Study on Yangxue Qingnao Granule(养血清脑颗粒) in Treating Chronic Cerebrovascular Insufficiency

Objective:To observe the therapeutic effect of Yangxue Qingnao granule (养血清脑颗粒,YXQNG) in treating chronic cerebrovascular insufficiency (CCI) and its possible mechanism. Methods:Eighty-three patients with CCI were randomly divided into YXQNG and nimodipine (ND) groups, the score of vertigo and the change in cerebral blood velocity before and after treatment were observed. And in the animal experiment, the authors adopted bilateral ligation of cervical carotid communis artery to establish CCI rat models in order to observe the effect of YXQNG and ND on incubation period of vertigo in rats and on memory performance. Results: After clinical treatment, the vertigo score of YXQNG group was 2.34, and that of the ND group was 4.18, the comparison between the two groups showed that the difference was significant (P＜0.05). After treatment, the middle cerebral artery mean velocity (MCA Vm) of YXQNG group was 64. 78cm/s, vertebral artery mean velocity (VA Vm) was 29.78 cm/s, while that of ND group was 60.34 cm/s and 23. 23 cm/s respectively, the comparison between these two groups showing statistical significance and the difference being obvious (P＜0.05). Experimental study showed that the rats in the model group after 12weeks learning and memory were markedly lowered, the vertigo incubation period significantly lengthened,and compared with that of the model group, learning and memory of the YXQNG group was markedly improved and vertigo incubation period shortened, with the difference from that of the ND group insignificant, P ＞0.05. Conclusion: YXQNG could effectively improve CCI patients' vertigo and other clinical symptoms and increase the cerebral blood flow, lessen the vertigo incubation of model group rats, elevate model group rats'memory performance.     

Clinical Observation on Effect of Ruangan Granule (软肝颗粒剂 ) in Treating Chronic Hepatitic Liver Fibrosis

ＣｈｒｏｎｉｃｈｅｐａｔｉｔｉｓＢｉｓｔｈｅｃｈｉｅｆｆａｃｔｏｒｔｈａｔｉｎ ｄｕｃｅｓｌｉｖｅｒｆｉｂｒｏｓｉｓａｎｄｆｕｒｔｈｅｒｌｅａｄｓｔｏｌｉｖｅｒｃｉｒｒｈｏｓｉｓｉｎＣｈｉｎａ．Ｔｈｅｒｅｉｓｎｏｅｆｆｅｃｔｉｖｅｔｒｅａｔｍｅｎｔｏｒｒｅ     

Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats

Objective:To observe the therapeutic effect of Yangxue Qingnao Granule（养血清脑颗粒, YXQNG） on cognitive impairment induced by chronic cerebral hypoperfusion and to investigate its impact on oxidative stress,apoptosis,and the cholinergic system.Methods:Adult male Wistar rats were subjected to chronic cerebral hypoperfusion by permanent occlusion of bilateral common carotid arteries（2-VO）.Thirty rats were randomly assigned to one of the five treatment groups in a 1:1:1:1:1 ratio:sham operation plus normal saline treatment,2-VO plus normal saline treatment,2-VO plus YXQNG at a dose of 2 g·kg（-1）·d^-1 or 4 g·kg（-1）·d^-1, or 2-VO plus rivastigmine 2 mgkg^-1·d^-1.The Morris water maze test was used to assess the spatial memory retrieval.Apoptosis,total antioxide capacity（T-AOC）,acetylcholine esterase（AchE） and choline acetyl transferase（ChAT） activities in the hippocampus and the cortex were investigated.Results:In the chronic cerebral hypoperfusion model,the 2-VO plus saline treatment resulted in impaired special learning as shown by the significantly prolonged escape latency and shorter swim time in the first quadrant as compared to the sham operation.The impairment was associated with apoptosis and significant decreases in T-AOC,AchE and ChAT activities in the hippocampus and the cortex.Treatment with YXQNG at either 2 g·kg（-1）·d^-1 or 4 g·kg（-1）·d^-1 dose,or rivastigmine resulted in significantly shorter escape latencies and longer swim time in the first quadrant.YXQNG at both doses,but not rivastigmine,had significant reduction in apoptosis,and significant increases in T-AOC and ChAT activity in both the hippocampus and the cortex.Unlike rivastigmine,neither dose of YXQNG showed significant reduction in AchE activity.Conclusions:YXQNG ameliorated cognitive impairment induced by chronic cerebral hypoperfusion.The protective effect may be mediated through its regulation of apoptosis and activities of T-AOC and ChAT in the hippocampus and cortex of the rats in the chronic cerebral hypoperfusion model,a mechanism that is different from rivastigmine.     

Clinical Observation on Effect of Shenqi Fuzheng(参芪扶正)Injection Combined with Chemotherapy in Treating Post-operational Patients with Colorectal Carcinoma

Chemotherapy(CT)is the most impor-tant therapeutic means in treating post-oper-ational patients with colorectal carcinoma(CA),but its efficacy is often affected bythe toxic side-effects of CT agents.TCMcould reinforce body resistance and tonifythe qi,alleviate the toxic side-effects of CT,thus strengthening the efficacy of organismagainst tumor.Shenqi Fuzheng(参芪扶正,     

Clinical Observation on the Effect of Zengse Pill (增色丸) in Treating Patients with Vitiligo of Qi-stagnancy and Blood-stasis Syndrome Type

Objective:To observe the clinical efficacy of Zengse Pill(增色丸,ZSP)on patients with vitiligo of qi-stagnancy and blood-stasis syndrome type(V-QB),and to preliminarily explore its mechanism of action.Methods:Sixty-five V-QB patients,with their diagnosis confirmed by clinical examination,were randomized by digital table method into two groups,with 31 patients in the control group and 34 in the treatment group.Cobamamide(2 tablets)was administered orally to all patients,and Psoralea tincture(a self-formulated preparation)was applied externally thrice a day.In addition,for patients in the treatment group,ZSP was given orally,at 5 pills per dose,3 times every day.The therapeutic course for both groups was 3 months.Patients were re-examined every half-month,and changes in the skin lesions were observed and recorded.The levels of lymphocyte subsets,serum immune globulin,and complement C3 and C4 in patients were determined before and after the therapeutic course and compared with the corresponding indexes determined in 21 healthy subjects.Results:The total effective rate in the treatment group was 82.4%,which was markedly higher than that in the control group(54.8%),showing a significant difference(P<0.05).After treatment,CD_4~ percentage,CD_4~ /CD_8~ ratio,and blood levels of C3 and C4 increased,while CD_8~ percentage decreased in the treatment group(P<0.05 or P<0.01).All these indexes remained unchanged in the control group,and the respective comparisons between groups showed significant differences(P<0.01).Conclusion:ZSP has a definite clinical effect on the treatment of V-QB but with no evident adverse reactions,and it can increase the CD_4~ percentage,CD_4~ /CD_8~ ratio,and the levels of serum C3 and C4,thus regulating the immunity of the organism,which might be one of its mechanisms of action.     

Clinical Observation on Methotrexate Combined with Chinese Preparations in Treating Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is an auto-immune disease, the cause of which is not clear. It manifested joint change as chief lesion, is a frequently encountered, common disease. In recent years the disease modifying antirheumatic drugs (DMARDs) combined application in treating RA has conducted many studies in domestic study and abroad, indicating that it can effectively retard the progressing of the disease. Meanwhile the domestic reports on the Chinese medicine (CM) in treating RA has obtained some efficacy, but the long-term efficacy was not sure. From May 1999 to August, 2001, the authors have applied and observed methotrexate (MTX) combined with CM preparation and MTX combined with western medicine (WM) in treating 43 cases of RA, the report is as follows.     

Clinical Observation on Effect of Kaixin Capsule （开心胶囊） in Treating 40 Patients with Diabetic Myocardial Ischemia

Objective： To observe the effect of Kaixin Capsule （开心胶囊, KXC） on myocardial ischemia and plasma endothelin （ET） level in patients with diabetic heart disease （DHD）. Methods： The 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine, and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC, with the therapeutic course for both groups as 60 days. Results： On ECG, the total effective rate and markedly ef- fective rate in the treated group was 85. 0% and 37. 5% respectively, higher than those in the control group＇s 68.7% and 28. 1% respectively, and showing significant difference between the two groups （P〈 0.05）. The level of ET in patients in both groups was significantly higher than normal range, after treatment, but reduced to different extent, and the comparison between them also showed that the difference was significant （P〈0.05）. Conclusion： KXC might, by way of inhibiting and blocking the release of ET, lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.     

Clinical Observation on Effect of Kanglaite(康莱特)in Treating Pulmonary Carcinoma Patients withLung-Qi Deficienoy and ImmunologicInadequacy sfter Pneumonectomy

Kanglaite(KLT)injectionismadeoftheeffectiveanti--tumorextractofcoixseed,andinitialstudiesindicatedthatithastheeffectofkillingtumorcelldirectly,strengtheningQiofMiddle--Jiao(th#,portionofthebodyhousingtheStomachandSpleen)andimprovingimmunityoforganism.ThestudywasattemptedtoilluminatethetherapeuticeffectsofKLTonpulmonarycarcinoma(PC)patientswithLung--QiDeficiencyandimmunologicinadequacy(LDll)afterpneumonectomy.METHODSClinicalM8terialsThe36PCpatientsobservedwereselectedfromOctober1996…     

Clinical Observation of Tiaojining (调激宁) Granule Combined with Corticosterone in Treating Infantile Primary Nephrotic Syndrome

ＩｎｏｒｄｅｒｔｏｏｂｓｅｒｖｅｔｈｅｅｆｆｅｃｔｏｆＴｉａｏｊｉｎ ｉｎｇｇｒａｎｕｌｅ（调激宁，ＴＪＮＧ）ｃｏｍｂｉｎｅｄｗｉｔｈｃｏｒｔｉｃｏｓｔｅｒｏｉｄｓ（ＣＳ）ｔｏｅｎｈａｎｃｅｔｈｅｅｆｆｉｃａｃｙａｎｄａｌｌｅｖｉａｔｅｔｈｅｓｉｄｅ ｅｆｆｅｃｔｓ，ｔｈｅａｕｔｈｏｒｓｕｓｅｄｔｈｅｃｏｍｂｉｎａｔｉｏｎｔｈｅｒａｐｙｏｆＴＪＮＧａｎｄＣＳｉｎｔｒｅａｔｉｎｇｉｎｆａｎｔｉｌｅｐｒｉｍａｒｙｎｅｐｈｒｏｔｉｃｓｙｎｄｒｏｍｅ（ＩＰＮＳ）ｉｎ 1 990 - 1 996，ａｎｄｔｈｅｆｏｌｌｏｗ…     

Clinical Study on Effect of Fuzheng Kangbai Granule on Long-Term Survival of Patients with Acute Leukemia

Atthepresenttime,chemotherapyisthechieftreatmentofacuteleukemia(AL).Butwhilechemotherapyeliminatespathogens,italsodamagetheorganismitself.Andtherefore,whenALhasgottencompleteremissionbychemotherapyandenteredintominimalresidualleukemia(MRL)state,thepatientswould,inevitably,sufferfromDeficiency,showingthecharacteristicsof"bodyimpairmentafterEvilpathogenremoved"and"bothDeficiencyofQiandYinSyndrome"(l).Theauthorsexpectedtorebuildandrestoretheimmunefunction,andtopreventtherecurrenceandprolongt…     

Clinical Study on Effect of Shenfu Injection(参附注射液)in Treating Senile Cerebral Infarction

Objective:To explore the clinical effectand mechanism of Shenfu Injection(SFI)intreating senile cerebral infarction.Methods:Eighty-two aged patients with cerebral in-farction were randomly divided into the trea-ted group treated with SFI and the controlgroup treated with Venoruton.The clinicaleffect was observed,the hemorrheologic and     

Observation on Effect of Shenmai In jection (参麦注射液) in Treating Patients of Congestive Heart Failure

Ｈｅａｒｔｆａｉｌｕｒｅｉｓａｐｒｏｇｒｅｓｓｉｖｅｆａｔａｌｐａｔｈｏｌｏｇｉｃａｌｐｒｏｃｅｓｓ．Ａｌｏｎｇｗｉｔｈｔｈｅａｇｉｎｇｐｒｏｂｌｅｍｉｎｏｕｒｓｏｃｉｅｔｙ,ｔｈｅｐｒｏｇｒｅｓｓｉｎａｎｔｉｈｙｐｅｒｔｅｎｓｉｏｎｔｒｅａｔｍｅｎｔａｎｄｔｈｅｃｏｍｂｉｎｉｎｇｕｓｅｏｆｔｈｒｏｍｂｏｌｙｓｉｓａｎｄａｓｐｉｒｉｎｉｎｒｅｃｅｎｔｙｅａｒｓ,ｔｈｅｍｏｒｔａｌｉｔｙｏｆｃｏｒｏｎａｒｙｈｅａｒｔｄｉｓｅａｓｅｈａｓｂｅｅｎｌｏｗｅｒｅｄｆｒｏｍ30%ｉｎｔｈｅ1960ｓｔｏ6%,ａｎ…     

Observation on Effect of Yi'an Decoction(胰安汤) in Treating 65 Patients of Acute Pancreatitis

Ａｃｕｔｅｐａｎｃｒｅａｔｉｔｉｓ（ＡＰ）ｏｎｓｅｔｓｓｕｄｄｅｎｌｙ,ａｎｄｓｅｒｉｏｕｓｌｙ．Ｃｕｒｒｅｎｔｖｉｅｗｔｅｎｄｓｔｏｔｒｅａｔｉｔｎｏｎｏｐｅｒａｔｉｖｅｌｙ．Ｓｉｎｃｅ 1 994,ｔｈｅａｕｔｈｏｒｓｈａｖｅｔｒｅａｔｅｄ 1 0 0ＡＰ ｐａｔ     

Clinical Observation on Effect of Combination of Zhuanyindan (转阴丹) and Hormone in Treating MaleInfertility with Positive Antisperm Antibody

Objective:To explore the therapeutic effect of combination of Zhuanyindan (ZYD, 转阴丹, a self-made Chinese herbal preparation) and hormone in treating male infertility with positive antisperm antibody and its influence on nitric oxide (NO) level. Methods:Eighty-two patients were randomly divided (according to the digital list) into the WM group (n = 20, treated with prednisone), the TCM group (n=28, treated with ZYD) and the ICWM group (n=34, treated with prednisone plus ZYD). The clinical effect, negative converting rate of antisperm antibody, changes of NO level in semen and various parameters of sperm motion before and after treatment were observed. Results: The total effective rate in the ICWM group was 88.2%, that in theTCM group 75. 0% and in the WM group 65. 0%. Significant difference was seen in the ICWM and TCM group before and after treatment in NO level, sperm motion parameters, including linear motion speed, linearity, propulsion, whip frequency, sperm vitality and mean moving angle, and qu     

Effect of Xuesaitong Soft Capsule(血塞通软胶囊)on Hemorrheology and in Auxiliarily Treating Patients with Acute Cerebral Infarction

Objective: To observe the therapeutic effect of Xuesaitong soft capsule(血塞通软胶囊,XST)and its effect on platelet counts, coagulation factor 1 (CF1) as well as hemorrheologic indexes in treating patients with acute cerebral infarction (ACI). Methods: Two hundred and four patients with ACI were assigned into two groups, the control group ( n = 96) and the treated group ( n = 108). They were all treated with conventional Western medicines, including mannitol, troxerutin, citicoline, piracetam and aspirin, while to the treated group, XST was given additionally through oral intake, twice a day, 2 capsules each time for 8successive weeks. The clinical efficacy was evaluated according to the nerve function deficits scoring and the changes of platelet count. CF1 and hemorrhe.ological indexes were measured before and after treatment. Results: The total effective rate was 87.0% in the treated group, and 87.5% in the control group, respectively, showing insignificant difference between them. But the markedly effective rate in the treated group (66.7%) was significantly higher than that in the control group (27.1%, P＜0.01). The count of platelet was not changed significantly in both groups after treatment, while CF1 inthem evidently lowered at the end of the 4th and 8th weeks of treatment, but showed insignificant difference between the two groups. The hematocrit, whole blood viscosity and plasma viscosity in both groups were all improved significantly after treatment, but also showed insignificant difference in comparison of the two groups. Conclusion: XST has good efficacy in auxiliary treatment of patients with ACI, though its mechanism remains to be further explored.     

Clinical Observation on Effect of Shuanghuang Shengbai Granule (双黄升白冲剂) on Chemotherapy Induced Myelosuppression in Tumor Patients and on Ultrastructure of Bone Marrow in Mice

ＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅｈａｓｓｈｏｗｎｔｈｅｒａｐｅｕｔｉｃａｎｄｐｒｅｖｅｎｔｉｖｅｅｆｆｅｃｔｏｎｍｙｅｌｏｓｕｐ ｐｒｅｓｓｉｏｎｉｎｄｕｃｅｄｂｙｃｈｅｍｏｔｈｅｒａｐｙ,ｂｕｔｉｔｗａｓｏｆｔｅｎｕｓｅｄｉｎｐｒｉｍａｒｉｌｙｔｒｅａｔｅｄｃａｓｅｓｏｒｃａｓｅｓｗｉｔｈｍｉｌｄｍｙｅｌｏｓｕｐｐｒｅｓｓｉｏｎ．Ｔｏ ｐｒｅｐａｒｅａＣｈｉｎｅｓｅｈｅｒｂａｌｄｒｕｇｗｉｔｈｌｅｕｋｏｃｙｔｅｉｎｃｒｅａｓｉｎｇｅｆｆｅｃｔｏｎｐａｔｉｅｎｔｓｗｉｔｈｒａｔ…     

Clinical Observation on Treatment of 30 Patients with Mild-Medium Cerebral Infarction by Supplementary Electro-acupuncture Therapy

ＦｒｏｍＳｅｐ． 1997ｔｏＦｅｂ． 2 0 0 2，ｂａｓｅｄｏｎｃｏｎ ｖｅｎｔｉｏｎａｌｔｒｅａｔｍｅｎｔ，ｇｏｏｄｅｆｆｅｃｔｗａｓｏｂｔａｉｎｅｄｂｙｅｌｅｃｔｒｏ -ａｃｕｐｕｎｃｔｕｒｅ（ＥＡ）ｉｎｔｈｅｔｒｅａｔｍｅｎｔｏｆ 30 ｐａ ｔｉｅｎｔｓｏｆｃｅ     

Effect of Tianhuang Granule(田黄冲剂) on Intracranial Pressure and Serum Matrix Metalloproteinase-9 in Patients with Acute Cerebral Hemorrhage

<正>Objective:To study the effect and mechanism of Tianhuang Granule(田黄冲剂,THG)on hydrocephalus in the patients with acute cerebral hemorrhage(ACH)through intracranial pressure(ICP) monitoring,serum matrix metalloproteinase-9(MMP-9)level observation,and National Institutes of Health Stroke Scale(NIHSS)scoring(for nerve function deficit).Methods:Sixty patients with ACH were equally randomized into two groups by lottery,the control group and the THG group;all were treated with conventional therapy, but to the patients in the THG group,THG was given orally in addition for 28 days.Changes of ICP,MMP-9 expression,and NIHSS scores,as well as the degree of cerebral hematoma and hydrocephalus(by cranial CT scanning)in the patients,were estimated and compared.Results:(1)ICP was lowered more significantly in the THG group,showing a significant difference between groups on day 7(P0.05).(2)MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group.(3)The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3(P0.05),but in the control group,the day of significant reduction was delayed to day 14,and the degrees on day 7 and day 14 in the two groups were significantly different(P0.05 and P0.01).(4)NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28(P0.05 and P0.01).Conclusion:THG can effectively lower ICP,down-regulate MMP-9 expression,promote the absorption of cerebral hematoma and hydrocephalus,and improve the nerve function,showing a clinical effectiveness than conventional therapy.     

Clinical Observation on the Effect of Zengse Pill （增色丸） in Treating Patients with Vitiligo of Qi-stagnancy and Blood-stasis Syndrome Type

Objective： To observe the clinical efficacy of Zengse Pill （增色丸, ZSP） on patients with vitiligo of qi-stagnancy and blood-stasis syndrome type （V-QB）, and to preliminarily explore its mechanism of action. Methods： Sixty-five V-QB patients, with their diagnosis confirmed by clinical examination, were randomized by digital table method into two groups, with 31 patients in the control group and 34 in the treatment group. Cobamamide （2 tablets） was administered orally to all patients, and Psoralea tincture （a self-formulated preparation） was applied externally thrice a day. In addition, for patients in the treatment group, ZSP was given orally, at 5 pills per dose, 3 times every day. The therapeutic course for both groups was 3 months. Patients were re-examined every half-month, and changes in the skin lesions were observed and recorded. The levels of lymphocyte subsets, serum immune globulin, and complement C3 and C4 in patients were determined before and after the therapeutic course and compared with the corresponding indexes determined in 21 healthy subjects, Results： The total effective rate in the treatment group was 82.4%, which was markedly higher than that in the control group （54.8%）, showing a significant difference （P〈O.05）. After treatment, CD4^＋ percentage, CD4^＋/CD8^＋ratio, and blood levels of C3 and C4 increased, while CD8^＋ percentage decreased in the treatment group （P〈0.05 or P〈0.01）. All these indexes remained unchanged in the control group, and the respective comparisons between groups showed significant differences （P〈0.01）. Conclusion： ZSP has a definite clinical effect on the treatment of V-QB but with no evident adverse reactions, and it can increase the CD4^＋ percentage, CD4^＋/CD8^＋ ratio, and the levels of serum C3 and C4, thus regulating the immunity of the organism, which might be one of its mechanisms of action.