应用1064nm Nd:YAG激光多模式序贯治疗寻常性痤疮

目的:观察1 064nm Nd:YAG激光多种模式序贯治疗面部寻常性痤疮的疗效。方法:应用1 064nm Nd:YAG激光的三种治疗模式序贯治疗40例面部寻常性痤疮患者,病情Ⅱ~Ⅳ级,每4周治疗1次,连续治疗4次,每次治疗前及最后1次治疗结束后4周观察记录临床反应并拍摄皮损照片。结果:40例患者,疗程结束后4周观察,总有效率85%,治疗期间未发现任何不良反应。结论:采用1 064nm Nd:YAG激光多模式序贯治疗中、重度寻常性痤疮安全、有效。     

两种波长强脉冲光联合治疗面部寻常性痤疮疗效观察

目的:观察420nm与540nm强脉冲光联合治疗面部寻常性痤疮的疗效.方法:采用420nm与540nm强脉冲光联合治疗面部寻常性痤疮50例,病情Ⅱ ～ Ⅲ级.整个疗程共治疗8次,每次治疗间隔1周,观察记录临床反应.治疗前后拍摄面部及皮损图片,对比观察疗效.结果:患者的病情均得到了改善,经1个疗程治疗后治愈率66％;治疗期间,未发现其他不良反应.结论:联合应用420nm与540nm强脉冲光治疗面部寻常性痤疮为一种有效方法,疗程较短,治疗过程安全.     

侵入式点阵射频治疗面部凹陷性瘢痕疗效观察及安全性分析

目的:观察侵入式点阵射频在面部凹陷性痤疮瘢痕治疗中的临床疗效和安全性。方法:对20处面部凹陷性痤疮瘢痕进行一次侵入式点阵射频治疗,随访6个月,记录治疗前后凹陷性痤疮瘢痕的ECCA权重评分、VAS评分以及治疗中、治疗后的不良反应。结果:治疗后面部凹陷性痤疮瘢痕明显改善。治疗前后ECCA权重评分比较P≤0.01,差异有统计学意义。VAS评分平均(2.84±1.12)分。治疗后1周内12处面部治疗区出现粉刺,2个月内皮肤表面粗糙度和紧实度临时性加重,无1例患者出现皮肤灼伤、水疱、色素沉着和感染等不良反应。结论:侵入式点阵射频治疗面部凹陷性痤疮瘢痕安全、有效。     

强脉冲光治疗面部寻常性痤疮85例疗效观察

目的:观察强脉冲光治疗面部寻常性痤疮及改善痤疮后红斑、色素沉着的临床疗效。方法:采用飞顿二号激光光子工作站420~950nm光子手具治疗炎性痤疮患者,1次/周,4次后评价疗效,然后用540/570~950nm手具继续治疗痤疮后红斑、色素沉着,1次/月,3次后评价疗效。结果:85例患者中炎性痤疮的痊愈率达14.1%,有效率达97.6%。痤疮后红斑、色素沉着的痊愈率达5.9%,有效率达96.5%。结论:强脉冲光治疗面部寻常性痤疮及痤疮后红斑、色素沉着有效、无创,不良反应少,可广泛应用于临床。     

强脉冲光治疗面部寻常型痤疮

目的：观察强脉冲光治疗面部寻常型痤疮的疗效.方法：应用光子痤疮治疗仪治疗31例面部寻常型痤疮患者,病情Ⅱ～Ⅲ级（炎性和非炎性皮损总数分别为31～50个和51～100个）,治疗波长415nm,每周2次,治疗4～6周,观察记录临床反应,每周拍摄皮损图像.结果：31例患者总有效率61%,皮脂溢出减少率55.7%.治疗期间,未发现刺激、皮炎等不良反应.结论：强脉冲光（415nm）照射治疗痤疮疗效较好,疗程较短,治疗过程安全,可以作为治疗Ⅱ～Ⅲ级炎性痤疮的有效方法,尤其对于不能耐受内服或外用药物治疗者提供了一种安全有效的治疗方法。     

低能量Q开关Nd:YAG激光联合胶原贴敷料治疗面部寻常性痤疮疗效观察

目的:观察低能量Q开关Nd:YAG激光联合胶原贴敷料治疗面部寻常性痤疮的临床疗效。方法:98例寻常性痤疮患者,采用半侧面部对照观察,分为两组。治疗组:左侧面部,先用粉刺针清除皮损,再采用低能量Q开关Nd:YAG激光联合使用胶原贴敷料治疗;对照组:右侧面部,采用低能量Q开关Nd:YAG激光联合使用胶原贴敷料治疗。激光治疗两周1次,6次为1个疗程。98例患者均进行1个疗程的Q开关Nd:YAG激光治疗,观察治疗后皮损改善的效果及不良反应。结果:治疗组痤疮皮损改善有效率(90.82%)明显高于对照组(71.43%),两组差异有统计学意义(P0.01),两组患者在激光治疗后均配合使用胶原贴敷料,能明显缓解患者皮肤的灼热感及干燥敏感。结论:低能量Q开关Nd:YAG激光联合胶原贴敷料治疗面部寻常性痤疮,面部先用粉刺针清除皮损,联合治疗效果确切,且不良反应发生率低。     

红蓝光联合治疗面部寻常性痤疮的临床观察

目的:观察和评价红蓝光联合治疗面部寻常性痤疮的疗效。方法:应用红蓝光联合治疗40例面部寻常性痤疮患者,每周2次,共治疗8次。结果:总有效率为60.00%。非炎性及炎性皮损平均改善率分别为55.57%和70.04%,两者差异具有统计学意义,未见明显不良反应。结论:红蓝光治疗痤疮,对炎症型皮损及非炎症型皮损均有良好的治疗效果,不良反应少,患者依从性良好。     

高强度窄谱蓝光治疗面部寻常性痤疮临床观察

目的:观察高强度窄谱蓝光治疗面部寻常性痤疮的疗效。方法:应用波长为405～420nm的高强度窄谱蓝光治疗93例面部寻常性痤疮患者,每周2次,共治疗8次。计数患者炎性皮损(丘疹、脓疱、结节和囊肿)、非炎性皮损(粉刺)及皮损总数来计算改善率;观察患者治疗前后皮肤黑素指数、红斑指数、皮脂分泌及角质层含水量的变化情况。结果:治疗结束时,总有效率为82.80%。非炎性及炎性皮损平均改善率分别为51.67%和68.90%;患者面部红斑指数及皮脂分泌显著降低,而黑素指数及角质层含水量与治疗前比较无显著变化。随访3个月,总有效率与治疗结束时相比差异无统计学意义。结论:高强度窄谱蓝光治疗面部寻常性痤疮疗效显著,且可以减轻皮肤红斑、减少皮脂分泌。     

粉刺挤压术联合红蓝光照射治疗寻常性痤疮疗效观察与护理

目的:探讨粉刺挤压术联合红蓝光照射治疗寻常性痤疮的疗效及护理要点。方法:对132例寻常性痤疮患者采用粉刺挤压术联合红蓝光照射治疗,并配合做好护理工作。结果:132例患者经4周治疗后,痊愈105例(79.55%),显效19例(14.39%),有效8例(6.06%),无效0例,总有效率为93.94%。结论:粉刺挤压术联合红蓝光照射是治疗寻常性痤疮的有效治疗方法,良好的护理措施能保证和提高联合治疗寻常性痤疮的疗效。     

多磺酸粘多糖乳膏辅助治疗痤疮的临床疗效观察

目的：观察多磺酸粘多糖乳膏辅助治疗痤疮的临床疗效和安全性,掌握多磺酸粘多糖乳膏的使用方法.方法：选择寻常性痤疮患者60例,随机分成治疗组和对照组,两组患者均口服盐酸米诺环素胶囊50mg每天2次,配合面部护理1周1次,双波长595nm/1064nm脉冲燃料激光,2～3周/次.对照组无外用药,治疗组外用多磺酸乳膏粘多糖,2次/天,4周为1个疗程.由两名皮肤科医生对患者进行痤疮皮损面积和严重程度指数评分,红斑消退及瘢痕形成的观察,采用自身前后对照进行疗效观察,记录患者出现的不良反应.结果：治疗组1周后,丘疹、脓疱大部分消退,随着疗程的增加,丘疹、脓疱消退,红色印迹明显变淡,未见瘢痕形成.有效率83.33％;对照组1周后丘疹、脓疱明显减少,4周后丘疹大部分消退,脓疱变小.有明显的红色印迹,未见瘢痕形成,有效率为63.33％.结论：多磺酸粘多糖乳膏配合双波长595nm/1064nm激光治疗面部寻常性痤疮快捷、安全、有效.     

红-蓝光联合治疗寻常痤疮的疗效

目的 探讨红-蓝光联合治疗寻常痤疮临床疗效.方法 对65例痤疮患者采用红-蓝光联合照射治疗,每位患者每次使用蓝光照射20～25 min,然后使用红-蓝光联合照射5～10 min,每周2次,连续照射4周为1个疗程.轻度痤疮患者治疗1个疗程,中、重度痤疮患者连续治疗1～2个疗程.结果 经过系统治疗后,所有患者痤疮皮损均有明显改善且无副作用,轻度痤疮有效率为80%,中度痤疮有效率为89.4%,重度痤疮有效率为88.2%.结论 应用红-蓝光联合治疗寻常痤疮是安全且有效的治疗方法.     

Red Light Phototherapy Alone Is Effective for Acne Vulgaris: Randomized, Single-Blinded Clinical Trial

BACKGROUND: Recently, a demand for safe and effective treatment of acne has been increasing. Although visible light has attracted attention as a new option, the effect of red light alone has not yet been evaluated. OBJECTIVES: The objective was to assess the efficacy of red light phototherapy with a portable device in acne vulgaris. METHODS: Twenty-eight volunteers with mild to moderate acne were treated with portable red light-emitting devices in this split-face randomized trial. The right or left side of the face was randomized to treatment side and phototherapy was performed for 15 minutes twice a day for 8 weeks. Clinical photographs, lesion counts, and a visual analog scale (VAS) were used to assess each side of the face at baseline and Weeks 1, 2, 4, and 8, and a split-face comparison was performed. RESULTS: The percent improvement in noninflammatory and inflammatory lesion counts of the treated side was significant compared to the control side (p<.005). VAS decreased from 3.9 to 1.9 on the treatment side and the difference between the treatment and control sides was significant at Week 8 (p<.005). CONCLUSIONS: This study shows that red light phototherapy alone can be a new therapeutic option for acne vulgaris.     

Nonablative Radiofrequency for Active Acne Vulgaris: The use of Deep Dermal Heat in the Treatment of Moderate to Severe Active Acne Vulgaris (Thermotherapy): A Report of 22 Patients

BACKGROUND: Acne vulgaris is an exceedingly common condition in adolescence and may extend into adult life in some individuals. Even though this condition is at times minimized, it has been found to have a profound impact in the quality of life of many affected individuals. Acne scarring can be even more of a source of psychological and social problems than active acne is, and when inadequately treated, the latter can lead to the former. Moderate and severe acne vulgaris usually require a regimen of systemic and/or topical medications, which are given for several months or even years and frequently require multiple visits to the physician office, the laboratory, etc. This results in loss of time at school and considerable expense. Side effects from medications and the frequent need to use alternative drugs when there is no response to medical treatment are possible. OBJECTIVE: To evaluate the role of a novel medical device that uses radiofrequency as a source of energy to produce volumetric tissue heating, while sparing the epidermis, allowing for a procedure with no down time and no postoperative care required. METHODS: Twenty-two patients, 10 women and 12 men, ranging in age from 16 to 28, with moderate to severe, scarring, cystic, active, acne vulgaris participated. Only nine of these patients were on concomitant medical treatment such as oral antibiotics or topical agents. All 22 patients were treated with a new nonablative radiofrequency unit, which delivers a concomitant spray of cryogen for epidermal sparing. One session was done in 20 patients and two sessions in 2 patients. The average fluence per energy delivery was 72 J/cm2. Follow-up ranged from 1 to 8 months. Patient questionnaires and active acne lesion counts were used to evaluate the response to treatment. RESULTS: Excellent response was seen in 82% (n=18). Modest response was seen in 9% (n=2), and no response was seen in 9% (n=2); t-test on active lesion counts before treatment and after treatment was less than 0.009004. No side effects were identified on any of these patients. No down time from the procedure was seen. Only topical anesthesia, ELA-Max 5% (Ferndale Labs, Ferndale, MI) was used; 59% of patients were on no acne medication before, during, or after the procedure. CONCLUSIONS: Nonablative radiofrequency appears to be a new safe and effective treatment alternative for moderate to severe acne vulgaris. Further research is in progress to evaluate this treatment modality in a larger number of patients.     

红/蓝光光动力联合五味消毒饮治疗中重度寻常性痤疮临床观察及护理

目的：研究红/蓝光光动力联合五味消毒饮治疗寻常性痤疮的临床效果及护理要求。方法：治疗组采用红/蓝光光动力痤疮治疗仪,每周治疗2次,2次蓝光2次红光交替进行,疗程4周,每次治疗时间20min,剂量48 J/cm2。同时口服五味消毒饮,每日1剂;对照组仅口服五味消毒饮,每日1剂。结果：治疗组痊愈4例、显效31例、有效12例、无效3例;对照组痊愈1例、显效24例、有效20例、无效13例,治疗组有效率明显高于对照组,差异有统计学意义（P〈0.05）。结论：红/蓝光光动力联合五味消毒饮治疗寻常性痤疮为一种无创、安全、有效的新方法。     

5%硫磺溶液结合强脉冲光治疗中重度痤疮疗效观察

目的：观察5%硫磺溶液联合强脉冲光（1PL）治疗寻常性痤疮的疗效及安全性。方法：将229例寻常性痤疮患者随机分成两组,两组均外涂5%硫磺溶液至患处,2次/日,4周为1个疗程。治疗组采用强脉冲光治疗仪治疗,每周1次,连续4次为1个疗程;对照组口服维胺酯胶囊25mg,3次/日,4周为1个疗程。结果：治疗组有效率为83.08%,对照组总有效率为72.04%,两组比较有显著性差异（P〈0.05）,治疗组副作用包括短暂且可耐受的轻微红肿、发热或局部刺痛感。结论：5%硫磺溶液结合强脉冲光照射治疗寻常性痤疮优于维胺酯胶囊治疗,是一种可选择用于治疗中重度痤疮的较安全、有效的方法。     

两种波长强脉冲光“4＋3”联合治疗痤疮及痤疮后红斑的疗效

目的 评价两种波长强脉冲光（intensive pulsed light,IPL）以“4＋3”方式联合治疗面部痤疮和痤疮后红斑的疗效.方法 将80例面部痤疮患者分为治疗组和对照组,每组各40例.治疗组先单独采用420 nm波长IPL治疗4次,每次间隔1周;再采用420 nm和540 nm两种波长IPL联合治疗3次,每次间隔4周.对照组外用0.1％阿达帕林凝胶,每晚1次,共16周.结果 （1）4周炎性皮损治疗有效率：治疗组65.0％（26/40）,对照组47.5％（19/40）,两组差异有统计学意义（P＜0.05）;16周炎性皮损治疗有效率：治疗组85.0％（34/40）,对照组62.5％（25/40）,两组差异有统计学意义（P＜0.05）.（2）红斑治疗有效率：治疗组90.0％（36/40）,对照组37.5％（15/40）,两组差异有统计学意义（P＜0.01）.结论 采用“4＋3”方式联合使用420 nm和540 nm两种波长IPL治疗痤疮和痤疮后红斑安全、有效.     

盐酸多西环素胶囊治疗寻常痤疮的临床观察

目的：为评价盐酸多西环素胶囊治疗寻常痤疮的疗效及不良反应。方法：对60例寻常痤疮随机分为二组治疗,A组（30例）用盐酸多西环素胶囊治疗,B组（30例）用二甲胺四环素胶囊治疗, 治疗时间为21天,结果：治疗前后,A组和B组的炎性皮损数减少明显（P＜0．05）,盐酸多西环素胶囊组无明显不良反应,结论：盐酸多西环素胶囊治疗寻常痤疮有效,副作用少。     

Nonablative Phototherapy for Acne Vulgaris Using the KTP 532 nm Laser

BACKGROUND: Acne vulgaris is an acute inflammatory disease of the pilosebaceous units. The bastion of treatment for acne vulgaris has been the use of topical and systemic therapies. Despite many modalities available for treatment, there exists an imperative need for effective noninvasive treatments that reduce the risks of medication side effects. OBJECTIVE: To study the safety and efficacy of the potassium titanyl phosphate (KTP) 532 nm pulsed laser for the treatment of acne vulgaris. METHODS: Twenty-six subjects, clinically evaluated with moderate facial acne, were enrolled in this single-center prospective trial. The entire facial area for each subject was divided in half and randomly designated as either a treatment or a control side. Each subject was treated with four laser exposures using a KTP 532 nm laser with continuous contact cooling. The results were assessed at 1 and 4 weeks post-final treatment. Primary outcome measures were Micha?lsson acne severity score and adverse treatment effects. Secondary outcome measures included subjective evaluations from the investigator and patients assessing their overall percent satisfaction. RESULTS: Primary outcome analysis in the Micha?lsson acne severity score demonstrated a mean 34.9% (p = .011) and 20.7% (p = .25) reduction at the 1-week and 4-week post-final treatments, respectively. Subjective investigator evaluations of overall percent satisfaction indicated that all patients demonstrated a minimum 50% overall satisfaction in treatment outcomes at the 4-week follow-up period. No side effects were encountered. CONCLUSION: Use of the KTP 532 nm laser for the treatment and management of acne vulgaris is both safe and effective, with positive results enduring up to 4 weeks post-treatment.     

3%甲硝唑霜治疗寻常性痤疮疗效及安全性的研究

目的 通过使用3％甲硝唑霜与5％过氧化苯甲酰对寻常性痤疮治疗效果的比较观察，从而评价3％甲硝唑霜治疗寻常性痤疮的疗效和安全性。方法 采用开放对照临床实验，用3％甲硝唑霜与5％过氧化苯甲酰分别对97例寻常性痤疮患者进行治疗（3％甲硝唑霜组48例，5％过氧化苯甲酰组49例），疗程12周，在治疗的第2、4、8、12周进行随访，并在治疗的第8周、12周判断疗效。结果 3％甲硝唑霜疗效为81.4％，5％过氧化苯甲酰疗效为78．2％，经秩和检验P〉0．05，两者治疗寻常性痤疮的疗效差别无统计学意义；3％甲硝唑霜不良反应发生率2．08％，5％过氧化苯甲酰不良反应发生率38．3％，经秩和检验P〈0．05，二者差别有统计学意义，前者安全性高于后者。结论 3％甲硝唑霜是治疗寻常性痤疮安全和有效的药物。