全身免疫炎症指数预测上尿路结石术后尿脓毒血症发生的列线图模型

目的 探讨术前全身免疫炎症指数(systemic immune-inflammation, SII)与输尿管软镜碎石术后尿脓毒血症发生的相关性的预测价值，并建立术前列线图预测模型。方法 回顾性分析2020年8月～2021年10月我院接受输尿管软镜碎石术治疗的329例病人的临床资料。依据术后是否发生尿脓毒血症，分为脓毒血症组及非脓毒血症组。采用单因素及多因素Logistic回归分析各指标与尿脓毒血症的相关性。根据受试者工作特征(receiver operating characteristic, ROC)曲线确定相关临床指标的临界值，并计算曲线下面积(the area under curve,AUC)评估其诊断效能。最后基于风险模型筛选的独立预测因素，应用R软件建立预测术后尿脓毒血症发生的列线图模型并计算C-index,通过校准曲线评估其准确性。结果 本研究共19例(5.8%)病人术后发生脓毒血症。多因素分析显示，女性(OR=5.407,P=0.014),手术时间(OR=1.029,P=0.039),结石直径(OR=6.311,P=0.041),SII(OR=1.005,P<0.0...     

输尿管软镜碎石术并发尿源性脓毒血症的危险因素分析

目的探讨输尿管软镜碎石术并发尿源性脓毒血症的危险因素。方法分析2013年8月至2014年12月在我院接受输尿管软镜碎石术的187例患者的临床资料,按照回顾性病例对照研究设计,对输尿管软镜碎石术并发尿源性脓毒血症的21例病例和未发生尿源性脓毒血症的病例166例对照,首先进行单因素分析,然后对有统计学意义的资料采用Logistic回归方法进行多因素分析。结果本研究单因素分析中,结石大小、性别、糖尿病、手术时间、尿培养阳性与输尿管软镜碎石术并发尿源性脓毒血症密切相关(P0.05)。多因素非条件Logistic回归分析显示性别(OR=0.293)、结石大小(OR=1.135)、尿培养阳性(OR=9.883)为独立危险因素。结论性别、结石大小、尿培养阳性等是输尿管软镜碎石术并发尿源性脓毒血症独立危险因素。因此术前术中要控制危险因素,减少尿源性脓毒血症的发生。     

输尿管软镜碎石术后尿脓毒血症的危险因素分析

目的探讨输尿管软镜联合钬激光治疗肾结石术后发生尿脓毒血的危险因素。 方法回顾性分析南方医科大学附属江门医院自2015年1月至2016年9月期间66例输尿管软镜术后患者的临床资料。对患者的一般资料进行收集整理,统计分析输尿管软镜术后尿脓毒血症的危险因素。 结果66例肾结石患者均顺利完成输尿管软镜联合钬激光碎石手术,术后9例（13.6%）患者发生尿脓毒血症。术后尿脓毒血症危险因素的单因素分析中,脓尿、结石大小、手术持续时间、感染性结石有统计学意义（P<0.05）。在对包括年龄、性别、糖尿病史、高血压病史、结石手术史、肾功能不全、肾盂积水、术前尿细菌培养、结石大小、脓尿、手术持续时间、感染性结石等作为自变量的多因素Logistic回归分析中,术后尿脓毒血症的危险因素有脓尿（P=0.019）,手术持续时间（P=0.021）,感染性结石（P=0.032）。 结论脓尿、手术持续时间、感染性结石是输尿管软镜碎石术后尿脓毒血症的危险因素。     

上尿路结石治疗与尿脓毒血症

上尿路结石治疗的主要微创手术方法是经皮肾镜碎石取石术和逆行途径的肾内手术。此两种手术围手术期都存在感染性并发症发生的风险，严重时会并发尿脓毒血症。结石引发的梗阻及并发的感染、碎石术导致结石内部的细菌及致热原的释放都是引发尿路感染或者全身炎症反应综合征，甚至尿脓毒血症的重要因素。深入认识上尿路结石治疗过程中尿脓毒血症发生的环节、危险因素及术中应该注意的事项对尿脓毒血症的预防和治疗具有重要的意义。现就上尿路结石治疗与尿脓毒血症的关系做简要概述。     

输尿管软镜碎石术后并发尿源性脓毒血症的相关因素及防治策略分析

目的探讨输尿管软镜碎石术后并发尿源性脓毒血症的相关危险因素及如何防治尿源性脓毒血症的措施。方法回顾性分析2015年1月至2016年6月在本院接受输尿管软镜碎石术的198例患者的临床资料,采用统计学方法对输尿管软镜碎石术并发尿源性脓毒血症的26例病例组和未发生尿源性脓毒血症的172例对照组进行相关因素的回顾性分析。结果单因素分析结果显示性别,结石大小,手术时间、糖尿病、尿培养与输尿管软镜碎石术后并发尿源性脓毒血症密切相关(P0.05)。多因素Logistic回归分析结果显示性别(OR=0.331),结石大小(OR=1.139),尿培养阳性(OR=8.992)为独立危险因素(P值均0.05)。结论女性,大结石,尿培养阳性等患者,行输尿管软镜碎石术后,更容易并发尿源性脓毒血症。应对此类高危患者采取必要预防感染措施,以减少其尿源性脓毒血症的发生。     

数学建模在输尿管镜术前预测尿源性脓毒血症的作用

目的探究输尿管镜术前预测尿源性脓毒血症的危险因素,初步建立数学模型预测术后尿源性脓毒血症。方法收集2011年12月至2016年12月在本院及浙江省人民医院进行输尿管镜治疗的2105例输尿管结石患者的一般病史资料,通过多元回归分析确定输尿管镜术前预测尿源性脓毒血症的危险因素并建立预测模型。结果肾积水程度、结石直径以及菌尿是输尿管镜术后尿源性脓毒血症发生的危险因素(P0.05);Logistic预测概率模型,公式为P=1/(1+exp-(3.17+1.88×肾积水程度+1.27×结石直径+1.67×菌尿),其作为预测指标,ROC曲线,曲线下面积约为0.891,灵敏度为84.21%,特异度为82.19%。结论肾积水程度、结石直径以及菌尿是输尿管镜术后尿源性脓毒血症发生的独立危险因素,通过这3个独立危险因素建立的输尿管镜术后尿源性脓毒血症发生概率模型预测尿源性脓毒血症的发生具有可行性。     

术前/术后2h血白细胞比联合qSOFA对输尿管软镜术后尿脓毒血症的预测价值

目的探讨术前/术后2 h血白细胞比联合快速序贯器官衰竭评分(qSOFA)对输尿管软镜术后发生尿脓毒血症的预测价值。方法回顾性分析2015年9月至2018年7月于上海交通大学附属第一人民医院因上尿路结石行输尿管软镜碎石取石术患者的病例资料。共2364例患者,男1613例,女751例。年龄(54.9±14.0)岁。体质指数(23.9±2.8)kg/m^2。结石最大径(10.9±6.2)mm。结石位于左侧1305例,右侧1018例,双侧41例。术前体温(36.8±0.4)℃。血糖(5.7±1.5)mmol/L。血WBC(7.4±4.6)×10^9/L,中性粒细胞0.62±0.11。C反应蛋白(20.1±59.3)mg/L,降钙素原(1.6±11.8)μg/L,白细胞介素-6(11.3±32.9)pg/ml。术前清洁中段尿细菌培养阳性465例。qSOFA诊断尿脓毒血症的标准为:①呼吸频率≥22次/分;②收缩压≤100 mmHg(1 mmHg=0.133 kPa);③精神状态改变。满足1项记1分,qSOFA≥2分为阳性,诊断为尿脓毒血症。结果本研究2364例的手术时间(39.3±23.0)min。术后2 h血WBC(6.7±2.9)×10^9/L,中性粒细胞0.70±0.12。qSOFA评分阳性69例,阴性2295例。15例术后发生尿脓毒血症,发生率为0.6%。尿脓毒血症组和非尿脓毒血症组qSOFA阳性患者例数分别为15例和54例,术前/术后2 h血WBC比分别为2.5±1.6和0.7±0.2。单因素分析结果显示:女性(χ^2=16.20,P<0.001)、结石体积大(t=2.14,P=0.050)、术前血WBC(t=2.51,P=0.025)、中性粒细胞(t=2.90,P=0.012)、C反应蛋白(t=2.58,0.028)、降钙素原(t=16.09,P<0.001)、白细胞介素-6(t=7.88,P=0.032)升高、术前清洁中段尿细菌培养阳性(χ^2=21.10,P<0.001)、术前/术后2 h血WBC比>1(t=4.51,P=0.001)、qSOFA阳性(χ^2=502.10,P<0.001)与术后尿脓毒血症发生有关。将qSOFA阳性且术前/术后2 h血WBC比>1的患者定义为尿脓毒血症高危患者。单独使用qSOFA的受试者工作特征曲线下面积(AUC)为0.98,阳性预测值为21.7%;单独使用术前/术后2 h血WBC比的AUC为0.98,特异性为60.0%,阳性预测值为38.5%;qSOFA联合术前/术后2 h血WBC比的AUC为1.00,特异性为98.3%,阳性预测值为93.8%,与前两者相比其预测效力明显提高。结论qSOFA阳性联合术前/术后2 h血WBC比>1可以在术后2 h早期、快速、准确地预测输尿管软镜碎石取石术后尿脓毒血症的发生。     

输尿管镜下钬激光联合封堵取石导管治疗输尿管中上段结石的护理配合

本文总结我科2012年1月~2013年12月输尿管镜下钬激光联合封堵取石导管治疗输尿管中上段结石84例的护理配合经验。所有患者围术期均能积极配合治疗和护理,76例成功取石,无结石残留;6例输尿管上段结石移至肾内,其中3例改输尿管软镜下碎石,3例改经皮肾镜碎石取石术;2例输尿管结石严重扭曲,置入封堵导管失败,改开放手术取石。术中无输尿管穿孔、输尿管黏膜撕脱、大出血等严重并发症,术后无发生尿源性脓毒血症发生。我们认为充分的术前准备,娴熟的术中护理配合是保证手术顺利进行及提高手术效率的有效护理措施,也是患者术后顺利康复的必要条件。     

恒压灌注下MPCNL术后并发尿源性脓毒血症的危险因素分析及预测模型的建立

目的分析恒压灌注下微通道经皮肾镜碎石术(MPCNL)后并发尿源性脓毒血症的相关危险因素, 并建立logistic回归预测模型。方法回顾性分析2018年12月至2020年12月期间在本院行恒压灌注下MPCNL治疗的56例上尿路结石患者的临床资料, 以术后发生尿源性脓毒血症的患者为病例组(26例), 采用巢式病例对照研究方法, 以1∶5的比例匹配同期对照组(130例)。采用单因素及多因素logistic回归分析筛选恒压灌注下MPCNL术后尿源性脓毒血症发生的危险因素, 建立logistic回归预测模型, 用Bootstrap再抽样法(1 000次)进行模型内部验证。采用Hosmer-Lemeshow检验对所建立的预测模型的拟合优度进行评估, 采用受试者工作特征(ROC)曲线下面积对该模型的预测效能进行评定。结果单因素分析结果表明:性别、泌尿系结石手术史、肾积水、术前尿白细胞(WBC)≥2+、术前尿亚硝酸盐(NIT)阳性、术前血中性粒细胞与淋巴细胞比例(NLR)≥2.5与恒压灌注下MPCNL术后尿源性脓毒血症的发生均有相关性(均P<0.05);多因素logistic回归分析结果显示:女...     

经皮肾穿刺造瘘术在输尿管结石合并尿脓毒血症中应用的临床研究

目的 探讨经皮肾穿刺造瘘术治疗输尿管结石合并尿脓毒血症对预防感染性休克的可行性及安全性分析.方法 对本院201 1年1月至2014年12月输尿管结石合并尿脓毒血症患者46例,在积极抗感染治疗的同时,行经皮肾穿刺造瘘术外引流,观察和分析患者经皮肾穿刺造瘘术前2h和术后48h血白细胞计数(WBC)、中性粒细胞比例(NEUR)、C反应蛋白(CRP)、降钙素原(PCT)等感染性指标变化情况以及行输尿管镜碎石术后尿脓毒血症及感染性休克发生情况.结果 46例患者中,44例顺利行经皮肾穿刺造瘘术外引流,2例行输尿管镜下双J管置入内引流术.术后48h复查血WBC、NEUR、CRP和PCT感染性指标均较前术前2h明显下降差异有统计学意义.44例经皮肾穿刺造瘘术患者待感染控制及引流充分后再行输尿管镜碎石术,术后无1例出现感染性休克.结论 对于输尿管结石合并尿脓毒血症患者,采取经皮肾穿刺造瘘术外引流和积极的抗感染治疗,有利于预防输尿管镜碎石术后感染性休克和严重感染性并发症的发生.     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.