Plasma cell granuloma (inflammatory pseudotumor) of the spinal cord meninges: report of a case.

A case of plasma cell granuloma (inflammatory pseudotumor) arising in the meninges of cervical spinal cord of a 37-year-old Japanese man is presented. The diagnosis was made by analogy with the similar lesions known in the lung. Its histology was characterized by infiltration of three kinds of cells; histiocytes with slight epithelioid appearance, plasma cells with numerous Russell bodies, and lymphocytes. Electron microscopy of the formalin-fixed tissue was useful for the identification of these cells, particularly of histiocytes. Although extrapulmonary plasma cell granulomas have been reported, this is the first case, to our knowledge, of this type "tumor" in the spinal cord meninges. Differential diagnoses have been briefly discussed.     

肺炎性假瘤38例临床分析

目的　分析肺炎性假瘤的诊断与治疗 ,以期降低误诊率 ,提高诊断水平。方法　回顾性总结了近 1 0余年肺炎性假瘤 (IPL)病人 38例。结果　术前 31例误诊 ,误诊率 76 .3 % (2 9/ 38)。误诊为肺癌 1 9例 ,良性肿瘤 7例 ,结核球3例 ,其他 2例。 38例全部手术治疗 ,肺叶切除 2 4例 ,楔形切除 1 3例 ,剔除 1例。结论　充分了解IPL的病理发展过程 ,在病史询问、临床资料及X片的综合分析基础上做出正确诊断 ,有望降低误诊率     

Plasma cell granuloma of the tonsil

Plasma cell granuloma (inflammatory pseudotumor) has been described most commonly in the lung. Review of the English literature fails to reveal occurrence of such a lesion in the tonsil. We are reporting such a case presenting as a unilateral tonsillar mass in a 63-year-old man. A more typical case of plasma cell granuloma of lung is also presented to illustrate the similarity between the tonsillar and pulmonary lesions.     

Plasma cell granuloma of the heart

A case of plasma cell granuloma arising in the free ventricular wall and involving the coronary arteries of a 10-month-old female infant is presented. Morphologic characteristics were comparable with those of plasma cell granulomas arising elsewhere. The histologic, immunohistochemical, and ultrastructural observations, and in particular the quiescent clinical course of the disease and its control with anti-inflammatory medication, favor a nonneoplastic nature of the lesion. This report documents the presence of an intracardiac plasma cell granuloma for the second time in the medical literature.     

Plasma cell granuloma of jaw

A 65 year old Punjabi male presented with an exophytic lesion, 3 Cm. in diameter, which was pedunculated, on the attached gingiva. It was situated on the right side, near the motars. On histological examination, it was diagnosed as plasma cell granuloma.     

肺炎性假瘤诊断和治疗的探讨

报道154例经手术切除、病理证实的肺炎性极病。男112例,女42例。占我院同期肺切除术的9．3％（154／1656）。发现年龄从22～75岁,平均49．68岁。X线及胸部CT易与肺癌或其它肺良性肿瘤相混淆。但当：1．肺边缘型肿瘤,直径小于4cm,边界青且肺门不大。2．边缘型肿块与胸膜、纵隔、隔肌粘连,形成“桃尖征”或“慧星尾征”。3．如有数月内X片可供比较,且肿块无明显增大或略有缩小者,可做肺炎性假瘤的考虑。治疗以手术为主,如肿物位于肺边缘,建议本中冰冻切片以明确病理诊断,手术应最大限度地保留患者的肺功能。     

肺炎性假瘤的诊断与外科治疗

 自1967年1月至1993年6月，我科手术治疗肺炎性假瘤100例，占同期手术治疗肺部肿瘤及瘤样病变病例的6.4%（100/1552）。本组中女性较多，平均发病年龄47岁，平均病史为5.5个月，病变多数位于右肺。术前对本病尚无特殊诊断方法，确诊有赖于术后病理学检查。本组中有4例为炎性假瘤与肺癌并存，说明本病有恶性变的可能。对肺炎性假瘤应采取积极的手术治疗。手术原则就是最大限度地保留正常肺组织.     

Follicular dendritic reticulum cell tumor mimicking inflammatory pseudotumor of the spleen

In the course of a routine clinical check up of the 54 year old male a splenic well circumscribed tumor like mass of 12 cm in diameter was discovered. Splenectomy with removal of splenic hilar lymph nodes and liver wedge biopsy were performed. Four years later the patient is symptom free. In the removed spleen the tumor like lesion showed a pattern consistent with the diagnosis of inflammatory pseudotumor. However, besides lymphocytes, plasma cells, macrophages, eosinophils and myofibroblasts a high number of slightly polymorphic, frequently binucleated cells positive for CD 21 and CD23 were seen. These cells which were scattered or formed smaller or larger groups and fascicles were considered to represent follicular dendritic reticulum cells (FDRCs) and the lesion a FDRC tumor. Flow cytometric DNA ploidy analysis showed a hyperdiploid cell population inside the tumor like lesion. Besides FDRC tumors of high and of intermediate malignancy the present case may represent a low grade type of moderate proliferation activity. The FDRCs of the lesion and a few smaller spindle cells were EBER positive indicative of the presence of EBV. No EBER positive cells were seen in the uninvolved spleen.     

An inflammatory pseudotumor of the appendix

A 41-year-old male, complaining of an abdominal pain and suspected of having acute appendicitis, underwent examination on hospitalization. Ultrasonography revealed a tumorous lesion of the appendix. Thus, a laparotomy was performed and mass lesions were found in the mid and distal parts of the appendix. A subsequent histological examination revealed an inflammatory pseudotumor consisting of remarkable eosinophilic cell and fibroblastic infiltrations, similar to that seen in a inflammatory fibroid polyp (Helwig). Although such lesions, polypoid in appearance, have been found to occur in the stomach and intestines, to find them in the appendix is extremely rare. In this instance, as the growth of this mass of lesions was more predominant in the wall rather than in intraluminal area, it was decided that pseudotumor was the appropriate term to describe this case.     

Plasma cell granuloma of the lung, response to radiation therapy: report of a single case.

A benign, inflammatory lung mass was discovered in a healthy 15-year-old boy who had no chest symptoms. A biopsy was performed, but total removal was not attempted. The histologic diagnosis was plasma cell granuloma of the lung. Because of progressive enlargement of the lung mass, radiation therapy was given and the mass has slowly regressed. Although surgery of these lung lesions is the preferred treatment, radiation therapy should be considered if there is no regression or if the mass continues to enlarge.     

Plasma cell granuloma of the nasal cavity treated by radiation therapy.

Plasma cell granuloma is a rare, benign tumor most commonly found in the lungs in patients younger than 30 years. Although presentation has been reported at a number of other anatomic sites, this report is the first of plasma cell granuloma of the nasal cavity. The tumor was initially resected, but progression was seen at 1-month follow-up. Because further surgery to completely eradicate the tumor would have been extensive and disfiguring, 40-Gy external beam radiation was given in 20 fractions using a three-field wedge technique. Most recent clinical follow-up at 27 months showed local control. Surgery remains the treatment of choice for plasma cell granuloma when the disease can be completely resected. However, irradiation can also be effective in patients with recurrent or inoperable local disease.     

肺部炎性假瘤的诊断及外科治疗(附51例报告)

背景与目的肺部炎性假瘤的临床症状、影像学表现缺乏特征性,易误诊,从而影响到治疗。本文中我们主要总结肺部炎性假瘤的特点,为正确诊断、妥善选择手术方式提供依据。方法总结中国医学科学院肿瘤医院胸外科自1990年1月至2000年3月手术治疗51例肺部炎性假瘤患者的临床资料,病理结果均经我院病理科确认,所有患者随访满3年。结果51例炎性假瘤患者术前仅3例(5.9%)明确诊断为炎性假瘤;24例(47.1%)诊断为良性病变;10例(19.6%)诊断为肺占位性病变,良恶性待鉴别;14例(27.4%)诊断为肺癌。全组均行手术治疗,其中行病灶摘除术22例(43.1%),行楔形切除术4例(7.8%),行肺段切除术2例(3.9%),行肺叶切除术23例(45.1%);术后1例(2.0%)出现并发症,有3例失访,其余均健康生存。结论肺部炎性假瘤依靠临床症状和影像学术前明确诊断有一定困难,应尽早手术治疗,主要依靠手术中取病变组织做病理检查决定手术方式,以局部病灶切除和肺叶切除为主。     

肺部炎性假瘤的临床诊治

目的:探讨肺部炎性假瘤的临床特点、诊断和治疗.方法:对59例肺部炎性假瘤患者的临床资料进行回顾性分析.结果:52例行手术治疗,1例术后因呼吸衰竭死亡,术前仅17 例(28.8%)诊断正确.结论:肺部炎性假瘤在临床症状和影像学上与肺癌较难鉴别,虽属良性,宜积极手术治疗;肺部炎性假瘤可能存在恶性潜能和复发可能,须加强术后随访.     

MRI在肝脏炎性假瘤诊断中的应用

目的:探讨MRI平扫及动态增强扫描在肝脏炎性假瘤(IPL)诊断中的应用价值.方法:回顾性分析经临床病理证实的11例肝脏炎性假瘤的MRI表现,并与病理进行对照.结果: 术前诊断良性病变10例,1例误诊为恶性肿瘤,其中诊断为炎性假瘤者7例.T1WI上5例为等信号,6例为低信号.T2WI上3例呈低信号,5例呈略高信号,3例呈等信号.多期动态扫描:动脉期未见明显强化,仅1例见轻度强化,在静脉期及平衡期见强化,强化方式基本一致,只是强化程度平衡期较静脉期略轻,强化方式多样,偏心性或周边不均匀环行强化,或呈间隔样强化,强化持续时间较长.结论:MRI诊断IPL具有一定的特异性,结合病史,MRI平扫及动态增强扫描,能对肝脏炎性假瘤作出诊断.     

MRI在肝脏炎性假瘤诊断中的应用

目的：探讨MRI平扫及动态增强扫描在肝脏炎性假瘤（IPL）诊断中的应用价值。方法：回顾性分析经临床病理证实的11例肝脏炎性假瘤的MRI表现，并与病理进行对照。结果：术前诊断良性病变10例，1例误诊为恶性肿瘤，其中诊断为炎性假瘤者7例。T1WI上5例为等信号。6例为低信号。T2WI上3例呈低信号，5例呈略高信号。3例呈等信号。多期动态扫描：动脉期未见明显强化，仅1例见轻度强化，在静脉期及平衡期见强化，强化方式基本一致，只是强化程度平衡期较静脉期略轻。强化方式多样，偏心性或周边不均匀环行强化。或呈间隔样强化，强化持续时间较长。结论．MRI诊断IPL具有一定的特异性，结合病史，MRI平扫及动态增强扫描，能对肝脏炎性假瘤作出诊断。     

A case of cholangiocarcinoma mimicking inflammatory pseudotumor

A 75-year-old man presenting with low-grade fever was referredto our hospital. Blood test showed remarkable leukocytosis     

Muscular pseudotumor of the breast following doxorubicin and radiation therapy for oat cell carcinoma of the lung

Two male patients developed muscular pseudotumor of the breast following combined treatment of radiation and chemotherapy with cyclophosphamide, doxorubicin, methotrexate and procarbazine for oat cell carcinoma of the lung. The pathologic findings of the biopsy specimens revealed muscle and capillary changes similar to previously reported myocardiotoxicity from doxorubicin and radiation therapy. Discussed is a possible additive or synergistic toxic effect of doxorubicin and radiation therapy in the development of muscular pseudotumor of the breast.