Effects of Bacterial Endotoxin on α-Synuclein Expression in the Lymph Node Leukocytes of Rats

The effects of bacterial LPS on the expression of early apoptosis marker (annexin V) and immunoreactive α-synuclein in mononuclear leukocytes of the mesenteric lymph nodes of rats were studied in vivo and in vitro. Injection of LPS increased the number of lymphocytes with high expression of immunoreactive α-synuclein in cell nucleus and cytoplasm (by 68.6±8.1%) and stimulated apoptosis in this population (by 96.0±3.6% of the control). The expression of α-synuclein in macrophages increased only in the cytoplasm and this increase was not paralleled by stimulation of apoptosis in these cells. The data indicate that LPS-induced elevation of α-synuclein in lymphocytes is a component of the mechanism of programmed death in these cells. The increase of α-synuclein expression in macrophages can be related to processes associated with their stimulation.     

Response of Pituitary—Thyroid Axis to a Short-Term Shift in Deuterium Content in the Body

Bulletin of Experimental Biology and Medicine - We studied functional changes in rat pituitary—thyroid axis after a short-term shift in deuterium body content. Male Wistar rats consumed...     

Expression of the Apoptosis Inhibitor Survivin and its correlation with Thymidine Kinase and Axillary Lymph Node Metastasis in Breast Cancer

1 Introduction Many molecular factors have been demonstrated to interfere with cellular proliferation and programmed cell death.One of these factors is a recently discovered member of the “inhibitor of apoptosis protein(IAP)” called survivin. Survivin is abundantly expressed in most solid and hematologic malignancies, but undetectable in normal adult tissues. Interference with survivin function induces pleiotropic cell-division defects and apoptosis. Cytosolic thymidine kinase (TK) is a m…     

Differentiated Brain Activity in Response to Faces of “Own” Versus “Unfamiliar” Babies in Primipara Mothers: An Electrophysiological Study

Experiences with one's own infant attune the parent nervous system to infant stimuli. To explore the effects of motherhood on brain activity patterns, electroencephalogram (EEG) was recorded while primipara mothers of 3- and 6-month-olds viewed images of faces of their own child and an unfamiliar but appearance-matched child. Mothers of 3- and 6-month-olds showed equivalent early-wave (N/P1 “visual” and N170 “face-sensitive”) responses to own and unfamiliar baby faces but differentiating late-wave (N/P600 “familiar/?novel”) activity to own versus unfamiliar infant faces. Based on 3 months experience with their own infant's face, mothers' brain patterns give evidence of distinctive late-wave (recognition) sensitivity.