体质指数对移植肾功能恢复的影响

目的 探讨体质指数(body mass index,BMI)对肾移植术后移植肾功能恢复的影响.方法 回顾性分析2009年5月至2015年3月在昆明医科大学第一附属医院器官移植中心行活体供肾移植术的104例受者的临床资料,根据《中国成人超重和肥胖症预防控制指南》推荐的标准,将所有符合要求的受者分为消瘦组(BMI＜ 18.5 kg/m2)、正常组(BMI 18.5～23.9 kg,/n2)、肥胖和超重组(BMI＞ 23.9 kg/m2),比较3组移植肾术后1周、2周、3周、1个月、3个月、6个月及1年血肌酐(Cr)变化、移植肾功能延迟恢复(delayed graft function,DGF)、1年内急性排斥反应(acute rejection,AR)发生率.结果 消瘦组与正常组DGF和AR发生率差异无统计学意义(P＞0.05);肥胖和超重组DGF及AR发生率较正常组明显增高,差异有统计学意义(P＜0.05).消瘦组、正常组、肥胖和超重组移植肾术后1周、2周、3周、1个月、3个月、6个月及1年Cr变化均与BMI呈正比例关系,体型肥胖的受者Cr较体型瘦弱或正常者高,肾功能恢复慢.结论 BMI是DGF、AR的独立影响因素,肥胖和超重的受者术后发生DGF和AR风险高,Cr达到正常范围所需时间长,移植肾功能恢复慢.     

临床常用营养指标与卧床老年患者体质指数的相关性研究

目的探讨卧床老年患者体质指数(BMI)与相关营养学指标的关系,建立利用相关营养学指标推算卧床老年患者BMI的方程。方法采集330例住院老年患者的营养学指标,将BMI与上述指标进行相关性分析,采用多元逐步回归分析寻求BMI最佳替代值的回归方程,并对回归方程的预测能力进行ROC曲线诊断试验评价。结果大多数营养学指标与BMI的相关性较好(P0.05,P0.01);以上臂围、小腿围、身高为自变量建立的三元回归方程对BMI有较好的预测效果;ROC曲线下面积为0.901。结论以上臂围、小腿围、身高为自变量建立的三元回归方程预测卧床老年患者的BMI值简单经济、适用性较强。     

激素替代治疗对围绝经期妇女体质指数的影响

目的 探讨激素替代治疗(HT)对围绝经期妇女体质指数影响.方法 将接受利雏爱治疗的28例围绝经期妇女设为观察组,接受协坤治疗的48例为对照组;分别于HT前和HT第1、3、6、12、24疗程后测体重、身高,计算体质指数.比较HT前后脂肪超量总发生率及体质指数.结果 两组HT前后脂肪超量发生率及体质指数比较,差异无显著性意义(均P＞0.05).结论 围绝经期妇女HT后体质指数无变化,不必担心因此导致的肥胖.     

体质指数过低对全膝关节置换术后疗效的影响

[目的]探究术前体质指数(body mass index,BMI)过低对全膝关节置换术后功能恢复的影响.[方法]回顾性分析2015年01月～2017年12月于本院行全膝关节置换术的176例患者,其中,低BMI(BMI＜18.5 kg/m2)35例;正常BMI(18.5 kg/m2≤BMI＜25 kg/m2)141例.对...     

肝脏纤维化指数对原发性肝癌患者外科治疗后生存状况的影响

目的 探讨肝脏纤维化指数（FI）对原发性肝癌患者外科治疗后生存状况的影响。方法 选取2010年1月至2014年12月期间我院收治的82例行肝切除术的原发性肝癌患者为研究对象,根据术前血FI水平分为高纤维化程度组（FI>5.4,n=45）和低纤维化程度组（FI≤5.4,n=37）。采用Kaplan-Meier法计算两组患者的无瘤生存率,并采用log-rank检验进行比较。采用单因素与多因素Cox回归分析影响术后复发的有关危险因素。结果 随访结果表明,全部患者的1、3、5年的无瘤生存率为79.7%、68.2%、32.7%。其中高肝纤维化组、低肝纤维化组的1、3、5年的无瘤生存率分别为69.8%、32.5%、21.6%与93.8%、45.3%、45.3%,差异有统计学意义（P<0.05）。多因素Cox回归分析结果表明术前AFP-L₃≥10%、FI>5.4、有脉管瘤栓及术后肝功能不全是患者术后复发的独立危险因素,差异有统计学意义（P<0.05）。结论 术前FI>5.4是原发性肝癌患者术后复发的独立危险因素,对患者的预后具有一定的预测价值。     

BNP、TnT和TnI水平对预测重症脓毒症和脓毒症休克患者预后的临床意义

目的：探讨监测脑利钠肽、肌钙蛋白T和肌钙蛋白I对重症脓毒症及脓毒症休克患者预后的意义。方法回顾性分析重症脓毒症和脓毒症休克患者58例的临床资料。其中重度脓毒症28例,脓毒症休克30例。监测患者确诊当天BNP、TnT和TnI水平。分析BNP、TnT和TnI水平与患者预后的关系。结果重症脓毒症组患者TNT水平显著低于脓毒症休克组（P＜0.01）。死亡患者BNP、TNT及TNI水平显著高于存活患者（P＜0.01）。BNP对预测死亡具有统计学意义（ROC下面积0.794,P＜0.01）,TNT对预测死亡具有统计学意义（ROC下面积0.527,P＜0.05）。结论BNP、TnT对重症脓毒症及脓毒症休克患者的预后具有预测作用。     

不同体质指数患者行腹腔镜全子宫切除术的近期临床疗效分析

目的：探讨不同体质指数（body mass index,BMI）的患者行腹腔镜全子宫切除术（total laparoscopic hysterectomy,TLH）的临床治疗效果。方法：回顾分析为244例患者行TLH的临床资料。将患者分为理想、超重和肥胖3组,体重过轻的患者并入理想组。理想组128例（52.5%）,BMI范围17.7~23.9kg/m2;超重组66例（27.0%）,BMI 24.1~27.9kg/m2;肥胖组50例（20.5%）,BMI 28~38.2kg/m2。观察各组病例近期临床治疗效果。结果：理想、超重和肥胖组平均手术时间分别为（81.3±25.5）min、（89.5±27.8）min和（90.7±26.0）min,理想组的手术时间短于其他两组（P〈0.05）,超重组和肥胖组的手术时间差异无统计学意义（P〉0.05）。估计术中出血量分别为（41.8±21.3）ml、（47.4±22.7）ml和（47.0±32.8）ml;手术前后血红蛋白含量变化分别为（-6.8±8.4）g/L、（-6.4±8.2）g/L和（-4.4±7.7）g/L;术后肛门排气时间分别为（1.8±0.7）d、（1.9±0.7）d和（1.9±0.7）d;术后平均住院时间分别为（8.3±1.7）d、（8.4±1.3）d和（8.6±1.7）d;术后平均体温第1天分别为（37.0±0.3）℃、（37.0±0.4）℃和（36.9±0.3）℃,第2天分别为（36.8±0.3）℃、（36.9±0.3）℃和（36.8±0.3）℃,第3天分别为（36.7±0.2）℃、（36.7±0.3）℃和（36.7±0.2）℃,3组之间差异无统计学意义（P〉0.05）。3组总并发症发生率为2%,理想组术中膀胱损伤2例（0.8%）;超重组术后感染3例,包括不明原因的发热2例（0.8%）,上呼吸道感染1例（0.4%）。结论：BMI对TLH的近期临床疗效影响较小。需要全子宫切除的肥胖患者行TLH安全有效,严格掌握腹腔镜的手术适应证,部分肥胖患者可将TLH作为全子宫切除术的新选择。     

连续肾替代治疗对严重烧伤脓毒症患者血浆内毒素和细胞因子水平的影响

目的　分析连续肾替代治疗 (continuousrenalreplacementtherapy,CRRT)对严重烧伤脓毒症患者血浆内毒素和细胞因子水平的影响。　方法　对 10例应用CRRT及 10例应用常规疗法治疗的严重烧伤脓毒症患者血浆内毒素和细胞因子 (TNFα、IL 1β、IL 6、IL 8)浓度变化进行比较分析。　结果　严重烧伤脓毒症患者应用CRRT后血浆内毒素、细胞因子浓度较治疗前明显下降 ,其下降速度与常规治疗组比较差异有非常显著性意义 (P <0 .0 1)。　结论　严重烧伤脓毒症患者应用CRRT能有效降低血浆内毒素和细胞因子浓度     

体质指数与乳腺癌淋巴结转移关系的研究

目的 研究体质指数（BMI）与我国女性乳腺癌淋巴结转移的关系,为乳腺癌患者评估预后、实施有效治疗提供适当参考资料.方法 明确乳腺癌患者为首次患病,用BMI确定入选研究对象的肥胖程度,分析424例乳腺癌患者BMI与淋巴结转移的关系.结果 乳腺癌患者平均 BMI为（25.81±3.57） kg/m^2,处于肥胖状态,BMI与乳腺癌腋窝淋巴结转移有关（P＜0.05）.结论 通过BMI测定有助于评估乳腺癌患者预后,为她们治疗方案的制定提供参考依据.肥胖患者预后可能更差,患病后减轻体重应该对预后有益.     

The impact of body mass index on the development of systemic inflammatory response syndrome and sepsis in patients with polytrauma

Purpose

Obesity is a growing problem in industrial nations. Our aim was to examine how overweight patients coped with systemic inflammatory response syndrome (SIRS) after polytrauma.

Methods

A total of 651 patients were included in this retrospective study, with an ISS ≥ 16 and age ≥ 16 years. The sample was subdivided into three groups: body mass index (BMI; all in kg/m²) < 25, BMI 25–30 and BMI > 30, or low, intermediate and high BMI. The SIRS score was measured over 31 days after admission together with measurements of C-reactive protein (CRP), interleukin-6 (IL-6) and procalcitonin (PCT). Data are given as the mean ± SEM if not otherwise indicated. Kruskal–Wallis and χ² tests were used for statistical analysis and the significance level was set at p < .05.

Results

The maximum SIRS score was reached in the low BMI-group at 3.4 ± 0.4, vs. 2.3 ± 0.1 and 2.5 ± 0.2 in the intermediate BMI-group and high BMI-group, respectively (p < .0001). However, the maximum SIRS score was reached earlier in the BMI 25–30 group at 1.8 ± 0.2 days, vs. 3.4 ± 0.4 and 2.5 ± 0.2 days in the BMI < 25 and BMI > 30 groups, respectively (p < .0001). The incidence of sepsis was significantly higher in the low BMI group at 46.1%, vs. 0.2% and 0% in the BMI 25–30 and BMI > 30 groups, respectively (p < .0001). No significant differences in the CRP, IL-6 or PCT levels were found between groups.

Conclusions

A higher BMI seemed to be protective for these patients with polytrauma-associated inflammatory problems.     

身体质量指数与肝癌患者术后肝功能预后的关系

目的 探讨身体质量指数(BMI)与肝癌患者手术后肝功能恢复的关系.方法 按照BMI把患者分为正常体质量组、超体质量组和肥胖体质量组.每组患者记录手术前后白蛋白、总胆红素、谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)低...     

体质量指数对机器人辅助腹腔镜全子宫切除术的影响

目的:探讨体质量指数(Body mass index,BMI)对机器人辅助腹腔镜全子宫切除术的影响。方法:收集中国医科大学附属第一医院妇科行机器人辅助腹腔镜全子宫切除术的131例患者的临床资料,根据体质量指数的不同,将患者分为正常体重组(BMI<24kg/m²)、超重组(BMI为24~28kg/m²)和肥胖组(BMI≥28kg/m²),比较三组患者年龄、术前有内科合并症(高血压、冠心病或糖尿病)患者的占比、手术时间、中转开腹率,以及术后血红蛋白下降程度、排气时间、术后住院日等。结果:超重组和肥胖组术前有内科合并症(高血压、冠心病或糖尿病)患者的比例超过正常体重组。而在年龄、手术时间、术后血红蛋白下降程度、排气时间、术后住院日方面,体重正常组与超重组及肥胖组比较,差异无统计学意义(P>0.05),所有患者无1例中转开腹。结论:机器人辅助腹腔镜全子宫切除术对于超重及肥胖的患者是安全、可行的,在患者基础条件不佳的情况下,可以获得与正常体重患者相似的术中及术后结局,是一种可以选择的手术方式。     

Body mass index,body fat percentage,and the effect of body fat mass on SWL success

Objectives In the present study, we investigated the effects of the Body Mass Index (BMI), the Body Fat Percentage (BFP), and the Body Fat Mass (BFM) on success of SWL, prospectively. Patients and methods The BMI, BFP, BFM values of patients, who were treated by SWL due to upper urinary system stone disease (pelvis renalis, upper ureter, kidney lower and upper calices) between January and December 2005 in our hospital’s urolithiasis center, were measured. Patients with stones smaller than 5 mm or larger than 20 mm and patients who had a stone localized somewhere other than in the upper urinary system, were not included in the study. Patients evaluated to be clinically successful according to the SWL were put in group 1, and the other patients who were not successful were included in group 2. Results About 158 (97 male, 61 female) patients aged between 16 and 92 (mean 36.69 (±13.22) years), put on SWL therapy due to presence of upper urinary system stone disease, were included in the study. While the mean BMI was 23.97 ± 0.4 in group 1 and 25.98 ± 0.5 (P = 0.02) in group 2, BFP was 23.85 ± 0.8 in group 1 and 29.19 ± 1.1 (P = 0.001) in group 2, and BFM was determined to be 16.74 ± 0.7 and 21.19 ± 1.01 (P = 0.001) in group 2. Regarding all the parameters (BMI, BFP, BFM), the statistical analyses carried out between the groups showed significant differences. Conclusion BFP and BFM parameters are also important factors along with the BMI in providing a successful SWL treatment. All the parameters should be considered regarding the success of the treatment and the patients should be informed.     

50岁以下男性年龄及体质量指数对血清前列腺特异抗原的影响

目的 分析<50岁男性血清PSA水平的影响因素. 方法 2006年9月至2008年11月健康检查<50岁男性6808例.分别测量身高、体质量,并计算体质量指数(BMI),检测血清PSA水平.将人群按年龄分为10岁～、20岁～、30岁～和40～49岁4组,按WHO亚太地区BMI水平分级标准分为消瘦(BMI<18.5 kg/m~2)、正常(BMI 18.5～22.9 kg/m~2)、超重(BMI 23.0～24.9kg/m~2)、肥胖(BMI 25.0～29.9 kg/m~2)、极度肥胖(BMI≥30.0 kg/m~2)5组.方差分析比较各年龄组和各BMI组人群PSA水平差异.并进行Spearman相关性分析. 结果 6808例平均年龄(39.2±7.0)岁,平均BMI指数(25.6±4.7)kg/m~2,平均PSA(0.89±0.56)ng/ml.单因素方差分析表明:10岁～年龄组PSA水平与其他3个年龄组间差异有统计学意义(P<0.01),其他3个年龄组问差异无统计学意义.各年龄组按照BMl分组比较,除10岁～组外,其余3组中随BMI增加,PSA水平降低,差异有统计学意义(P<0.01).相关性分析结果 显示年龄与PSA呈显著正相关(P<0.0001),BMI与PSA呈显著负相关(P<0.0001). 结论 男性青春期PSA变化明显,20～50岁间PSA增长缓慢,PSA水平与BMI呈负相关关系,在青年人群中评价PSA结果 应考虑上述影响因素.     

体质量指数变化与老年胃癌患者营养状态和预后的关系

目的：探讨体质量指数（BMI）变化与老年胃癌患者营养状态和预后的关系。 方法： 纳入老年（≥65岁）胃癌患者116例,计算患者入院前1年内BMI变化量,根据血清白蛋白值和淋巴细胞总数计算预后营养指数（PNI）,采用Pearson相关分析BMI变化量与PNI的相关性。通过ROC曲线、生存分析和COX风险回归模型评价BMI变化量与患者预后的关系。 结果：116例老年胃癌患者的BMI变化值（降低）为（2.67±2.11）kg/m2,PNI为44.18±9.31,两者呈负相关（r=-0.87,P=0.003）;BMI变化量预测患者死亡的敏感性为72.73%,特异性为73.34%,分界值为3.36 kg/m2（P<0.001）;按该值将患者分为高BMI变化量组（BMI降低值≥3.36 kg/m2）和低BMI变化量组（BMI降低值<3.36 kg/m2）比较,结果显示,两组患者在PNI、分化程度、肿瘤最大径、浸润深度、淋巴转移、TNM分期和手术根治度上差异有统计学意义（均P<0.05）;高BMI变化量组生存率明显低于低BMI变化量组（P<0.05）;BMI变化量是老年胃癌患者预后的独立影响因素（HR=1.72,95% CI=1.31~2.26,P=0.002）。 结论：BMI变化能较好地反映老年胃癌患者的炎症营养状态,BMI显著降低者预后不良。

     

Association of body mass index and urine pH in patients with urolithiasis

Increase in body size increases the risk of renal stone formation. The mechanism explaining this relationship remains unclear. Urine pH is one of the important factors for urinary stone formation. The purpose of this study was to determine whether there is an association between urine pH and body mass index (BMI) in patients with urolithiasis. Medical charts review that included 342 urinary stone formers (248 men and 94 women). Data obtained included patient sex, age, BMI, urine pH at diagnosis, and stone composition. The patients were classified as normal weight (18.5 ≤ BMI < 24), overweight (24 ≤ BMI < 27), or obese (BMI ≥ 27). The mean urine pH of the normal body weight, overweight, and obese groups was 6.25, 6.14, and 6.00, respectively (P < 0.05). Urine pH is inversely related to BMI among patients with urolithiasis. Among patients with urolithiasis, higher BMI will have lower urine pH. This may explain why obesity is associated with an increased risk of nephrolithiasis. Weight loss should be explored as a potential treatment to prevent kidney stone formation. The prevention of urinary stone disease gives clinicians an additional reason to encourage weight reduction through diet.     

体脂率及体重指数与丙泊酚麻醉用量的相关性

目的观察患者体脂率及BMI对丙泊酚麻醉用量的影响,并得出丙泊酚麻醉用量简便的计算公式。方法选择我院择期行腹腔镜手术患者104例,男46例,女58例,年龄25~59岁,ASAⅠ或Ⅱ级,根据BMI和体脂率将患者分为四组:A组,BMI25.0kg/m~2,体脂率25%(男)或35%(女);B组,BMI25.0kg/m~2,体脂率≥25%(男)或≥35%(女);C组,BMI≥25.0kg/m~2,体脂率25%(男)或35%(女);D组,BMI≥25.0kg/m~2,体脂率≥25%(男)或≥35%(女)。所有患者均采用统一的麻醉方案,BIS闭环靶控目标值设为45~55。记录患者麻醉诱导、麻醉维持时丙泊酚使用量以及拔管时间。纳入所有患者的性别、BMI和体脂率等构建多元线性回归模型。结果 D组丙泊酚麻醉诱导剂量明显高于A、B、C组(P0.05);B组和D组的前1h和前2h每公斤体重丙泊酚用量均明显低于A组(P0.05),A组和C组的每公斤体重丙泊酚用量差异无统计学意义,B组和D组的每公斤体重丙泊酚用量差异无统计学意义;四组拔管时间差异无统计学意义。回归公式:前1h丙泊酚用量(mg/kg)=7.715+1.900×性别(男=0,女=1)-0.125×体脂率。结论BMI或体脂率越高的患者在维持麻醉状态时每公斤体重丙泊酚使用量越少;当BMI与体脂率衡量肥胖发生矛盾时,体脂率与患者每公斤体重丙泊酚麻醉用量相关性更好。     

老年患者低体重指数增加术后谵妄风险:前瞻性队列研究

目的分析老年患者术后谵妄的危险因素,探究体重指数(BMI)与老年患者术后谵妄的关系。方法本研究为前瞻、观察性队列研究。2011年5月至2013年11月全身麻醉下接受非心脏手术后入ICU的老年患者350例,年龄≥65岁。使用CAM-ICU法每天2次评估术后7d内谵妄发生情况。使用Logistic多因素回归分析评估术后谵妄的危险因素。结果共79例(22.6%)患者发生术后谵妄。参照WHO亚洲人BMI参考标准,将患者分为偏瘦(BMI18.5kg/m2)、正常(BMI18.5~22.9kg/m2)、偏胖(BMI 23.0~24.9kg/m2)、肥胖(BMI 25.0~29.9kg/m2)、重度肥胖(BMI≥30.0kg/m2)5个等级,将BMI分级代入Logistic多因素回归模型,结果显示与正常BMI者比较,偏瘦者术后谵妄风险增加(OR 2.551,95%CI 1.101~5.909,P=0.029),而偏胖、肥胖与重度肥胖者不增加术后谵妄风险。对BMI进行ROC曲线分析,得出谵妄风险增加的拐点BMI为20.0kg/m2,根据此拐点将BMI转换为二分类变量并代入Logistic多因素回归模型,结果显示BMI20.0kg/m2者术后谵妄发生风险明显增加(OR 2.679,95%CI 1.438~4.990,P=0.001)。结论对于非心脏手术后进入ICU的老年患者,低体重指数(BMI20.0kg/m2)是增加术后谵妄风险的独立危险因素之一。     

Sagittal spinopelvic alignment and body mass index in patients with degenerative spondylolisthesis

The sagittal orientation and osteoarthritis of facet joints, paravertebral muscular dystrophy and loss of ligament strength represent mechanical factors leading to degenerative spondylolisthesis. The importance of sagittal spinopelvic imbalance has been described for the developmental spondylolisthesis with isthmic lysis. However, it remains unclear if these mechanisms play a role in the pathogenesis of degenerative spondylolisthesis. The purpose of this study was to analyze the sagittal spinopelvic alignment, the body mass index (BMI) and facet joint degeneration in degenerative spondylolisthesis. A group of 49 patients with L4–L5 degenerative spondylolisthesis (12 males, 37 females, average age 65.9 years) was compared to a reference group of 77 patients with low back pain without spondylolisthesis (41 males, 36 females, average age 65.5 years). The patient’s height and weight were assessed to calculate the BMI. The following parameters were measured on lateral lumbar radiographs in standing position: L1–S1 lordosis, segmental lordosis from L1–L2 to L5–S1, pelvic tilt, pelvic incidence and sacral slope. The sagittal orientation and the presence of osteoarthritis of the facet joints were determined from transversal plane computed tomography (CT). The average BMI was significantly higher (P = 0.030) in the spondylolisthesis group compared to the reference group (28.2 vs. 24.8) and 71.4% of the spondylolisthesis patients had a BMI > 25. The radiographic analysis showed a significant increase of the following parameters in spondylolisthesis: pelvic tilt (25.6° vs. 21.0°; P = 0.046), sacral slope (42.3° vs. 33.4°; P = 0.002), pelvic incidence (66.2° vs. 54.2°; P = 0.001), L1–S1 lordosis (57.2° vs. 49.6°; P = 0.045). The segmental lumbar lordosis was significantly higher (P < 0.05) at L1–L2 and L2–L3 in spondylolisthesis. The CT analysis of L4–L5 facet joints showed a sagittal orientation in the spondylolisthesis group (36.5° vs. 44.4°; P = 0.001). The anatomic orientation of the pelvis with a high incidence and sacral slope seems to represent a predisposing factor for degenerative spondylolisthesis. Although the L1–S1 lordosis keeps comparable to the reference group, the increase of pelvic tilt suggests a posterior tilt of the pelvis as a compensation mechanism in patients with high pelvic incidence. The detailed analysis of segmental lordosis revealed that the lordosis increased at the levels above the spondylolisthesis, which might subsequently increase posterior stress on facet joints. The association of overweight and a relatively vertical inclination of the S1 endplate is predisposing for an anterior translation of L4 on L5. Furthermore, the sagittally oriented facet joints do not retain this anterior vertebral displacement.