窦性组织细胞增生性巨淋巴结病一例分析

窦性组织细胞增生性巨淋巴结病(sinushistiocytosiswith massivelymphadenopathy,SHML),是一种罕见疾病,临床上易被误诊,结合我院收治的一例患者,对该病的诊疗作一回顾。1病例报告患者女,45岁。1999年3月无明显诱因出现左腋下肿块,约“鹅蛋”大小,压痛,继之左乳肿痛,伴间断发热     

Castleman病2例报告及文献复习

Castleman病（Castleman’s disease，CD）为淋巴结非典型增生性疾病，首先由Castleman在1956年总结报告该类病例而被命名。其临床表现具有很大的异质性，一般根据病变累及部位分为局灶型和多中心型。多中心型CD可合并多个系统损害，造成诊断的困难，现就我科近期诊治的2例多中心型CD病例，结合文献对其临床特点和治疗进展报告如下。     

Rosai-Dorfman病一例及文献分析

目的探讨Rosai-Dorfman病（RDD）的临床表现、诊断、组织特征及治疗。方法研究RDD1例,结合文献回顾分析。结果RDD1例,病理见大量淋巴细胞、浆细胞及组织细胞,并有吞噬淋巴细胞现象,免疫组化S-100强阳性。本病临床表现多样,易误诊。结论RDD是良性的组织细胞增生性疾病,预后主要取决于患者的免疫功能状态、淋巴结受累数目及结外器官受累部位,诊断主要依靠病理及免疫组化,治疗上以综合治疗为主,治疗后应随访。     

特发性窦性组织细胞增生性巨淋巴结一例报告

特发性窦性组织细胞增生性巨淋巴结一例报告贾平主治医师周婕空军兰州医院首钢总医院病理科（７３００７０）患者男性，１６岁，因发现双侧腹股沟肿物一年，于１９９３年８月就诊。体检一般情况好，右腹股沟可触及约６×４×３ｃｍ肿块，表现尚光滑、质较硬，可轻度活动。...     

无淋巴结肿大的皮肤Rosai Dorfman病1例及文献复习

Rosai Dorfman 病( RDD ), 又称窦组织细胞增生伴巨大淋巴结病, 临床少见, 易与淋巴系统和皮肤肿瘤混淆。本病可有多种表现形式, 但淋巴结病是其基本特点。     

窦组织细胞增生伴巨大淋巴结病2例及文献复习

 窦组织细胞增生伴巨大淋巴结病(sinus histiocytosis with massive lymphadenopathy，SHML)是一种罕见的淋巴组织增生性病变。由Rosai和Dorfman于1969年首先报道及研究，国内仅见零星报道。现报道2例，并结合文献着重讨论其临床病理特征及鉴别诊断。     

巨大胰岛素瘤1例报告并文献复习

胰岛素瘤在临床中少见,它由产生胰岛素的β细胞组成,分泌大量胰岛素使血胰岛素浓度升高,引起低血糖,出现低血糖症候群。１９９８年１月我们收治１例位于胰头处的巨大胰岛素瘤,经手术治疗,治愈出院。现结合文献分析如下。１病例介绍患者,男,２３岁,住院号９９７８...     

Castleman病1例报道并文献复习

目的 了解Castleman病(CD)的病理学特点、临床表现及治疗方法，为其准确诊断和有效治疗提供依据。方法 报告1例多中心性CD患者，并复习相关文献加以分析和讨论。结果 该患者诊断为多中心性Castleman病，透明血管型，曾误诊为恶性淋巴瘤，行2次手术均复发。进行COP方案化疗2周期，肿大淋巴结明显缩小，体温正常。结论 Castleman病需依靠病理学诊断确诊，多中心性CD的治疗以综合治疗为主。     

Sinus histiocytosis mimicking metastatic melanoma in lymph nodes of a patient with a large joint prosthesis: Case report and review of the literature

Malignant melanoma metastases to regional lymph nodes may be mimicked by several non-neoplastic processes, including sinus histiocytosis induced by fragments shed from joint prostheses. A patient who had an elective lymph node dissection for malignant melanoma and was found to have “post-prosthesis lymph node histiocytosis” resembling metastatic disease is described. Knowledge of the patient's past history of a total shoulder joint replacement along with the use of polarized light microscopy to identify birefringent particles of prosthetic debris allows for an accurate histologic diagnosis. © 1995 Wiley-Liss, Inc.     

Castleman's disease in the left upper retroperitoneal space mimicking an adrenal neoplasm: report of a case and literature review

Castleman's disease is a rare disorder characterized by benign proliferation of lymphoid tissue. Most cases occur as a mediastinal mass, although extrathoracic involvement including nodal and extranodal locations has been reported. The left suprarenal location of this localized disease may be mistaken for an adrenal tumor. We report a case of a 51-year-old woman with a Castleman's tumor located superomedial to the upper pole of the left kidney that mimicked an adrenal neoplasm.     

疑似肾盂癌合并castleman病1例并文献复习

目的:提高对Castleman病(Castleman’s disease,CD)累及肾脏的临床特征认识。方法:结合1例疑似肾盂癌合并Castleman病临床资料进行文献复习。结果:患者,女,70岁,因发热4天住院,入院诊断:左肾盂占位。行手术治疗,术后确诊Castleman病。结论:Castleman病引起肾脏损害较少见,且临床表现不典型,如遇此种类似病例尽早行肿大淋巴结活检,以期尽早帮助明确诊断。     

Castleman病转化为霍奇金淋巴瘤一例并文献复习

 目的　分析Castleman病的病因及发病机制、临床及病理特点、诊断、治疗及预后。方法　对1例Castleman病转化为霍奇金淋巴瘤的病例进行分析并进行文献综述。结果　Castleman病是一种以滤泡增生和毛细血管增生为组织学特征的淋巴结良性增生性疾病。根据病理学特点分为透明血管（HV）型、浆细胞（PV）型及兼有两者特点的混合细胞型。其临床表现复杂多变,除淋巴结肿大外尚可有全身表现及多系统受累症状,早期确诊主要靠组织病理学诊断,病理类型不同预后也不同,局灶型（LCD）患者预后良好,可能长期带病生存,多中心型（MCD）具有侵袭性,预后差。结论　Castleman病不同的病理类型其临床表现及预后也不同。     

头皮血管内皮细胞瘤一例报告及文献复习

为了探讨头皮血管内皮细胞瘤的发病机制及综合治疗,分析1例头皮血管内皮细胞瘤患者的临床表现及治疗并回顾分析相关文献。患者接受了病变扩大切除手术治疗,术后给予放化疗。3个月后局部复发,14个月后死于肺转移。复习82例头皮血管内皮细胞瘤患者临床资料,75.6%的患者进行了手术治疗,其中48.8%的患者进行了术后化疗/放疗,26.8%的患者只进行了手术切除。初步研究结果提示,头皮血管内皮细胞瘤是一种少见的、具有侵袭性生长的恶性病变,其最适治疗方法为手术切除加广泛的放疗,但局部复发及远处再发的可能性较高。化疗可能起到短期缓解的作用。     

肾上腺皮质癌1例报道并文献回顾

目的:探讨肾上腺皮质癌的临床表现、诊断及治疗方法。方法:报道我科近期收治的1例肾上腺皮质癌患者的临床资料,并检索中国知网、PubMed等数据库,进行文献回顾,对该病的临床特征及诊断要点、治疗方法及最新的研究进展进行归纳总结。结果:本例患者以腹痛为首发临床表现,影像学提示肾上腺肿瘤,行腹腔镜切除,术后20天查PET/CT提示多发转移,给予依托泊苷+顺铂化疗4周期后进展,遂应用吉西他滨联合卡培他滨化疗1周期,出现脑转移后行放疗。结论:肾上腺皮质癌是一种罕见的泌尿系恶性肿瘤,且预后差。诊断应结合临床表现、肾上腺皮质激素水平、影像学检查及病理结果。治疗方面首推多学科会诊（MDT）,早期患者首选手术,术后需根据疾病分期、分级选择辅助治疗,复发转移的患者可给予化疗、放疗、米托坦、免疫治疗等。     

局灶性Castleman病17例报告并文献复习

背景与目的:Castleman病(Castleman;sdisease,CD)又称血管滤泡性淋巴组织增生或巨大淋巴结增生,是一种少见的原因未明的反应性淋巴结病。本研究报告17例局灶性Castleman病(local Castleman;s disease,LCD)的临床特点和疗效,结合复习相关文献,以提高对LCD的诊治水平。方法:回顾性分析中山大学肿瘤防治中心从1995年8月至2006年7月收治的17例LCD患者临床资料。结果:无临床症状患者14例,有临床症状者3例,淋巴结呈单个或多个聚集,淋巴结最大径1.2～10.4cm,其中11例位于颈部,3例位于纵隔,位于肺部、肠系膜、肾上腺区各1例。其中透明血管型15例,浆细胞型1例,混合型1例,均经术后病理确诊。1例透明血管型CD出现脾大、白蛋白降低(25.6g/L)、球蛋白升高(80.0g/L)、大便潜血( );1例浆细胞型CD出现中度贫血(95.0g/L)、尿蛋白( )、大便潜血( );余15例患者实验室检查结果均在正常范围内。17例患者均行肿物切除术,术后失访2例,余15例随访1～129个月,中位随访时间25个月,现均生存,无肿瘤复发。结论:LCD主要表现为单一部位的淋巴结肿大,以透明血管型为主,多无临床症状和实验室检查异常结果。CT检查对诊断有一定帮助,但确诊仍靠病理。手术切除疗效好,术后可长期生存。     

Retrospective Study of Castleman＇s Disease： A Report of Fourteen Cases and Review of the Literature

OBJECTIVE To enhance the understanding of Castleman＇s disease （CD）, and to improve its diagnosis and management. METHODS Clinical features and related information on diagnosis and treatment of 14 cases of CD were retrospectively analyzed and the literature reviewed. RESULTS Based on the clinical classification, localized CD was found in 8 of the 14 cases. Both the results of lymph node biopsy and histopathology indicated they were a hyaline-vascular type. The multicentric type CD was detected in 6 cases, among which 4 were plasma cell type and 2 mixed type based on histopathologic examination. There were a variety of clinical situations in the 14 cases, with a lack of specificity. They were previously misdiagnosed as other diseases, and final diagnosis depended on a histopathologic examination. The 8 patients with localized CD underwent excision, without recurrence up to now. The 6 patients with multicentric-type CD were treated with glucocorticoids or combined chemotherapy, and all achieved remission. CONCLUSIONS CD has complicated clinical manifestations and is difficult to diagnose. Lymph node biopsy is important for early diagnosis. An optimal curative effect can be achieved with a suitable therapeutic option, based on histopathology and clinical classification.     

仅以全身淋巴结转移为特征的直肠乙状结肠交界处大肠腺癌 1 例报道及文献复习简

目的：探讨结直肠癌的转移途径和临床治疗。方法：总结1例以全身淋巴结转移为特征的直肠乙状结肠交界处大肠腺癌患者的临床资料及诊疗过程,并复习国内外相关文献。结果：结直肠癌临床仅有全身淋巴结转移罕见。结论：结直肠癌是常见的消化道恶性肿瘤,其中直肠乙状结肠交界处肠癌具有一定特殊性,探讨其转移方式能更好地指导治疗。