗死范围积分(1.71±0.58),应用Pearson相关分析发现AMI梗死范围积分与入院血糖及脂蛋白(α)水平存在相关性(r=0.28,P=0.007...