三维对比增强磁共振血管成像诊断复杂多发性大动脉炎1例

1病例介绍 患者男,39岁,因“突发右侧肢体无力、言语不能5d”于2010年1月6日收住我院.患者入院前5d无明显诱因活动中突发右侧肢体无力,伴右上肢麻木、持物不稳,尚能行走,但不稳,伴头晕,无视物旋转、耳鸣、听力减退,伴双额部头痛,呈阵发性搏动性,伴不能言语,但能听懂他人话意,无呕吐、视物模糊,无口角歪斜、吞咽困难、饮水呛咳,于当地医院行颅脑磁共振成像(magnetic resonance imaging,MRI)示“左侧额顶叶脑梗死”,经治疗(具体不详)后未见明显好转.于入我院2天前出现右侧肢体无力加重,不能行走、持物,为进一步诊治转我院.底节区、科医师.     

结肠癌合并Trousseau综合征一例

1病例简介 患者男性,61岁,山东人,主因“左侧肢体无力20余天”,于2008年4月24日由当地医院转入我院。患者于人院20d前在接电话时突发头晕,伴有左侧肢体无力,无视物旋转及视物成双,无耳鸣,持续约20min后自行缓解。3d后,患者早晨起床后出现左侧肢体无力,但尚能行走及持物,约半小时候后左侧肢体无力加重,     

特殊类型的低灌注脑梗死1例

1病例介绍 患者,男,49岁,主因“反复发作性左侧肢体无力4d,加重伴胡言乱语1d”于2012年3月21日收住我院。患者入院前4d无明显诱因活动中突发一过性左侧肢体无力,持物及行走不稳,伴左。     

急性缺血性卒中闭塞血管自发再通1例分析

临床资料患者,男性,58岁主因“左侧肢体无力伴言语不利1月余”于2005-10-27以“脑梗死”收入院。患者1月前突发左侧肢体无力,伴言语不利。当时头CT检查未见异常。次日肢体无力加重,左上肢无法活动,10分钟后稍有缓解。2小时后肢体无力再次加重且未缓解于2005-9-20入院。既往精神     

大脑中动脉血管内溶栓并支架置入术治疗一例

1病例简介患者,男性,45岁,主因“突发左侧肢体无力2．5 h”于2005年9月23日10时30分在我院急诊就诊。患者于入院前2．5 h无明显诱因突发左肢无力,逐渐加重,不能持物、行走,无言语不清,无头痛、头晕,无饮水呛咳,无视物旋转及视物成双。我院急诊查体:双侧血压125/75mm Hg。意识清,言语欠流利,额纹对称,左侧中枢性面瘫。左侧上肢肌     

特发性椎动脉夹层1例

1病例简介患者,男性,36岁,公司职员。主因“突发右侧肢体无力3d”,于2005年10月19日21:00收入我院。患者于入院前3d晨起床刷牙时突发右侧肢体麻木,从右下肢向上肢发展,伴右侧肢体无力及左侧顶枕部疼痛。右肢体无力表现为右手持物不稳,     

华法林致自发性脊髓硬膜外出血一例

<正>1病例报告患者女,55岁。因"突发四肢麻木无力,伴尿便障碍1d"于2015-01-26 16:30收入作者医院。入院前一天凌晨3:00患者开始出现左侧肢体麻木无力,进行性加重,18:00出现右侧肢体麻木无力,伴尿便障碍。既往有风心病病史,本次入院5年前行二尖瓣换瓣手术,平素口服华法林4.5mg,1次/d,否认外伤史。入院查体:体温38.3℃,血压130/80mmHg(1 mmHg=0.133kPa),意识清楚,言     

海绵状血管瘤伴脑干出血一例

1病例简介患者,男性,47岁,主因“突发右侧肢体无力伴言语不清1d”,急诊以“脑出血”收住院。患者入院前1d,于劳累后突然出现右侧肢体麻木无力,不能行走及持物,言语欠流利,伴头晕,无明显视物旋转,无复视,无头痛、恶心、呕吐。     

以脑卒中样症状起病的新型隐球菌脑膜脑炎一例

<正>1 病例报告患者男，46岁。因“左侧肢体无力、言语不清3.5 h, 意识障碍1 h”于2022-6-28入院。入院前3.5 h无明显诱因出现左侧肢体无力，左上肢可抬起，左手握力减退，可站立，身体向左侧偏斜，伴言语不清，尚能正常交流，无头晕、头痛、恶心、呕吐、吞咽困难、饮水呛咳、视物不清、视物旋转、肢体麻木等，1 h前出现意识障碍，躁动不安，问话不答，无抽搐、大小便失禁，遂就诊于作者医院。既往有高血压病史6年，     

伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病致老年脑叶出血1例报道

<正>1病例介绍患者男性,67岁。主因“头晕1天,视物不清20小时”于2022年4月25日入院。患者入院前1天无明显诱因出现头晕,伴左侧视物不清、恶心,无眩晕、复视、头痛、呕吐、言语不清、肢体无力,来首都医科大学附属北京朝阳医院急诊,行头颅CT检查,示“右侧枕叶多发团片状高密度影,周围环绕脑组织水肿”（图1A）,以“右侧枕叶脑出血”收入院。既往史：偏头痛病史30年,平均2～3次/月,不伴头痛先兆,近5年发作次数减少。     

Sensitization to caffeine and cross-sensitization to amphetamine: influence of individual response to caffeine

The present study evaluated the ability of a subchronic intermittent administration of caffeine to induce a sensitized motor response and correlated the individual susceptibility of rats to acute caffeine to the development of sensitization. Moreover, individual susceptibility to caffeine and development of motor behaviour sensitization were correlated to the behavioural response obtained after a challenge with amphetamine. To this end, rats were subdivided in "low" and "high" responders according to their individual susceptibility to acute caffeine established on the basis of the motor activity observed after the first caffeine administration. "Low" and "high" responder rats were then repeatedly and intermittently treated with caffeine (15 mg/kg, i.p.), or vehicle, every other day for fourteen days. Three days after treatment discontinuation, behavioural activation induced by acute amphetamine (0.5 mg/kg, s.c.) was measured in vehicle- and caffeine-pretreated rats. Subchronic caffeine resulted in motor sensitization of a variable degree among rats and no difference were observed between "low" and "high" responders. Moreover, caffeine pretreatment potentiated the behavioural effects of amphetamine according to the degree of caffeine sensitization but not to individual susceptibility to acute caffeine. These results demonstrate that individual susceptibility to acute caffeine does not influence the modifications in caffeine motor effects produced by its subchronic administration and does not affect the enhancement of acute behavioural effects of amphetamine in caffeine-pretreated rats, rather sensitization to subchronic caffeine administration critically influences the behavioural effects of amphetamine.     

Failure of kindling to alter susceptibility to kainic acid

In this study, the interaction between electrical kindling and kainic acid seizures was investigated. Prepubescent male rats were kindled using hourly, suprathreshold stimulations. Two days later the kindled rats and their non-kindled controls received systemic injections of either 6, 10, or 17 mg/kg of kainic acid. No differences in response to kainic acid were seen between the two groups. These data demonstrate that the kindled brain does not uniformly exhibit a lower seizure threshold to all convulsants, but is dependent on the agents subsequently used to induce the seizures.     

Hypohidrosis Related to the Administration of Topiramate to Children

PURPOSE: Topiramate (TPM) is an antiepileptic agent, first licensed in the United Kingdom in 1994, that is used in the treatment of patients with refractory seizure disorders. TPM is a monosaccharide d-fructose derivate, with sulfamate function, and so far, few adverse side effects have been reported. METHODS: We describe three patients with epilepsy who were treated with TPM and developed hypohidrosis, heat and exercise intolerance, as well as fever. The sudomotor function was assessed after peripheral stimulation with pilocarpine iontophoresis. RESULTS: Sweat response was reduced in all three patients. Signs and symptoms ceased after drug suppression. CONCLUSIONS: This side effect associated with TPM, which has not been described previously, can be clinically significant during heat stress and exercise challenge.