腹腔镜脾切除及门奇静脉断流术10例报告

目的探讨腹腔镜脾切除和门奇静脉断流术的手术方法、安全性和有效性.方法从2000年1月至2005年7月为10例肝硬化门静脉高压症继发性脾功能亢进和上消化道出血患者进行了完全腹腔下脾切除和门奇静脉断流术,其中2例加做上腹小切口、管形吻合器食管下段横断和吻合术.结果本组10例腹腔镜脾切除和门奇静脉断流术全部完成,无1例需中转开腹手术.手术时间4.5～5.5 h,出血量100～400ml,术后住院8～15 d.结论腹腔镜脾切除和门奇静脉断流术在技术上是切实可行的,对机体创伤小、疗效确定.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

腹腔镜断流术处理门静脉高压症临床研究

目的 探讨腹腔镜脾切除和断流术的手术方法、安全性和有效性.方法 从2000年1月至2007年4月为30例肝硬化门静脉高压症、继发性脾功能亢进和上消化道出血的病人进行了腹腔镜脾切除和门奇静脉断流术,其中2例于上腹部作小切口,再行管型吻合器完成食管下段横断再吻合术,3例完全腹腔镜下应用腔内管型吻合器行食管下段横断和吻合术.结果 该组30例病人手术均获成功.无1例中转开腹手术,手术时间4～5.5 h,出血量60～400 ml,术后24 h～5 d肛门恢复排气,无严重并发症发生,术后住院8～15 d,平均12 d.术后1个月复查食管吞钡显示食管曲张静脉较术前明显减轻.随访22例1个月至4年,脾功能亢进基本纠正、无肝性脑病、未再发生呕血或黑便.结论 腹腔镜脾切除和门奇静脉断流术是安全、有效的,为临床处理门静脉高压症和上消化道出血提供了一种新的治疗选择.     

Laparoscopic azygoportal disconnection procedure with a bipolar feedback controlled sealing system in a porcine model

BACKGROUND: To examine the feasibility of a new, minimally invasive procedure for the devascularization of the proximal stomach and distal esophagus to prevent recurrent variceal bleeding in portal hypertension in a new animal model. MATERIAL AND METHODS: Portal hypertension was created by laparoscopic clip ligation of the portal vein on 20 pigs. After 2 weeks the azygoportal disconnection procedure was performed with the LigaSure-ATLAS instrument. RESULTS: There were 16 pigs out of 20 that survived both operations. Two died during introduction of anesthesia, one because of a cardiac arrest (second operation). One pig died resulting from necrosis of the gastric and esophageal wall. Autopsy (2 weeks later) showed that there was a complete arterial devascularization. At autopsy, none of the remaining 16 pigs had esophageal varices or necrosis of the stomach or esophagus. CONCLUSION: Laparoscopic azygoportal disconnection is a less invasive method for the prevention of rebleeding and seems to be safely performed with the LigaSure-ATLAS instrument.     

Modified laparoscopic and open splenectomy and azygoportal disconnection for portal hypertension

Background

Laparoscopic splenectomy and azygoportal disconnection has been reported safe, feasible and minimally invasive for patients with portal hypertension. We have developed an even less invasive technique, modified laparoscopic splenectomy and azygoportal disconnection, and compared outcomes of modified laparoscopic splenectomy and azygoportal disconnection and open splenectomy and azygoportal disconnection in patients with portal hypertension.

Methods

We retrospectively evaluated outcomes in 107 cirrhotic patients with portal hypertensive bleeding and secondary hypersplenism who underwent modified laparoscopic splenectomy and azygoportal disconnection (n = 37) or open splenectomy and azygoportal disconnection (n = 70) between January 2010 and February 2013. Their demographic, intraoperative, and postoperative variables were compared.

Results

Modified laparoscopic splenectomy and azygoportal disconnection was successful in all patients, with none requiring conversion to open surgery or having significant perioperative complications. Operation time was significantly longer for modified laparoscopic splenectomy and azygoportal disconnection than open splenectomy and azygoportal disconnection (P < 0.0001), but estimated intraoperative blood loss (P = 0.0004); volume of intraoperative blood transfusion (P < 0.05); visual analog scale pain score on the first postoperative day (P < 0.0001); times to first oral intake (P < 0.0001), passage of flatus (P = 0.0004), and off-bed activity (P < 0.0001); postoperative hospital stay (P < 0.0001); postoperative days of temperature >38.0 °C (P = 0.002); white blood cell counts on postoperative days 1 (P < 0.0001) and 7 (P < 0.05) were significantly reduced in the modified laparoscopic splenectomy and azygoportal disconnection group. The percentage of patients experiencing postoperative complications was significantly lower in the modified laparoscopic splenectomy and azygoportal disconnection group than in the open splenectomy and azygoportal disconnection group (13.5 % [5/37] vs. 35.7 % [25/70], P < 0.05).

Conclusions

The less invasive modified laparoscopic splenectomy and azygoportal disconnection group is a feasible, effective, and safe surgical procedure for liver cirrhosis patients with portal hypertensive bleeding and hypersplenism.     

腹腔镜脾切除联合贲门周围血管离断术在门静脉高压症中的应用

目的探讨腹腔镜脾切除联合贲门周围血管离断术的手术方法、临床效果及应用价值。方法回顾性分析2009年7月至2012年7月期间,笔者所在医院科室施行的腹腔镜下脾切除加贲门周围血管离断术治疗肝硬变门静脉高压症23例患者的临床资料。结果 23例患者中,有2例中转开腹,21例顺利完成腹腔镜脾切除加贲门周围血管离断术。手术时间230～380 min,平均290 min;术中失血量300～1 500 mL,平均620 mL;术后禁食1～3 d,平均2 d;术后住院时间8～14 d,平均10 d。结论腹腔镜脾切除加贲门周围血管离断术安全可行,对机体创伤小,术后并发症少,疗效确切。     

腹腔镜与开腹手术治疗门脉高压症的对比研究

目的探讨腹腔镜与开腹手术行脾切除联合贲门周围血管离断术治疗门脉高压症的手术效果。 方法回顾性分析2013年3月至2018年12月因门脉高压、脾大、脾功能亢进及食管胃底静脉曲张行脾切除术联合贲门周围血管离断术的患者资料,其中腹腔镜下手术21例(腹腔镜组),开腹手术50例(开腹组)。应用GraphPad Prism 6.0软件对所有数据进行分析。术中、术后相关指标采用( ±s)表示,独立样本t检验;并发症发生率采用χ²检验。P<0.05为差异有统计学意义。 结果与开腹组比较,腹腔镜组手术时间较长(P<0. 05),而术中出血量、切口长度、术后排气时间、镇痛药物使用次数、引流管拔除时间、术后住院时间、术后切口感染率均少于开腹组(P<0. 05);两组间的腹腔出血、腹、盆腔积液、肺部感染、胰瘘以及门静脉血栓形成差异无统计学意义(P>0.05)。 结论腹腔镜手术治疗门脉高压症行脾切除联合贲门周围血管离断术具有手术创伤小、术中出血少、术后恢复快、术后切口感染率低、住院时间短等优点,腹腔镜手术治疗门脉高压症是安全、可行的。     

Laparoscopic splenectomy and azygoportal disconnection with intraoperative splenic blood salvage

Background

Intraoperative blood salvage can reduce or avoid perioperative allogeneic blood transfusion. Salvaging the blood in the portal hypertension-induced enlarged spleen becomes an issue of concern during devascularization surgery because an enlarged spleen accommodates a large red cell pool. We report 20 cases of laparoscopic splenectomy and azygoportal disconnection and present the advantages of the use of intraoperative splenic blood salvage during the procedure.

Methods

A total of 20 cirrhotic patients with esophagogastric variceal bleeding refractory to treatment with β-blockers and endoscopic therapy were studied. Laparoscopic splenectomy with azygoportal disconnection was performed. During the procedure, an intraoperative autologous blood salvage device recovered the splenic blood. The perioperative data were recorded from various viewpoints.

Results

The operative time was 3.1?±?0.3?h and the blood loss was 70.5?±?32.5?ml. The weight of the excised and morcellated spleen was 826.0?±?155.1?g. The volume of autotransfused blood was 541.0?±?150.4?ml. No patient received a perioperative allogeneic blood transfusion. There were no significant complications either intraoperatively or postoperatively. The hemoglobin value increased from 9.3?±?0.8 to 11.5?±?1.1?g/dl at postoperative day 1 (p?Conclusion Laparoscopic splenectomy with azygoportal disconnection is a feasible, effective, and safe surgical method for the treatment of bleeding portal hypertension. Intraoperative splenic blood salvage can avoid the risk associated with allogeneic transfusion during the procedure, with an advantage of significantly increased postoperative hemoglobin levels.     

Novel technique of laparoscopic azygoportal disconnection for treatment of esophageal varicosis: preliminary experience with five patients

Background: Liver cirrhosis leads frequently to the development of ascites and a formation of varicose veins in the esophagus. The latter presents increased mortality risk. Recently, significant progress in laparoscopic technology enabled devascularization of the proximal stomach in a less invasive way. The results experienced by five patients are presented. Methods: Laparoscopic azygoportal disconnection was performed by means of novel technique (Danis procedure) in five men with esophagus varices bleeding (2nd to 11th events) and liver cirrhosis stage Child-Pugh B and C. This procedure was performed after all other methods had either failed to prevent recurrent bleeding or were refused by the patient. Five ports were positioned on the upper abdominal wall. The veins in the lesser omentum were divided by means of the LigaSure-Atlas device. The stomach coronary vein was visualized, and all the proximal branches toward the esophagus as well as the short gastric vessels were divided. The diaphragm hiatus was opened, and the distal esophagus was dissected. The paraesophageal venous collaterals also were divided, and the remaining varicose veins of the esophagus were interrupted by transmural stitching. Results: All the patients survived the minimally invasive procedure. Two of them died 9 and 16 months after surgery, respectively, because of liver insufficiency. No bleeding event from varicose veins in the esophagus occurred postoperatively. Conclusion: Laparoscopic azygoportal disconnection is a less invasive method for prevention of rebleeding from varicose veins in the esophagus. Further studies are necessary to confirm these preliminary results.     

完全腹腔镜下脾切除联合贲门周围血管离断术的临床应用

目的 探讨完全腹腔镜下脾切除联合贲门周围血管离断术的适应证和临床应用价值.方法 分析对40例肝硬化门静脉高压症脾亢患者采用完全腹腔镜下脾切除联合贲门周围血管离断术的临床资料.结果 本组中36例顺利完成完全腹腔镜下脾切除联合贲门周围血管离断术,4例中转开腹,平均手术时间(224±54)min,平均术中出血量(296±209)ml,无严重并发症.结论 对门静脉高压脾亢患者选择性地采用完全腹腔镜下脾切除联合贲门周围血管离断术是一种可供选择的安全、有效的微创方法.     

完全腹腔镜脾切除加门奇静脉断流术治疗门静脉高压症

目的:探讨完全腹腔镜脾切除加门奇静脉断流术治疗门静脉高压症的可行性、安全性和优缺点。方法:回顾分析我院2005年1月至2007年12月收治的12例肝硬化门静脉高压症合并脾功能亢进、上消化道出血(呕血或黑便史)患者的临床资料,12例均施行完全腹腔镜脾切除加门奇静脉断流术。结果:12例患者均在腹腔镜下完成手术,平均手术时间210min,术中平均出血340ml,平均住院12d,术后随访3~36个月。无一例发生再出血。结论:完全腹腔镜脾切除加门奇静脉断流术安全可行,疗效确切,是值得临床推广的治疗门静脉高压症的微创手术方式。