前庭综合征患者伴发焦虑抑郁情绪的调查

目的分析前庭综合征患者的焦虑及抑郁情况,并分析其影响因素。方法 2019年01月14至16日中的一天对全国多家医院耳鼻咽喉头颈外科及神经内科眩晕门诊就诊的患者进行问卷调查,采用眩晕病史问卷记录眩晕相关情况,抑郁筛查量表(PHQ–9)和广泛性焦虑量表(GAD–7)测定其抑郁和焦虑情况。结果急性前庭综合征、发作性前庭综合征、慢性前庭综合征患者分别为59例(19.3%)、208例(68.2%)、38例(12.5%);男女比例约1:2。女性患者较男性患者更易伴发抑郁情绪(P=0.027<0.05),且女性患者伴发抑郁情绪的程度明显高于男性患者(P=0.001<0.05);女性患者较男性患者更易伴发焦虑情绪(P=0.007<0.05),女性患者伴发焦虑情绪的程度明显高于男性患者(P=0.001<0.05)。前庭综合征患者中伴发抑郁情绪的共有130例(42.6%),伴发焦虑情绪的共有132例(43.2%),不同诊断类型的前庭综合征患者在伴发抑郁情绪比例的差异无统计学意义(P=0.077>0.05),慢性前庭综合征患者伴发焦虑情绪的概率大于发作性及急性前庭综合征患者(P=0.007<0.05),不同诊断类型前庭综合征的患者在焦虑程度上的差异无统计学意义(P=0.462>0.05)。结论前庭综合征患者中,发作性前庭综合征的患者占比最大,急性前庭综合征次之,慢性前庭综合征最少;女性患者多于男性,女性患者较男性更易伴发抑郁、焦虑情绪;女性患者的抑郁程度、焦虑程度更重。慢性前庭综合征患者较发作性前庭综合征、急性前庭综合征更易伴发焦虑情绪,但各型前庭综合征患者之间的焦虑程度无明显差异。     

4630例屈光手术前患者免疫四项检测结果分析

目的分析激光角膜屈光手术前患者乙型肝炎病毒表面anti-原(HBsAg)、丙型肝炎病毒anti-体(anti-HCV)、梅毒螺旋体anti-体(anti-TP)和免疫缺陷病毒anti-体(anti-HIV)4项指标的感染情况,规范手术管理。方法采用酶联免疫法对拟行激光角膜屈光矫正手术的患者4630例(9200眼)进行上述四项感染指标检测,并对结果进行回顾统计分析。结果4630例受检者总阳性检出率为3.02%(140例),HBsAg、anti-HCV、anti-TP和anti-HIV的阳性检出率分别为2.13%(99例)、0.19%(9例)、0.62%(29例)和0.06%(3例),男性感染阳性率高于女性(χ^2=8.04,P=0.01),男性HBsAg和anti-HIV发病率高于女性(χ^2=16.11,6.05,P均<0.01)。结论激光角膜屈光手术前检测患者的感染指标有助于了解其感染状态,降低手术源性感染风险,提高手术的安全性。     

突发性聋患者糖皮质激素治疗前后外周血单个核细胞Nrf2表达分析

目的 探讨突发性聋(sudden sensorineural hearing loss,SSNHL)患者体内转录因子NF-E2相关因子2(nuclear factor erythroid2 related factor,Nrf2)的变化及其与糖皮质激素(glucocorticoid,GC)抵抗的关系.方法 分离30例SSNHL患者治疗前后外周血单个核细胞(peripheral blood mononuclear cells,PBMCs),提取总RNA,采用实时荧光定量PCR(quantitative real time PCR,QRT-PCR)方法检测其PBMCs中Nrf2 mRNA的表达量.根据就诊时间及用药情况将这30例SSNHL患者分为初发组(7例)和难治组(23例);难治组又根据听力恢复是否≥15 dB分为GC有效组(10例)及抵抗组(13例);选择10例听力正常的志愿者为对照组;比较各组SSNHL患者治疗前后Nrf2 mRNA表达量及与GC抵抗的关系.结果 ①30例患者中,治疗前难治组、初发组Nrf2 mR-NA表达量分别为0.520±0.049、0.514±0.052,两组间差异无统计学意义(F=0.052,P=0.911),但均低于对照组(0.607±0.106)(F=6.483,P=0.004);②治疗前难治组中GC有效组、抵抗组患耳0.25～8 kHz平均听阈(pure tone average,PTA)分别为81.75±13.28和91.80±13.79 dB HL,治疗后分别为54.67±15.65和89.87±13.98 dB HL.治疗后GC有效组Nrf2 mRNA表达量(0.560±0.051)较治疗前(0.510±0.028)有所上调(t=3.007,P=0.015),而GC抵抗组Nrf2 mRNA表达量(0.519±0.054)较治疗前(0.526±0.060)无明显变化(t=0.485,P=0.636).结论 Nrf2表达上调或下降可能参与SSNHL的发生发展;难治性SSNHL患者GC抵抗的机制可能与Nrf2低表达相关,上调Nrf2可能改善难治性SSNHL患者对GC的敏感性和预后.     

突发性极重度聋与全聋的预后特点及差异

Objective To clarify the different prognostic characteristics between profound sudden sensorineural hearing loss (SSNHL) and total SSNHL. Methods The patients with SSNHL who visited Eye Ear Nose and Throat Hospital from June 2007 to September 2008 were reviewed retrospectively. All the 204 patients, with pure tone average (PTA) threshold more than 90 dB, were enrolled and divided into two groups, including total SSNHL and profound SSNHL groups. The relationship between recovery rate and prognostic factors including the age, complications, time period between onset and therapy was analyzed.Results There were 57 cases of total SSNHL and 147 cases of profound SSNHL in this series. Tinnitus was complained in more than 90% of the patients in both groups, which was higher than that of dizziness and ear fullness. Dizziness was present in 64. 9% (37/57) patient with total SSNHL group and 45.6% (67/147)patients with profound SSNHL, which had significant difference between the two groups (x2 = 5.72,P =0. 017). The PTA threshold improvement in total SSNHL group and profound SSNHL group was (36. 4 ±19.3) dB and (40. 2 ±21.3) dB respectively, which was no significant difference between the two groups (t = 1. 165 ,P =0. 245). The cured patients were all those received therapy within 1 week following the onset of SSNHL, which was of 2. 6% (1/38) patients in the total SSNHL group and 14. 3% (14/98) patients in the profound SSNHL group(P =0. 045). Furthermore, 3.5% (2/57) patients in total SSNHL group as well as 29. 9% (44/147) patients in profound SSNHL group obtained a good result with PTA threshold ≤50 dB after therapy(x2 = 15.92,P = 0. 001 ). In addition, the favorable prognosis was related with the onsettherapy time point( P = 0. 001 ), but not related to the patients' age. Conclusion Profound SSNHL and total SSNHL though both with PTA threshold > 90 dB had significant differences recovery rate and need to be studied separately.     

血胆固醇及纤维蛋白原水平与突发性聋相关性分析

目的探讨血胆固醇及纤维蛋白原水平对突发性聋(sudden sensorineural hearing loss,SSNHL)发生率和疗效的影响.方法选择2017年1月~2019年5月符合纳入标准的64例SSNHL患者和84名年龄和性别匹配的对照受试者作为研究对象,分析纤维蛋白原、总胆固醇、高密度脂蛋白(high-density lipoprotein,HDL)和低密度脂蛋白(low density lipoprotein,LDL)的血浆浓度对SSNHL发生率和疗效的影响.结果右侧单侧SSNHL占50%,左侧单侧SSNHL占42.2%,双侧同时发病占7.8%,白细胞计数升高占34.4%,C-反应蛋白(C-reactive protein,CRP)水平升高占20.3%.在SSNHL发生率的比较中,诊疗组患者的纤维蛋白原的血浆浓度与对照组相比显著升高[(357±68)mg/dl vs(239±109)mg/dl,P=0.001],诊疗组患者平均HDL血浆浓度与对照组相比有所降低[(1.47±0.41)mmol/L vs(1.80±0.43)mmol/L,P=0.01].在SSNHL疗效的比较中,显效组患者纤维蛋白原的血浆浓度与对照组相比显著升高(P=0.019).结论低HDL胆固醇血浆浓度可能是SSNHL的危险因素之一.纤维蛋白原水平升高和炎症指标的升高可能表明SSNHL的危险性增加.高纤维蛋白原水平与SSNHL预后不良有关,血清纤维蛋白原水平可以作为使用降低血清纤维蛋白原和血液黏度疗法的有用标志物.     

突发性极重度聋与全聋的预后特点及差异

Objective To clarify the different prognostic characteristics between profound sudden sensorineural hearing loss (SSNHL) and total SSNHL. Methods The patients with SSNHL who visited Eye Ear Nose and Throat Hospital from June 2007 to September 2008 were reviewed retrospectively. All the 204 patients, with pure tone average (PTA) threshold more than 90 dB, were enrolled and divided into two groups, including total SSNHL and profound SSNHL groups. The relationship between recovery rate and prognostic factors including the age, complications, time period between onset and therapy was analyzed.Results There were 57 cases of total SSNHL and 147 cases of profound SSNHL in this series. Tinnitus was complained in more than 90% of the patients in both groups, which was higher than that of dizziness and ear fullness. Dizziness was present in 64. 9% (37/57) patient with total SSNHL group and 45.6% (67/147)patients with profound SSNHL, which had significant difference between the two groups (x2 = 5.72,P =0. 017). The PTA threshold improvement in total SSNHL group and profound SSNHL group was (36. 4 ±19.3) dB and (40. 2 ±21.3) dB respectively, which was no significant difference between the two groups (t = 1. 165 ,P =0. 245). The cured patients were all those received therapy within 1 week following the onset of SSNHL, which was of 2. 6% (1/38) patients in the total SSNHL group and 14. 3% (14/98) patients in the profound SSNHL group(P =0. 045). Furthermore, 3.5% (2/57) patients in total SSNHL group as well as 29. 9% (44/147) patients in profound SSNHL group obtained a good result with PTA threshold ≤50 dB after therapy(x2 = 15.92,P = 0. 001 ). In addition, the favorable prognosis was related with the onsettherapy time point( P = 0. 001 ), but not related to the patients' age. Conclusion Profound SSNHL and total SSNHL though both with PTA threshold > 90 dB had significant differences recovery rate and need to be studied separately.     

银杏叶提取物治疗突发性感音神经性聋临床疗效及对血液流变学的影响

目的　探讨银杏叶提取物在突发性感音神经性聋（sudden sensorineural hearing loss,SSNHL）治疗中的应用价值。方法　将138例SSNHL患者按照数字随机表 法分为2组,每组69例;对照组给予地塞米松磷酸钠注射液、前列地尔注射液治疗,研究组在对照组用药基础上给予银杏叶提取物治疗。比较两组患者治疗前后听阈和血液流变学指标,并比较两组治愈率和总有效率。结果　治疗后研究组低频下降型、高频下降型和全频下降型患者听阈均低于对照组（t =3.194、3.847、3.516,P＜0.01）;全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度和红细胞聚集指数均低于对照组（t =4.405、3.356、8.910、4.608、3.356,P＜0.01）,红细胞变形指数高于对照组（t =2.937,P＜0.01）,治愈率和总有效率高于对照组（χ2=4.739、6.824,P＜0.05）。结论　银杏叶提取物可有效帮助患者恢复听力,改善血液流变学指标,提高SSNHL治愈率和总有效率,安全性好,有临床应用价值。     

血小板相关参数与突发性聋相关性分析

目的 探讨血小板相关参数中血小板计数（PLT）、血小板平均体积（MPV）、血小板/淋巴细胞比值（PLR）与不同类型突发性聋（SSNHL）发病的关系及对预后的影响。方法 121例SSNHL患者分为4组,其中低频下降型38例,高频下降型20例,平坦下降型31例,全聋型32例。同时根据疗效判定又将不同类型的SSNHL患者分别分为改善和未改善。并收集相同时期121例健康人作为对照组。比较SSNHL患者PLT、MPV、淋巴细胞绝对值、PLR与对照组的差异、不同类型SSNHL患者之间的差异及不同类型SSNHL患者治疗后改善与未改善患者之间的差异。结果 SSNHL患者与对照组间PLT、淋巴细胞绝对值、PLR比较,差异均具有统计学意义（P均<0.05）。不同类型SSNHL患者组间参数比较, PLR差异具有统计学意义（P<0.05）。不同类型SSNHL患者治疗改善与未改善参数比较,PLT、MPV、淋巴细胞绝对值、PLR差异均无统计学意义（P均>0.05）。结论 SSNHL患者PLT及PLR高于对照组,提示血小板在SSNHL的发病机制中起重要作用,炎症也可能是SSNHL发病的重要因素。但不同类型SSNHL的预后与PLT、MPV、PLR无关。     

儿童腺样体肥大并发分泌性中耳炎与变应性鼻炎发病的相关性分析

目的:分析儿童腺样体肥大群体中并发分泌性中耳炎(OME)与变应性鼻炎(AR)发病之间的相关性。方法:回顾性分析287例腺样体肥大患儿中并发OME的发病情况,有无AR病史,有无鼻类固醇激素使用病史等资料。结果:所有腺样体肥大患儿在不考虑鼻类固醇激素的作用下,伴AR组和不伴AR组中OME发生率分别为25.56%和32.47%,二者差异无统计学意义(χ2=1.643,P>0.05)。对未使用鼻类固醇激素治疗的患儿进行分组分析,伴AR组OME发病率为51.11%,明显高于对照组(32.26%)(χ2=5.019,P<0.05)。伴AR患儿中,使用鼻类固醇激素组中OME发生率为12.50%,明显低于不使用鼻类固醇激素组中OME的发生率(51.11%)(χ2=23.32,P<0.01)。结论:腺样体肥大患儿中OME的发病率较高,其中AR是影响OME发病的一个重要因素。鼻腔类固醇激素的使用可以减少OME的发病率,对中耳炎的治疗有一定效果,具体疗效评估及治疗机制尚需进一步研究。     

耳鼻咽喉门诊咽喉良性病变老年患者喉镜观察与嗓音声学分析

目的 探讨耳鼻咽喉门诊咽喉良性病变老年患者喉部形态特点及嗓音声学特征。方法 选取就诊的101例咽喉良性病变老年患者(≥60岁,男54例,女47例)为研究对象,行电子鼻咽喉镜检查、动态喉镜检查、咽喉反流症状指数评分(RSI评分)、反流体征评分(RFS评分)、嗓音声学分析检测,并对结果进行分析。结果 以声嘶为主诉就诊的老年患者男性明显高于女性(男性占53.7%,女性占29.8%),以咽痛与咽部异物感为主诉就诊的老年患者,男性比例略低于女性,分别为8.5%、13.0%,16.7%∶27.7%;合并胃病的老年患者,男性与女性比例为53.7%∶48.9%;有高血压等其他合并症的老年患者,男女基本持平,分48.1%、55.3%。老年患者动态喉镜结果中有声带闭合不全及黏膜波减弱表现的患者中男性比例略高于女性,分别为27.8%、10.6%、48.1%∶38.3%。有吸烟饮酒病史的老年患者RSI评分与无吸烟饮酒病史的老年患者之间无差异,然而有吸烟饮酒病史的老年患者RFS评分明显高于无吸烟饮酒病史的老年患者(P=0.001,P=0.001)。在对老年患者嗓音声学分析的研究中发现,性别、鼻部疾病及吸烟饮酒不...     

突发性极重度聋与全聋的预后特点及差异

目的 研究突发性极重度聋和全聋的预后特点及差异.方法 回顾性研究复旦大学附属眼耳鼻喉科医院2007年6月至2008年9月收治的初始平均纯音听阈(pure tone average,PTA)>90 dB、随访完整的204例患者,分为全聋和极重度聋两组,对两组的预后进行比较,并对预后与年龄、并发症、发病-就诊时间进行相关性分析.结果 全聋组57例,极重度聋组147例,耳鸣、眩晕、耳闷三大伴随症状中,耳鸣的伴随率最高,两组均达90%以上,眩晕的伴随率全聋组为64.9%(37/57),极重度聋组为45.6%(67/147),两组间差异有统计学意义(x2=5.72,P=0.017).治疗后全聋组PTA下降(36.4±19.3)dB,极重度聋组下降(40.2±21. 3)dB,差异无统计学意义(t=1.165,P=0.245).两组痊愈者均为1周内接受治疗者,全聋组痊愈率为2.6%(1/38),极重度聋组为14.3%(14/98),两组间差异有统计学意义(Fisher确切概率法,P=0.045).全聋组治疗后PTA≤50 dB的患者占3.5%(2/57),极重度聋组达29.9%(44/147),两组间差异有统计学意义(x2=15.92,P=0.001).两组的预后与发病-就诊的时间有关(P值均为0.01),与年龄无关.结论 初始PTA>90 dB的突发性聋可分为极重度聋与全聋,两者预后有差异,需分开进行研究.     

2型糖尿病并微血管病变突发性聋患者的临床特征及预后分析

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)并微血管病变突发性聋(突聋)患者的临床特点及预后。方法分析2013年12月至2019年5月诊治的436例突聋患者的临床资料,根据是否合并T2DM并微血管病变分为T2DM微血管病变组(A组,31例)、T2DM无微血管病变组(B组,103例)和无糖尿病组(C组,302例),对比分析3组患者的临床特征及预后。结果A和B组患者的空腹血糖(FBG)及糖化血红蛋白(HbA1c)水平均高于C组,且A组高于B组,差异有统计学意义(P<0.05);A组极重度聋比例(54.83%,17/31)明显高于B组(29.13%,30/103)和C组(19.87%,60/302);A组患者全聋型比例(58.06%,18/31)明显高于B组(37.86%,39/103)及C组(26.16%,79/302),差异均有统计学意义(均为P<0.05)。治疗后A组患者的痊愈率和总有效率分别为6.45%和35.48%,低于B组(分别为11.65%和53.40%),且A、B两组均低于C组(分别为22.19%和71.85%),差异均有统计学意义(均为P<0.05)。结论伴有T2DM尤其是并发微血管病变的突聋患者听力损失较重,听阈曲线以全聋型为主,预后差;微血管病变可能是T2DM影响突聋预后的潜在机制。     

Pregnancy is not a risk factor for idiopathic sudden sensorineural hearing loss: A nationwide population-based study

Conclusion Sudden sensorineural hearing loss (SSNHL) in pregnancy is rare. It usually occurs in the third trimester. SSNHL in pregnancy does not increase risks during delivery or subsequent stroke.

Objectives This study aimed to investigate the incidence and to determine the factors associated with SSNHL in pregnancy.

Method Data were retrieved from Taiwan's National Health Insurance Database (NHIRD), covering the years 2000–2009. Patients admitted for SSNHL during pregnancy were enrolled. An age-matched controlled cohort was randomly selected from pregnant women without SSNHL in the NHIRD. The clinical characteristics of both cohorts were collected for further analyses.

Results Thirty-three patients with SSNHL in pregnancy were enrolled. The estimated incidence of SSNHL in pregnancy in Taiwan was 2.71 per 100,000 pregnancies. The incidence of SSNHL in pregnancy was lower than that of the general female population. The incidence of SSNHL in the third trimester was higher compared to the other two. The incidence of SSNHL occurring in the 30–39 years old age group was higher than other groups. Women with better socioeconomic status had a higher incidence of SSNHL. There were no identified systemic diseases before SSNHL. Two patients had pre-eclampsia and one patient had premature delivery. Nevertheless, SSNHL in pregnancy did not increase the risk for stroke.     

Impact of methionine synthase gene and methylenetetrahydrofolate reductase gene polymorphisms on the risk of sudden sensorineural hearing loss

Idiopathic sudden sensorineural hearing loss (SSNHL) represents a frequently encountered otological disease of unknown etiology. In recent years, several inherited risk factors have been found in the pathogenesis of vascular diseases. In the present study, we determined whether specific polymorphism or the combination of polymorphisms in folate-dependent homocysteine metabolism genes can act as predisposing inherited vascular risk factors in the development of SSNHL. We conducted a prospective case-control study using DNA samples extracted from 81 patients diagnosed as suffering from SSNHL and 264 healthy control subjects. Three functional polymorphisms were analyzed by polymerase chain reaction amplification, restriction enzyme digestion, and DNA fragment separation by electrophoresis: methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, and methionine synthase (MTR) A2756G polymorphisms. The prevalence of the homozygous genotype of MTR 2756GG in the SSNHL patients (9%) was significantly higher than in the control group (4%) (p = 0.011). The allelic frequency of the G allele of the MTR A2756G polymorphism among SSNHL patients (12.5%) was also significantly higher than in the control group (5%) (p = 0.033). The prevalence of patients possessing two polymorphisms (31%) and three polymorphisms (17%) in the SSNHL group was significantly higher than in the control group (23 and 9%, respectively; p = 0.019). The frequency of patients with a very high rank risk (double homozygous) was significantly higher in the SSNHL group, MTHFR 677TT/MTR 2675GG--7%, than the frequency of patients in the control group, MTHFR 677TT/MTR 2675GG--3% (p = 0.030). Certain polymorphisms in genes encoding enzymes in the folate-dependent homocysteine metabolism are associated with SSNHL. In our case-control study, a significant association between MTR 2756GG genotype and SSNHL was found which may represent an inherited vascular risk factor in the pathogenesis of SSNHL.     

Increased incidence in hospitalised patients with sudden sensorineural hearing loss: a 14-year nationwide population-based study

Abstract

Objective: To conduct a 14-year nationwide study on the epidemiologic incidence in patients with sudden sensorineural hearing loss (SSNHL).

Design: Retrospective cross-sectional design.

Study sample: Data of patients hospitalised with the diagnosis of SSNHL from 2000 to 2013, extracted from the Taiwan National Health Insurance Research Database.

Results: In total, 31,258 patients were included. The mean age was 50.30?±?16.70?years. Males (53.5%) were more commonly diagnosed with SSNHL than females (46.5%). The patients most commonly presented with SSNHL were in the age group of 45–64?years. The crude incidence of SSNHL from 2000 to 2013 was 9.76 per 100,000 people per year. The annual incidence rate shows a steady increased from 5.15 in 2000 to 13.97 per 100,000 people in 2013 with a statistical significance (p?<?0.001).

Conclusion: This 14-year nationwide study indicated an increased incidence rate of SSNHL. This necessitates the development of additional treatment modalities to enhance the prognosis and the clarification of the underlying mechanism of this enigmatic disease.     

突发性聋伴良性阵发性位置性眩晕预后影响的Meta分析

目的探讨突发性聋伴良性阵发性位置性眩晕对其预后产生的影响。方法在中国知网、万方、维普、中国生物医学文献数据库(China biology medicine diss,CBMdisc)、超星数字图书馆等中文数据库和Medline、Embase、Cochrane Library、Ovid SP等英文数据库中检索2010~2020年公开发表的伴BPPV对于SSNHL预后影响的病例对照研究,采用Cochrane Handbook 6.0评价纳入文献的质量,并用RevMan 5.4和Stata软件包对符合质量标准的研究进行Meta分析,选用I2和P值进行异质性检验,根据纳入文献的异质性使用随机效应模型或固定效应模式,在95%置信区间内计算比值比(odds ratio,OR)。结果共检索文献数量541篇,最终纳入10篇,均为中文文献,Meta分析结果表明SSNHL伴BPPV的总有效率显著低于不伴BPPV(OR=0.50,95%CI为0.39~0.65,P<0.01);SSNHL伴的痊愈率显著低于不伴BPPV(OR=0.37,95%CI为0.16~0.88,P=0.02)。结论SSNHL并发BPPV的患者预后较不并发BPPV的患者差。     

Investigation of vitamin D levels in patients with Sudden Sensory-Neural Hearing Loss and its effect on treatment

BackgroundDue to high prevalence of vitamin D deficiency and the possible association with Sudden Sensory-Neural Hearing Loss (SSNHL) finding the main causes and appropriate treatments are highly essential. This study aimed to investigate vitamin D levels in patients suffering SSNHL and its effect on response to treatment.Materials and methodsThis cross-sectional study was performed on two groups of case (34 SSNHL patients) and control (34 healthy subjects without risk of hearing loss). All patient information such as age, sex, audiogram illustration of hearing frequency and the level of vitamin D were recorded at baseline. Patients with SSNHL received routine treatments such as 10 days of 1 mg/kg/day steroid and the response or lack of complete response to treatment was recorded and analyzed according to the audiometry.ResultsVitamin D level in SSNHL group with a mean of 19.28 ± 9.56 ng/ml was significantly less than the control group (25.71 ± 11.21 ng/ml; P value < 0.001). After treatment, 76.5% were completely recovered and 23.5% did not recover completely. Factors such as age, sex and level of initial hearing loss did not have a significant effect on the response to treatment, but the level of vitamin D in these patients had a significant relationship with the response to treatment (P value = 0.004); so that all patients with sufficient vitamin D level had completely recovered, versus 87.5% of patients with vitamin D deficiency and 12.5% of insufficient vitamin D had no response to treatment.ConclusionAccording to the results of the present study, the prevalence of vitamin D deficiency in patients with SSNHL was more than healthy people. SSNHL patients with deficient vitamin D had the highest percentage of no response to treatment.     

Characterization of otologic symptoms appearing after COVID-19 vaccination

ObjectivesAnecdotal reports of sudden sensorineural hearing loss (SSNHL) following COVID-19 vaccination have emerged in the otolaryngology community. Studies have demonstrated no association between COVID-19 vaccination and SSNHL. We aim to characterize the spectrum of otologic symptoms following COVID-19 vaccination.MethodsA cross-sectional study of patients seen in the otology clinic at an academic center was performed. Patients completed a questionnaire on the development of new otologic symptoms within 4 weeks of COVID-19 vaccination. Diagnostic and audiometric data was collected retrospectively for patients reporting otologic symptoms.ResultsBetween May and July 2021, 500 patients were screened. Median age was 56.6 years old, with 59.4 % female and 40.2 % male. 420 patients (84.0 %) were vaccinated, with 58.4 % receiving Pfizer, 29.1 % receiving Moderna, and 3.8 % receiving Johnson & Johnson. 61 patients (14.5 %) reported one or more otologic symptoms within 4 weeks of vaccination, including 21 (5.0 %) with hearing loss, 26 (6.2 %) with tinnitus, 33 (7.9 %) with dizziness, and 19 (4.5 %) with vertigo. Of the 16 patients (3.2 %) reporting tinnitus with no associated hearing loss, 8 were diagnosed with subjective tinnitus and 4 were diagnosed with temporomandibular joint syndrome. Of the 18 patients reporting hearing loss, 11 had exacerbations of underlying pathologies (e.g. Meniere's disease, presbycusis) and 7 were newly diagnosed with SSNHL (1.4 %).ConclusionsPatients reporting otologic symptoms following COVID-19 vaccination received various diagnoses of uncertain etiology. The incidence of SSNHL in these patients is comparable to the general otology patient population. Additional studies are required to determine the incidence of specific diagnoses following vaccination.     

重度突发性聋患者急性期与恢复期听皮层磁共振波谱分析

目的 利用氢质子磁共振波谱(1H-MRS)技术,研究单侧重度突发性聋患者急性期与恢复过程中听皮层的代谢变化。方法 选取右耳重度突发性聋急性期患者15例(发病时间＜1周),经过常规治疗3个月后恢复期患者9例,健康志愿者10例作为对照组。将全部受试者行磁共振波谱检测,测定双侧颞横回N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、γ-氨基丁酸(GABA)、谷氨酰胺及谷氨酸复合物(Glu)的峰下面积并计算NAA/ Cr、Cho/Cr、GABA/ Cr、Glu/Cr的比值。分析重度突聋急性期与3个月后双侧听皮层代谢差异。结果 与对照组相比,突聋急性期双侧NAA/Cr、双侧Cho/Cr,右侧GABA/Cr、右侧Glu/Cr比值无明显差异(P＞0.05),而左侧听皮层GABA/Cr比值明显下降,Glu/Cr明显上升(P＜0.05)。突聋3个月组双侧NAA/Cr、右侧Cho/Cr、右侧GABA/Cr、右侧Glu/Cr比值无明显差异(P＞0.05)。左侧Cho/Cr比值稍下降,GABA/Cr比值略上升但仍低于对照组,Glu/Cr比值略下降但仍高于对照组(P<0.05)。结论 磁共振波谱可以为人体活体听皮层代谢物浓度改变提供有价值的信息;突聋患者对侧听皮层GABA、Glu代谢异常,提示听觉中枢可能发生代谢改变、功能重组。     

Relationships among drinking and smoking habits,history of diseases,body mass index and idiopathic sudden sensorineural hearing loss in Japanese patients

Abstract

Objectives: To present the cardiovascular risk factors in idiopathic sudden sensorineural hearing loss (SSNHL) patients enrolled in a nationwide epidemiological survey of hearing disorders in Japan.

Materials and methods: We compiled the cardiovascular risk factors in 3073 idiopathic SSNHL subjects (1621 men and 1452 women) and compared their proportions with controls as part of the National Health and Nutrition Survey in Japan, 2014. The cardiovascular risk factors consisted of drinking and smoking habits, a history of five conditions related to cardiovascular disease and body mass index.

Results: The proportion of current smokers was significantly higher among men aged 50–59, 60–69 and 70+ and among women aged 30–39, 40–49 and 60–69. The proportion of patients with a history of diabetes mellitus was significantly higher among men aged 50–59, 60–69 and 70+, but not in women. In addition, male and female SSNHL subjects aged 60–69 showed lower proportions of current drinking; and female SSNHL subjects aged 60–69 showed higher proportions of overweight (BMI ≥25?kg/m²).

Conclusions: The present cross-sectional study revealed showed significantly higher proportions of current smokers among both men and women as well as those with a history of diabetes mellitus among men across many age groups in patients with idiopathic SSNHL compared with the controls.