共查询到20条相似文献,搜索用时 46 毫秒
1.
Elaine Gibson Kevin Brazil Michael D Coughlin Claudia Emerson Francois Fournier Lisa Schwartz Karen V Szala-Meneok Karen M Weisbaum Donald J Willison 《BMC medical ethics》2008,9(1):17
Background
The amount of research utilizing health information has increased dramatically over the last ten years. Many institutions have extensive biobank holdings collected over a number of years for clinical and teaching purposes, but are uncertain as to the proper circumstances in which to permit research uses of these samples. Research Ethics Boards (REBs) in Canada and elsewhere in the world are grappling with these issues, but lack clear guidance regarding their role in the creation of and access to registries and biobanks. 相似文献2.
A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data
Background
In the studies of genomics, it is essential to select a small number of genes that are more significant than the others for the association studies of disease susceptibility. In this work, our goal was to compare computational tools with and without feature selection for predicting chronic fatigue syndrome (CFS) using genetic factors such as single nucleotide polymorphisms (SNPs). 相似文献3.
Juan Merlo Kristina Bengtsson-Boström Ulf Lindblad Lennart Råstam Olle Melander 《BMC medical genetics》2006,7(1):14-9
Background
Individuals belonging to the same family share a number of genetic as well as environmental circumstances that may condition a common SBP level. Among the genetic factors, the angiotensin converting enzyme (ACE) gene I/D polymorphism appears as a possible candidate as it might influence both SBP and the pharmacological effect of ACE inhibitors. We aimed to combine genetic epidemiology with public health ideas concerning life-course and multilevel epidemiology in order to understand the role of familial factors regarding individual SBP. 相似文献4.
Danielle A Southern Steven Lewis Colleen J Maxwell James R Dunn Tom W Noseworthy Gail Corbett Karen Thomas William A Ghali 《BMC medical research methodology》2008,8(1):57
Background
Some populations targeted in survey research can be hard to reach, either because of lack of contact information, or non-existent databases to inform sampling. Here, we present a methodological "case-report" of the yield of a multi-step survey study assessing views on health care among American emigres to Canada, a hard-to-reach population. 相似文献5.
Sara Urowitz David Wiljer Emma Apatu Gunther Eysenbach Claudette DeLenardo Tamara Harth Howard Pai Kevin J Leonard 《BMC medical informatics and decision making》2008,8(1):33
Background
Access to personal health information through the electronic health record (EHR) is an innovative means to enable people to be active participants in their own health care. Currently this is not an available option for consumers of health. The absence of a key technology, the EHR, is a significant obstacle to providing patient accessible electronic records. To assess the readiness for the implementation and adoption of EHRs in Canada, a national scan was conducted to determine organizational readiness and willingness for patient accessible electronic records. 相似文献6.
Clare C Constantine Lyle C Gurrin Christine E McLaren Melanie Bahlo Gregory J Anderson Chris D Vulpe Susan M Forrest Katrina J Allen Dorota M Gertig the HealthIron Investigators 《BMC medical genetics》2008,9(1):18
Background
We report our experience of selecting tag SNPs in 35 genes involved in iron metabolism in a cohort study seeking to discover genetic modifiers of hereditary hemochromatosis. 相似文献7.
Background
The role of the pediatrician as genetic counselor is ideal because pediatricians have medical knowledge and experience with genetic disorders (e.g. Down syndrome). Moreover, pediatricians can provide comprehensive care in a medical home to patients with genetic disorders. However, changes in the curriculum of the pediatric resident are necessary to address the future challenges of effectively communicating genetic information to patients. The objective of this study was to explore these challenges and make recommendations for training to adequately prepare pediatricians for their future role as genetic counselors. 相似文献8.
Background
The CanMEDS Health Advocate role, one of seven roles mandated by the Royal College of Physicians and Surgeons Canada, pertains to a physician's responsibility to use their expertise and influence to advance the wellbeing of patients, communities, and populations. We conducted our study to examine resident attitudes and self-reported competencies related to health advocacy, due to limited information in the literature on this topic. 相似文献9.
Sharon Johnston Clare Liddy William Hogg Melissa Donskov Grant Russell Elizabeth Gyorfi-Dyke 《BMC medical research methodology》2010,10(1):109
Background
While some research has been conducted examining recruitment methods to engage physicians and practices in primary care research, further research is needed on recruitment methodology as it remains a recurrent challenge and plays a crucial role in primary care research. This paper reviews recruitment strategies, common challenges, and innovative practices from five recent primary care health services research studies in Ontario, Canada. 相似文献10.
Background
Despite the critical importance of well-being during residency training, only a few Canadian studies have examined stress in residency and none have examined well-being resources. No recent studies have reported any significant concerns with respect to perceived stress levels in residency. We investigated the level of perceived stress, mental health and understanding and need for well-being resources among resident physicians in training programs in Alberta, Canada. 相似文献11.
Chunsheng He Daniel E Weeks Steven Buyske Goncalo R Abecasis William C Stewart Tara C Matise The Enhanced Map Consortium 《BMC medical genetics》2011,12(1):15
Background
Accurate genetic maps are required for successful and efficient linkage mapping of disease genes. However, most available genome-wide genetic maps were built using only small collections of pedigrees, and therefore have large sampling errors. A large set of genetic studies genotyped by the NHLBI Mammalian Genotyping Service (MGS) provide appropriate data for generating more accurate maps. 相似文献12.
Margo C Orchard Mark J Dobrow Lawrence Paszat Hedy Jiang Patrick Brown 《BMC medical informatics and decision making》2009,9(1):38-11
Background
The use of electronic health records (EHRs) to support the organization and delivery of healthcare is evolving rapidly. However, little is known regarding potential variation in access to EHRs by provider type or care setting. This paper reports on observed variation in the perceptions of access to EHRs by a wide range of cancer care providers covering diverse cancer care settings in Ontario, Canada. 相似文献13.
Della Kwan Heather S Boon Kristine Hirschkorn Sandy Welsh Tannis Jurgens Lynda Eccott Shirley Heschuk Glenn G Griener Jillian C Cohen-Kohler 《BMC complementary and alternative medicine》2008,8(1):40
Background
Natural health products (NHPs) such as herbs, vitamins and homeopathic medicines, are currently available for sale in most Canadian pharmacies. However, most pharmacists report that they have limited knowledge about these products which have been regulated in Canada as a specific sub-category of drugs. In this paper, consumers' and practicing pharmacists' perceptions of pharmacists' professional responsibilities with respect to NHPs are examined. 相似文献14.
Background
Autism is a highly heritable complex neurodevelopmental disorder, therefore identifying its genetic basis has been challenging. To date, numerous susceptibility genes and chromosomal abnormalities have been reported in association with autism, but most discoveries either fail to be replicated or account for a small effect. Thus, in most cases the underlying causative genetic mechanisms are not fully understood. In the present work, the Autism Genetic Database (AGD) was developed as a literature-driven, web-based, and easy to access database designed with the aim of creating a comprehensive repository for all the currently reported genes and genomic copy number variations (CNVs) associated with autism in order to further facilitate the assessment of these autism susceptibility genetic factors. 相似文献15.
16.
Background
Research into health and health-care seeking behaviour amongst immigrant populations suggests that culturally-based behaviours change over time towards those prevalent in the host culture. Such acculturation of immigrant groups occurs as part of the interaction of immigrants with mainstream culture. This study examined the acculturation of Ghanaian immigrants in Greater Toronto Area (Canada) focusing particularly on attitudes towards and usage of Ghanaian traditional medicine (TRM). 相似文献17.
Jo B Middlemass research fellow Momina F Yazdani Joe Kai Penelope J Standen Nadeem Qureshi 《The British journal of general practice》2014,64(622):e282-e289
Background
While primary care systematically offers conventional cardiovascular risk assessment, genetic tests for coronary heart disease (CHD) are increasingly commercially available to patients. It is unclear how individuals may respond to these new sources of risk information.Aim
To explore how patients who have had a recent conventional cardiovascular risk assessment, perceive additional information from genetic testing for CHD.Design and setting
Qualitative interview study in 12 practices in Nottinghamshire from both urban and rural settings.Method
Interviews were conducted with 29 adults, who consented to genetic testing after having had a conventional cardiovascular risk assessment.Results
Individuals’ principal motivation for genetic testing was their family history of CHD and a desire to convey the results to their children. After testing, however, there was limited recall of genetic test results and scepticism about the value of informing their children. Participants dealt with conflicting findings from the genetic test, family history, and conventional assessment by either focusing on genetic risk or environmental lifestyle factors. In some participants, genetic test results appeared to reinforce healthy behaviour but others were falsely reassured, despite having an ‘above-average’ conventional cardiovascular risk score.Conclusion
Although genetic testing was acceptable, participants were unclear how to interpret genetic risk results. To facilitate healthy behaviour, health professionals should explore patients’ understanding of genetic test results in light of their family history and conventional risk assessment. 相似文献18.
Nanfang Li Wenli Luo Zhang Juhong Jin Yang Hongmei Wang Ling Zhou Jianhang Chang 《BMC medical genetics》2010,11(1):124
Background
Hypertension is a complex disease influenced by multiple genetic and environmental factors. The Kazakh ethnic group is characterized by a relatively high prevalence of hypertension. Previous research indicates that the FURIN gene may play a pivotal role in the renin-angiotensin system and maintaining the sodium-electrolyte balance. Because these systems influence blood pressure regulation, we considered FURIN as a candidate gene for hypertension. The purpose of this study was to systematically investigate the association between genetic variations in the FURIN gene and essential hypertension in a Xinjiang Kazakh population. 相似文献19.
Kaphingst KA McBride CM Wade C Alford SH Brody LC Baxevanis AD 《Journal of medical Internet research》2010,12(3):e41-Sep;12(3):e41
Background
Few data exist to inform concerns raised by online direct-to-consumer marketing of genetic susceptibility tests, such as those offered by commercial entities like 23andme, Navigenics, and DNA Direct. The Multiplex Initiative, a population-based study of healthy adults, provides the first opportunity to evaluate how use of a Web-based decision tool that conveyed information about a genetic susceptibility test influenced individuals’ test decisions.Objective
To inform the ongoing debate over whether individuals offered genetic susceptibility testing without the involvement of a health care provider (eg, through direct-to-consumer testing) can make informed decisions about testing when guided by online decision aids.Methods
Participants were 526 members of a large health maintenance organization aged 25 to 40 years old who visited a study website. Multivariate logistic regression models were tested to examine the association of website usage with downstream test decisions.Results
Participants viewed an average of 2.9 of the 4 pages introducing the multiplex test, 2.2 of the 8 pages describing the health conditions, and 3.2 of the 15 pages describing the genes. For each page viewed, participants were more likely to describe their decision-making as easy (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.01-1.07) and to decide to be tested (OR 1.08, 95% CI 1.05-1.11).Conclusions
Healthy adults in this study perceived Web-based genomic information presented using evidence-based communications approaches to be helpful in supporting both decisions to test and not to test. Continued research is needed to ensure that these results generalize to target groups with lower literacy and less Internet savvy. 相似文献20.
Anniken Hamang Geir Egil Eide Karin Nordin Berit Rokne Cathrine Bjorvatn Nina ?yen 《BMC medical genetics》2010,11(1):27