共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
3.
4.
5.
6.
7.
Extended Release Naltrexone for Alcohol Use Disorders: Quasi‐Experimental Effects on Mortality and Subsequent Detoxification Episodes 下载免费PDF全文
Alex H. S. Harris Thomas Bowe Aaron C. Del Re Andrea K. Finlay Elizabeth Oliva Hugh L. Myrick Anna D. Rubinsky 《Alcoholism, clinical and experimental research》2015,39(1):79-83
8.
Effects of the Opioid System Modulator,Samidorphan, on Measures of Alcohol Consumption and Patient‐Reported Outcomes in Adults with Alcohol Dependence 下载免费PDF全文
Stephanie S. O'Malley Mark S. Todtenkopf Yangchun Du Elliot Ehrich Bernard L. Silverman 《Alcoholism, clinical and experimental research》2018,42(10):2011-2021
9.
Effect of Varenicline Combined with High‐Dose Alcohol on Craving,Subjective Intoxication,Perceptual Motor Response,and Executive Cognitive Function in Adults with Alcohol Use Disorders: Preliminary Findings 下载免费PDF全文
Terril L. Verplaetse Brian P. Pittman Julia M. Shi Jeanette M. Tetrault Sabrina Coppola Sherry A. McKee 《Alcoholism, clinical and experimental research》2016,40(7):1567-1576
10.
Randall L. Barbour Asefa Gebrewold Burton M. Altura 《Alcoholism, clinical and experimental research》1993,17(6):1319-1324
Dose-response effects of acute ethanol infusions were studied, noninvasively, in the unopened brain to examine the hypothesis that ethanol can induce stroke-like events as a consequence of cerebral vasospasm and tissue ischemia. By using a single sending and receiving fiber, an optical backscatter measurement (500–800 nm) was used to monitor the levels of deoxyhemoglobin (DH), reduced cytochrome oxidase (rCO), and relative tissue blood content in a closed cranium preparation. Anesthetized rats were prepared by cannulating a branch of the internal carotid artery and subjected to either bolus infusions (1.25 or 2.5 μm ethanol in Ringers/g tissue) or to constant infusions of 5 or 10% ethanol at various rates (0.30–2.92 μm /g/min). To facilitate optical penetration, a portion of the left parietal cranium was shaved to a translucent appearance. Results showed that low, bolus doses of ethanol typically produced a slight increase (5–10%) in the oxyhemoglobin signal, indicating that vasodilation had probably occurred. Higher doses, however, produced a prompt and significant reduction in the hemoglobin signal, increased levels of DH, and a rise in rCO suggesting a vasoconstrictor response leading to ischemia had occurred, followed by recovery within 3–5 min. Constant infusions of ethanol produced a similar cerebral vascular response, in a dose-related manner, but of a more sustained nature. At levels of 50–60% of the maximum bolus dose, the effect was more pronounced, accompanied by an increase in the levels of rCO (by 50–90%). Control experiments using identical volumes/flow rates of Ringers solution produced no significant alterations in the optical spectrum. Overall, these data indicate that, depending on dose: (a) ethanol can induce vasodilatory or vasoconstrictor effects in the intact brain; (b) the more pronounced effects involve vasospasm in the cortical microcirculation leading to global ischemia; and (c) optical measurements permit direct noninvasive assessment of the cerebral vascular effects of alcohol and, potentially, other substances of abuse 相似文献
11.
12.
Parameters of Context‐Induced Ethanol (EtOH)‐Seeking in Alcohol‐Preferring (P) Rats: Temporal Analysis,Effects of Repeated Deprivation,and EtOH Priming Injections 下载免费PDF全文
Sheketha R. Hauser Gerald A. Deehan Jr Christopher P. Knight Jamie E. Toalston William J. McBride Zachary A. Rodd 《Alcoholism, clinical and experimental research》2016,40(10):2229-2239
13.
14.
Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized,Double‐Blind,Placebo‐Controlled Clinical Trial 下载免费PDF全文
Sandra W. Jacobson R. Colin Carter Christopher D. Molteno Mark E. Stanton Jane S. Herbert Nadine M. Lindinger Catherine E. Lewis Neil C. Dodge H. Eugene Hoyme Steven H. Zeisel Ernesta M. Meintjes Christopher P. Duggan Joseph L. Jacobson 《Alcoholism, clinical and experimental research》2018,42(7):1327-1341
15.
16.
Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized,Double‐Blind,Placebo‐Controlled Trial 下载免费PDF全文
Glauce L. Lima Juliane Paupitz Nadia E. Aikawa Liliam Takayama Eloisa Bonfa Rosa M. R. Pereira 《Arthritis care & research》2016,68(1):91-98
17.
Gender‐Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs 下载免费PDF全文
Ovidiu Dan Iancu Alex M. Colville Beth Wilmot Robert Searles Priscila Darakjian Christina Zheng Shannon McWeeney Sunita Kawane John C. Crabbe Pamela Metten Denesa Oberbeck Robert Hitzemann 《Alcoholism, clinical and experimental research》2018,42(8):1454-1465
18.
19.