药物雾化治疗疱疹性口炎的临床研究

目的:观察超声雾化吸入治疗疱疹性口炎的临床疗效。方法:86例疱疹性口炎患者随机分为两组,雾化组46例采用地塞米松、病毒唑、庆大霉素、靡蛋白酶超声雾化吸入治疗;对照组40例采用洗必泰及西瓜霜喷剂一般对症处理。结果:雾化组溃疡、充血、疼痛改善值均大于对照组;平均病程(5.01±1.27)d,明显短于对照组,总有效率91.31%,与对照组相比有显著性差异(P<0.05)。结论:药物超声雾化吸入治疗疱疹性口炎能明显改善症状、减轻病人痛苦并能缩短疗程且无明显不良反应,是治疗疱疹性口炎的较好方法。     

超声雾化吸入治疗小儿疱疹性龈口炎临床观察

目的：观察超声雾化吸入治疗小儿疱疹性龈口炎的临床效果。方法：146例疱疹性龈口炎忠儿，治疗组77例采用常规治疗（抗病毒口服液及抗生素口服）＋超声雾化吸入，对照组69例采用常规治疗，不进行超声雾化吸入，观察临床疗效。结果：治疗组有效率为93．5％，对照组为71．3％，两组之间比较有显著性差异（P〈0．01）。结论：超声雾化吸入治疗小儿疱疹性龈口炎疗程短，见效快，无副作用。     

干扰素雾化治疗疱疹性口炎疗效观察

疱疹性口炎是因感染Ⅰ型单纯疱疹病毒所致的口腔粘膜、咽喉、口腔周围与颜面部皮肤的疱疹。多见于6岁以下儿童，尤其是6个月～2岁的要幼儿，起病急、易传染。近年来，笔者采用干扰素雾化给药法治疗200例疱疹性口炎取得较好的疗效。     

口含型干扰素治疗疱疹性口炎初步探讨

口含型干扰素治疗疱疹性口炎初步探讨广州市儿童医院（５１０１２０）邓利琴裴霞常汝虚疱疹性口炎是因感染Ｉ型单纯疱疹病毒所致的口腔粘膜病。近来我们采用口含型干扰素糖丸治疗７０例疱疹性口炎，取得较理想疗效。现报告如下。材料和方法１．观察对象，１９９６年６月至...     

����ҽ�������Ӥ�׶������Կ��׵��ٴ��о�

目的    观察中西医结合治疗婴幼儿疱疹性口炎的临床疗效。方法    对2006年1月至2009年6月北京市海淀区中医医院口腔科门诊收治的48例婴幼儿疱疹性口炎患者,随机分为治疗组和对照组,对照组予以阿昔洛韦联合过氧化氢（H2O2）液湿敷黏膜,治疗组在对照组基础上,加用中药制剂睡前湿敷黏膜。观察两组的发热持续时间及溃疡愈合情况,并计算治疗有效率。结果    （1） 治疗组有效率（91.67％）明显高于对照组（62.50%）, 差异有统计学意义 （P < 0.05）。（2）治疗组的发热持续时间［（2.25±0.69）d］和溃疡愈合时间［（3.3l±1.66）d］均较对照组［（3.38±1.50）d和（4.18±0.67）d］明显缩短,差异均有统计学意义 （P < 0.05）。结论    中西医结合治疗小儿婴幼儿疱疹性口炎疗效显著,值得临床推广使用。     

用α和γ干扰素软膏治疗小儿疱疹性口炎

干扰素不仅有抗病毒作用,而且有免疫调节作用。根据抗原特异性分为α、β和γ干扰素。作者研究α和γ干扰素软膏治疗小儿疱疹性口炎的临床效果,根据唾液分泌型IgA含量评定局部免疫。资料和方法治疗急性疱疹性口炎129例,患儿1～5岁;复发性疱疹性口炎加重期49例,患儿4～12岁。治疗用软膏每g含α或γ干扰素2×10~4IU,苯佐卡因0.1;加维尼林胶10g。先清洁口腔和牙齿,用胰蛋白酶、糜蛋白酶清除病变区坏死物,然后在患处均匀地涂布软膏。     

吴茱萸治疗疱疹性口炎54例临床观察

疱疹性口炎多见于婴幼儿。自1980年10月至1988年10月笔者用陈醋调吴茱萸粉贴敷两足的涌泉穴治疗婴幼儿的疱疹性口炎54例收到了良好效果,现报告如下: 1 药物使用方法 将吴茱萸研成细粉,取5g用陈醋调成糊状,平均分开两份,贴敷于患儿两足的涌泉穴,用塑料纸和     

简摘

治疗中度复发性疱疹性口炎152例,大多数发病时体温升高,颌下淋巴结发炎,部分患者关节痛。口腔粘膜、唇和唇红缘糜烂并常伴有面部皮肤疱疹。经细胞学检查确诊。随机分3组,第1组51例,局部用1％苯佐卡因乳剂治疗。第2组50例,用人白细胞干扰素软膏(活性20 000IU/g)。第3组51例,用商品抗病毒药0.5％Oxolin软膏。     

加味导赤白虎汤治疗口腔单纯疱疹的初步研究

对口腔单纯疱疹原发性疱疹性口炎和复发性疱疹性口炎病人191例进行了研究,随机选取47例为对照组。治疗组144例服用加味导赤白虎汤冲剂治疗。对照组中,22例使用各种抗生素,25例服用银柴冲剂。结果显示治疗组疗效明显优于抗生素组和银柴冲剂组,且治疗组未出现任何毒副反应。将加味导赤白虎汤冲剂,在体外作组织培养内的抗病毒实验,证明该冲剂在稀释成1∶10至1∶320的浓度内对腺病毒7型有灭活作用,而对原代人胚肾细胞无毒害性。推论该冲剂对单纯疤疹病毒可能有抑制作用。     

利巴韦林治疗疱疹性口炎44例疗效观察

疱疹性口炎是儿童常见病，是由病毒引起的粘膜损害。我们应用利巴韦林（ＲＩＢＡＶＩＲＩＮ）治疗儿童疱疹性口炎４４例，经临观察，取得较满意的效果，现报告如下。临床资料１病例选则：患儿分两组：治疗组４４例，男２５例，女１９例；对照组３８例，男２３例，女１５例...     

The use of the ultrasonic spraying of interferon and larifan solutions for treating acute herpetic stomatitis in children]

Ultrasonic spraying of drug solutions was used in the treatment of 100 children suffering from acute herpetic stomatitis and its efficacy compared to that of common spraying of drugs in 100 children of the reference group. The results evidence that ultrasonic spraying accelerates cure by 2-3 days and is drug-saving. Interferon was found to be the most effective drug for acute herpetic stomatitis; larifan, used for the first time in the treatment of this condition, was inferior to it, though still effective enough.     

Effectiveness of microwave disinfection of complete dentures on the treatment of Candida-related denture stomatitis

The effectiveness of microwave disinfection of maxillary complete dentures on the treatment of Candida-related denture stomatitis was evaluated. Patients (n = 60) were randomly assigned to one of four treatment groups of 15 subjects each; Control group: patients performed the routine denture care; Mw group: patients had their upper denture microwaved (650 W per 6 min) three times per week for 30 days; group MwMz: patients received the treatment of Mw group in conjunction with topical application of miconazole three times per day for 30 days; group Mz: patients received the antifungal therapy of group MwMz. Cytological smears and mycological cultures were taken from the dentures and the palates of all patients before treatment at day 15 and 30 of treatment and at follow-up (days 60 and 90). The effectiveness of the treatments was evaluated by Kruskal-Wallis and Mann-Whitney tests. Microbial and clinical analysis of the control group demonstrated no significant decrease in the candidal infection over the clinical trial. Smears and cultures of palates and dentures of the groups Mw and MwMz exhibited absence of Candida at day 15 and 30 of treatment. On day 60 and 90, few mycelial forms were observed on 11 denture smears (36.6%) from groups Mw and MwMz, but not on the palatal smears. Miconazole (group Mz) neither caused significant reduction of palatal inflammation nor eradicated Candida from the dentures and palates. Microwaving dentures was effective for the treatment of denture stomatitis. The recurrence of Candida on microwaved dentures at follow-up was dramatically reduced.     

中药治疗婴幼儿疱疹性龈口炎的临床疗效观察

目的探讨中药方剂对婴幼儿疱疹性龈口炎的治疗效果,以期找到减少患者病痛的最佳治疗方案。方法收集婴幼儿疱疹性龈口炎60例,年龄6～24个月,随机分为中医治疗组和西医治疗组,各30例。中医治疗组用新的中药方剂进行治疗;西医治疗组用病毒唑注射和龙胆紫局部涂搽治疗,有感染者给予青霉素静脉注射。所有患者行血常规检查。比较新中药方剂与常规方法在疗效上的差异。结果中药治疗组的有效率为93.3%(28/30),高于西医治疗组66.7%(20/30),差异有统计学意义(P<0.05);中药治疗组的发热持续时间和溃疡愈合时间分别为(2.80±0.72)d和(3.00±0.96)d,较西医治疗组的发热持续时间(4.54±1.06)d和溃疡愈合时间(4.57±1.16)d,均明显缩短,且差异有统计学意义(P<0.05)。结论新的中药方剂能有效控制婴幼儿疱疹性龈口炎的症状并缩短病程。     

局部含漱治疗患糖尿病老年人义齿性口炎的疗效观察

目的：探讨仅局部应用含漱液治疗老年Ⅱ型糖尿病患者义齿性口炎的疗效。方法：将63例患有义齿性口炎的老年糖尿患者根据糖尿病控制情况分成控制较好组（31例）和控制不良组（32例）及无全身系统性疾病的义齿性口炎患者组成的对照组（20例）,3组均采取局部使用0.1%西吡氯铵含漱液和5%碳酸氢钠溶液交替含漱的治疗方法,对临床疗效进行观察比较。结果：控制较好组临床有效率（90.32%）明显高于控制不良组（50%）,稍低于对照组（95%）,P〈0.01。结论：老年Ⅱ型糖尿病患者义齿性口炎使用局部含漱液治疗完全可以控制病情,此外还需控制好血糖,保持口腔和义齿清洁,才能达到治愈的目的。     

金因肽对过敏性口炎的临床疗效观察

目的　观察金因肽对过敏性口炎的临床疗效。方法　选择 2 0例过敏性口炎患者 ,随机分成两组 ,治疗组用金因肽溶液喷洒损害区 ,对照组喷洒安慰剂 ,将疗效进行对比研究。结果　治疗组平均愈合时间为 3d ,而对照组为 5 .5d ,治疗组的有效率 (60 % )显著高于对照组 (10 % ) (P <0 .0 5 ) ,治疗组的总有效率 (10 0 % )亦显著高于对照组 (60 % ) (P <0 .0 5 )。结论　金因肽能快速促进过敏性口炎、溃疡类病损的愈合     

Comparison of different treatment methods for localized and generalized simple denture stomatitis

SUMMARY The purpose of this study was to compare the treatment effects of fluconazole, fluconazole plus chlorhexidine and the fitting of new dentures upon the treatment of denture stomatitis and 15 subjects with clinical evidence of localized simple denture stomatitis were investigated clinically and mycologically. Patients with clinical evidence of generalized simple denture stomatitis were divided into three treatment groups. The first group was given 50 mg of fluconazole tablets daily for 2 weeks. The second group were instructed to apply chlorhexidine solution to the inner surface of the denture twice a day in addition to fluconazole treatment for 2 weeks. New dentures were constructed for the third group. Patients with clinical evidence of localized simple denture stomatitis were fitted new dentures without antifungal therapy. Palatal swabs were taken from each subject before, immediately after, and 2 weeks after the end of treatment, and the samples were examined mycologically in order to identify yeast colonies. It was found that for generalized simple denture stomatitis, treatment with fluconazole plus chlorhexidine resulted in better improvement of palatal inflammation than that by either fluconazole or the fitting of new dentures without medication. Whereas fitting new dentures did not reduce inflammation in patients with generalized simple denture stomatitis, the beneficial effects of prosthetic treatment were seen in patients with localized simple denture stomatitis.     

Use of an immunoglobulin with targeted action for the prevention and treatment of recurrent herpetic stomatitis in children

The results of parenteral (2 to 3 injections of 1.5 to 3 ml once on 3-rd to 4-th day) application of the prepared immunoglobulin with the titer of antiherpetic antibodies of 1:512 to 1:1024 in combined treatment of 2 groups of patients are summarized. In 34 children aged 2 to 12 years recurrent herpetic stomatitis was at its exacerbation. In 27 patients aged 1 to 3 an acute (primary) herpetic stomatitis was present and the group was considered, on grounds of the originally designed prognostic system, as being at high risk of transition into the chronic frequently exacerbating form of the disease. Positive immediate anti-recidive and preventive effect was obtained and confirmed in 12 to 24 months' follow-up.     

Changes of the immune status of children with relapsing herpetic stomatitis, suffering from allergic diseases, during licopide treatment

The efficiency of licopide in combination with traditional treatment was evaluated in 59 children aged 1-14 years suffering from allergic diseases and relapsing herpetic stomatitis. Immunological studies were carried out before and after a course of therapy: local oral immunity, cellular immunity (in the blast transformation test with phytohemagglutinin), lymphocyte populations and subpopulations, humoral immunity values (IgA, IgM, IgG, and IgE), and C3 complement component were evaluated. The results indicate that licopide in complex with traditional methods normalized the immunological values, had a favorable impact on the course of relapsing herpetic stomatitis, and led to a stable remission of allergic diseases (p<0.001).