共查询到20条相似文献,搜索用时 19 毫秒
1.
Jae-Hyeok Lee Won-Ho Cho Seung-Heon Cha Dong-Wan Kang 《Journal of Korean Neurosurgical Society》2015,57(2):143-146
Chorea-acanthocytosis (ChAc) is a rare hereditary disorder characterized by involuntary choreiform movements and erythrocytic acanthocytosis. Pharmacotherapy for control of involuntary movements has generally been of limited benefit. Deep brain stimulation (DBS) has recently been used for treatment of some refractory cases of ChAc. We report here on the effect of bilateral high-frequency DBS of globus pallidus interna in a patient with ChAc. 相似文献
2.
3.
Remarkable Clinical Improvement with Bilateral Globus Pallidus Internus Deep Brain Stimulation in a Case of Lesch–Nyhan Disease: Five‐Year Follow‐Up 下载免费PDF全文
Fabián Piedimonte MD Juan Carlos Andreani MD Leandro Piedimonte MD Federico Micheli MD Pablo Graff MD Valeria Bacaro PhD 《Neuromodulation》2015,18(2):118-122
4.
5.
Kazumichi Yamada MD PhD Tadashi Hamasaki MD PhD Yu Hasegawa MD PhD Jun‐ichi Kuratsu MD PhD 《Neuromodulation》2013,16(3):219-225
Objectives: We retrospectively investigated the correlation between disease duration and the therapeutic effect of globus pallidus internus (GPi) stimulation in patients with primary cervical dystonia (CD). Materials and Methods: Eight patients with CD unresponsive to medical treatments underwent bilateral GPi deep brain stimulation (DBS). They were followed for 63.5 ± 38.2 months (mean ± standard deviation) and were assessed before and at 1, 12, 24, and 36 months after surgery and at their final visit to our outpatient clinic using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Univariate analysis was performed to identify factors that affected their postoperative TWSTRS score. Results: At last follow‐up, disease severity and the degree of disability and pain on the TWSTRS were significantly improved by 70.2%, 76.1%, and 87.1%, respectively (p < 0.05, Wilcoxon signed‐rank test). Neither age nor preoperative CD severity was predictive of postoperative improvement; however, the disease duration affected their reduction rate of TWSTRS severity score at each time point investigated (p < 0.05). Conclusions: Bilateral GPi‐DBS is an effective long‐term therapy in patients with CD. The delivery of GPi stimulation in the earlier course of CD may yield greater postoperative improvement. 相似文献
6.
7.
8.
9.
Daniel G. Di Luca MD Carolina Ramirez-Gomez MD Jurgen Germann PhD Brendan Santyr MD Alexandre Boutet MD MSc PhD Luka Milosevic PhD Anthony E. Lang MD Suneil K. Kalia MD PhD Andres M. Lozano MD PhD Alfonso Fasano MD PhD FAAN 《Movement disorders》2023,38(11):2121-2125
Background
Multiple system atrophy with parkinsonism (MSA-P) is a progressive condition with no effective treatment.Objective
The aim of this study was to describe the safety and efficacy of deep brain stimulation (DBS) of globus pallidus pars interna and externa in a cohort of patients with MSA-P.Methods
Six patients were included. Changes in Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III), Parkinson's Disease Questionnaire (PDQ-39) scores, and levodopa equivalent daily dose were compared before and after DBS. Electrode localization and volume tissue activation were calculated.Results
DBS surgery did not result in any major adverse events or intraoperative complications. Overall, no differences in MDS-UPDRS III scores were demonstrated (55.2 ± 17.6 preoperatively compared with 67.3 ± 19.2 at 1 year after surgery), although transient improvement in mobility and dyskinesia was reported in some subjects.Conclusions
Globus pallidus pars interna and externa DBS for patients with MSA-P did not result in major complications, although it did not provide significant clinical benefit as measured by MDS-UPDRS III. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 相似文献10.
11.
《Brain stimulation》2014,7(2):179-181
BackgroundDeep brain stimulation is the surgical procedure of choice in patients with Parkinson's disease. The subthalamic nucleus and the globus pallidus interna are the two most common targets used to treat Parkinson's disease.MethodsWe describe three patients with previous effective subthalamic deep brain stimulation in whom globus pallidus interna deep brain stimulation was performed as “rescue” surgery, 8 years after the original operation.ResultsTwo years after globus pallidus surgery the reduction of dystonia and dyskinesias led to an improvement of motor symptoms. In two patients, painful dystonias disappeared and motor fluctuations markedly improved. One patient achieved an improvement in freezing.ConclusionAfter 24 months of follow up, our observations suggest that globus pallidus deep brain stimulation, can improve motor fluctuations, dyskinesia and axial symptoms. 相似文献
12.
Seon Tak Jin Myung Ki Lee Ju Young Ghang Seong Man Jeon 《Journal of Korean Neurosurgical Society》2012,52(3):261-263
The experience of pediatric deep brain stimulation (DBS) of the globus pallidus internus (GPi) in the treatment of early-onset DYT1 generalized dystonia is still limited. Here, we report the surgical experience of bilateral GPi-DBS under general anesthesia by using microelectrode recording in a 7-year-old girl with early-onset DYT1 generalized dystonia. Excellent improvement of her dystonia without neurological complications was achieved. This case report demonstrates that GPi-DBS is an effective and safe method for the treatment of medically refractory early-onset DYT1 generalized dystonia in children. 相似文献
13.
Sandra Dehning MD Jan‐Hinnerk Mehrkens MD Norbert Müller MD PhD Kai Bötzel MD 《Movement disorders》2008,23(9):1300-1302
We report on a female patient with Tourette syndrome and a 12‐month follow‐up after chronic deep brain stimulation in the globus pallidus internus which resulted in excellent remission of motor and vocal tics. © 2008 Movement Disorder Society 相似文献
14.
15.
16.
Elena Moro Andres M. Lozano Pierre Pollak Yves Agid Stig Rehncrona Jens Volkmann Jaime Kulisevsky Jose A. Obeso Alberto Albanese Marwan I. Hariz Niall P. Quinn Jans D. Speelman Alim L. Benabid Valerie Fraix Alexandre Mendes Marie‐Laure Welter Jean‐Luc Houeto Philippe Cornu Didier Dormont Annalena L. Tornqvist Ron Ekberg Alfons Schnitzler Lars Timmermann Lars Wojtecki Andres Gironell Maria C. Rodriguez‐Oroz Jorge Guridi Anna R. Bentivoglio Maria F. Contarino Luigi Romito Massimo Scerrati Marc Janssens Anthony E. Lang 《Movement disorders》2010,25(5):578-586
We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society 相似文献
17.
Suzhen Lin Yimei Shu Chencheng Zhang Lingbing Wang Peng Huang Yixin Pan Jianqing Ding Bomin Sun Dianyou Li Yiwen Wu 《European journal of neurology》2023,30(9):2629-2640
Background and purpose
Bilateral deep brain stimulation (DBS) surgery targeting the globus pallidus internus (GPi) or the subthalamic nucleus (STN) is widely used in medication-refractory dystonia. However, evidence regarding target selection considering various symptoms remains limited. This study aimed to compare the effectiveness of these two targets in patients with isolated dystonia.Methods
This retrospective study evaluated 71 consecutive patients (GPi-DBS group, n = 32; STN-DBS group, n = 39) with isolated dystonia. Burke–Fahn–Marsden Dystonia Rating Scale scores and quality of life were evaluated preoperatively and at 1, 6, 12, and 36 months postoperatively. Cognition and mental status were assessed preoperatively and at 36 months postoperatively.Results
Targeting the STN (STN-DBS) yielded effects within 1 month (65% vs. 44%; p = 0.0076) and was superior at 1 year (70% vs. 51%; p = 0.0112) and 3 years (74% vs. 59%; p = 0.0138). For individual symptoms, STN-DBS was preferable for eye involvement (81% vs. 56%; p = 0.0255), whereas targeting the GPi (GPi-DBS) was better for axis symptoms, especially for the trunk (82% vs. 94%; p = 0.015). STN-DBS was also favorable for generalized dystonia at 36-month follow-up (p = 0.04) and required less electrical energy (p < 0.0001). Disability, quality of life, and depression and anxiety measures were also improved. Neither target influenced cognition.Conclusions
We demonstrated that the GPi and STN are safe and effective targets for isolated dystonia. The STN has the benefits of fast action and low battery consumption, and is superior for ocular dystonia and generalized dystonia, while the GPi is better for trunk involvement. These findings may offer guidance for future DBS target selection for different types of dystonia. 相似文献18.
Fengqiao Sun Xiaohua Zhang Sheng Dong Yuqing Zhang Jiping Li Yunpeng Wang Jin Zhu 《Neuromodulation》2022,25(2):286-295
ObjectivesPallidal deep brain stimulation (DBS) for refractory Tourette syndrome (TS) is often applied using a high frequency. The effectiveness of low-frequency long-term stimulation is unknown. We aimed to evaluate the clinical efficacy of low-frequency DBS applied to the globus pallidus pars internus (GPi) at 65 Hz for the treatment of TS, with long-term follow-up, to provide data for the optimization of stimulation parameters.Materials and MethodsA total of six patients with refractory TS were implanted with electrodes in the GPi and were assigned to receive low-frequency (65 Hz) DBS programming. Assessments were performed pre-DBS and at 3, 12, and a median of 34 (range 26–48) months post-DBS. The primary outcome was tic severity, as assessed by the Yale Global Tic Severity Scale (YGTSS), and the secondary outcomes were comorbid behavioral disorders, mood, functioning, and quality of life.ResultsWe noted significant differences in the YGTSS scores between the baseline and the post-DBS follow-ups (p = 0.01). At the final follow-up, four of six (66.6%) patients had a greater than 50% reduction in the YGTSS score, whereas the remaining two patients showed a mild worsening of tic severity. The secondary outcome measures also showed remarkable improvements in associated behavioral disorders, mood, functioning, and quality of life. Stimulation-induced adverse effects were not reported, although a device-related complication (an uncomfortable feeling in the neck) occurred in one patient.ConclusionsThe results of this study indicated that low-frequency DBS represents an effective and practical treatment for refractory TS with comparable efficacy to high-frequency DBS. 相似文献
19.
20.
Joerg Mueller MD Inger M. Skogseid MD Reiner Benecke MD Andreas Kupsch MD Thomas Trottenberg MD Werner Poewe MD Gerd H. Schneider MD Wilhelm Eisner MD Alexander Wolters MD J.U. Müller MD Günther Deuschl MD Marcus O. Pinsker MD Geir K. Roeste MD Juliane Vollmer‐Haase MD Angela Brentrup MD Martin Krause MD Volker Tronnier MD Alfons Schnitzler MD Jüergen Voges MD Guido Nikkhah MD PhD Jan Vesper MD Markus Naumann MD Jens Volkmann MD Deep‐Brain Stimulation for Dystonia Study Group 《Movement disorders》2008,23(1):131-134
As part of the first randomized, sham‐timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health‐related quality of life (HRQoL) was assessed by SF‐36. After the 3‐month sham‐controlled phase, significant HRQoL improvement occurred only in the active‐stimulation group. The open‐label extension phase resulted in a significant improvement in all SF‐36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia. © 2007 Movement Disorder Society 相似文献