共查询到20条相似文献,搜索用时 109 毫秒
1.
Lee YT Tsai YC Yang YK Hsu KT Liao SC Wu CH Cheng BC Chen JB Lee CH Lee CT 《Nephrology (Carlton, Vic.)》2011,16(7):663-671
Aim: The aim of this analysis was to know whether these three cytokine polymorphisms, including interleukin‐6 (IL‐6; ?572 G/C), tumour necrosis factor‐α (TNF‐α; ?308 G/A), and IL‐10 (–592 A/C) have an effect on baseline peritoneal transport property and longitudinal evolution of peritoneal function. Methods: A total of 141 stable peritoneal dialysis (PD) patients with mean treatment duration of 84.4 ± 34.2 months were enrolled. We genotyped these three cytokine polymorphisms, together with clinical parameters that were included as factors affecting longitudinal change of property of peritoneal transport over the first 3 year period after commencing therapy. Results: There was no significant association between genotypes and baseline peritoneal transport property. The ?592 A/C polymorphism of IL‐10 was associated with longitudinal change of peritoneal transport. The ratio of D/P creatinine was significantly higher in patients with AA than those with CC/CA genotypes at 12 months (0.65 ± 0.11 vs 0.62 ± 0.09, P = 0.048) and 24 months (0.64 ± 0.12 vs 0.59 ± 0.09, P = 0.018). In addition, patients with increased peritoneal transport have greater frequency distribution of AA genotype and A allele. Logistic regression analysis revealed that ?592 A allele was an independent predictor for the increase in D/P creatinine over the first 12 month period (odds ratio: 2.482, P = 0.017). There was no correlation between either polymorphism of IL‐6 ?572 (G/C) or TNF‐α?308 (G/A) and longitudinal change of peritoneal function. Conclusions: Single nucleotide polymorphism of IL‐10 ?592 (A/C) was associated with longitudinal evolution of peritoneal transport rate in PD patients rather than the baseline peritoneal characteristics. 相似文献
2.
Jacek Waniewski Olof Heimbürger rzej Werynski Min Sun Park † Bengt Lindholm 《Artificial organs》1995,19(4):295-306
Abstract: To investigate possible effects of glucose concentration, dwell time, and peritoneal reabsorption on the combined diffusive and convective peritoneal solute transport, dialysate to plasma concentration ratios (D/P) and solute clearances were evaluated for 6-h peritoneal dwell studies with 1.36, 2.27, and 3.86% glucose solutions. The diffusive mass transport coefficient, KBD, and sieving coefficient, S, were estimated using the Babb-Randerson-Farrell model of peritoneal transport. Dialysate volumes over time and peritoneal reabsorption rates, KR, were assessed using radiolabeled iodinated serum albumin (RISA). The transport parameters were estimated with and without peritoneal reabsorption of solutes taken into account. To test the stability of the transport parameters throughout a single peritoneal dwell, KBD and S values were estimated for the initial 3–120 min, the final 120–360 min, and the entire 3–360 min dwell period for dialysis with 3.86% glucose solution. The transport parameters did not differ between the three dialysis fluids although clearances of small solutes were higher with the 3.86% solution. Values of KBD, but not S, were dependent on the correction for peritoneal reabsorption of solutes. Computer simulations showed that S could be estimated even with the 1.36% glucose solution. A significant change of the transport parameters, with increased values of KBD during the initial period of the dwell, was found for urea, potassium, sodium, and total protein during dialysis with the 3.86% solution. S values for urea and potassium were close to 1 during the initial period whereas unphysical (higher than 1) S values were found for the whole dwell period. The transient increase of KBD during the initial part of the dwell may reflect changes in the peritoneal barrier possibly induced by fresh dialysis fluid. In conclusion, the transport parameters KBD and S are not influenced by the concentration of glucose in the dialysis fluid. Moreover, the estimation of KBD but not of 5 is dependent on the assumed rate of peritoneal reabsorption. Finally, the current results challenge the assumption that KBD and S are constant throughout a peritoneal dialysis exchange. 相似文献
3.
Management of peritoneal-surface malignancy: the surgeon’s role 总被引:6,自引:0,他引:6
P. H. Sugarbaker 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1999,384(6):576-587
Background: Peritoneal surface malignancy can result from seeding of gastrointestinal cancer or abdominopelvic sarcoma; it can also occur
as a primary disease, for example, peritoneal mesothelioma. In the past, this clinical situation was treated only with palliative
intent. Methods: An aggressive approach to peritoneal surface malignancy involves peritonectomy procedures, perioperative intraperitoneal
chemotherapy and knowledgeable patient selection. The clinical assessments necessary for valid clinical judgements include
the cancer histopathology (invasive vs expansive progression), the preoperative abdominal and pelvic computed tomogram, the
peritoneal cancer index and the completeness of cytoreduction score. Proper patient selection is mandatory for optimizing
the results of treatment. Results: In a series of phase-II studies, appendiceal tumors with peritoneal seeding was the paradigm for success with a 75% long-term
survival in properly selected patients. Carcinomatosis from colon cancer had an overall 5-year survival of 20% but with selected
patients this reached 50%. Also, sarcomatosis patients overall had only a 10% 5-year survival but selected patients had a
75% survival. In all malignancies, early aggressive treatment of minimal peritoneal surface dissemination showed the greatest
benefit. Conclusions: The surgeon must accept responsibility for knowledgeable management of peritoneal surface dissemination of cancer. A curative
approach has been demonstrated in large phase-II studies. Adjuvant studies with perioperative intraperitoneal chemotherapy
in diseases where peritoneal surface spread occurs are indicated.
Received: 1 April 1999 Accepted: 3 June 1999 相似文献
4.
Wen-Hung Huang Yung-Chang Chen Cheng-Chieh Hung Jeng-Yi Huang Ja-Liang Lin 《Renal failure》2013,35(7):835-841
Background. Atherosclerotic vascular change affecting the lower extremities is the most common peripheral vascular disease. Ankle-brachial index (ABI) and toe-brachial index (TBI) are common, non-invasive diagnostic tests for atherosclerosis in the lower extremities. Peritoneum is a vascular-based structure. The use of glucose-based hyperosmolar solutions for PD patients results in a significant increase in blood glucose load and can be considered atherogenic. The association between ABI or TBI values and peritoneal function in patients undergoing peritoneal dialysis remains unclear. We presumed that the risk factors for atherosclerosis in large and small vessels may differ. Methods. A total of 146 peritoneal dialysis patients, 41 males and 105 females (119 without diabetes and 27 with diabetes), received peritoneal dialysis for more than four months. Patients who had dialysis-related peritonitis within six months prior to this study were excluded. The ABI or TBI was determined using an automated, non-invasive, waveform analysis device. Results. The ABI value correlated positively with mean arterial pressure and TBI value. The TBI value correlated positively with ABI value and inversely with fasting serum glucose and serum total cholesterol concentrations. Peritoneal function was not correlated with ABI or TBI. Conclusion. This cross-sectional study demonstrated that risk factors in peritoneal dialysis patients for atherosclerosis in large vessels and small vessels differed. Interestingly, peritoneal function test is not associated with ABI or TBI value. However, further investigation of the association between ABI or TBI value and cardiovascular events is required for this patient group. 相似文献
5.
P. Harter MD PhD M. Hahmann H. J. Lueck MD PhD M. Poelcher MD PhD P. Wimberger MD PhD O. Ortmann MD PhD U. Canzler MD PhD B. Richter MD PhD U. Wagner MD PhD A. Hasenburg MD PhD A. Burges MD PhD S. Loibl MD PhD W. Meier MD PhD J. Huober MD PhD D. Fink MD PhD W. Schroeder MD PhD K. Muenstedt MD PhD B. Schmalfeldt MD PhD G. Emons MD PhD A. du Bois MD PhD 《Annals of surgical oncology》2009,16(5):1324-1330
Background Almost all retrospective trials pointed out that a benefit of surgery for recurrent ovarian cancer may be limited to patients
in whom a macroscopic complete resection could be achieved. Peritoneal carcinomatosis has been reported to be either a negative
predictor for resectability or a negative prognostic factor, or both. The role of peritoneal carcinomatosis in a multicenter
trial was investigated.
Methods Exploratory analysis of the DESKTOP I trial (multicenter trial of patients undergoing surgery for recurrent ovarian cancer,
2000 to 2003).
Results A total of 125 patients (50%) who underwent surgery for recurrent ovarian cancer had peritoneal carcinomatosis. Univariate
analyses showed worse overall survival for patients with peritoneal carcinomatosis compared with patients without carcinomatosis
(P < .0001). Patients with and without peritoneal carcinomatosis had a complete resection rate of 26% and 74%, respectively (P < .0001). This corresponded with the observation that patients with complete resection had a better prognosis than those with
minimal residual disease of 1 to 5 mm, which commonly reflects peritoneal carcinomatosis (P = .0002). However, patients who underwent complete resection, despite peritoneal carcinomatosis, had a 2-year survival rate
of 77%, which was similar to the 2-year survival rate of patients with completely debulked disease who did not have peritoneal
carcinomatosis (81%) (P = .96). Analysis of prognostic factors did not show any independent effect of peritoneal carcinomatosis on survival in patients
who underwent complete resection.
Conclusions Peritoneal carcinomatosis was a negative predictor for complete resection but had no effect on prognosis if complete resection
could be achieved. Improving surgical skills might be one step to increase the proportion of patients who might benefit from
surgery for recurrent disease. 相似文献
6.
RENGIN ELSURER BARIS AFSAR SIREN SEZER F NURHAN OZDEMIR MEHMET HABERAL 《Nephrology (Carlton, Vic.)》2009,14(8):712-715
Aim: High peritoneal transport status is a determinant of morbidity and mortality in peritoneal dialysis (PD) patients. It was hypothesized that 24 h peritoneal albumin leakage predicted 2 year prospective cardiovascular outcome and survival in patients receiving PD. Methods: Sixty‐six patients were included. A simplified peritoneal equilibration test was performed and 24 h peritoneal albumin leakage was calculated. Patients were followed up for 2 years. Patient outcome (alive or dead) and occurrence of a cardiovascular event were recorded. Results: During a 2 year follow‐up period, 10 (15.2%) patients had suffered from a cardiovascular event and seven (10.6%) patients had died. Patients who had suffered from a cardiovascular event during the follow up period were older (54.0 ± 9.4 years vs 44.3 ± 14.5 years, P = 0.025), had lower serum pre‐albumin concentrations (29.3 ± 10.0 g/dL vs 36.0 ± 9.2 g/dL, P = 0.034) and had higher 24 h peritoneal albumin leakage (median, 3.4 g/day (1.66–15.4 g/day) vs 2.4 g/day (0.76–7.31 g/day), P = 0.011) than patients who did not suffer from a cardiovascular event. In the Cox proportional hazards multivariate analysis of factors which differed significantly between patients with and without a cardiovascular event (age, serum pre‐albumin and 24 h peritoneal albumin leakage), only advanced age (hazards ratio, 1.083; 95% confidence interval, 1.023–1.147, P = 0.006) was an independent predictor of a cardiovascular event. Conclusion: In contrast to the hypothesis, 24 h peritoneal albumin leakage is not a predictor of 2 year prospective cardiovascular outcome and patient survival. Only advanced age independently predicts the occurrence of a cardiovascular event in patients receiving PD. 相似文献
7.
《Renal failure》2013,35(4):419-423
Lactobacilli are part of the normal gastrointestinal and female genitourinary flora in humans and they are seldom pathogenic and rarely cause human disease. In the literature, Lactobacillus peritonitis was most common in immunocompromised patients, including patients under chronic peritoneal dialysis. We also suspect that the presence of Lactobacillus spp. in the peritoneal fluid might indicate the leakage of normal flora from a perforated intraabdominal hollow organ. To access the versatile clinical pictures of Lactobacillus peritonitis, this investigation retrospectively reviewed the medical records for Lactobacillus spp. isolated from peritoneal fluid from July 1998 to January 2002 at Chang‐Gung Memorial Hospital, Taipei, Taiwan. A total of 10 patients were enrolled in the study. Six of these 10 patients had concomitant intraabdominal hollow organ perforation, and peritoneal fluid cultures in these six patients also contained bacteria other than Lactobacillus spp. All six patients had recently experienced either abdominal surgery or blunt abdominal trauma. The remaining four patients who had not undergone surgery had decompensated liver cirrhosis with ascites and spontaneous bacterial peritonitis. The results suggested that the presence of Lactobacillus spp. in the peritoneal fluid other than immunocompromised patients should raise the suspicion of hollow organ perforation in patients with recent abdominal surgery or blunt abdominal trauma. 相似文献
8.
9.
Background: It has been shown that residual renal function but not peritoneal clearance predicted patients’ survival in peritoneal dialysis
therapy. In the present study, we tried to explore the potential causes resulting in the difference between residual renal
function and peritoneal dialysis in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods: A cross sectional study was performed during July and August 2003 to evaluate the dialysis adequacy in CAPD patients who
were clinically stable and had daily urinary volume more than 100 ml. Results: A total of 45 patients (male 27 and female 18) with an average ( ± SD) age of 61.76 ± 13.27 years were included in this
study. The daily urinary volume and dialysate ultrafiltration volume were 570.33 ± 395.47 ml and 726.09 ± 454.01 ml, respectively.
Peritoneal urea clearance (Kt/V) correlated significantly with the drained daily dialysate volume (r = 0.362, P < 0.01), but not with peritoneal net fluid removal (ultrafiltration) (r = 0.232, P > 0.05) and sodium removal (r = 0.139, P > 0.05). On the other hand, there were strong positive correlations between residual renal Kt/V and daily urine volume (r = 0.802, P < 0.001), as well as between residual renal Kt/V and urinary sodium removal (r = 0.670, P < 0.001). Conclusions: High residual renal Kt/Vurea represents both higher solute clearance and higher sodium and fluid removal, but higher peritoneal
Kt/Vurea is not necessarily associated with better sodium and fluid removal. This dissociation might explain the differences
on the survival of patients and peritoneal clearances. 相似文献
10.
Increased peritoneal permeability is associated with decreased fluid and small-solute removal and higher mortality in CAPD patients 总被引:18,自引:7,他引:11
Wang T; Heimbuger O; Waniewski J; Bergstrom J; Lindholm B 《Nephrology, dialysis, transplantation》1998,13(5):1242-1249
Background: Recent studies suggest that increased
peritoneal membrane permeability is associated with higher morbidity and
mortality in peritoneal dialysis patients. It is not known, however,
whether the difference in clinical outcome among different peritoneal
transport groups is due to differences in peritoneal fluid and solute
removal. In the present study, we compared the peritoneal fluid and solute
transport and clinical outcome in CAPD patients with high (H), high-average
(H-A), low-average (L-A) and low (L) peritoneal transport patterns.
Design: A 6-h study was performed in 46 patients with
frequent dialysate and plasma samples using 21 of 3.86% glucose dialysate
with 131I albumin as an intraperitoneal volume
marker. The patients were divided into four transport groups according to
their D/P of creatinine at 240 min. Results: The
results showed that high transporters had significantly lower peritoneal
fluid and small-solute removal but high glucose absorption and high protein
loss during a 6-h exchange. The serum albumin was lower and blood pressure
and triglycerides were higher in high transporters compared with the other
groups. Two-year patient survival from the start of CAPD treatment was
significantly lower for high transporters (64, 85, 90 and 100% for H, H-A,
L-A and L respectively, P<0.01). The 1-year patient survival from
the dwell study was also significantly lower in high transporters (16, 63,
90 and 100% for each group, P<0.01).
Conclusion: Our results suggest that high transporters
remove less fluid and small solutes and have higher protein loss and
increased glucose absorption. These alterations may contribute to fluid
overload, malnutrition and lipid abnormalities that perhaps contribute to
the increased mortality among the high transporters. Key
words: CAPD, adequacy, peritoneal transport, mortality
相似文献
11.
Nathan Legband Arielle Black Craig Kreikemeier-Bower Benjamin S. Terry 《Journal of investigative surgery》2019,32(4):321-330
Purpose/Aim: In developing a novel peritoneal oxygenation therapy, catheters implanted into the peritoneal cavity became obstructed with omental tissue and prevented the infusion and removal of fluid from the peritoneal cavity. The obstruction of peritoneal catheters is a significant failure in researching various peritoneal treatments as further fluid administration is no longer possible. The purpose of this preliminary study was to determine the most effective catheter design for infusion and removal of fluid into the peritoneal cavity of rats. Materials and Methods: Four types of catheters were tested including the Jackson-Pratt, round fluted drain, flat fluted drain, and an original design. Three of each catheter type were surgically placed into the peritoneal cavity of rats (n = 12). In order to test the efficacy of each catheter, saline was infused and extracted twice daily. Catheters were scored on a weighted scale based on the amount of time they remained patent, the subjective force needed for extraction/infusion, and the amount of saline removed. Results: The round and flat fluted drain catheters remained patent for the full duration of the study (12 days) compared to the other models which failed after 7 days. These catheters also yielded a high average for extracted saline volume and an easy extraction/infusion. Conclusions: The round and flat fluted drain catheters were recognized as viable options to be used in rats for peritoneal drain studies of up to 12 days. 相似文献
12.
Fibrinolytic capacity in peritoneal fluid after laparoscopic and conventional colorectal resection: data from a randomized controlled trial 总被引:2,自引:1,他引:1
Background A reduced peritoneal fibrinolytic capacity after surgery is currently accepted to be the main cause for postoperative adhesions. The aim of this prospective randomized trial was to determine the fibrinolytic activity in peritoneal fluid after laparoscopic as compared to conventional colorectal resection.Methods A randomized controlled trial in parallel with the multicenter trial Lapkon II was conducted. Peritoneal fluid was sampled via drain at 2, 8, and 24 h after elective laparoscopic (n=14; LAP) and conventional (n=16; CON) colorectal resections. Activities and concentrations of tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAI-1) and t-PA/PAI complex were determined in all specimen by ELISA kits.Results There was no difference in age, sex or body mass index between both groups. Postoperatively, t-PA activity decreased in both groups and was lower 2 h after closing the abdomen in the laparoscopic group (p<0.05). PAI-1 activity and concentration increased in both groups. Difference between the groups was measured for PAI-1 concentration after 24 h (p<0.05). There were no differences between the groups regarding t-PA concentrations, PAI-1 activity and t-PA/PAI complex.Conclusions After closing the abdominal cavity, postoperative changes in fibrinolytic capacity of peritoneal fluid can be determined in samples collected by a drain. However, there were no major differences in the postoperative course of fibrinolytic capacity in peritoneal fluid after laparoscopic and conventional colorectal resections. 相似文献
13.
Purpose/Aim: Colorectal malignity is one of the most common forms of cancer. The finding of free intraperitoneal colorectal cancer cells during surgery has been shown to be associated with poor outcome. The aim of this study was to develop an experimental model designed to investigate adhesion of colorectal cancer cells to the peritoneal surface. Materials and methods: Two human experimental models were developed, the first using cultured mesothelial cells and the second consisting of an ex vivo model of peritoneal tissue. Both models were subjected to standardized trauma, following which labeled colorectal cancer cells (Colo205) were introduced. Adhesion of tumor cells was monitored using microscopy and detection of fluorochromes. Results: The mesothelial cell layers and peritoneal membranes remained viable in culture medium for several weeks. In our experimental model, the tumor cells added were seen to adhere to the edges of the traumatized area in cluster formations. Conclusions: The use of human peritoneal tissue in an ex vivo model would appear to be a potentially useful tool for the study of interaction between human peritoneal membrane and free tumor cells. Experimental surgical trauma increases the ability of tumor cells to adhere to the peritoneal membrane. This ex vivo model should be useful in future studies on biological interactions between peritoneum and tumor cells in the search for novel forms of peritoneal cancer therapy. 相似文献
14.
Second-look Surgery after Cytoreduction and Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Colorectal Cancer: Analysis of Prognostic Features 总被引:11,自引:0,他引:11
p
= 0.04) and
the completeness of resection at the time of the second look
(
p
= 0.066). In addition, a limited extent of
peritoneal carcinomatosis distribution found at the time of the second
look predicted a favorable result. A new objective assessment of
peritoneal carcinomatosis, the peritoneal cancer index, was found to be
of help during patient selection (
p
= 0.066). We
concluded that second-look surgery with potential curative intent
should be considered in patients who had a complete initial
cytoreduction and those in whom total removal of the recurrence is
judged possible at the time of the second look. At the time of
abdominal exploration, a limited distribution and volume of peritoneal
carcinomatosis as defined by the peritoneal cancer index should be
considered. Palliative debulking procedures should be used to alleviate
symptoms in other patients.RID=" ID=" <E5>Correspondence to:</E5> P.H. Sugarbaker, M.D. 相似文献
15.
《Renal failure》2013,35(7):958-966
AbstractBackground/Aims: The present study investigated whether Rho-kinase inhibition had a therapeutic role on the pathogenesis of peritoneal fibrosis and angiogenesis. Methods: A rat model of peritoneal dialysis was induced by a daily intraperitoneal infusion of 4.25% Dianeal. Those rats were treated with Rho-kinase inhibitor, fasudil. Immunofluorescence, Western blot and RT-PCR were used to detect the expression of TGF-β1, Collagen I, αSMA and VEGF in each group. Microvessel density (MVD) was measured by immunohistochemistry. Rho-kinase activity was determined by western immunoblotting. Results: Rho-kinase was activated in the peritoneum of the PD group, which was inhibited by fasudil. Compared with PD group, the mRNA and protein expressions of TGF-β1, αSMA and Collagen I were significantly downregulated in fasudil treatment groups in a dose-dependent manner, and the expression of VEGF and peritoneal MVD was also significantly downregulated in fasudil treatment groups in a dose-dependent manner. Conclusion: The Rho-kinase was activated in the peritoneum of the peritoneal dialysis rats, and the inhibition of Rho-kinase by fasudil can remarkably decrease peritoneal fibrosis and angiogenesis. 相似文献
16.
Sequential changes in the cell mediators of peritoneal and wound fluids after surgery 总被引:1,自引:0,他引:1
Akira Tokunaga Masahiko Onda Itsuo Fujita Takeshi Okuda Takashi Mizutani Teruo Kiyama Norio Matsukura Thomas K. Hunt 《Surgery today》1993,23(9):841-844
The concentrations of cell mediators in the peritoneal and wound fluids of patients who underwent abdominal surgery or mastectomy were determined sequentially and compared with the concomitant changes in blood components. The level of interleukin-6 (IL-6) in the peritoneal and wound fluids was significantly higher than the plasma level after gastrectomy (P<0.001), cholecystectomy (P<0.05), and mastectomy (P<0.05), although the level of plasma IL-6 was also higher postoperatively than before surgery (P<0.001, P<0.05). Significantly higher levels of tumor necrosis factor- were detected in the peritoneal and wound fluids (P<0.01, P<0.05, respectively) after surgery despite its absence in plasma. A platelet-specific protein and a protein specific for fibroblasts were also measured. Thus, mediators derived from various cells were shown to be present in human peritoneal and wound fluids, indicating that the local production of these mediators plays an important role in the process of tissue repair. 相似文献
17.
Many studies have reported the prevalence of transfusion-transmitted virus (TTV) infection in hemodialysis patients, but few reports studied the prevalence of TTV infection in peritoneal dialysis patients. In this study, we determined the prevalence of TTV in a peritoneal dialysis population in Taiwan and related its prevalence with history of blood transfusion, serum hepatitis B surface antigen (HBsAg), antibody to hepatitis C virus (anti-HCV), and serum aminotransferases (AST and ALT) levels. Serum samples from 47 peritoneal dialysis patients and a control group of 43 patients at health examination were studied for TTV viremia by using polymerase chain reaction. The rate of blood transfusion exposure (p < 0.0001), female gender (p = 0.001), younger age (p?=?0.0014), and serum AST level (p?=?0.012) were significantly higher in peritoneal dialysis patients. The prevalence of TTV viremia was not significantly different between peritoneal dialysis patients and the control group (23.4% vs. 37.2%). TTV infection was not associated with evident liver diseases in peritoneal dialysis patients, and the infection rate was not different between automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD) patients. There was no statistically significant association between TTV infection and age, gender, transfusion history, duration of peritoneal dialysis, AST level, ALT level, HBsAg, or anti-HCV seropositivity in peritoneal dialysis patients. Our results suggest that TTV infection is not associated with evident liver diseases, and there is no difference between TTV infection in healthy individuals and peritoneal dialysis patients. TTV transmission probably occurs via routes unrelated to peritoneal dialysis. 相似文献
18.
Dimitrios G. Oreopoulos 《Seminars in dialysis》2004,17(5):346-348
Peritoneal Dialysis International (PDI) started in 1988 as a four‐page document (Peritoneal Dialysis Bulletin) intended to inform all those who visited the Toronto Western Hospital peritoneal dialysis unit about advances in peritoneal dialysis. Soon it became a journal distributed free of charge to 13,000 individuals. Subsequently it became the official publication of the International Society for Peritoneal Dialysis. For many years it was the main forum for publication of the best articles in peritoneal dialysis. As a result, in 1997, its “impact factor” increased to 2.129, putting it in fourth position among the nephrology journals. PDI greatly stimulated the expansion of peritoneal dialysis in the 1980s and 1990s, and remains the main source of knowledge on clinical and investigative aspects of peritoneal dialysis. 相似文献
19.
Rodriguez A; Diz N; Cubillo L; Plana J; Riscos M; Delgado R; Herrera C; Ribes E; Molina F; Heras M; Gonzalez A; Canton C; Fernandez A; Laborda E; Zurita M; Giron F; Santana P 《Nephrology, dialysis, transplantation》1998,13(9):2335-2340
Background: A prospective sequential study on
continuous ambulatory peritoneal dialysis (CAPD) and three techniques of
automated peritoneal dialysis (APD) was conducted to assess peritoneal
clearances, the influence of peritoneal permeability on nocturnal APD
clearances and the suitability of the peritoneal equilibration test (PET)
for predicting clearances on APD. Methods: After
performing a PET, a series of clinical, biochemical and dialysis adequacy
markers were evaluated after 2 months on CAPD, continuous cycling
peritoneal dialysis (CCPD) and tidal volume peritoneal dialysis (TPD) with
50% and 25% tidal volumes. Forty five patients participated and 33
completed the study. Results: Serum urea and
creatinine decreased significantly whereas haemoglobin and glucose
increased. Mean peritoneal urea clearance (1/week) was
55.40±8.76 on CAPD, 74.82±12.62 on CCPD,
69.20±14.63 on TPD (tidal 50%) and 66.89±13.23 on TPD
(tidal 25%); mean creatinine clearance (1/week/1.73
m2) was 42.80±9.95,
52.19±11.11, 51.31±13.3 and 49.17±11.83
respectively. Both clearances were significantly lower on CAPD than on APD
(<0.001). CCPD was the automated technique that provided the best
nocturnal urea clearance (P<0.01). Nocturnal creatinine clearance
did not show significant differences between CCPD and TPD (tidal 50%),
being better with both techniques than with TPD (tidal 25%). There were
statistically significant differences between nocturnal dialysate to plasma
(D/P) ratios and those corresponding to the nearest times in the PET. The
urea D/P ratio at 180 min and the creatinine D/P ratio at 240 min of the
PET were the parameters that better estimated nocturnal clearances on APD.
Conclusions: This study confirms that TPD does not
improve the results of CCPD. Significant differences between D/P ratios
during actual nocturnal cycles and PETs were observed. Key
words: automated peritoneal dialysis; CAPD; clearances; PET
相似文献
20.
《Renal failure》2013,35(9):1123-1124
Streptococcus agalactiae causes a rare and often fatal peritonitis in continuous ambulatory peritoneal dialysis (CAPD). A 52-year-old white female with Alport and chronic kidney disease was initiated on CAPD treatment. Nineteen months later she had a S. agalactiae peritonitis identified and received initially gentamicin–cephalothin, which was changed to ceftazidime, tobramycin, and vancomycin. Recovery started after peritoneal catheter removal. After 3 weeks, severe leucopenia occurred. Granulokine and steroids were given. Six weeks later, she felt well and an abdominal video laparoscopic procedure disclosed a diffuse peritoneal fibrosis, precluding CAPD resumption. She is now doing well on hemodialysis (HD). 相似文献