Unsettled infant behaviour and health service use: a cross-sectional community survey in Melbourne, Australia

Aims: To investigate factors associated with health service use by women and their infants in Victoria, Australia. Methods: Cross‐sectional screening survey of 875 women with 4‐month‐old infants attending immunisation clinics in five local government areas in Melbourne between May 2007 and August 2008. The self‐report instrument assessed socio‐demographic characteristics, unsettled infant behaviour, maternal mood (Edinburgh Postnatal Depression Scale) and, the outcome, health service use during the first 4 months post‐partum. Results: Mothers and their infants used on average 2.8 different health services in the first 4 months post‐partum (range 0–8). After adjustment for other factors, high health service use (defined as >3 different services) was more common in mothers whose infants were unsettled with persistent crying, resistance to soothing and poor sleep. A one‐point increase on the unsettled infant behaviour measure was associated with an 8% (2–14%) increase in the use of >3 services, 9% (3–16%) in use of emergency departments, 7% (2–13%) in use of telephone helplines and 9% (3–14%) of parenting services. Poorer maternal mental health was also implicated with a one‐point increase on the Edinburgh Postnatal Depression Scale associated with a 4% (0.4–8%) increase in the likelihood of using more than three services. Conclusions: Unsettled infant behaviour is associated with increased use of multiple health services. The high use of emergency departments by families with unsettled infants found in this study suggests that enhancement of primary health‐care capacity might be required.     

Metabolic syndrome in youth: a cross-sectional school-based survey

AIM: To assess the prevalence of metabolic syndrome (MetS) among students attending vocational secondary school (VSE). VSE provides practice-oriented education in which young people learn a specific occupation. Previously we reported VSE to be the type of education with the highest prevalence of overweight and obesity. METHODS: All data were collected in a cross-sectional school-based survey. Subjects were recruited from a community sample of 869 adolescents in 14 secondary schools. In this total sample all components of the metabolic syndrome were assessed in a subgroup of 506 students. MetS was defined analogous to National Cholesterol Education Program: Adult Treatment Panel III criteria, with modifications for students under 19 years of age. RESULTS: In the subsample (n=506) 4.1% of the students had metabolic syndrome. There was a significant difference in the prevalence of metabolic syndrome among BMI categories (p<0.001). The prevalence of metabolic syndrome was higher in obese students (39.1%) than in overweight students (2.8%) and normal weight students (0.3%). CONCLUSION: Being overweight or obese substantially increases the risk for metabolic syndrome, even in an adolescent school population.     

Appropriate antibiotic use for acute otitis media: what consumers find using Web searches

The use of the Internet for health information is growing, but there is little control over the timeliness of updates or the accuracy of the information. Recent changes in recommendations for the treatment of acute otitis media were made in an effort to decrease the unnecessary use of antibiotics. We conducted a systematic review of Web sites to determine if consumers are likely to find appropriate information. Only 31% of relevant Web sites found explain the new "watch and wait" recommendation, and 41% include a recommendation to finish the full course of prescribed antibiotics. Web sites that include an update date, are reviewed by a physician, provide references, and have a nonprofit-type domain are more likely to contain updated information. Physicians should be aware that their patients might visit the office with expectations based on outdated information found on the Web. Organizations making recommendations should consider how to disseminate new information through the Web.     

Treatment of acute diarrhoea in practice

The recommended treatment for acute diarrhoea includes oral rehydration and rapid refeeding is increasingly recommended. The objective of this study was to assess the home use of oral rehydration, and rehydration and realimentation in hospital. The parents of children (aged less than 4 y) with acute diarrhoea answered questions on supplementary fluids and diet during the current diarrhoea at home ( n = 129). The admitted patients ( n = 60) were weighed daily and food consumption was measured (consecutive 3-d food record). Oral rehydration had been attempted in 67% of the children managed at the outpatient department and in 65% of those admitted. The total energy intake was on average 697 kcal (95% confidence interval 639–755), which is two-thirds of that recommended for the age group. Oral rehydration has become accepted in the management of acute diarrhoea, while rapid realimentation is not yet equally endorsed.     

Hypo-osmolar sucrose oral rehydration solutions in acute diarrhoea: a pilot study

Based on studies showing improved absorption of hypo-osmolar oral rehydration solutions (ORS) with reduced glucose and sodium concentration, a hypo-osmolar ORS with sucrose replacing glucose (sodium 60, potassium 15, chloride 60, citrate 5, sucrose 58mmoll^?1, calculated osmolality 198mOsmkg^?1) was compared with mildly hyperosmolar glucose ORS (WHO) in 46 children aged 6–30 months with acute diarrhoea and dehydration. In the hypo-osmolar sucrose ORS group (n = 18) faecal output was less by 30% during the initial 24 and 48 h compared with controls, suggesting better absorption. Sucrose may be a suitable alternative to glucose in an absorption-efficient hypo-osmolar ORS.     

Hypotonic oral rehydration solution in acute diarrhoea: a controlled clinical trial

In a controlled trial, a hypotonic oral rehydration solution (ORS) (Na⁺67, K⁺20, CP66, citrate 7, glucose 89mmol/1 osmolality 249 mosmol/kg) was compared with a standard WHO-ORS (Na⁺90, K⁺20, Cl^-80, citrate 10, glucose lllmmol/1, osmolality 311 mosmol/kg) in 60 children aged 5-24 months with acute watery diarrhoea. In the hypotonic ORS group, stool frequency, proportion of children who vomited, ORS requirements and purging rate over 24-48 h were reduced by 33% ( p = 0.01), 30% ( p = 0.02), 21% ( p = 0.067) and 21% ( p = 0.03), respectively. The proportion of children who vomited and the purging rate over 48 h were reduced by 23% ( p = 0.03) and 10% ( p = 0.097), respectively. Serum electrolytes after 48 h were comparable. The beneficial effect of hypotonic ORS was most marked in, and largely contributed by, the subgroup negative for rotavirus.     

Saccharomyces boulardii in acute childhood diarrhoea: a randomized, placebo-controlled study

OBJECTIVE: To evaluate the efficacy of the probiotic yeast Saccharomyces boulardii (S. boulardii) as an adjuvant to oral rehydration solution (ORS) in shortening the duration of acute infectious gastroenteritis in children less than 2 years old in ambulatory care. MATERIALS AND METHODS: In a period of 1 year, 100 outpatients between 3 and 24 months old presenting with acute mild to moderate diarrhoea of less than 7 days duration, were included in a double-blind, randomized, placebo-controlled trial evaluating the efficacy of S. boulardii administered for 6 days. Twelve children were lost in follow-up; the data of 88 children could be analysed (44 in the placebo and 44 in the S. boulardii group). Seventy-two patients were followed for one month (37 in the placebo and 35 in the S. boulardii group) allowing the calculation of the duration of diarrhoea. RESULTS: The mean duration of diarrhoea was 6.16 days (range 2-13 days) in the placebo group and 4.70 days (range 2-10 days) in the S. boulardii group (p<0.05). On the 4th day, the patients in the S. boulardii group passed 2.5+/-1.4 stools/day versus 3.5+/-1.8 in the placebo group (p<0.001). The risk of having diarrhoea lasting more than 7 days was lower in the S. boulardii group (3/44 versus 12/44; RR 0.25; 95% CI 0.1-0.8). In no patient diarrhoea persisted longer than 14 days. A statistically significant difference was observed in the number of stools on the 4th and 7th day favouring the subgroup that received early treatment (within the first 48 h of the onset of diarrhoea). The administration of antibiotics before inclusion did not make any difference. CONCLUSION: S. boulardii as an adjuvant to ORS in ambulatory care in children less than 2 years old with mild or moderate acute diarrhoea decreased the duration of diarrhoea, accelerated recovery and reduced the risk of prolonged diarrhoea. The data also indicate increased efficacy if S. boulardii is administered within the first 48 h of the onset of diarrhoea.     

Type of milk feeding during acute diarrhoea and the risk of persistent diarrhoea: a case control study

The role of feeding breast milk, unmodified bovine milk or adapted infant formula during acute diarrhoea in protecting against or causing persistence of the episodes was investigated in a population-based case control study in an urban area of north India. After adjustment for confounding variables, exclusive breast-feeding was associated with an odds ratio of 0.06 (95% CI 0.002-2.1), a 16.5 times lower odds in favour of developing persistence of an episode. Infants fed unmodified bovine milk in addition to breast milk had an odds of 2.5 times (95% CI 1.0-9.9) in favour of developing persistence of acute diarrhoea ( p = 0.04). In infants receiving unmodified bovine milk and no breast milk, this odds ratio was 11.1 (95% CI 1.0-228.8) ( p = 0.05). This study indicates that promoting exclusive breastfeeding may reduce the persistence of diarrhoea over and above its effect in decreasing the incidence of acute diarrhoea. In urban areas of the developing countries where working mothers often use milk supplementation beyond the age of three months, our findings suggest that use of adapted spray dried formula may be safer than unmodified bovine milk with respect to the risk of developing persistent diarrhoea.     

Dexamethasone and antibiotics for the empirical treatment of bacterial meningitis in Canadian children: A survey of paediatric infectious diseases specialists

PURPOSE:

With the changing epidemiology of the etiological agents causing bacterial meningitis in Canada, the purposes of this study were to determine what empirical antibiotic(s) is/are advocated, and whether dexamethasone is recommended as adjunctive therapy by paediatric infectious diseases specialists for suspected meningitis caused by Streptococcus pneumoniae, Neisseria meningitides, Haemophilus influenzae type b, and partially treated (PT) bacterial meningitis.

METHODS:

A questionnaire invoking the specialists’ preferred choices in treating bacterial meningitis was circulated by e-mail in March 1999 to 41 paediatric infectious diseases specialists or microbiologists (Paediatric Investigators Collaborative Network on Infections in Canada [PICNIC] members) who practised in 13 paediatric centres located in eight provinces.

RESULTS:

Thirty-two (78% response rate) replies were received by July 1999 from 11 paediatric centres in seven provinces. Dexamethasone was recommended by 11 of 32 (34%) respondents for suspected S pneumoniae, four of 32 (12%) for suspected N meningitides, 18 of 32 (56%) for suspected H influenzae type b and five of 32 (16%) for suspected PT meningitis. A trend for more frequent recommended use of dexamethasone for S pneumoniae, H influenzae type b and N meningitides meningitis was found in eastern provinces (Ontario, Quebec and Nova Scotia), as opposed to the western provinces (Manitoba, Saskatchewan, Alberta and British Columbia). The most commonly recommended first line empirical antibiotic therapy was vancomycin plus 3rd-generation cephalosporin (V+3C). This was recommended by 27 of 32 (84%) respondents for suspected S pneumoniae, seven of 32 (22%) for suspected N meningitides, six of 32 (19%) for suspected H influenzae type b and 24 of 32 (75%) for PT meningitis; the remainder recommended using a 3C empirically for each type of meningitis. The major reason cited by respondents for using V+3C for suspected S pneumoniae was the presence of high-and intermediate-level penicillin-resistant S pneumoniae in their centres. No differences were found in the choice of antibiotic(s) between practitioners in the eastern and western provinces.

CONCLUSIONS:

Although regional differences exist, the majority of paediatric infectious diseases experts no longer favour the use of dexamethasone for empirical therapy in most cases of bacterial meningitis. V+3C has become the regimen of choice in Canada for most cases of suspected bacterial meningitis.     

单中心儿科呼吸病房住院医嘱超说明书用药横断面调查

目的：调查吉林大学第一医院（我院）儿科呼吸病房住院病历医嘱的超说明书用药情况, 分析超说明书用药的影响因素。方法：以横断面研究设计试验方案,采用等距抽样原则,从2014年9月至2015年9月我院HIS系统儿科呼吸病房的连续的0~18岁连续住院病历中抽取500份病历,提取与用药有关的全部医嘱,排除嘱托医嘱、退药医嘱、领药医嘱和0.9%氯化钠注射液等类似的医嘱。采集病历的一般信息和医嘱信息,判断每条医嘱的超说明用药情况,从年龄、药品种类、疾病和医嘱类型等方面行分层分析,采用Logistic回归法分析超说明书用药的影响因素。结果进入本文分析的500份病历包括465例患儿,共提取18 082条医嘱,住院用药医嘱16 618条,出院带药医嘱1 464条;涉及196种药物,主要为呼吸系统用药和系统抗感染药医嘱。①500份病历的超说明书用药率为100%,超说明书用药医嘱4 717条（26.1%）,平均每份病历超说明书用药9.4条医嘱,平均每份病历每日超说明书用药1.4条医嘱。②无儿童用法和用量超说明书用药的发生率（17.4%）是其他类型超说明书用药发生率总和的2倍。③不同年龄阶段：总体超说明书用药发生率差异有统计学意义,年龄越小超说明书用药发生率越高（P=0.000）。④不同药物品种：总体超说明书用药发生率,系统抗感染药（35.7%）、呼吸系统用药（32.1%）和心血管系统用药（21.8%）较高;抗病毒药物高于抗细菌药物（P=0.000）,均主要集中于无儿童用法用量;抗哮喘药高于镇咳祛痰药（P=0.020）,前者主要集中于无儿童用法用量,后者主要集中于无给药途径和无儿童用法用量;超禁忌用药见于消化系统用药和其他药物。⑤不同疾病类型：总体超说明书用药发生率由高到低依次为肺炎、重症肺炎、支气管炎、支气管哮喘、其他疾病、咽炎和支气管异物。⑥不同医嘱类型：总体超说明书发生率出院带药医嘱高于住院用药医嘱。⑦Logistic回归分析：与婴儿相比,学龄期+青春期超说明书用药风险降低了20%;与系统抗感染药相比,呼吸系统超说明书用药风险降低了15%;与肺炎相比,其余疾病的超说明书用药风险均有所降低;与高级职称相比,中级职称和初级职称超说明书用药风险降低86%和84%。结论：儿科呼吸病房超说明书用药现象普遍存在,无儿童用法用量是最主要的超说明书用药类型,其次为超给药途径。     

Characteristics of neonatal intensive care unit patients in North Carolina: a cross-sectional survey

A shortage of neonatal intensive care facilities has been encountered in some areas of the country including North Carolina. To examine possible solutions to this health care delivery problem, a cross-sectional survey of all the neonatal intensive care units in North Carolina was performed to examine characteristics of patients occupying the beds in these facilities. It was found that a substantial amount of chronic care is now occurring in neonatal intensive care beds, with 38% of occupants of neonatal intensive care beds being 31 days of age or older and 3% being mechanically ventilated at 91 days of age or older. In addition, according to criteria established for this study, a substantial number of "convalescent" patients (32%) were occupying beds in neonatal intensive care units. It is concluded that an increase in both intermediate/convalescent care beds and establishment of chronic care facilities in North Carolina, rather than an increase in intensive care beds in these units, would alleviate the shortage of neonatal intensive care facilities. Further, the characteristics of the population occupying neonatal intensive care unit beds should be considered by health planners in addition to occupancy rate, when new facilities are being established.