蛋氨酸硒联合NB-UVB治疗银屑病疗效及对TNF-α水平的影响

目的:评价蛋氨酸硒联合NB-UVB照射治疗寻常型银屑病的疗效及对血清TNF-α的影响。方法:将73例患者随机分为两组,治疗组39例,采用NB-UVB照射,隔日1次,同时口服蛋氨酸硒(100μg/片)。对照组34例,采用NB-UVB照射,隔日1次。治疗4周后观察疗效并测定血清中TNF-α和Se含量。结果:治疗组与对照组有效率分别为89.74%和70.59%,两组差异有统计学意义(P0.05);两组TNF-α水平治疗前后分别为1.76±0.35、1.41±0.48和1.67±0.44、1.43±0.41,治疗后均明显降低(P0.05),但两组间差异无统计学意义(P0.05)。结论:Se联合NB-UVB照射治疗寻常型银屑病疗效优于单用NB-UVB照射,但对于降低TNF-α水平二者可能无协同作用。     

温泉浴结合NB-UVB治疗寻常型银屑病疗效观察

我科应用天然汤头温泉结合窄谱中波紫外线（NB—UVB）治疗银屑病，取得满意的疗效，现报道如下。     

以NB-UVB为主的联合疗法治疗寻常型银屑病疗效观察

采用NB-UVB照射,糠馏油硼酸氧化锌糊剂(PBZS)封包,泽它洗剂洗浴的三联疗法或增加转移因子注射的四联疗法治疗240例寻常型银屑病住院患者。以邮寄调查问卷的方式对患者进行以复发情况和治疗满意度为主的随访。结果:NB-UVB为主的联合疗法同以往方法相比使患者住院时间明显缩短,四联治疗组有效率比三联治疗组高,复发率为86.7%,平均复发时间为4.2个月。转移因子具有增强治疗效果的作用。     

NB-UVB治疗银屑病的机制

银屑病是一种以角质形成细胞过度增生为特点的慢性炎症性皮肤病,NB-UVB是波长在290～320nm之间的紫外线,可以通过诱导细胞凋亡以及影响多种细胞因子的释放起到治疗银屑病的作用。     

NB-UVB光疗致寻常型银屑病加重2例

窄谱中波紫外线（NB-UVB）光疗治疗寻常型银屑病近来成为一个热点,我科近2年来以NB-UVB光疗治疗了200例患者,大部分获得了满意的疗效,但是有2例患者在治疗中出现红斑反应后皮损增多,现报道如下.     

NB-UVB治疗寻常型银屑病328例疗效观察

窄谱中波紫外线（NB-UVB）治疗银屑病的疗效已得到肯定。我科使用NB-UVB治疗银屑病328例，并在随后1年里对所有病人进行随访；现对疗效及复发情况总结如下。     

窄谱中波紫外线不同照射剂量治疗寻常性银屑病临床疗效观察

目的：观察311nm窄谱中波紫外线（NB—UVB）不同照射剂量以及维持照射治疗寻常性银屑病的疗效及安全性。方法：采用半身、单盲、不同照射剂量方案治疗25例寻常性银屑病患者．回顾性分析维持照射以及不干预方案对银屑病复发的影响。结果：92％的患者银屑病皮损面积和严重度指数（PASI）评分改善率〉75％;大剂量方案起效较快;低增量方案的平均累积剂量较低,平均治疗次数较多,平均治疗费用也较高;维持照射以及不干预方案对于患者1年后的复发率无明显影响。结论：NB—UVB治疗寻常性银屑病疗效好、不良反应小;低增量方案有望在取得满意疗效的同时降低紫外线治疗的潜在风险;对已取得满意疗效的银屑病患者不建议采用维持光疗方案。     

窄谱UVB治疗对银屑病患者外周血单一核细胞CD28和CD80表达的影响

目的: 观察311 nm窄谱中波紫外线(NB-UVB)治疗寻常型银屑病后对患者外周血单一核细胞(PBMC)CD28和CD80表达的影响.方法: 50例患者采取NB-UVB照射治疗,利用流式细胞仪检测光疗患者PBMC中CD28和CD80水平.结果: 光疗前患者PBMC中CD28和CD80阳性细胞数较正常人显著升高(P＜0.01),光疗后患者PBMC中CD28和CD80阳性细胞数较光疗前显著下降(P＜0.01,P＜0.05).结论: NB-UVB治疗可下调寻常型银屑病患者外周血单一核细胞CD28和CD80表达,这可能是NB-UVB治疗寻常型银屑病的机制之一.     

窄谱UVB对银屑病患者外周血单一核细胞CD40和CD40L表达的影响

目的:观察窄谱中波紫外线(NB-UVB)对寻常型银屑病的疗效及治疗前后对患者外周血单一核细胞CD40和CD40L表达的影响.方法:50例患者采取NB-UVB照射治疗,以PASI评价疗效,并利用流式细胞仪对光疗前后患者及正常人PBMC中CD40和CD40L进行检测.结果: NB-UVB治疗寻常型银屑病临床有效率为90%;光疗前患者PBMC中CD40和CD40L阳性细胞数较正常人显著升高(P<0.01),光疗后患者PBMC中CD40和CD40L阳性细胞数较光疗前显著下降(P<0.01).结论:下调寻常型银屑病患者外周血单一核细胞CD40和CD40L表达可能是NB-UVB治疗寻常型银屑病的机制之一.     

窄谱中波紫外线治疗寻常型银屑病2087例疗效观察

目的观察窄谱中波紫外线(NB-UVB)治疗寻常型银屑病的临床疗效及安全性。方法回顾性分析采用NB-UVB治疗2087例银屑病患者的有效率,治疗频次及不良反应等。结果NB-UVB治疗寻常型银屑病有效率为84.20%,平均治疗频次17.6次,不良反应以灼烧感、红斑、瘙痒为主。结论NB-UVB治疗寻常型银屑病,安全有效,患者依从性高,但其疗效与寻常型银屑病的分期及分型有关。     

UVA与UVB治疗寻常型银屑病临床对照研究

目的：评价煤焦油软膏外用联合UVA＋UVB照射治疗寻常型银屑病的疗效及安全性。方法：91例寻常型银屑病患者外用煤焦油软膏联合UVA＋UVB照射，并与53例寻常型银屑病患者外用煤焦油软膏联合UVA、51例联合UVB照射进行对比观察。结果：治疗8周后UVA＋UVB组痊愈率为63．74％，总有效率为98．90％，明显高于UVA组和UVB组；治疗2周、4周、6周和8周后PASI评分均较治疗前明显下降，UVA＋UVB组与UVA组、UVB组对比有显著性差异；1年内复发率UVA＋UVB组27．66％，明显低于UVA组或UVB组。结论：外用煤焦油软膏联合UVA＋UVB照射治疗寻常型银屑病较单纯联合UVA或UVB照射疗效高、复发率低。     

308nm单频准分子光治疗寻常性银屑病和掌跖银屑病临床疗效观察

目的:评估308nm单频准分子光局部照射治疗寻常性银屑病和掌跖银屑病的临床疗效及安全性。方法:采用单频准分子光局部照射治疗35例寻常性银屑病和15例掌跖银屑病患者皮损,每周照射1次或2次,每2周评估疗效1次,并记录不良反应。结果:30例寻常性银屑病患者经16次照射,有效率达70%,慢性斑块型疗效较好。15例掌跖银屑病患者经25次照射,有效率为53.3%。单频准分子光局部照射主要不良反应为瘙痒,局部出现红斑,偶有水疱。结论:308nm单频准分子光局部照射治疗寻常性银屑病和掌跖银屑病见效快,疗程短,且不良反应少。     

311nm窄谱中波紫外线照射治疗寻常性银屑病疗效观察

目的观察311nm窄谱中波紫外线(NB-UVB)照射治疗寻常性银屑病的疗效及其影响因素。方法单独采用NB-UVB照射或联合糠馏油硼酸氧化锌软膏(PBZS)封包治疗寻常性银屑病87例,并以银屑病面积和严重度指数(PASI)评价疗效,分析性别、皮肤类型、临床分型及临床分期对疗效的影响,同时对采用其他方法治疗的30例寻常性银屑病患者进行回顾性的评价。结果在(17.60±4.42)d、(16.90±5.80)d、(25.80±6.67)d治疗后,NB-UVB组、NB-UVB+PBZS组及回顾分析组治疗前后PASI评分改善率分别为(76.3±24.6)%、(88.1±28.7)%、(76.5±26.2)%;与回顾分析组比较,NB-UVB组与其疗效相当(P>0.05),但治疗时间显著缩短(P<0.05),而NB-UVB+PBZS组则在更短的治疗时间(P<0.05)取得了更好的疗效(P<0.05);疗效相关因素分析表明,点滴状略优于斑块状、进行期略优于静止期(0.01相似文献   

百癣夏塔热片联合窄波UVB治疗寻常型银屑病疗效评价

目的:评价百癣夏塔热片联合窄波UVB治疗寻常型银屑病的疗效。方法:87例患者随机分为2组,治疗组(42例)采用百癣夏塔热片联合窄波UVB治疗,对照组(45例)仅窄波UVB照射,两组均外擦醋酸曲安尿素软膏,疗程均为8周。结果:两组有效率分别为92.9%和77.8%,差异有显著性(P0.05)。结论:百癣夏塔热片联合窄波UVB治疗寻常型银屑病有效。     

寻常型银屑病中DUSP1和DUSP4的表达

目的：检测DUSP1和DUSP4在寻常型银屑病患者皮损的表达水平。方法：Real-time PCR和Western Blot分别检测18例寻常型银屑病皮肤组织和15名正常对照皮肤组织中DUSP1和DUSP4 mRNA及相关蛋白的表达情况。结果：银屑病组DUSP1 mRNA和蛋白的相对表达量分别为0.0939±0.0048和0.5165±0.0254,低于正常对照组的0.2486±0.0060和1.2432±0.3260,差异有统计学意义（Ps＜0.05）。银屑病组DUSP4 mRNA和蛋白的相对表达量为0.3718±0.0370和0.8018±0.0770,与正常对照组比较（0.3645±0.0286和1.3677±0.2287）,差异无统计学意义（Ps＞0.05）。结论：DUSP1表达水平降低可能与寻常型银屑病发生发展有关。     

Evaluation of vaseline oil applied prior to UVB TL01 phototherapy in the treatment of psoriasis

BACKGROUND: Use of emollient prior to phototherapy could enhance UV transmission through psoriasis plaques on the condition that the emollient is not photoprotective. Emollient pretreatment with narrow-band phototherapy (313 nm) has not been studied extensively. We conducted a study to assess if vaseline oil prior to UVB TL01, in chronic psoriasis plaques could accelerate psoriasis clearance. METHODS: Fifteen patients with chronic psoriasis plaques were enrolled in a prospective, single-blind, controlled study. For each patient, one to three symmetrical pairs of plaque were selected and scored initially and after every six exposures. RESULTS: On the vaseline oil pretreated side, significantly more plaques were cleared, especially in severe psoriasis. Scaling and infiltration were significantly improved. Application of vaseline oil was more interesting in thick and scaly psoriasis probably because the oil penetrates the intercellular space allowing an optical matching effect which increases the UV transmission. CONCLUSION: We strongly recommend vaseline oil pretreatment with UVB TL01 phototherapy in psoriasis, especially in severe psoriasis.     

Comparison of the efficacy of calcipotriol and maxacalcitol in combination with narrow-band ultraviolet B therapy for the treatment of psoriasis vulgaris

BACKGROUND: Combination treatment with topical vitamin D(3) and narrow-band ultraviolet B (UVB) radiation is effective against psoriasis vulgaris. We compared the efficacy of the topical vitamin D(3) derivatives calcipotriol and maxacalcitol in combination therapy. MATERIALS AND METHODS: In this retrospective observational study, 21 patients admitted to Nagoya City University Hospital between April 2001 and September 2004 were enrolled. RESULTS: Combination treatment with calcipotriol or maxacalcitol and narrow-band UVB was effective against psoriasis vulgaris. Calcipotriol induced a more rapid improvement and required lower levels of narrow-band UVB irradiation to be effective. Serum calcium levels were slightly increased after 4 weeks of treatment, but there was no significant difference between the two groups. No other adverse effects were observed in either of the two groups. CONCLUSION: The findings of this retrospective observational study indicated that combination treatment with topical vitamin D(3) derivatives and narrow-band UVB is effective against psoriasis without any obvious side-effects. These findings provide further evidence that calcipotriol has advantages over maxacalcitol regarding the narrow-band UVB-accumulated treatment dose and improvement rate of psoriasis area and severity index (PASI) scores.     

HLA-G在寻常性银屑病中的表达

以往的研究显示,人类白细胞抗原G(HLA-G)是一种免疫耐受分子,它与许多临床疾病有密切联系[1].我们应用免疫组化标记亲合素生物素-链霉亲合素法(LAB-SA)对寻常性银屑病皮损中HLA-G进行检测,以探讨HLA-G在寻常性银屑病中的表达.