脂质体阿霉素治疗SRS淋巴瘤小鼠的心脏病理变化

将阿霉素包封在多层脂质体中,与游离阿霉素比较,观察治疗SRS淋巴瘤小鼠过程中小鼠心脏的病理改变。当剂量均为15mg/kg时,光镜见游离阿霉素治疗组小鼠心肌组织单核细胞浸润,肌细胞肿胀,广泛空泡变性,易见细胞坏死;而脂质体阿霉素组仅见心肌细胞轻度肿胀,少见空泡变性,未见坏死。电镜观察到游离阿霉素组小鼠心肌细胞线粒体肿胀、破裂,肌丝断裂、溶解。而脂质体阿霉素组仅见局灶性肌丝片段丢失。结果表明,脂质体载药能明显降低阿霉素的心脏毒性。     

ISOLATED LEVOCARDIA WITH SITUS INVERSUS (A Case Report)

A case of isolated levocardia with situs inversus is reported. The child had a normally formed spleen, which is uncommon in such cases.KEY WORDS: Isolated levocardia, Situs inversus     

肝硬化合并肺血管病变：附30例病理解剖分析

随机复查尸检30例肝硬化HE染色肺切片。观察肺泡水平即500μm以下肺小动静脉、毛细血管的分布及变性状态,并将其它病尸检10例作对照。30例中三尖瓣剖开口径扩张>12cm者20%;左右肺重均>对照组;肺淤血100%;肺小动脉变性16.6%,500μm以下肺小动脉数目100倍视野显现增多者73%;扩张肥厚且数目增加、中膜平滑肌增厚者33%(壁厚平均22.57μm);镜下肺胸膜20%局部血管扩张与食道静脉曲张图象相似。如作肺胸膜活检,发现500μm以下肺小动脉及毛细血管有上述所见者有助于肺动脉高压诊断。     

自展式血管内支架治疗Budd—Chiari综合征（附24例报告）

目的报告２４例Ｂｕｄｄ－Ｃｈｉａｒｉ综合征（ＢＣＳ）的介入治疗结果。方法在Ｘ线电视透视下，采用经皮血管成形术（ＰＴＡ）及血管内支架（ｓｔｅｎｔ）置入治疗下腔静脉和（或）肝静脉阻塞；下腔静脉支架２０例，副肝静脉支架１例，下腔静脉和肝左静脉双支架３例。结果２４例２７支血管皆一次性开通及支架置入获得成功。下腔静脉平均压力术前为３．５４±０．９１ｋＰａ，术后即刻降为２．０２±０．９８ｋＰａ。１例副肝静脉术前压力为３．２２ｋＰａ，术后即刻降为２．０６ｋＰａ。３例肝左静脉压力术前平均为６．１７±０．８２ｋＰａ，术后降为２．３５±０．８６ｋＰａ。术后随访平均４．６个月（１～１４个月），下腔静脉保持通畅，支架扩张良好，无移位。主要临床症状及体征消失者２１例，明显改善者３例，无严重并发症发生。结论介入治疗ＢＣＳ是一种安全有效的方法。在３支主肝静脉严重阻塞时，开通副肝静脉是治疗肝静脉型ＢＣＳ的有效途径。     

GRAVES' DISEASE WITH ORGANIC MOOD SYNDROME (A Case Report)

A case of Graves'' disease with organic mood syndrome in a 3G year old man is reported. Patient had thyrotoxicosis and developed features of mania while in the hospital which necessitated antipsychotic drug therapy.KEY WORDS: Graves'' disease, ManiaFrank psychotic decompensation occurring in the background of Graves'' disease is an explosive clinical situation as manifestations range from severe manic excitement to total apathy. Although rare, the gravity of such situation warrants energetic intervention on both fronts. One such instance of organic mood syndrome with Graves'' disease is being presented, highlighting the problems encountered in the management.     

桥本脑病1例报告

报告1例桥本脑病患者的诊治。     

Glycyrrhizin-Induced Pseudohyperaldosteronism:A Case Report

<正>Licorice,also known as Radix Glycyrrhizae,is a natural sweetener and widely used as a drug,and it has been considered to be a healthy natural substance with few side effects.~((1,2))Pseudo hyperaldosteronism(PsHA),which is characterized by hypertension,hypokalemia and alkalosis,should be considered when licorice or its related products are excessively ingested.Moreover,