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1.
Jimenez RE Shoup M Cohen AM Paty PB Guillem J Wong WD 《Diseases of the colon and rectum》2003,46(12):1619-1625
Purpose Total pelvic exenteration is performed infrequently in selected patients with locally advanced or recurrent colorectal cancer.
We reviewed our contemporary experience with pelvic exenteration for colorectal cancer to identify selection criteria and
prognostic factors for longterm survival. METHODS: Between 1991 and 2000, 55 patients (males, 29; median age, 62 years) undergoing
total pelvic exenteration for colorectal cancer were identified from a prospective database. Clinicopathologic variables were
evaluated as prognostic indicators of long-term survival by log-rank test and multivariate Cox regression. RESULTS: Indications
for surgery were recurrent colorectal cancer in 71 percent and primary colorectal cancer in 29 percent. Of 39 patients with
recurrent colorectal cancer, 85 percent had previous radiotherapy, and 64 percent had previous abdominoperineal resection.
At the time of pelvic exenteration, 49 percent of patients received intraoperative radiation, and 20 percent required sacrectomy.
Complete resection with negative margins was achieved in 73 percent. Perioperative mortality after pelvic exenteration was
5.5 percent, and complications included perineal wound infection (40 percent), pelvic abscess (20 percent), abdominal wound
infection (18 percent), and cardiopulmonary events (18 percent). Median disease-specific survival for all patients was 48.9
(range, 3.2-105.6) months. Univariate analysis identified five factors associated with decreased survival: male gender, recurrent
colorectal cancer, previous abdominoperineal resection, positive surgical margin, and administration of intraoperative radiation.
On multivariate analysis, only previous abdominoperineal resection was an independent predictor of unfavorable outcome (P
< 0.04). CONCLUSIONS: Total pelvic exenteration can be performed safely in highly selected patients with colorectal cancer
and can result in significantly prolonged survival. Less satisfactory outcomes are observed in patients whose indication for
pelvic exenteration is recurrent colorectal cancer after abdominoperineal resection.
Presented at the meeting of The American Society of Colon and Rectal Surgeons, Chicago, Illinois, June 3 to 7, 2002. 相似文献
2.
Identification of extracapsular invasion of the metastatic lymph nodes as a useful prognostic sign in patients with resectable colorectal cancer 总被引:2,自引:2,他引:0
Dr. Ko Komuta M.D. Sadayuki Okudaira M.D. Masashi Haraguchi M.D. Junichiro Furui M.D. Takashi Kanematsu M.D. 《Diseases of the colon and rectum》2001,44(12):1838-1844
PURPOSE: The present study was undertaken to evaluate whether the microscopic patterns of distribution and extracapsular invasion of cancer cells in the regional lymph nodes were linked to the survival rates for patients with advanced colorectal cancer who undergo a curative surgical resection. METHODS: Two hundred ninety-six surgically resected metastatic lymph nodes from 84 patients with node-positive colorectal cancer were microscopically examined. The distribution of cancer cells in the lymph nodes were grouped into two types: type A (> or =50 percent cancer) and type B (<50 percent cancer). The extracapsular invasion of cancer cells in the nodes were divided into three subgroups: pattern X (no evidence of cancer cell invasion into the adjacent tissue); pattern Y (less than five cancer cells were seen in the adjacent tissue); and pattern Z (more than five cancer cells invaded the adjacent tissue). The patients, based on these microscopic manifestations of metastatic patterns in the nodes, were divided into three groups: Group 1, patients with pattern X nodal metastases only; Group 2, patients with pattern Y and pattern (X + Y) nodal metastases; and Group 3, patients with pattern Z, pattern (X + Z), pattern (Y + Z), and pattern (X + Y + Z) nodal metastases. RESULTS: The survival rates and disease-free survival rates for patients with metastatic lymph nodes showing an extracapsular invasion pattern (Groups 2 and 3) were significantly worse than those for patients with metastatic nodes showing no extracapsular invasion pattern only (Group 1; P < 0.01). There was no significant difference for the above-cited survival rates among the groups classified according to the Dukes and TNM systems. CONCLUSIONS: It is the thesis of this article that the identification of extracapsular invasion of the metastatic lymph nodes can be taken as a useful prognostic sign in patients with resectable colorectal cancer. 相似文献
3.
Pelvic Exenteration and Sacral Resection for Locally Advanced Primary and Recurrent Rectal Cancer 总被引:15,自引:1,他引:14
PURPOSE: The only possibility of a surgical cure in patients with locally advanced primary or recurrent rectal cancer would be an extended resection such as pelvic exenteration and sacral resection. The aim of this study was to evaluate the safety, tolerability, and survival benefits of these procedures. METHODS: Between 1988 and 1999, 64 patients with locally advanced primary or recurrent rectal cancer underwent abdominoperineal resection, with sacral resection in 9 patients, anterior pelvic exenteration in 8 patients, total pelvic exenteration in 27 patients, and total pelvic exenteration with sacral resection in 20 patients. RESULTS: Rates of morbidity, reoperation, and mortality were 50, 4.5, and 0 percent in 22 patients with primary cancer, and 60, 2.4, and 2.4 percent in 42 patients with recurrent disease, respectively. Major complications, such as sepsis, intra-abdominal abscess, and enteric fistula caused one hospital death and reoperation in two patients. In 21 patients who underwent curative resection for primary cancer, the overall five-year survival rates were 74.1 percent for Dukes B and 47.4 percent for Dukes C, although the difference was not statistically significant. Thirty patients with recurrent cancer who underwent curative resection had significantly improved survival, with a five-year survival rate of 22.9 percent, compared with 12 patients who underwent palliative resection, resulting in a survival rate of 0 percent (P = 0.0065). CONCLUSIONS: Pelvic exenteration and sacral resection for primary or recurrent rectal cancer are tolerable procedures with a low mortality rate. Although they provide a survival benefit if curative resection is possible, the associated morbidity remains high and should be followed up closely. 相似文献
4.
Outcome of Total Pelvic Exenteration for Primary Rectal Cancer 总被引:7,自引:0,他引:7
Ike H Shimada H Yamaguchi S Ichikawa Y Fujii S Ohki S 《Diseases of the colon and rectum》2003,46(4):474-480
PURPOSE: This retrospective study identifies the clinicopathologic factors (age, gender, size of tumor, location, tumor stage, lymph node metastasis, histologic differentiation, and adjuvant therapies) that are useful in predicting long-term survival in patients undergoing total pelvic exenteration for advanced primary rectal cancer. METHODS: We reviewed the medical records of 71 patients with stage T3 or T4 primary rectal cancer who underwent a curative total pelvic exenteration. The effects of various clinical variables on long-term survival were analyzed. RESULTS: The postoperative mortality, hospital death, and morbidity rates were 1.4, 4.2, and 66.2 percent, respectively. The overall five-year survival rate after total pelvic exenteration was 54.1 percent. The five-year survival rate was 65.7 percent for patients with T3 lesions and 39 percent for patients with T4 lesions. A univariate analysis showed that postoperative survival was affected by age, tumor stage, and lymph node metastasis, while a multivariate analysis showed that age and lymph node metastasis were independent prognostic factors. CONCLUSION: Total pelvic exenteration may enable long-term survival in younger patients with stage T3 or T4 primary rectal cancer and little or no lymph node metastasis. 相似文献
5.
BACKGROUND/AIMS: Although total pelvic exenteration (TPE) may lead to local tumor control and improved quality of life in patients with locally advanced colorectal cancer, an adequate understanding of prognostic factors, indications and potential complications associated with these procedures is needed. METHODOLOGY: Records for 15 patients, who underwent TPE for colorectal adenocarcinoma at Oita Prefectural Hospital between January 1983 and November 2001, were reviewed, retrospectively. RESULTS: Ten (66.7%) had positive lymphatic involvement, seven (46.7%) had positive vascular involvement, and three (20%) had positive lymph node metastases. Bladder involvement histologically was evident in eight patients (53.3%). With regard to diagnostic assessment of bladder involvement using CT, the sensitivity and specificity were 83.3% and 60%, respectively. Six of 15 patients (40%) developed complications. Overall local recurrence was observed in 6 (40%) of the 15. The cumulative overall 5-year survival rate of the 15 patients in this study was 54.7%. In the univariate analysis, vascular involvement significantly influenced survival. CONCLUSIONS: TPE appears to be relatively safe and effective for treatment of locally advanced colorectal adenocarcinoma. Vascular involvement was recognized as the only reliable prognostic clinicopathological characteristic. 相似文献
6.
Sacral Resection for Recurrent Rectal Cancer: Analysis of Morbidity and Treatment Results 总被引:4,自引:0,他引:4
Melton GB Paty PB Boland PJ Healey JH Savatta SG Casas-Ganem JE Guillem JG Weiser MR Cohen AM Minsky BD Wong WD Temple LK 《Diseases of the colon and rectum》2006,49(8):1099-1107
Purpose Composite sacropelvic resection for locally advanced recurrent rectal cancer is a high-risk procedure that benefits select
patients. We reviewed our recent institutional experience to evaluate case selection, morbidity, and outcomes.
Methods Between 1987 and 2004, 29 patients underwent composite resection for recurrent locoregional rectal cancer (17 females; median
age, 60 years). Clinicopathologic indicators were evaluated as indicators of survival by log-rank test and Cox proportional
hazards model.
Results Of 29 total patients, 27 (93 percent) received radiotherapy with their previous surgery (n = 10; 34 percent) or before sacrectomy
(n = 17; 59 percent), and 12 (41 percent) received intraoperative therapy. Sacral resections were performed at S2/S3 (55 percent)
or S4/S5 (45 percent) using anterior (41 percent) or combined anterior-posterior approach (59 percent), with adherence to
(62 percent) or cortical invasion in (38 percent) the sacrum. A majority of those who had undergone previous abdominoperineal
resection had total exenteration (9/13), whereas most patients who had undergone a previous sphincter-preserving procedure
had abdominoperineal resection (12/16) and none had exenteration. Pedicle flaps (omental, 11; abdominal rectus, 7) often were
used. A median of five (range, 1–33) units of blood was given intraoperatively. Transfusions were associated with previous
abdominoperineal resection (P < 0.03), correlating strongly with postoperative morbidity (P < 0.02). There were 33 complications in 17 (59 percent) patients, most commonly perineal wound breakdown (9 (31 percent))
and pelvic abscess (5 (17 percent)). Median hospital stay was 18 (range, 7–56) days, significantly longer in patients with
previous abdominoperineal resection (P < 0.02) or postoperative morbidity (P < 0.03). The only postoperative death was from pelvic sepsis. Resection was complete (R0) in 18 patients (62 percent), with
microscopically positive margins (R1) in 10 (34 percent) and grossly positive margins (R2) in 1 (3 percent). Two-year and
five-year recurrence rates were 47 and 85 percent, respectively; disease-specific survival was 63 and 20 percent, respectively.
Less transfusion (P = 0.03), R0 resection (P = 0.005), lack of anterior organ involvement (P = 0.02), and absence of cortical bone invasion (P < 0.001) were associated with better survival on univariate analysis; original colorectal cancer stage was not.
Conclusions Sacrectomy for rectal cancer is a high-risk procedure that can achieve clear resection margins with low mortality in select
patients. This procedure has a low cure rate but may provide local disease control with acceptable morbidity.
Presented at the meeting of The American Society of Colon and Rectal Surgeons, Philadelphia, Pennsylvania, April 30 to May
5, 2005.
Reprints are not available. 相似文献
7.
Total pelvic exenteration for locally advanced rectal carcinoma 总被引:9,自引:0,他引:9
Dr. Shou Ye Liu M.D. Ya Nong Wang M.D. Wei Qi Zhu M.D. Wei Lie Gu M.D. Hong Fu M.D. 《Diseases of the colon and rectum》1994,37(2):172-174
Total pelvic exenteration was performed in 31 patients (30 males and 1 female) who had rectal cancers involving adjoining pelvic structures. Twenty-nine patients had primary tumors and two had recurrent diseases after previous abdominoperineal resection. Preoperative irradiation was used in nine patients with fixed tumors. When performing the surgical procedure, we also actively employed lateral node dissection to make the operation more radical. Three patients (one with primary tumor and two with recurrent) underwent the exenteration with partial sacrectomy because of the sacral involvement and they all died of local failure within 15 months. The overall 5-year survival rate was 52 percent for all patients and 56 percent for those who had primary tumors. The results suggest that total pelvic exenteration with lateral node dissection should be performed for locally advanced rectal cancer if the tumor is not completely fixed to the pelvic wall and preoperative irradiation should be used to convert a fixed tumor to a resectable one. 相似文献
8.
Weiser MR Landmann RG Wong WD Shia J Guillem JG Temple LK Minsky BD Cohen AM Paty PB 《Diseases of the colon and rectum》2005,48(6):1169-1175
PURPOSE This study examines surgical salvage of locally recurrent rectal cancer following transanal excision of early tumors.METHODS Through retrospective review of a colorectal database we identified 50 patients who underwent attempted surgical salvage for local recurrence following initial transanal excision of T1 or T2 rectal cancer. Eight patients had resectable synchronous distant disease. Clinicopathologic variables were associated with extent of surgery required for salvage and outcome.RESULTS Salvage procedures included abdominoperineal resection (31), low anterior resection (11), total pelvic exenteration (4), and transanal excision (3). One patient had unresectable disease at exploration, requiring diverting ostomy. Of the 49 patients who underwent successful salvage, 27 (55 percent) required an extended pelvic dissection with en bloc resection of one or more of the following structures: pelvic sidewall and autonomic nerves (18); coccyx or portion of sacrum (6); prostate (5); seminal vesicle (5); bladder (4); portion of the vagina (3); ureter (2); ovary (1); and uterus (1). Complete pathologic resection (R0) was accomplished in 47 of 49 patients. Of the eight patients with distant and local recurrence, two underwent synchronous resection and six had delayed metastasectomy. With a median follow-up of 33 months, 29 patients had recurred or died of disease at the time of this analysis. Five-year disease-specific survival was 53 percent. Factors predictive of survival included evidence of any mucosal recurrence on endoscopy, low presalvage carcinoembryonic antigen, and absence of poor pathologic features (lymphovascular and perineural invasion). Patients who required an extended pelvic resection had a worse survival rate.CONCLUSION Pelvic recurrence following transanal excision of early rectal cancer is often locally advanced, requiring an extended pelvic dissection with en bloc resection of adjacent pelvic organs to achieve salvage. The long-term outcome in patients undergoing resection is less than expected, considering the early stage of their initial disease. When contemplating local excision for early rectal cancer, the risk of local recurrence, the extent and morbidity of surgery required for salvage, and the modest cure rate following salvage should be considered.Read at the meeting of The American Society of Colon and Rectal Surgeons, Dallas, Texas, May 8 to 13, 2004.Reprints are not available. 相似文献
9.
Interpretation of Magnetic Resonance Imaging for Locally Advanced Rectal Carcinoma After Preoperative Chemoradiation Therapy 总被引:4,自引:0,他引:4
Kuo LJ Chern MC Tsou MH Liu MC Jian JJ Chen CM Chung YL Fang WT 《Diseases of the colon and rectum》2005,48(1):23-28
PURPOSE: Neoadjuvant concomitant chemoradiotherapy has been used in cases of locally advanced rectal cancer to preserve sphincter function, decrease local recurrence, and improve survival. Preoperative staging is essential for planning and providing optimal therapy. The purpose of this study is to determine the accuracy of staging with magnetic resonance imaging and to define any factors that interfere in interpretation of images obtained after preoperative chemoradiation therapy.METHODS: Thirty-six patients with biopsy-proven, locally advanced rectal cancer were treated with preoperative concomitant 5-fluorouracil-based chemotherapy and radiation, followed six to eight weeks later by radical surgery. Preoperative magnetic resonance images were reinterpreted by one radiologist and the results compared with histopathologic staging.RESULTS: T-level downstaging occurred in 10 of 36 patients (28 percent), and N-level downstaging occurred in 29 of 36 patients (80 percent) after completion of chemoradiation therapy. Pathologic complete remission after chemoradiotherapy occurred in five patients (12 percent). Of the 36 patients, 17 (47 percent) were overstaged and 2 (6 percent) were understaged in T-level, whereas 10 patients (28 percent) were overstaged and 3 patients (8 percent) were understaged in N-level. The accuracy of magnetic resonance imaging for determining depth of wall invasion was 47 percent, with 64 percent accuracy for nodal staging.CONCLUSIONS: Magnetic resonance imaging is commonly used in staging of pelvic malignancies because of its fine resolution, but chemoradiotherapy may decrease its accuracy. Thickening of the rectal wall after radiation by marked fibrosis, and peritumoral infiltration of inflammatory cells and vascular proliferation may contribute to overestimation of stage. By contrast, pathologic residual cancer beneath normal mural structure after chemoradiation therapy may result in understaging of rectal cancer.Presented at the Scientific Meeting of the Taiwan Surgical Association, Taipei, Taiwan, March 27 to 28, 2004. 相似文献
10.
Tumor Invasion of Lymph Node Capsules in Patients with Dukes C Colorectal Adenocarcinoma 总被引:2,自引:1,他引:1
Purpose The objective of this study was to investigate the correlation between the microscopic findings of positive lymph nodes, especially
focusing on capsular invasion, and the outcome after curative surgical resection of colorectal cancer.
Methods We analyzed 480 positive lymph nodes from 155 consecutive patients with Stage III colorectal cancer to determine the frequency
and significance of lymph node capsular invasion. Recurrence-free and cancer-specific survival rates were assessed in the
patients with and without lymph node capsular invasion.
Results Between April 1995 and December 2000, 406 consecutive patients with primary colorectal cancer underwent curative resection.
Regional lymph node metastases were present in 155 cases (38.2 percent). During the median follow-up period of 4.8 years,
41 patients (26.5 percent) developed recurrent disease and 28 patients died of cancer. Lymph node capsular invasion was detected
in one or more lymph nodes from 75 cases (48.3 percent). The five-year recurrence-free rate was 56.1 percent in this group,
whereas in the 80 patients without lymph node capsular invasion the rate was 88 percent (P<0.01). Features that were associated with recurrent disease were greater number of positive lymph nodes, venous invasion
in primary tumor, infiltrative growth pattern of intranodal tumor, and presence of lymph node capsular invasion. Multivariate
analysis identified lymph node capsular invasion as the only significant prognostic factor for recurrence. In multivariate
analysis with regard to survival, lymph node capsular invasion, venous invasion, and number of positive nodes remained as
significant prognostic factors.
Conclusions Lymph node capsular invasion, determined by routine hematoxylin-eosin staining, is a potent prognostic factor in Stage III
colorectal cancer.
Read in part at the meeting of The International Society of University Colon and Rectal Surgeons, Budapest, Hungary, June
9, 2004.
Reprints are not available. 相似文献
11.
Vitelli CE Crenca F Fortunato L Di Nardo A Farina M Mustacciuoli G 《Techniques in coloproctology》2003,7(3):159-163
Abstract.
Background:
We describe our experience with exenterative pelvic
surgery for colorectal cancer in a small community
hospital.
Methods:
We retrospectively evaluated 26 consecutive patients (14
women) with locally advanced (n=16) or recurrent (n=10)
colorectal adenocarcinomas who underwent pelvic exenterations
between August 1990 and December 2001 in our service.
Results:
Seventeen patients had posterior pelvic exenteration
(PPE), eight had total pelvic exenteration (TPE) and one had TPE
with internal hemipelvectomy. Major morbidity occurred in 12
patients (46%), causing 3 deaths (11%) in the immediate
postoperative period. Fourteen of 23 patients who survived the
immediate postoperative period have relapsed (61%). At a median
follow-up of 42 months, the 5-year survival is 38%.
Conclusion:
Pelvic exenterative procedures can be offered to patients
with bulky or recurrent colorectal carcinomas with adequate
results and satisfactory palliation, even in a community
setting.Presented in part at the 25th Meeting of the Italian
Surgical Oncology Society, September 2001. 相似文献
12.
Multivisceral resections for primary advanced rectal cancer 总被引:5,自引:1,他引:4
Sökmen S Terzi C Unek T Alanyali H Füzün M 《International journal of colorectal disease》1999,14(6):282-285
Fixation of the locally advanced rectal tumor at the time of operation is an important prognostic variable. It may be difficult
to determine whether fixation is caused by inflammatory adhesions or by direct tumor extension tethering the tumor to the
surrounding pelvic structures. Extended en bloc removal of the locally advanced rectal cancer with involved adjacent organ(s)
increases the resectability rate. We examined the perioperative mortality and morbidity and the prognosis of patients undergoing
multivisceral resections for advanced primary rectal cancers. Of 83 patients with rectal cancers 20 (24%) had locally advanced
tumors. Cases were divided into Gunderson-Sosin stages B3 and C3 and were further stratified into those with histologically confirmed carcinomatous invasion of the adjacent organ and those
with inflammatory adhesions. Perioperative mortality was 5%. Only five patients (24%) showed histopathological confirmation
of carcinomatous adhesion into adjacent organ(s)/structure(s). Histological confirmation of contiguous tumor spread was higher
in C3 patients. There was no significant difference between patients with positive and negative histopathological confirmation
of malignant spread in terms of survival rates. Multivisceral resections can be performed safely for locally advanced rectal
cancers with acceptable mortality and morbidity rates. The presence of local tumor extension does not mean incurability, and
sound surgical judgement should dictate that in the face of a tethered lesion one must extend the surgical intervention radically
to resect any tumor en bloc.
Accepted: 13 October 1999 相似文献
13.
Dr. Jin-ichi Hida M.D. Masayuki Yasutomi M.D. Takamasa Maruyama M.D. Kiyoshige Fujimoto M.D. Akihiro Nakajima M.D. Toshihiro Uchida M.D. Tsukasa Wakano M.D. Tadao Tokoro M.D. Ryuichi Kubo M.D. Katsuhisa Shindo M.D. 《Diseases of the colon and rectum》1998,41(8):984-987
PURPOSE: In surgery for rectal cancer, it is unclear whether the inferior mesenteric artery should be ligated at a high or low position. The study contained herein was undertaken to clarify the indications for high ligation of the inferior mesenteric artery. METHODS: Subjects included 198 patients with rectal cancer who underwent resection with high ligation of the inferior mesenteric artery. Nodal metastases were examined by the clearing method. RESULTS: The incidence of metastases to the lymph nodes surrounding the origin of the inferior mesenteric artery (root nodes) was 8.6 percent. Inferior mesenteric artery root nodal metastases occurred more frequently with pT3 and pT4 cancer. The five-year survival rate in patients with inferior mesenteric artery root nodal metastases was 38.5 percent; this rate was significantly lower than in those without inferior mesenteric artery root nodal metastases (73.4 percent). CONCLUSIONS: Although the five-year survival rate in patients with inferior mesenteric artery root nodal metastases was lower than in those without metastases, inferior mesenteric artery root nodal dissection should be performed after high ligation of the inferior mesenteric artery for patients with pT3 and pT4 cancers. 相似文献
14.
Intraoperative pelvic brachytherapy for treatment of locally advanced or recurrent colorectal cancer
R. S. Turley B. G. Czito J. C. Haney D. S. Tyler C. R. Mantyh J. Migaly 《Techniques in coloproctology》2013,17(1):95-100
Background
The aim of this study was to evaluate the efficacy and morbidity of intraoperative radiation therapy (IORT) for advanced colorectal cancer.Methods
All patients undergoing IORT for locally advanced rectal cancer from 2001–2009 were reviewed for cancer recurrence, survival, and procedure-related morbidity. Cumulative event rates were estimated using the method of Kaplan and Meier.Results
Twenty-nine patients with locally advanced (n = 8) or recurrent (n = 21) rectal cancers were treated with IORT and resection. Surgical interventions included low anterior resection, abdominoperineal resection, pelvic exenteration, and a variety of non-anatomic resections of pelvic recurrences. R0 resections were achieved in 16 patients, while R1 resections were achieved in 10, and margins were grossly positive in 3 patients. IORT was delivered to all patients over a median area of 48 (42–72) cm2 at a median dose of 12 (12–15) Gy. Local and overall recurrence rates were 24 % (locally advanced group) and 45 % (recurrent group). Median disease-free and overall survival were 25 and 40 months respectively at a median follow-up of 26 (18–42) months. The short-term (≤30 days) complication rate was 45 %. Eight patients developed local wound complications, 5 of which required operative intervention. Four patients developed intra-abdominal abscesses requiring drainage. Long-term (>30 days) complications were identified in 11 patients (38 %) and included long-term wound complications (n = 3), ureteral obstruction requiring stenting (n = 1), neurogenic bladder (n = 3), enteric fistulae (n = 2), small bowel obstruction (n = 1), and neuropathic pain (n = 1).Conclusions
Intraoperative brachytherapy is a viable IORT option during pelvic surgery for locally advanced or recurrent colorectal cancer but is associated with high postoperative morbidity. Whether intraoperative brachytherapy can improve local recurrence rates for locally advanced or recurrent colorectal cancer will require further prospective investigation. 相似文献15.
16.
BACKGROUND/AIMS: Local recurrence occurs in 10 to 30% of patients with rectal cancer following curative resection. However treatment of choice remains controversial. We assessed the results of total pelvic exenteration for locally recurrent cancer of the rectum retrospectively. METHODOLOGY: We reviewed medical charts of 45 patients with rectal cancer who underwent curative total pelvic exenteration for local recurrence. The cause of recurrence was classified into four groups: anastomotic, surgical cut-end, implantation, and lymphatic based on pathologic findings and computed tomography. Long-term survival was correlated with clinicopathologic variables. RESULTS: Postoperative morbidity was 77.8% and in-hospital death occurred in 13.3% of patients. The overall 5-year survival rate was 14.1%. The 5-year survival rates stratified according to the expectation of curability were 31.6% for absolutely curative resection, 7.8% for relatively curative resection, and 0% for non-curative resection. Multivariate analysis revealed that the disease-free interval was the only independent prognostic factor. There was no benefit from perioperative radiation or intraoperative continuous pelvic peritoneal perfusion of the pelvis. CONCLUSIONS: Total pelvic exenteration for local recurrence of rectal cancer can achieve long-term survival when curative resection is possible and the disease-free interval is long. 相似文献
17.
Extensive surgery after high-dose preoperative chemoradiotherapy for locally advanced recurrent rectal cancer 总被引:25,自引:3,他引:25
Rödel C Grabenbauer GG Matzel KE Schick C Fietkau R Papadopoulos T Martus P Hohenberger W Sauer R 《Diseases of the colon and rectum》2000,43(3):312-319
PURPOSE: This was a pilot study of high-dose preoperative concurrent radiation and chemotherapy before extensive surgery in patients with locally advanced recurrent rectal cancer. Here we report on curative resectability, acute toxicities during chemoradiotherapy, surgical complications, local control, and three-year survival rates achieved with this aggressive multimodal regimen. METHODS: Between 1994 and 1997, 35 previously nonirradiated patients with pelvic recurrence of rectal cancer were entered in the study. All patients presented with tumor contiguous or adherent to adjacent pelvic organs and were not deemed amenable to primary curative surgery. A total radiation dose of 50.4 Gy with a small-volume boost of 5.4 to 9 Gy was delivered in conventional fractionation (single dose, 1.8 Gy). 5-Fluorouracil was scheduled as a continuous infusion of 1,000 mg/m2/day on Days 1 to 5 and 29 to 33. Six weeks after completion of chemoradiotherapy, patients were reassessed for resectability, and radical surgery was attempted whenever feasible. RESULTS: After preoperative chemoradiotherapy 28 of 35 patients (80 percent) underwent resection with curative intent. In 16 of 35 patients (57 percent) extended resection of adjacent organs was performed. Resections with negative margins were achieved in 17 patients (61 percent); 9 patients had microscopic, and 2 patients had gross residual disease. There was no postoperative mortality. Fourteen patients (44 percent) experienced postoperative complications. Toxicity from chemoradiotherapy occurred mainly as diarrhea (National Cancer Institute Common Toxicity Criteria Grade 3; 23 percent), dermatitis (Grade 3; 11 percent), and leucopenia (Grade 3; 11 percent). One patient died of tumortoxic multiple organ failure during chemoradiotherapy. With a median follow-up of 27 months, local re-recurrence after curative resection was observed in only three patients (18 percent); six patients developed distant metastases. Three-year actuarial survival rate was significantly improved after complete resection (82 percent) as compared with noncurative surgery (38 percent;P=0.03). CONCLUSION: A combination of high-dose preoperative chemoradiotherapy followed by extended surgery can achieve clear resection margins in more than 60 percent of patients with recurrent rectal tumor not amenable to primary surgery. An encouraging trend evolved for this multimodal treatment to improve long-term local control and survival rate.Presented at the meeting of the German Society for Radiation Oncology, Radiation Biology and Medical Physics (DEGRO), Nürnberg, Germany, November 7 to 10, 1998. 相似文献
18.
Figueras J Torras J Valls C Llado L Ramos E Marti-Ragué J Serrano T Fabregat J 《Diseases of the colon and rectum》2007,50(4):478-488
PURPOSE: This study was designed to investigate survival after curative resection of colorectal liver metastases in patients with expanded indications. METHODS: A total of 501 patients had 545 liver resections for metastatic colorectal cancer. There were no predefined criteria for resectability with regard to the number or size of the tumors, locoregional invasion, or extrahepatic disease, except that resection had potential to be complete and macroscopically curative. All patients who had curative hepatic resection were advised to start postoperative adjuvant chemotherapy. RESULTS: A total of 259 patients had expanded indications (52 percent), including 14 with liver metastases >10 cm, 194 with bilateral deposits, 140 with four or more liver metastases, and 73 with extrahepatic disease. The overall actuarial survival rates at one, three, five, and ten years were 88, 67, 45, and 36 percent, respectively, for patients with classic indications and 84, 53, 34, and 24 percent, respectively, for patients with expanded indications (P = 0.0009). In the group of expanded indications, there were more patients who received preoperative than postoperative chemotherapy: 72 (28 percent) vs. 18 (7 percent; P < 0.0001), and 148 (70 percent) vs. 131 (61 percent; P = 0.0466). In a multivariate analysis, four or more liver metastases and extrahepatic disease were independent predictors of poor outcome. Adjuvant chemotherapy significantly improved survival (P = 0.0002). CONCLUSIONS: This study suggested that liver resection should be indicated in patients with expanded indications. The extent of the benefits of preoperative and postoperative chemotherapy needs to be quantitated. 相似文献
19.
Psathakis D Schiedeck TH Krug F Oevermann E Kujath P Bruch HP 《Diseases of the colon and rectum》1999,42(12):1618-1625
PURPOSE: This study contributes to the characterization of primary colorectal signet-ring cell cancer in contrast to ordinary colorectal carcinoma. Primary colorectal signet-ring cell cancer is a rare but distinctive primary neoplasm of the large bowel with still-controversial clinicopathologic features. METHODS: Clinicopathologic features and survival data are evaluated in comparison with those of the ordinary colorectal adenocarcinoma (non-signet colorectal carcinoma) in a retrospective study matched for age, gender, grade, and stage. RESULTS: In a series of 1,600 consecutive colorectal cancer patients since 1979, 14 patients (0.88 percent) with a signet-ring cell cancer were identified. Gender ratio was balanced, and mean age was 67.5 years. The majority of patients had an advanced tumor stage at the time of diagnosis (57.1 percent Stage IV and 35.7 percent Stage III). Median survival time was only 16 months. In a study matched for age, gender, grade, and stage, a lower survival rate was found for patients with signet-ring cell cancer, but the difference did not reach statistical significance. In contrast to non-signet colorectal carcinoma, signet-ring cell cancer was characterized by a significantly higher incidence of peritoneal tumor spread (64.3 percent) and a lower incidence of hepatic metastases (14.3 percent). CONCLUSIONS: Signet-ring cell cancer represents a rare but distinctive primary neoplasm of the large bowel. It is frequently diagnosed in an advanced tumor stage, thus showing an overall poorer prognosis than nonsignet colorectal carcinoma. Usually only palliative surgery is possible. A high incidence of peritoneal seeding and a low incidence of hepatic metastasis is characteristic of signet-ring cell cancer. 相似文献
20.
BACKGROUND AND PURPOSE: In Japan, the incidence of colorectal cancer has increased remarkably since World War II, and interest in this cancer has grown rapidly among Japanese clinicians and pathologists. As a result, the Japanese Society for Cancer of the Colon and Rectum started a multi-institutional registry of colorectal cancer in 1980. The purpose of this report is to present an overview of the actual state of surgical and pathologic aspects of colorectal cancer treated in the leading hospitals in Japan. MATERIALS AND METHODS: Registry files of clinical and pathologic findings for 38,369 patients treated between 1974 and 1986 with five-year follow-up information and 26,360 patients treated between 1991 and 1994 with no follow-up information were reviewed. RESULTS: Numbers of registered patients have increased annually, reflecting a trend toward an increasing incidence of this cancer in Japan. Colon cancer increased more than rectal cancer in both genders. Resection of the primary lesion was achieved in more than 97 percent of patients who underwent surgical operation recently. The curative resection rate has improved from 65.1 to 79.1 percent for colon cancer and from 71.4 to 80.4 percent for rectal cancer between the 1974 and 1979 and the 1991 and 1994 periods, and operative mortality of those has decreased from 1.8 and 2 percent to 0.5 and 0.5 percent, respectively. There was a trend toward a decrease in locally advanced cancer in terms of cancer invasion into the bowel wall. Stage IV colon cancer also decreased from 22.9 to 16.6 percent with time. The five-year survival rate of each pTNM stage has gradually been improving and was especially evident for patients with Stages I, II, and III of rectal cancer. Overall five-year survival rates for colorectal cancer patients currently exceeds 60 percent. CONCLUSION: The overall incidence of colorectal cancer and the ratio of colon cancer to rectal cancer patients in Japan are increasing. Results of surgical treatment are satisfactory with respect to curative resection rate, operative mortality, and the five-year survival rate. Registry data of the Japanese Society for Cancer of the Colon and Rectum are useful for reporting the actual state of diagnosis, treatment, and end results of colorectal cancer in Japan. 相似文献