DENTAL CARIES IN AN ELDERLY POPULATION IN BRAZIL

This study evaluated dental caries according to the presence of natural teeth and sociodemographic conditions of an elderly population in the state of São Paulo, Brazil. Examinations were performed according to the World Health Organization''s guidelines. The sample of 1,192 elderly individuals aged 65 to 74 years was stratified according to the presence of teeth and the following variables: gender, race, age, city size and Human Development Index (HDI). The Mann Whitney and Kruskal Wallis tests were applied at a confidence level of 95% for analysis of results. In the total sample, 68.9% (n=822) were edentulous; the mean of present teeth was 3.5 and the DMFT was 30.2, being 28.5 of missing teeth. Among dentate individuals (n=370), the mean of present teeth was 11.3, the DMFT was 26.2 and the missing component accounted for 20.7 teeth. The differences observed in the evaluated conditions should be highlighted: the mean number of present teeth was higher among younger individuals (from 65 to 69 years) [12.1] and among those living in cities with high HDI [12.9]; the DMFT was lower among men [24.9] and non-Caucasians [25.1]. Based on these findings, it may be concluded that specific dental programs should be established, with emphasis on oral health promotion and dental caries control, as well as public health policies that may enhance the access to the services provided.     

DENTAL CARIES EXPERIENCE IN 12-YEAR-OLD SCHOOLCHILDREN IN SOUTHEASTERN BRAZIL

The aim of this study was to evaluate the prevalence of caries-free children using DMFT and significant caries (SiC) indexes in different caries prevalence groups in cities of the region of Campinas, São Paulo State, Brazil. The methodology proposed by the World Health Organization (1997) was used for caries diagnosis in 2,378 individuals. According to the DMFT index obtained in each evaluated city, 3 prevalence groups with representative samples were formed, being classified as low, moderate and high. SiC index was used to classify the one third of the population with the highest caries prevalence. In the low prevalence group, 32.4% of the children were caries free (DMFT=0), with mean DMFT of 2.29 and SiC index of 4.93. In the moderate prevalence group, 21.8% of the children were caries free, with mean DMFT of 3.36 and SiC of 6.74. Only 6.9% of the children in the high prevalence group were caries free and the mean DMFT was 5.54 (SiC=9.62). There was a great heterogeneity in dental caries distribution within the studied population, as well as a high caries prevalence considering the 3 classifications. Other indexes besides DMFT could be used to improve oral health assessment during establishment of the treatment plan and intervention.     

肉瘤的抑癌基因研究进展

肉瘤是异质性间叶组织来源恶性肿瘤 ,发病率低 ,占成人恶性肿瘤的 1%,占儿童恶性肿瘤的15 %,其组织学分型较多且伴有明显的遗传学改变。抑癌基因改变是肉瘤发生的重要机制之一 ,目前在肉瘤中已经发现了十余种抑癌基因的异常 ,现对目前研究较多的几种抑癌基因分子生物学方面的研究进展综述如下。1　ｐ5 3　　人类ｐ5 3基因定位于 17ｐ13.1,是目前已明确的一个抑癌基因 ,ｐ5 3基因突变与细胞的恶性转化和由低度恶性向高度恶性演进有关。转基因鼠模型已证实缺失ｐ5 3基因的鼠可自发形成肉瘤。肉瘤是含有种系ｐ5 3突变的Ｌｉ Ｆｒａｕｍｅｎｉ综…