Temporal effects of testosterone propionate injections on serum lipoprotein concentrations in rats.

The chronic abuse of androgenic anabolic steroids, a group of synthetic derivatives of testosterone, to improve athletic performance have demonstrated compromised serum lipoprotein concentrations reflecting an elevated risk for cardiovascular disease. While the detrimental alterations in the lipoprotein profile have been reported consistently for orally administered androgenic anabolic steroids, the reports examining the effects of parenteral administration of testosterone upon the lipid profile remain equivocal. PURPOSE: The purpose of this study was to determine whether compromised serum lipoprotein concentrations would be manifest in rats receiving testosterone injections (twice per week) over the time course of 7 wk. METHODS: Male rats were randomly assigned to either an experimental group (dose per injection, 3 mg x kg(-1) testosterone propionate solubilized in 1 mL of safflower oil) or a control group (injected with an isovolumic amount of safflower oil alone). The effects of the steroid regimen on the serum lipoprotein profiles were followed after 1, 3, 5, and 7 wk of injections. To assess the relative effects of testosterone propionate, testicular mass was determined at the time of sacrifice. RESULTS: Testicular mass (mean +/- SE) was significantly lower (P<0.01) in the experimental group, 3.08+/-0.03 g, compared with that in controls, 3.82+/-0.05 g, by week 3 and continued to decline for the remainder of the steroid regimen, reaching a nadir of 2.70+/-0.01 g at week 5. No significant differences were observed between groups for total serum cholesterol, serum triacylglycerols, or serum low density lipoprotein (LDL)-C at any time point. However, at week 7, serum high density lipoprotein (HDL)-C (mean +/- SE) was significantly lower (P<0.02) in the testosterone treated animals, 32+/-2 mg x dL(-1), compared with that in controls, 47+/-2 mg x dL(-1). As a result, the ratio of total cholesterol to HDL-C (mean +/- SE) significantly increased (P<0.02) by the seventh week in the testosterone treated group, 3.5+/-0.2, versus controls, 2.5+/-0.2. CONCLUSIONS: The results suggest that while testosterone propionate injections elicit a reduction in testicular mass within 3 wk, the lipoprotein profile is not altered until week 7. Further, the only compromised parameter under the conditions of this study is the decrease in serum HDL-C.     

Physical activity, smoking, alcohol consumption, body mass index, and plasma lipid profiles of military reserve officers

We assessed the physical activity level, smoking habits, alcohol consumption, ponderosity, and plasma lipid profiles of 688 middle-aged male reserve officers. When adjusting for Body Mass Index (BMI), individuals who reported physical activity of three or more times per week had significantly higher levels of high density lipoprotein cholesterol (HDL-C), lower total cholesterol (TC) to HDL-C, and low density lipoprotein cholesterol (LDL-C) to HDL-C ratios than inactive individuals of similar age and body weight. Triglyceride, TC, and LDL-C concentrations were similar in both active and inactive subjects.     

国产辛伐他汀治疗原发性高胆固醇血症的临床观察

为探讨国产辛伐他汀对原发性高胆固醇血症的调脂作用,本文观察了４２例高胆固醇血症患者,根据血清ＴＣ水平随机按１：１分验证组及对照组各１３例,另设１６例开放验证,验证组服用国产辛了汀;对照组均服用进口舒降之,疗程均为８周。验证组与对照组均服药８周,降血清总胆固醇分别为２４．６％和２４．１％;降低密度脂蛋白胆固醇分别为３４．７％和３４．９％;     

脑梗死患者血清同型半胱氨酸与小而密低密度脂蛋白胆固醇的关系

目的探讨血清同型半胱氨酸(Hcy)水平升高和小而密低密度脂蛋白胆固醇(sdLDL-C)水平在脑梗死发病中的作用。方法采用全自动生化分析仪检测124例脑梗死患者血清Hcy和sdLDL-C水平,同时检测血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血糖水平。根据头颅CT和磁共振检查证实后将患者分为多发性脑梗死组与单发性脑梗死组,观察其与Hcy及sdLDL-C的关系。结果脑梗死组血清Hcy及血脂水平明显高于对照组(HDL-C低于对照组),P<0.05,Hcy与sdLDL-C水平随脑梗死病变程度增加而升高(P<0.05)。Hcy和sdLDL-C与脑梗死病变程度密切相关(r=0.259和r=0.452,P<0.001)。结论 Hcy和sdLDL-C均是脑梗死发病的独立危险因素。     

Serum lipids in power athletes self-administering testosterone and anabolic steroids

The purpose of the present investigation was to study the effects of testosterone and anabolic steroids on serum lipids in power athletes. Altogether 11 national top-level adult athletes completed the study. Five of them volunteered for the study group and the rest for controls. The follow-up consisted of 9 months of a strength training period. During the first 6 months, the subjects in the study group self-administered androgenic steroids on an average of 57 +/- 24.9 mg/day. The most interesting observation was the extremely low high-density lipoprotein (HDL) and HDL2 cholesterol concentrations of the androgen users. After 8 weeks of training, the study group had significantly (P less than 0.05) lower HDL cholesterol concentrations than the control group (0.53 +/- 0.11 and 1.14 +/- 0.19 mmol/l, respectively). This difference remained significant from 8 to 32 weeks of training. No systematic changes were observed in the control group. The HDL2 cholesterol concentration decreased by about 80% (P less than 0.01) and HDL3 cholesterol by about 55% (P less than 0.01) from the onset values in the study group. A substantial decrease in HDL cholesterol to total cholesterol and in HDL2 cholesterol to HDL3 cholesterol ratios were also noticed under the influence of exogenous androgens. The results of this study suggest that the sustained use of testosterone and anabolic steroids have a marked unfavorable effect on the pattern of HDL cholesterol in the serum of male power athletes.     

饮用加银水对尾吊大鼠脂质代谢的影响

目的 研究饮用加银水对尾吊模拟失重大鼠红细胞膜流动性、血脂和血管内皮细胞的影响。方法 30只SD雄性大鼠随机分为地面对照组(GC组)、模拟失重对照组(SC组)和模拟失重饮用0．20mg／L加银水组(SS组)，实验期21d。观察大鼠血脂指标、红细胞膜流动性以及脱落循环内皮细胞数量的变化。结果 SC组大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)水平、HDL-C／TC比值以及红细胞膜流动性低于GC组，LDL-C(低密度脂蛋白胆固醇)／HDL-C比值和脱落循环内皮细胞数量高于GC组。SS组和SC组比较，SS组大鼠血清TC、LDL-C和LDL-C／HDL-C比值增高，HDL-C／TC比值和红细胞膜流动性降低。结论 长期饮用0．20mg／L加银水可以加重尾吊模拟失重大鼠脂质代谢的紊乱。     

三酰甘油/高密度脂蛋白胆固醇比值与糖尿病肾病的关系

目的探讨三酰甘油/高密度脂蛋白胆固醇(TG/HDL-C)比值与糖尿病肾病的关系。方法将340例糖尿病住院病人,分为糖尿病肾病组(n=103)和糖尿病无肾病组(n=237),检测血清TG和HDL-C水平,计算TG/HDL-C比值,进行比较分析。结果糖尿病肾病组血清TG/HDL-C比值水平为(2.676±2.984),糖尿病无肾病组为(1.713±1.482),两组相比,差异有非常显著性意义(t=3.9 5 6,P<0.0 0 1)。糖尿病肾病组TG/HDL-C比值异常率(69.9%)明显高于糖尿病无肾病组(44.7%),差异有显著性意义(χ2=18.24,P<0.01),也高于TG及HDL-C单项指标的异常率。结论血清TG/HDL-C比值与糖尿病肾病相关,可能是糖尿病肾病发生的一个危险因素。     

Counting Your Calcium

Abstract

Aims: We characterized the size of active National Football League (NFL) players by multiple criteria and analyzed their relation to traditional cardiovascular disease (CVD) risk factors with the objective of further clarifying the occurrence of cardiovascular risk factors in different player positions. Methods: This cross-sectional study was conducted in professional athletic training facilities. The participants were 504 active veteran players from a convenience sample of 12 NFL teams, grouped as interior linemen (IL) or all others (AO). Comparisons were made between the NFL groups and an age-equivalent general population database. Results: The IL group was significantly larger than AO by all size measures. Both groups were significantly larger than the Coronary Artery Risk Development in Young Adults (CARDIA) group. Mean percent body fat measurements in AO (mean, 13.4%; 95% confidence interval [CI], 12.9%–14%) and IL (mean, 25.2%; 95% CI, 24.4%–26%) groups were lower than estimates for the general population. Systolic blood pressure (BP) was higher in IL (mean, 131 mm Hg; 95% CI, 129–133 mm Hg) than AO (mean, 126 mm Hg; 95% CI, 125–127 mm Hg) and greater in both groups compared with the CARDIA group (mean, 112 mm Hg; 95% CI, 111–112 mm Hg). Mean low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (HDL-C), total cholesterol, triglycerides, and glucose were within the normal range for both IL and AO. Interior linemen had significantly lower HDL-C than AO and the CARDIA group. Both NFL groups had significantly lower fasting glucose than CARDIA. Conclusion: Body fat in active NFL players was lower than predicted by standard measures of obesity. Although the players were large, they were in the normal range for most CVD risk factors. Mean BP in the prehypertensive range was found in both NFL position groups, but was significantly higher in IL than in AO. Prehypertension in these athletes warrants vigilance.     

脂质/高密度脂蛋白胆固醇比值对急性脑梗死患者脑动脉狭窄的诊断价值

目的：探讨急性脑梗死患者脑动脉狭窄与脂质/高密度脂蛋白胆固醇（HDL-C）比值的相关性。方法：对263例住院急性脑梗死患者行头颅MRA检查,根据MRA所提示脑动脉狭窄的检查结果分为狭窄组（n=141）和对照组（n=122）。用全自动血生化分析仪测量患者的血生化指标。结果：狭窄组和对照组血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）水平及TG/HDL-C比值无显著性差异（P〉0.05）;血清TC/HDL-C及LDL-C/HDL-C比值有显著性差异（P〈0.05）,HDL-C水平狭窄组低于对照组（P〈0.05）。Logistic多元回归分析年龄和HDL-C降低是脑动脉狭窄的独立危险因素。结论：在急性脑梗死患者脑动脉狭窄评估中,TC/HDL-C和LDL-C/HDL-C比值是敏感性指标。     

Blood lipids in young distance runners

PURPOSE: The purpose of this study was to examine the age-and sex-associated variation in blood lipids among young athletes. METHODS: A mixed-longitudinal design was used to examine the development of blood lipids in competitive young distance runners followed from 1982 to 1985. Serial data included 99 annual measurements for 27 male subjects and 84 annual measurements for 27 female subjects aged 9-18 yr. Total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), and triglycerides (TG) were determined by standard procedures. RESULTS: In general, cross-sectional age group means showed that TC and LDL-C remained stable and HDL-C declined with age, especially in male subjects. TG increased with age. Age-related trends were statistically significant for HDL-C and TG in boys only (P < 0.05). TC and LDL-C were slightly greater in boys at all ages except 11, 15, and 17 yr (P > 0.05). HDL-C was similar between the sexes until 13 yr when values became greater in girls (3.2-13.8 mg.dL(-1)) (P < 0.05 in 17+ yr). No clear pattern of sex differences emerged for TG. Compared with the general population, blood lipids of young distance runners showed the following trends: 1) TC was above reference medians, 2) LDL-C tended to approximate or to be slightly above reference medians, 3) TG fluctuated about the reference medians, and 4) HDL-C was higher in distance runners compared to the reference medians before age 14 yr, but in the older age groups, especially male subjects, HDL-C either approximated or fell slightly below the reference medians. There was considerable variability in blood lipid levels among the runners. In 21 male and 18 female subjects with serial data for 3-5 yr, HDL-C declined 22.4 and 18.3 mg.dL(-1) (P < 0.05), whereas TG increased 18.0 and 14.0 mg.dL(-1)(P < 0.05 in female subjects only) in male and female subjects, respectively. Tracking coefficients over intervals of 3-5 yr were moderate to high (0.48-0.90), except for TG in male subjects (0.08). CONCLUSIONS: The results indicate that the development of blood lipids in young distance runners is similar to youth in the general population. In contrast to observations in adult endurance athletes, young distance runners did not possess a superior blood lipid profile except for HDL-C in the younger age groups.     

Resistance trained athletes using or not using anabolic steroids compared to runners: effects on cardiorespiratory variables, body composition, and plasma lipids.

OBJECTIVE--To determine whether there is a difference in cardiac size and function as well as in body composition, aerobic capacity, and blood lipids between resistance trained athletes who use anabolic steroids and those who do not, and to compare them to university cross country athletes. METHODS--Four groups of men were evaluated: recreational lifters, n = 11, lifting < 10 h.week-1; heavy lifters, n = 16, lifting > 10 h.week-1; steroid users, n = 8, same as heavy lifters and used steroids; runners, n = 8, university track members. Echocardiograms, body composition (hydrostatic weighing), maximum oxygen consumption (Vo2), and lipids were studied. RESULTS--As expected, Vo2 (ml.kg-1.min-1), was greatest in the runners, with no difference among the lifting groups. High density lipoprotein cholesterol in the steroid user group was lower than in heavy lifters or runners. Left ventricular internal diastolic dimension was similar among the groups. The left ventricular mass index of the steroid user group was significantly greater than recreational lifters, at 161 v 103. There was no difference among heavy lifters (127), runners (124), and steroid users. There was no compromise in diastolic function in any group. There were no differences among groups in resting or exercise blood pressure. CONCLUSIONS--Resistance training in the absence of steroid use results in the same positive effects on cardiac dimensions, diastolic function, and blood lipids as aerobic training.     

Effects of step aerobics and aerobic dancing on serum lipids and lipoproteins

BACKGROUND: To examine the effect of 8 weeks of step aerobics and aerobic dancing on blood lipids and lipoproteins. METHODS: EXPERIMENTAL DESIGN: Comparative training. SETTING: Two months of physical fitness program. PARTICIPANTS: Forty-five sedentary female college student volunteers randomly assigned to one of the three groups as step aerobics (n=15), aerobic dancing (n=15) and the control group (n=15). The step aerobics and aerobic dancing groups participated in sessions of 45 min per day, 3 days per week for 8 weeks with 60-70 percent of their heart rate reserve. MEASURES: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol levels (HDL-C), the ratio of total cholesterol to high-density lipoprotein cholesterol (TC:HDL-C). RESULTS: At the end of the 8 week period, a significant difference has been found between the step aerobics group and the control group and between the aerobic dancing group and the control group in TC levels (F[2,44]=8.38; p<0.01). A significant difference in HDL-C levels (F[2,44]=3.65; p<0.05) and TC:HDL-C ratio (F[2,44]=11.56; p<0.01) has been found only between the step aerobics group and the control group. CONCLUSIONS: These results indicate that step aerobics training is an effective training mode for modifying lipid and lipoprotein profiles of female college-aged students.     

Anabolic Steroid Use Among Athletes: Changes in HDL-C Levels

In brief: Despite warnings of possible risk to liver, prostate, and kidney function, the use of anabolic steroids has become widespread among athletes. This study examined the influence of oral and injected anabolic steroids on serum HDL-C levels in nine strength-trained men. The mean HDL-C concentration in these subjects was 17.0 ± 2.3 mg/100 ml, which was significantly lower (p ≤.05) than the means for untrained (46 ± 1.6 mg/100 ml) and strength-trained (44.6 ± 1.3 mg/100 ml) men who were not using these drugs. In light of the relationships reported between low levels of HDL-C and the incidence of coronary artery disease, the administration of these drugs to otherwise healthy men appears to be ethically and clinically inadvisable.     

老年前期与老年期原发性高血压患者血脂的变化及临床意义

目的探讨老年前期和老年期原发性高血压患者血脂变化及其临床意义。方法将160例原发性高血压患者分为老年前期与老年期两组,测定晨起空腹静脉血中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),将各指标与健康对照组以及高血压患者老年前期与老年期对比分析。结果高血压组TC、TG和LDL-C显著高于对照组,差异均有统计学意义(P<0.05),而HDL和HDL-C/TC则明显低于对照组,差异均有统计学意义(P<0.05)。高血压老年期组TC、TG和LDL-C水平高于老年前期组(P<0.05),而HDL-C和HDL-C/TC则低于老年前期组,差异均有统计学意义(P<0.05)。结论老年原发性高血压患者TC、TG和LDL-C增高,而HDL-C和HDL-C/TC降低,且老年期变化更为明显,提示老年原发性高血压患者应注意追踪观察血脂的变化。     

HDL-C Concentrations in Weight-Trained,Endurance-Trained,and Sedentary Females

In brief: Serum high-density lipoprotein cholesterol (HDL-C) levels and percent HDL-C were significantly higher in nine female endurance runners than in equal groups of female weight trainers and sedentary female controls. Weight trainers and controls showed no significant differences in HDL-C and percent HDL-C. Subjects who had higher HDL-C levels were more likely to be non-smokers who consumed little alcohol and did not use oral contraceptives. No significant dose-response relationships were found for either runners or weight trainers when daily training duration, weekly training frequency, and weekly mileage were correlated with HDL-C. It was concluded that HDL-C levels in females are associated with specific training methods.     

The effects of testosterone on lipids and eicosanoids in cynomolgus monkeys.

The effect of testosterone administration on plasma lipoproteins and eicosanoids was studied in 24 male cynomolgus monkeys. We hypothesized that elevated plasma testosterone would unfavorably alter plasma lipids as well as thromboxane A2 (TxA2) and prostacyclin (PGI2), two eicosanoids that have been linked to the increased incidence of atherosclerosis, myocardial ischemia, and thrombosis. To test our hypothesis, half of the monkeys (N = 12) were subjected to 10 wk of testosterone treatment, whereas the remaining monkeys (N = 12) received a sesame oil vehicle. The plasma concentrations of thromboxane B2 (TxB2) and 6-keto-PGF1 alpha, the stable metabolites of TxA2 and PGI2, respectively, were determined. Additionally, assays were conducted on total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Distribution of the HDL subfraction protein was measured by gradient gel electrophoresis. All monkeys exhibited significant increases in TC (P less than 0.001) and low density lipoprotein cholesterol (LDL-C) (P less than 0.001); however, monkeys who received testosterone also displayed significant increases in TxB2 (P less than 0.03) and decreases in HDL-C (P less than 0.03) compared with control monkeys. There was a trend in the HDL-C subfraction data, indicating that testosterone treatment may be associated with a decrease in the larger HDL2b subfraction and a corresponding increase in HDL3c. These results demonstrate that exogenous testosterone adversely alters cardiovascular risk profiles by increasing TXB2 production and decreasing HDL-C. Athletes who use testosterone as an anabolic androgenic steroid may have an increased risk for coronary heart disease.     

Immediate and delayed effects of marathon running on lipids and lipoproteins in women

The purpose of this investigation was to examine the immediate and delayed effects of prolonged strenuous exercise on plasma lipid and lipoprotein concentrations in female runners. Venous blood samples were collected from 12 female runners 24 h before, 10 min after, and 1, 3, and 5 d after running a 42 km marathon. Whole blood was analyzed for hematocrit and hemoglobin to determine plasma volume shifts. Plasma aliquots were assayed for total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglyceride concentrations, while low-density lipoprotein cholesterol (LDL-C) was estimated. Total cholesterol concentrations were significantly reduced 1 d following the exercise and were still lower 3 and 5 d post-marathon. LDL-C was lower immediately and 1 d after the marathon. HDL-C concentrations, corrected for changes in plasma volume, were elevated 24 h post-exercise. The ratio of HDL/total cholesterol was increased 24 h post-exercise. Triglyceride concentrations were elevated immediately following the marathon but returned to baseline levels by 24 h post-exercise. These results demonstrate that prolonged strenuous exercise in women produces changes in blood lipid profiles that can last for several days.     

Physical activity,hormone replacement therapy and plasma lipoprotein-lipid levels in postmenopausal women

We assessed the cross-sectional associations between hormone replacement therapy (HRT), habitual physical activity levels and plasma lipoprotein-lipid levels in postmenopausal women. Sedentary (n = 19), active nonathlete (n = 20) and endurance-trained (n = 21) postmenopausal women, with half of each group on and half not on HRT, underwent assessments of plasma lipids, VO2max, body composition, diet and common genetic variants. The groups' physical characteristics were generally similar though body weight was higher in the active nonathletes, and body fat was lower and VO2max higher in the athletes. HRT was associated with beneficial total cholesterol, LDL-C and HDL-C levels in sedentary and active nonathlete women. Plasma lipoprotein-lipid profiles were similar in women athletes on and not on HRT, with their profiles being only slightly better than sedentary and physically-active women on HRT. After controlling for HRT status, VO2max was correlated with total cholesterol (r = -0.51, p = 0.0001), LDL-C (r = -0.52, p = 0.0001), HDL-C (r = 0.25, p = 0.055), HDL 2 -C (r = 0.24, p = 0.08) and TG levels (r = -0.46, p = 0.0001). After controlling for HRT status, % body fat was correlated with total cholesterol (r = 0.43, p = 0.001), LDL-C (r = 0.38, p = 0.003), HDL-C (r = -0.29, p = 0.025), HDL 2 -C (r = -0,26, p = 0.07) and TG levels (r = 0.40, p = 0.002). Dietary fat intake was similar among the groups. APO E genotype was only associated with plasma lipid profiles in athletes, as those with at least one APO E2 allele tended to have better lipid profiles than those with only APO E3 or E4 alleles. Thus, HRT, exercise training and body composition are associated with plasma lipid levels in postmenopausal women; common polymorphic variations at key lipid metabolism-related gene loci also may interact with exercise training to affect their plasma lipid profiles.     

高血压对男性冠心病患者血脂和载脂蛋白的影响

 目的观察高血压对男性冠心病患者血脂和载脂蛋白的影响.方法将276例患者分为高血压病组(EH,83例)、冠心病组(CHD,85例)、高血压合并冠心病组(EH+CHD,108例).选择健康体检者106例作为对照组.比较三组患者的血脂和载脂蛋白的变化情况,并做分层分析.结果(1)三组患者的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(Apo B)水平均明显高于对照组,而高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A-I(Apo AI)和Apo AI/B的水平明显降低(P＜0.05).(2)未按年龄分组时,各项血脂水平在三组患者中差异无统计学意义.(3)按年龄分层后,≤55岁组中EH+CHD组TC、甘油三酯(TG)和LDL-C的水平最高.结论高血压患者存在血脂代谢紊乱,在合并冠心病时高血压对血脂具有叠加作用,应加强中青年男性高血压患者的调脂治疗.     

失血性休克大鼠血清脂质水平分析

目的对失血性休克大鼠血清脂质水平进行检测,探讨脂质代谢在失血性休克发生、发展中的变化规律及机制。方法雄性Wistar大鼠50只,随机分为5组(每组10只):正常对照(SHS)组;重度失血性休克(RHS)组;中度失血性休克(MHS)组,按休克后采血时间的不同又分为休克30 min(MHS-30 min)组、休克60 min(MHS-60 min)组及休克120 min(MHS-120 min)组。分别对各组血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)进行检测。结果 (1)MHS组与SHS组比较:TG显著上升(P<0.01),TC、HDL-C均显著降低(P均<0.01),而LDL-C无显著变化(P>0.05),HDL/LDL比值显著下降(P<0.01)。(2)RHS组与SHS组比较:TG、LDL-C显著上升(P均<0.01),TC、HDL-C显著降低(P均<0.01),HDL/LDL比值显著下降(P<0.01)。(3)RHS组与MHS组比较:TC、TG均显著降低(P<0.01);HDL-C及LDL-C无统计学差异(P均>0.05),而HDL/LDL比值显著下降(P<0.05)。(4)MHS三不同时间组之间比较:TC水平MSH-30 min组与MHS-60 min组比较无统计学差异(P>0.05),而MHS-60 min组显著高于MHS-120 min组(P<0.05);TG水平三组间差异显著,MHS-60 min组最高,分别是MHS-30 min组及MHS-120 min组的2.28倍和1.99倍(P均<0.01),而MHS-30 min组与MHS-120 min组比较无统计学差异(P>0.05);HDL-C水平MHS-60 min组显著低于MHS-30 min组(P<0.05),而MHS-60 min组与MHS-120 min组无统计学差异(P>0.05);LDL-C水平MHS-60 min组显著高于MHS-30 min组(P<0.01),而MHS-60 min组与MHS-120 min组无统计学差异(P>0.05);但HDL/LDL比值三组间均差异显著(P<0.01或0.05),呈进行性下降。结论不同程度失血性休克大鼠血清脂质水平存在明显差异,而且随着休克的发展脂质水平呈动态变化,血清脂质水平可反映失血性休克的严重程度及其动态进展。