同种异体骨关节移植并钢板置入内固定治疗桡骨远端骨巨细胞瘤9例

背景:桡骨远端骨巨细胞瘤瘤段切除后重建方法较多,但是各种重建方法术后腕关节功能均较差.有关大段同种异体骨重建桡骨远端骨关节缺失国内报道少.目的:观察应用瘤段切除、同种异体骨关节移植治疗桡骨远端骨巨细胞瘤的效果.设计、时间及地点:回顾性病例分,病例来自2003-07/2008-01四川大学华西医院骨科.对象:按纳入标准选择四川大学华西医院骨科收治的桡骨远端骨巨细胞瘤患者9例,男5例,女4例,年龄17～39岁,平均年龄29.6岁:其中左侧4例,右侧5例:按Campanacci影像学分级Ⅱ级3例,Ⅲ级6例.方法:全部患者均采用瘤段切除、同种异体桡骨远端骨关节移植,钢板内固定治疗,定期门诊随访,采用Mankin评分方法进行功能评定.主要观察指标:①腕关节活动度.②X射线平片表现.③Mankin评估结果及术后并发症.结果:9例患者均获得随访(门诊随访7例,电话随访2例),随访时间12～64个月.术后腕关节平均活动范围为掌屈32.8度.背伸44.4度;较术前掌屈29.4度,背伸26.7度明显提高.X射线可见骨愈合良好,未见明显骨质吸收.全部患者腕关节处均有不同程度的骨关节炎、关节间隙变窄等,但无疼痛出现.所有患者骨内无复发,仅1例术后2年软组织内复发,并再次行软组织内肿瘤切除,复发率为11%.9例患者中按Mankin标准评定,优3例,良4例,可1例,差1例,优良率为80%.所有患者未见肺部转移,异体骨植骨区及全身无排异反应,术后无感染、骨不连、不愈合、骨质明显吸收及钢板螺钉断裂松动等并发症.结论:瘤段切除复合同种异体骨移植重建腕关节治疗Campanaccim级、复发及合并病理性骨折的桡骨远端骨巨细胞瘤术后复发率低,腕关节活动明显改善.     

大块同种异体骨移植重建骨肿瘤巨大骨缺损78例

回顾性分析1999-08/2007-01解放军广州军区广州总医院骨科收治的骨肿瘤切除后骨缺损患者78例,男47例,女31例,年龄7～56岁,平均21.5岁.其巾骨巨细胞瘤34例,骨肉瘤12例,动脉瘤样骨囊肿11例,平滑肌肉瘤2例,腺泡状软组织细胞瘤1例,骨纤维结构不良18例.以Enneking外科分期标准为原则,对肿瘤进行切除.主要发病部为股骨上端,股骨干,股骨下端,胫骨上端,骨盆.重建方式以行大块骨移植63例,骨干移植10例,髂骨移植2例,人工关节-异体骨复合物移植3例.全部患者均获得随访,平均37.9个月.移植后结果以Mankin等所提出的评定标准为原则优36例,良29例,中4例,筹9例.出现局部排斥反应18例,予反复抽吸积液及抗排斥反应治疗7～54 d后症状消失,肿瘤复发7例,感染4例,骨不连5例,异体骨骨折1例,关节不稳定2例.大块片体骨与宿主骨在移植后1周就可在接合部卅现明显的骨痂生成,在接合部和异体骨表面尽量布满细小的异体骨或自体骨可明显加强骨诱导.提示采用大块异体骨重建骨肿瘤术后大的缺损,临床效果良好,取得满意效果.     

吻合旋髂深血管骨瓣在复发性股骨远端骨巨细胞瘤治疗中的应用

目的　探讨吻合旋髂深血管的游离髂骨移植在复发性股骨远端骨巨细胞瘤治疗中的临床疗效。方法　对 7例复发性股骨远端骨巨细胞瘤 ,肿瘤刮除后采用了吻合旋髂深血管的髂骨瓣作为植骨材料 ,采用螺钉固定。结果　本组 7例均获随访 ,时间 2～ 6年 ,平均 4 7年 ,所有患者均存活 ,移植骨与受区骨均获骨性愈合 ,无肿瘤复发。结论　吻合旋髂深血管的髂骨瓣具有独立血供和良好的支撑力。     

带监测皮岛的组合腓骨移植治疗股骨大段缺损对骨强度及负重行走能力的作用

背景应用吻合血管的游离腓骨移植治疗长管骨大段骨缺损疗效可靠,尤其是带监测皮岛的腓骨移植疗效更可靠,然而单腓骨移植修复负重长管骨则有折断的可能.目的探讨带监测皮岛的组合腓骨移植治疗股骨大段缺损的临床疗效.设计自身前后对照观察.单位广州市第一人民医院骨科脊柱外科.对象选择1995-07/2003-11广州市第一人民医院骨科脊柱外科收治的股骨骨缺损患者14例.部位股骨下端5例,股骨中段9例,骨缺损长度6～28 cm.干预带监测皮岛腓骨折断成双腓骨移植7例,带监测皮岛腓骨捆绑同种异体骨7例.监测皮岛大小3 cm×5 cm,切取腓骨长度16～32 cm.同种异体干冻骨长度12～28 cm.术后监测手术伤口及监测皮岛情况.主要观察指标患者骨缺损处带监测皮岛双腓骨或捆绑同种异体骨复合移植皮瓣成活情况、移植骨形态变化及负重行走能力.结果14例患者均进入结果分析.双腓骨组7例随访3年,捆绑同种异体骨组7例随访1年.14例监测皮岛全部成活,捆绑同种异体骨组1例术后3个月有黄色渗液而取出异体骨,其余6例随访显示移植腓骨与异体骨紧密结合,移植骨增粗、塑造,与受区股骨口径相当.两组患者术后6个月弃拐负重行走,移植骨无折断.结论带监测皮岛双腓骨或捆绑同种异体骨移植修复股骨缺损,可增加移植腓骨骨量和强度,减少或避免移植腓骨折断.     

四肢恶性骨肿瘤的切除与功能重建

我院自1985年起对15例四肢恶性骨肿瘤患者进行瘤段切除与重建,1例死亡,14例存活,取得良好疗效。1 临床资料.本组15例中男11例,女4例,年龄18～64岁。成骨肉瘤、软骨肉瘤各2例;骨旁骨肉瘤、纤维肉瘤各1例;恶性纤维组织细胞瘤3例;恶性骨巨细胞瘤Ⅱ级以上6例。肱骨上段及股骨下段各5例,股骨上段2例,肱骨干、胫骨下段及坐耻骨支各1例。2 手术方法.瘤段切除后带股骨干人工髋关节置换术2例;带股骨干人工膝关节置换术5例;腓骨移植     

股骨髁部骨巨细胞瘤切除后带蒂髌骨移植重建

股骨髁部是骨巨细胞瘤的好发部位,为了减少肿瘤的局部复发,目前大多数医生主张采用肿瘤切除及肢体功能重建手术。我们采用带蒂髌骨移植重建治疗切除的股骨髁部的骨巨细胞瘤６例,通过２～３年的随访,元一例复发,膝部功能恢复良好,取得较满意的效果。１ 临床资料１．１ 一般资料 本组手术共６例,男４例,女２例。年龄１９－４１岁。病程２个月－３年。肿瘤发生在股骨内侧髁５例,外侧髁１例;累及关节面者３例,上次瘤体刮除植骨后复发者１例。病理细胞学分级Ｉ级３例,ＩＩ级３例。１．２ 手术方法 患者取仰卧位,沿髌骨边缘作纵形前…     

自体腓骨移植重建桡骨远端巨细胞瘤切除后骨与关节缺损31例术后护理

目的:探讨自体腓骨移植重建桡骨远端巨细胞瘤切除后骨与关节缺损的术后护理方法。方法:对31例患者做好并发症(移植血管痉挛、腕关节脱位、肿瘤复发)的观察及护理,进行功能锻炼指导和出院指导。结果:术后随访41～169个月,平均86.3个月;吻合血管的腓骨移植患者愈合时间为3～9个月,平均5.1个月;单纯腓骨移植患者愈合时间为7～15个月,平均10.3个月。1例单纯腓骨移植患者术后出现骨不愈合;1例患者术后出现肿瘤局部复发,复发率为3.2%;5例患者术后出现桡腕关节脱位,其中3例行桡腕关节融合术,2例行石膏外固定后未再次发生脱位。结论:精心的术后护理可促进自体腓骨移植重建桡骨远端巨细胞瘤切除后骨与关节缺损患者术后康复。     

FINN返修型旋转绞链式全膝关节置换术的手术配合

我院自1996年～1999年4月,采用ＦＩＮＮ返修型旋转绞链式膝关节假体修复股骨下端大块骨缺损4例,并就其操作安装原理及手术护理要点进行讨论。1　临床资料4例患者中男性3例,女性1例;均为骨肿瘤患者,2例为原发恶性骨肿瘤切除后的骨关节重建,2例为恶性骨肿瘤保肢术后骨关节返修手术。具体情况见表1。表1　临床资料序号性别年龄(岁)部位诊断生存时间(ａ)初次手术1女23股骨下端骨肉瘤14瘤段切除灭活再植2男19股骨下端骨肉瘤2瘤段切除3男56股骨下端纤维肉瘤13瘤段切除异体骨移植4男34股骨下端恶性骨巨细胞瘤4瘤段切除2　手术资料病例2和病例4为原…     

大段同种异体骨移植术在胫骨中段骨肉瘤保肢中的应用

背景：胫骨中段骨肉瘤患者的保肢手术并发症多,其保肢手术方案是当前临床治疗中的难点之一。目的：回顾性分析接受大段同种异体骨移植治疗的胫骨中段骨肉瘤病例,评估其综合临床疗效。方法：7例胫骨中段骨肉瘤患者,完成同种异体骨移植前正规辅助化疗方案,并移植前确认无远处转移。7例患者均接受大段同种异体骨移植＋内固定术治疗,异体骨平均长度12.5 cm,移植中全部行腓肠肌肌瓣转移覆盖移植骨。移植后5例患者完成化疗方案,2例部分完成化疗方案。结果与结论：随访时间18-36个月。移植后1年局部复发1例,行截肢术后出现肺转移死亡;移植后1.5年肺转移1例,转移灶切除后存活;移植后2年死于肺转移1例;余4例无瘤生存。MSTS评分：平均26.5分。ISOLS评分：平均31分。4例未成年患者中,1例患者出现双下肢不等长畸形,患肢缩短2 cm。无移植后感染病例和移植后病理性骨折病例。结果提示,严格把握适应证的前提下,使用大段同种异体骨移植治疗胫骨中段骨肉瘤能够获得较好的移植后功能;移植中行腓肠肌肌瓣转移覆盖移植骨是降低移植后并发症的有效措施。     

同种异体骨治疗良性骨肿瘤摘除术后骨缺损

[目的]观察同种异体骨治疗良性骨肿瘤摘除术后骨缺损的愈合情况.[方法]对分别发生在肱骨、桡骨远端、股骨粗隆部、股骨颈、股骨干、胫骨以及跟骨部位且确诊为骨囊肿、骨性纤维结构不良、非骨化性纤维瘤和内生软骨瘤等良性骨肿瘤的37例患者在肿瘤摘除后应用同种异体骨移植修复骨缺损.随访时间8个月至10年.[结果]36例临床愈合,1例骨不连.随访中1例已临床愈合的病人发生再骨折.[结论]同种异体骨治疗良性骨肿瘤摘除术后骨缺损疗效可靠,但一些影响移植骨愈合的因素仍需进一步研究.     

钙磷骨水泥/复合脱蛋白骨关节移植修复兔股骨远端关节缺损

背景:研制有生物活性的人工关节是当前的重要课题,而载体+骨诱导因子+生长因子模式人工骨已被证实是理想的人工骨材料.目的:课题组创新性地采用钙磷骨水泥为载体,将其与骨形态发生蛋白及生长因子复合,并观察新型钙磷骨水泥/复合脱蛋白骨关节移植修复兔股骨远端关节缺损模型的成骨及血供重建能力.设计、时间及地点:随机对照动物实验,于2003-01/2006-06在重庆医科大学动物实验室完成.材料:取新鲜新西兰大白兔股骨远端(15 mm)制作脱蛋白骨关节,将人重组肿瘤坏死因子α、人重组骨形态发生蛋白2分别与钙磷骨水泥和脱蛋白骨关节复合,冷冻干燥,环氧乙烷消毒备用.方法:手术造成兔股骨远端15 mm关节缺损实验模型,将40只新西兰大白兔随机均分成两组:实验组将混合有人重组骨形态发生蛋白2、人重组肿瘤坏死因子α的钙磷骨水泥在异体脱蛋白骨关节表面涂层和髓腔内填塞后,置换一侧股骨远端;对照组进行单纯异体脱蛋白关节股骨远端移植.主要观察指标:植入后4,8,12,16周分别行X射线摄片以及组织学检查,观察骨缺损愈合情况、移植关节端成骨与成软骨情况;并于16周行血管造影,了解局部血供重建情况.结果:实验组在移植后第4周可观察到大量新生血管出现,网织状骨形成.至第12～16周时,复合脱蛋白骨关节完全存活,断端愈合.光镜下各时期的成骨面积实验组均大于对照组.股动脉血管造影示实验组移植部位周围血管数量明显多于对照组.结论:钙磷骨水泥/复合脱蛋白骨关节具有良好的成骨能力,在体内能促进股骨远端关节缺损的血供重建、愈合和替代.     

定制肿瘤型人工膝关节置换治疗膝关节周围恶性骨肿瘤

目的:观察应用定制肿瘤型人工膝关节置换治疗股骨远端、胫骨近端恶性骨肿瘤的临床效果.方法:回顾性分析2001-06/2008-10江苏大学附属医院骨科收治的膝关节周围恶性骨肿瘤患者29例,男19例,女10例;年龄17～65岁,平均38.5岁;股骨远端22例,胫骨近端7例.对肿瘤进行广泛切除或根治性切除后,采用定制肿瘤型人工膝关节置换重建:根据病理类型同时采用辅助化学、放射治疗.结果:所有患者均获随访,随访时问18~84个月,平均54.2个月;3年生存率79.8%,5年生存率63%.29例患者中2例于置换后35~48个月发生假体断裂,1例置换后44个月假体松动,经翻修术后功能恢复良好.2例软组织肿瘤复发,最终行截肢手术.置换后1年采用MSTS保肢评分系统对随访患者进行功能评价,结果显示股骨远端患者15.5～28.0分,平均23.5分;胫骨近端10.5~29.0分,平均22.4分.其中优8例,良15例,中5例,差1例,优良率为79%.本组患者术后均未出现浅表或深部感染.2例患者出现腓总神经损害,1例是肿瘤粘连术中分离时损伤,术后腓总神经支配区皮肤痛觉过敏,给予局部封闭、理疗等措施后好转,1例考虑是骨水泥压迫所致,经术后对症治疗,完全恢复.结论:定制肿瘤型人工膝关节置换治疗膝关节周围恶性骨肿瘤能保留良好的关节功能,是有效的保肢方法.     

肿瘤型假体置换治疗近关节部位骨巨细胞瘤37例临床分析

目的 评价肿瘤型假体置换治疗近关节部位骨巨细胞瘤(GCT)的疗效.方法 1998年1月至2008年1月收治近关节部位GCT 37例.股骨远端23例,胫骨近端10例,肱骨近端3例,股骨近端1例.Companacci分级,Ⅱ级9例,Ⅲ级28例.所有患者行瘤段切除、肿瘤型假体置换治疗.术后采用MsTS 93评分系统进行功能评价.结果 随访2～9年,1例术后2年3个月肿瘤局部复发,1例接受截肢手术.1例假体感染,2例假体松动.术后3年MSTS 93评分系统评分平均为(22.49±5.16)分.肢体功能评估优良率为89.2%(33/37).结论 肿瘤型假体置换是近关节部位GCT减少复发、重建功能的一种有效方法.     

Osteosarcoma in a patient with neurofibromatosis type 1: a case report and review of the literature

Neurofibromatosis type 1 (NF1) or von Recklinghausen's disease is a genetic disease generally characterized by café-au-lait spots and neurofibromas. Malignant tumors of the nervous system, such as malignant schwannomas, gliomas, or astrocytomas, have been well known to coexist with neurofibromatosis. However, occurrence of malignant tumors unrelated to the nervous system is rare. We report an unusual case of a 29-year-old NF1 female suffering from malignant peripheral nerve sheath tumor (MPNST) that eventually developed osteosarcoma in the proximal femur. Osteosarcoma is the most common high-grade malignant bone tumor in which the neoplastic cells produce osteoid. At 23 and 24 years old, she underwent excision of MPNST in the left posterior thigh. No osteosarcomatous portion was identified in these specimens. The patient underwent postoperative chemotherapy. At 29, left proximal thigh pain and swelling appeared. Computed tomography demonstrated cortical bone destruction in the left proximal femur where MPNST occurred. Magnetic resonance imaging revealed extraskeletal growth of the tumor. Bone scintigraphy demonstrated increased uptake in the left proximal femur. Hip disarticulation was performed. The removed tumor was composed of highly anaplastic cells. Lace-like irregular osteoid formation was observed among the tumor cells. MPNST component was totally absent. The tumor was diagnosed as osteoblastic type osteosarcoma. Two months after disarticulation the patient died of bilateral pulmonary metastasis. The correlation between the histogenesis of osteosarcoma and the genetic abnormality in NF1 patients has not been elucidated, but the finding of osteosarcomatous transformation in this case suggests the divergent cellular differentiation to mesenchymal malignant tumors of neuroectodermal tissue in NF1 patients.     

肩胛带恶性骨肿瘤切除术后肩关节功能的重建

目的探讨肩胛带部恶性骨肿瘤的切除分型、保肢治疗的方法及其结果。方法28例肩胛带部恶性骨肿瘤患者按照Malawer等提出的手术分类方法切除肿瘤,选择不同的方法进行保肢治疗,对患者进行肿瘤学结果评定,切除重建后功能评价。结果28例患者中,3例失访,25例随访时间9～96个月,平均54个月,局部复发6例,死亡11例,根据Enneking肢体功能评价标准：瘤段切除灭活再植患者平均得分23分,异体骨关节移植患者平均24分,同侧锁骨翻转移植患者平均24分,人工假体置换患者平均26分。肩胛骨部分切除患者平均28.5分,全肩胛骨切除、肱骨头悬吊术患者平均25分。结论肩胛带恶性骨肿瘤可以彻底切除;其保肢方法较多,大部分患者手部功能得以保留,肩关节无痛并有一定功能。     

Local experience in the surgical treatment of primary malignant and metastatic bone tumors of the proximal femur

Background. The introduction of new techniques for fixation of long bones and postresectional prosthetic replacement, combined with chemotherapy and radiotherapy, have created new possibilities for the surgical treatment of primary and metastatic bone tumors. The main problem is still the time of diagnosis and the proper choice of operative treatment. Material and methods. We examined a group 67 patients operated for tumor of the proximal femur between 1985 and 2004, consisting of 48 females (average age 57) and 19 males (average age 46.8). The follow-up period ranged from 1 to 24 years (average 5.7 years). Metastatic bone tumors were found in 51 cases, as compared to 16 primary bone tumors. The clinical outcomes were evaluated by orthopedic and radiological examination, using Enneking's functional scale, depending on the treatment method applied. Results. Following surgical excision of the bone tumor, total postresectional arthroplasty was performed, or, in some patients, hip hemiarthroplasty. In some cases resection of the tumor was followed by plate fixation or the application of an intramedullary device after the resection bone defect had been filled with methylmethacrylate. Conclusions. Excellent or good postoperative outcomes were obtained by 76% of the patients. In 18% of the patients there was tumor recurrence. The most common complication was either surgical wound infection caused by lowered immunity after chemotherapy or breakage of the stabilizing plates.     

长骨骨巨细胞瘤的影像诊断

目的比较X线、CT、MRI对骨巨细胞瘤的诊断特点及其鉴别诊断,以提高对骨巨细胞瘤的影像诊断能力。方法对23例经手术和病理证实的长骨骨巨细胞瘤的X线、CT、MRI表现进行影像对照、对比分析。结果长骨骨巨细胞瘤多发生在股骨下端和胫骨上端,X线表现为长管状骨骨端偏心性、膨胀性骨质破坏,骨壳多薄而完整,其间可见骨间隔,典型者构成皂泡样改变。CT扫描显示大多数骨壳并不完整,肿瘤内看不到真正的骨间隔。溶骨性巨细胞瘤呈溶骨性改变,多无完整的骨壳和骨间隔,肿瘤的边缘残留的骨壳仍保留膨胀的特征,并可看到和骨壳缺损区相一致的软组织肿块。CT还能清楚地显示肿瘤内有无出血、破坏、钙化等内部结构。肿瘤呈膨胀性破坏,T1WI呈均匀中等或低信号强度,T2WI呈混杂信号,有些区域呈高信号,为液化、坏死或出血。结论大多数骨巨细胞瘤有典型的X线表现,不难作出正确的诊断,结合CT、MRI可提高骨巨细胞瘤的诊断和鉴别诊断能力。     

The application of bone cement to fill the surgical defect after resection of a giant-cell tumor: A case report

Background. A case of a large bone defect treated with bone cement filler is discussed, and the usefulness and advantages of this treatment method are assessed. Case report. A 25-year-old male was admitted to our hospital with an intra-articular pathological fracture of the lateral femoral condyle due to an underlying giant cell tumor (stage I according to the Enneking classification). The tumor was surgically resected, and the walls of the post-operative bone defect were treated with a burr. The defect was then filled with bone cement (PMMA). The tumor was found to be histologically benign. Post-surgical treatment included immobilization in a cylinder cast and no weight bearing for a period of 8 weeks. The follow-up included frequent check-ups and repeated radiographs and CT scans. The follow-up period was 7 years, during which time no clinical or radiological signs of tumor recurrence were found. There was visible osteosclerosis surrounding the bone cement filler, which is believed to be a prognostically favorable finding, associated with a low risk of recurrence. The functional outcome of treatment was assessed with the Knee Rating Score. The patient gained a knee score of 100 points and a functional score of 100 points. Conclusions. The use of bone cement in order to fill a bone defect after tumor excision proved to be an effective and safe method to manage a giant-cell tumor of the bone. This method provided good biomechanical circumstances and allowed for good follow-up, as it enabled easy detection of possible tumor recurrence.     

人工肱骨头假体在治疗肱骨近端骨肿瘤中的应用

目的 探讨人工肱骨头假体在肱骨近端骨肿瘤治疗中的临床应用效果.方法 回顾性分析15例行骨肿瘤切除和人工肱骨头假体置换术肱骨近端骨肿瘤患者,其中骨肉瘤8例,骨巨细胞瘤4例,软骨肉瘤2例,纤维肉瘤1例.结果 术后随访平均(39±5)个月,手术时间平均(110±10)min,术中出血平均(600±41)ml.1例骨肉瘤患者于术后20个月死于复发伴全身多处转移,余14例按Enneking评分标准,末次随访时评分(23.3±3.7)分,总体优良率为84.6%(11/15).结论 采用人工肱骨头假体能有效地治疗肱骨近端骨肿瘤,具有良好的近期临床效果.

Abstract：

Objective To evaluate the clinical effects of the artificial humeral head prosthesis in the treatment of proximal humerus bone tumors. Methods Fifteen patients with proximal humerus bone tumor had excision of bone tumor and application of artificial humeral head prosthesis were analyzed retrospectively. Among them,8 patients had osteosarcoma,4 patients had giant cell tumor of bone,2 patients had chondrosarcoma, 1 patient had fibrosarcoma. Results All cases were followed up for average (39 ± 5 ) months after the surgery.The duration time of operation were( 110 ± 10) minutes in average. The bleeding volume during operation were (600 ± 41 ) ml in average. One patient with osteosarcoma died of recurrence and metastasis 20 months after the surgery. The functions of the other 14 patients were assessed by Enneking system and the average score was 23.3 ± 3.7. The overall rate of excellent or good results was 84.6% ( 11/15 ). Conclusion Limb salvage surgery with the artificial humeral head prosthesis is an efficacious treatment for proximal humerus bone tumors,which can improve short-term clinical outcome.     

人工肩关节假体置换治疗肱骨近端恶性骨肿瘤

目的：探讨人工肩关节假体置换治疗肱骨近端恶性骨肿瘤的疗效。方法：1985年8月至2003年8月我院共对35例肱骨近端恶性骨肿瘤患者行肿瘤瘤段切除,人工肩关节假体置换保肢术。其中骨肉瘤9例,骨巨细胞瘤9例,钵骨肉瘤5例,尤文氏肉瘤2例,恶性纤维组织细胞瘤3例,非霍奇金淋巴瘤2例,纤维肉瘤2例,转移癌3例。结果：35例患者中,5例失访,2例因肺部原发肿瘤死亡,6例因原发恶性骨肿瘤转移死亡,一2例因昂部复发而行前四分之一截肢术,1例因感染行假体翻修术;重建成功的20例患者无瘤生存,最长18年,最短6个月,平均6年,所有患者未发现假体松动或断裂。按Enneking骨骼肌肉肿瘤术后评估标准,平均评分24．6分,评分在24分以上者占65％。结论：人工肩关节假体置换在冶疗肱骨近端恶性肿瘤方面,不仅能保留患肢完整的外观形态,而且能在很大程度上保留上肢的功能,是一种值得肯定的治疗方法。