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近年来,随着内镜设备和技术的发展,内镜经鼻颅底外科技术在临床得到了更为广泛的应用,术后脑脊液漏是其主要的并发症之一,是制约内镜经鼻颅底外科技术发展的重要因素。确切牢靠的颅底重建技术可有效降低术后脑脊液漏的发生,提高内镜经鼻颅底外科手术的效果。该文就颅底重建的材料和技术方法及其进展进行综述。<title/>国际神经病学神经外科学杂志, 2022, 49(5): 72-76]  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=ABD40D695F11492AD2599EA25526DABB&language=2&ctl=14&etl=59" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">2.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=9F1B91391CD8DAC03FFACD022E5D0505" target="_blank">硬膜间断缝合技术在经鼻内镜颅底重建的应用</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%91%a8%e6%98%a5%e8%be%89" target="_blank">周春辉</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%91%a3%e8%b6%85" target="_blank">董超</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%9a%87%e7%94%ab%e7%bd%97%e9%94%b4" target="_blank">皇甫罗锴</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%9b%b2%e5%bf%97%e5%b3%b0" target="_blank">曲志峰</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b5%b5%e8%99%8e%e6%9e%97" target="_blank">赵虎林</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e5%89%91%e5%ae%81" target="_blank">张剑宁</a> <a class="a2" href="#">《中国微侵袭神经外科杂志》</a>2021,(6):250-253 </div> <div>目的 探讨硬膜间断缝合技术在经鼻内镜颅底重建的应用价值.方法 回顾性分析92例行内镜经鼻手术治疗中线颅底占位病例资料,均在常规经鼻内镜颅底重建中联合硬膜间断缝合技术.观察术中脑脊液漏分级,术后脑脊液漏与颅内感染等情况.结果 术中出现脑脊液漏49例.术后脑脊液漏6例,脑脊液漏发生率:0~Ⅰ级1.4%(1/70),Ⅱ~Ⅲ级...  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=9F1B91391CD8DAC03FFACD022E5D0505&language=0&ctl=20&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">3.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=902167809213773A7D392BF60E4EA6FE" target="_blank">经鼻内镜前颅底巨大脑膜瘤手术及颅底重建研究</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%91%a8%e8%b7%83%e9%a3%9e" target="_blank">周跃飞</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e4%bc%8a%e8%a5%bf%e6%89%8d" target="_blank">伊西才</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b5%b5%e5%85%a8%e6%88%90" target="_blank">赵全成</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b4%be%e9%b9%8f%e9%a3%9e" target="_blank">贾鹏飞</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%88%98%e5%8d%ab%e5%b9%b3" target="_blank">刘卫平</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%ab%98%e5%a4%a7%e5%ae%bd" target="_blank">高大宽</a> <a class="a2" href="#">《临床神经外科杂志》</a>2020,17(6):611-615,620 </div> <div>  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=902167809213773A7D392BF60E4EA6FE&language=0&ctl=21&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">4.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=365EA4178CD383F0D7873759F489B500" target="_blank">内镜下扩大经鼻蝶入路术中多层技术颅底重建</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%b1%95%e5%a6%82%e6%89%8d" target="_blank">展如才</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e5%90%88%e6%9e%97" target="_blank">张合林</a> <a class="a2" href="#">《中国微侵袭神经外科杂志》</a>2010,15(9):392-394 </div> <div>目的总结内镜下扩大经鼻蝶入路鞍区及鞍旁区多层技术重建颅底的经验。方法回顾性分析12例鞍区及鞍旁区肿瘤的临床资料,其中颅咽管瘤4例,鞍区脑膜瘤3例,巨大垂体腺瘤5例;均行内镜下扩大经鼻蝶入路肿瘤切除术,并采用多层技术进行颅底重建。结果所有病例肿瘤均达全切除,颅底重建均1次修补成功。术后部分临床症状明显改善。随访3~6个月,均未出现脑脊液漏、细菌性脑膜炎和张力性气颅等并发症。结论内镜下扩大经鼻蝶入路术中多层技术重建颅底是一种简单、安全、有效的方法。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=365EA4178CD383F0D7873759F489B500&language=2&ctl=20&etl=122" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">5.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=115D4DF0D1727C7F2E41D07F21A414DB" target="_blank">经鼻扩大入路至前颅底的内镜解剖学研究</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e6%b8%85" target="_blank">王清</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%b2%81%e6%99%93%e6%9d%b0" target="_blank">鲁晓杰</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e4%b8%a5%e6%ad%a3%e6%9d%91" target="_blank">严正村</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e9%b9%8f" target="_blank">王鹏</a> <a class="a2" href="#">《中华神经外科杂志》</a>2013,29(1) </div> <div>目的 探索神经内镜下经鼻扩大入路显露前颅底的可行性、手术适应证和并发症的防治.方法 分别运用直径4 mm,长度18 cm的0°、30°和45°硬质内镜(Karl Storz),在神经导航的引导下模拟手术过程,经双侧鼻腔采用经鼻扩大入路对尸头标本进行前颅底内镜解剖.定量测量各个解剖标志之间的距离和显露面积.结果 尸头标本上测量在鸡冠基底部两侧眶内侧壁的距离为平均(34.1 ±4.2)mm,筛板中部两眶内侧壁的距离为(24.7±3.l)mm,两侧前筛动脉之间的距离为(26.8±3.4) mm,两侧后筛动脉之间的距离为(24.3±4.1)mm,前后筛动脉在眶内侧壁的距离为(17.9±2.7)mm.内镜下前颅底可显露的面积是(430.6±53.4) mm2.在磨除筛板骨质后剪开硬膜可见嗅神经、大脑前纵裂和额叶直回.结论 在神经导航辅助引导下,神经内镜经鼻扩大入路至前颅底可提供宽广的手术视野,是处理前颅底病变的一种微侵袭方法.熟练的内镜技术、充分的内镜解剖知识和可靠的颅底重建是保障手术成功的重要因素.  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=115D4DF0D1727C7F2E41D07F21A414DB&language=2&ctl=18&etl=81" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">6.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=1284E872B3CFCA28F1A194B506808BFC" target="_blank">内镜下经鼻人路治疗颅底中央区恶性肿瘤</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b5%b5%e8%b5%8b" target="_blank">赵赋</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e5%8d%9a" target="_blank">王博</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%9d%a8%e6%99%ba%e5%90%9b" target="_blank">杨智君</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%90%b4%e8%83%9c%e7%94%b0" target="_blank">吴胜田</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e6%8c%af%e6%b0%91" target="_blank">王振民</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e6%99%b6" target="_blank">张晶</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%88%98%e4%b8%95%e6%a5%a0" target="_blank">刘丕楠</a> <a class="a2" href="#">《中国微侵袭神经外科杂志》</a>2013,18(5):193-196 </div> <div>目的探讨内镜下经鼻人路切除颅底中央区恶性肿瘤的手术方法和治疗效果。方法回顾性分析颅底恶性肿瘤32例。采用内镜下经鼻人路27例,颅一鼻联合人路5例;其中术后行一期颅底重建16例。结果肿瘤全切除15例,近全切除13例。部分切除4例。术后症状明显改善或缓解23例,无明显好转9例。主要并发症为:脑脊液鼻漏和颅内感染各1例,均治愈;无颅内出血及死亡病例。随访6,74个月,平均27.8个月;至随访期结束,无肿瘤复发10例,带瘤生存12例,死亡10例,5年生存率46.2%。病人术后3个月KPS评分比人院时显著提高(P〈0.05)。结论内镜下经鼻入路结合可靠的颅底重建,能有效切除颅底中央区恶性肿瘤,并提高病人近期生活质量。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=1284E872B3CFCA28F1A194B506808BFC&language=2&ctl=18&etl=80" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">7.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=10E651E7F135EB4826FD7B514627FE43" target="_blank">颅底硬膜缝合技术在内镜经鼻蝶入路鞍区肿瘤切除中的应用</a>   <em><strong></strong></em>    <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=10E651E7F135EB4826FD7B514627FE43' target='_blank'><img src='/ch/ext_images/free.gif' valign='bottom' title='点击此处可从《国际神经病学神经外科学杂志》网站下载免费的PDF全文' border='0'></a>   <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=10E651E7F135EB4826FD7B514627FE43' target='_blank'>下载免费PDF全文</a> </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%91%a8%e5%be%8b" target="_blank">周律</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e6%96%8c" target="_blank">王斌</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e6%af%85" target="_blank">王毅</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%90%95%e6%b3%a2" target="_blank">吕波</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%8d%95%e6%98%8e" target="_blank">单明</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%8f%b6%e9%9b%b7" target="_blank">叶雷</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%ab%98%e9%b9%8f" target="_blank">高鹏</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%a8%8b%e5%ae%8f%e4%bc%9f" target="_blank">程宏伟</a> <a class="a2" href="#">《国际神经病学神经外科学杂志》</a>2023,50(1):9-14 </div> <div><b>目的</b> 探讨颅底硬膜缝合技术在内镜经鼻蝶入路切除鞍区肿瘤后颅底重建中的可行性和可靠性。<b>方法</b> 分析安徽医科大学第一附属医院2019年1月—2021年7月在内镜下经鼻蝶入路切除鞍区肿瘤后采用颅底硬膜缝合技术处理的28例患者临床资料,并进行相关文献复习。<b>结果</b> 28例患者均存在术中脑脊液漏(CSFL),参照Esposito分级法,术中发生1级CSFL 14例,2级CSFL 10例,3级CSFL 4例。术中均采用了硬膜缝合技术修补鞍底,27例患者一期颅底重建成功,无术后CSFL发生,1例Rathkes囊肿患者术后出现CSFL,再次接受内镜下CSFL修补术,术后未再出现CSFL。<b>结论</b> 颅底缝合硬膜,可以对颅底产生较大的支撑力,重建效果确切,值得临床应用。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=10E651E7F135EB4826FD7B514627FE43&language=2&ctl=26&etl=110" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">8.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=2564A7948F61BD5C1591C8CF0F628F5D" target="_blank">经颅入路联合神经内镜下经鼻蝶入路手术防治侧颅底脑膜瘤术后脑脊液漏</a>   <em><strong></strong></em>    <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=2564A7948F61BD5C1591C8CF0F628F5D' target='_blank'><img src='/ch/ext_images/free.gif' valign='bottom' title='点击此处可从《中国临床神经外科杂志》网站下载免费的PDF全文' border='0'></a>   <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=2564A7948F61BD5C1591C8CF0F628F5D' target='_blank'>下载免费PDF全文</a> </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%83%9d%e6%99%93%e9%9d%99" target="_blank">郝晓静</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%ad%99%e6%99%93%e7%a5%af" target="_blank">孙晓祯</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%9d%8e%e6%85%a7" target="_blank">李慧</a> <a class="a2" href="#">《中国临床神经外科杂志》</a>2022,27(1):41-43 </div> <div>目的探讨经颅入路联合神经内镜下经鼻蝶入路手术防治侧颅底脑膜瘤术后脑脊液漏的效果。方法回顾性分析2016年1月至2020年8月经颅入路联合神经内镜下经鼻蝶入路手术治疗的20例侧颅底脑膜瘤的临床资料。结果 8例未延伸至海绵窦或眶上裂的肿瘤实现全切除;12例次全切除,为减少术后眼神经损伤的风险、有小块肿瘤残留在海绵窦或眶上裂。术后病理检查均为脑膜瘤(WHO分级Ⅰ级)。术后随访12~41个月,平均24.4个月,无脑脊液漏;13例肿瘤复发或进展,其中11例接受立体定向放疗,2例术后12、15个月再次手术。结论经颅入路联合神经内镜下经鼻蝶入路手术治疗侧颅底脑膜瘤,可有效预防术后脑脊液漏。当肿瘤切除导致经颅入路侧的带血管蒂皮瓣不可用、肿瘤延伸至副鼻窦时,建议优先考虑该种联合入路手术方式。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=2564A7948F61BD5C1591C8CF0F628F5D&language=0&ctl=32&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">9.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=2B998A6639011614EAB26303318512BD" target="_blank">经鼻入路神经内镜下手术修补脑脊液鼻漏</a>   <em><strong></strong></em>    <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=2B998A6639011614EAB26303318512BD' target='_blank'><img src='/ch/ext_images/free.gif' valign='bottom' title='点击此处可从《中国临床神经外科杂志》网站下载免费的PDF全文' border='0'></a>   <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=2B998A6639011614EAB26303318512BD' target='_blank'>下载免费PDF全文</a> </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b4%ba%e6%8c%af%e5%8d%8e" target="_blank">贺振华</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b4%be%e8%89%b3%e9%a3%9e%e6%9d%a8%e3%80%80%e5%bc%ba%e9%9b%92%e6%99%93%e4%b8%9c" target="_blank">贾艳飞杨 强雒晓东</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%a2%81%e9%9d%99%e6%95%8f%e6%9d%8e%e3%80%80%e5%bc%ba" target="_blank">袁静敏李 强</a> <a class="a2" href="#">《中国临床神经外科杂志》</a>2019,(3):141-143 </div> <div>目的 探讨经鼻入路神经内镜下脑脊液漏修补术的方法及相关问题。方法 回顾性分析2011年12月至2017年12月经鼻入路神经内镜下手术修补治疗的51例脑脊液鼻漏的临床资料,其中外伤性47例,自发性3例,医源性1例。根据漏口大小选择不同方法修补。结果 51例中,修补成功49例,2例术后发生颅内感染、脑脊液鼻漏,经保守治疗治愈。所有病例术后随访2~5年,均未再发生脑脊液漏。结论 经鼻入路神经内镜下脑脊液鼻漏修补术是脑脊液鼻漏的有效治疗手段。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=2B998A6639011614EAB26303318512BD&language=2&ctl=18&etl=66" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">10.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=7ABEE59D05554DF49466050985E5B5E5" target="_blank">内镜经鼻颅底外科的现状和展望</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e6%99%93%e5%bd%aa" target="_blank">张晓彪</a> <a class="a2" href="#">《中华神经外科疾病研究杂志》</a>2011,10(5):385-387 </div> <div>内镜神经外科目前已经成为微创神经外科的最重要和最活跃的领域之一。其中,内镜经鼻颅底外科运用天然腔道鼻腔、在不牵拉脑组织的情况下,能够充分暴露病变,最大限度的切除病变,以其微创、术后  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=7ABEE59D05554DF49466050985E5B5E5&language=0&ctl=14&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">11.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=958068FFBD5742C7E59FA2B09A3A47AB" target="_blank">内镜经鼻蝶手术治疗颅底脊索瘤</a>   <em><strong>总被引:3,自引:1,他引:3</strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e4%ba%9a%e5%8d%93" target="_blank">张亚卓</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e5%bf%a0%e8%af%9a" target="_blank">王忠诚</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b5%b5%e5%be%b7%e5%ae%89" target="_blank">赵德安</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%91%a8%e7%9b%8a%e6%b0%91" target="_blank">周益民</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e4%b8%96%e6%b8%8a" target="_blank">张世渊</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%ae%97%e7%bb%aa%e6%af%85" target="_blank">宗绪毅</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%ae%8b%e6%98%8e" target="_blank">宋明</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%a3%b4%e5%82%b2" target="_blank">裴傲</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b5%b5%e6%be%8e" target="_blank">赵澎</a> <a class="a2" href="#">《中华神经外科杂志》</a>2007,23(3):163-166 </div> <div>目的探讨内镜下经鼻蝶治疗颅底脊索瘤的技术、方法和手术指征。方法自2000年6月至2006年6月,应用神经内镜经鼻蝶入路手术治疗颅底脊索瘤30例。29例应用30°,70°硬性神经内镜,经鼻中隔和中鼻甲间入路,用高速磨钻磨除相应的骨性结构,显露肿瘤并分块切除。1例在显微外科下开颅切除颅内部分肿瘤,然后在神经内镜引导下,经鼻蝶切除斜坡、鞍区蝶筛窦、上颌窦、颞下窝的肿瘤。18例在术后6-12个月获得随访。结果肿瘤近全切除7例,次全切除16例,部分切除7例。24例术后获得一定程度上的临床症状和体征的改善,6例无变化。所有病人在术后7- 10d可恢复日常生活。1例在出院后20d因脑脊液漏再次入院做修补手术。随访的18例中,有4例在术后10-18个月复发,这4例均为广泛性生长的病例。结论内镜经鼻蝶手术治疗颅底脊索瘤有明显的优势。其操作简便安全;术中视野清楚,有利于显露;术后严重并发症少,病人恢复快,住院时间短。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=958068FFBD5742C7E59FA2B09A3A47AB&language=2&ctl=14&etl=46" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">12.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=9B64FAF062611465D4D83C6B840C2E92" target="_blank">经鼻蝶入路神经内镜手术鞍底重建方法的研究进展</a>   <em><strong></strong></em>    <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=9B64FAF062611465D4D83C6B840C2E92' target='_blank'><img src='/ch/ext_images/free.gif' valign='bottom' title='点击此处可从《中国临床神经外科杂志》网站下载免费的PDF全文' border='0'></a>   <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=9B64FAF062611465D4D83C6B840C2E92' target='_blank'>下载免费PDF全文</a> </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%8c%85%e7%92%90%e7%9a%93" target="_blank">包璐皓</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%ab%98%e6%88%90" target="_blank">高成</a> <a class="a2" href="#">《中国临床神经外科杂志》</a>2021,26(3):217-219 </div> <div>随着神经内镜技术的发展,越来越多的腹侧颅底病变和脑深部病变能够通过神经内镜手术切除,例如,约90%的垂体腺瘤能通过经鼻蝶入路神经内镜手术完成[1]。神经内镜手术与显微手术相比具有创伤小、术式简洁、显露满意、视野清晰等优点。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=9B64FAF062611465D4D83C6B840C2E92&language=0&ctl=22&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">13.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=6F7CE677FA695B766AC9E78CD7749EEA" target="_blank">颅底脊索瘤的内镜经鼻手术治疗分型及入路</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%a1%82%e6%9d%be%e6%9f%8f" target="_blank">桂松柏</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%ae%97%e7%bb%aa%e6%af%85" target="_blank">宗绪毅</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e6%96%b0%e7%94%9f" target="_blank">王新生</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%9d%8e%e5%82%a8%e5%bf%a0" target="_blank">李储忠</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b5%b5%e6%be%8e" target="_blank">赵澎</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%b2%81%e6%b6%a6%e6%98%a5" target="_blank">鲁润春</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e4%ba%9a%e5%8d%93" target="_blank">张亚卓</a> <a class="a2" href="#">《中华神经外科杂志》</a>2013,29(7) </div> <div>目的 探讨一种适合内镜经鼻手术治疗需要的颅底脊索瘤临床分型及入路选择方法.方法 回顾性分析2007年8月至2012年8月于我院使用内镜经鼻手术治疗的133例颅底脊索瘤病例资料.依据内镜经鼻手术斜坡解剖区域分类方法对脊索瘤进行临床分型.其中,主体位于颅底中线区域116例:(1)主体位于前颅底6例;(2)主体位于上斜坡7例;(3)主体位于上中斜坡42例;(4)主体位于中下斜坡8例;(5)主体位于下斜坡21例;(6)主体位于全斜坡32例.主体位于中线及中线旁区域(广泛型)17例.全部病人均行内镜经鼻手术切除.中线区域型共使用4种内镜经鼻手术入路:内镜经鼻-前颅底入路、内镜经鼻-上斜坡入路、内镜经鼻-中斜坡入路、内镜经鼻-下斜坡入路.广泛型使用内镜经鼻手术入路结合其他开颅手术入路进行肿瘤切除.结果 病变全切为26例(20%),次全切62例(47%),大部切除38例(29%),部分切除7例(5%).结论 制定适合内镜经鼻手术的斜坡解剖区域划分,并以此为基础对颅底脊索瘤进行临床分型,可以更好地指导内镜经鼻切除颅底脊索瘤的手术入路选择.  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=6F7CE677FA695B766AC9E78CD7749EEA&language=0&ctl=19&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">14.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=735FFE4E5DDA011B" target="_blank">内镜经鼻颅底外科理念的建立</a>   <em><strong>总被引:6,自引:1,他引:6</strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e7%a7%8b%e8%88%aa" target="_blank">张秋航</a> <a class="a2" href="#">《中国微侵袭神经外科杂志》</a>2006,11(10):433-434 </div> <div>众所周知.在我国显微神经外科理念的建立大概经历了20年。同样,人们对内镜经鼻颅底外科的认识也需要时间。对内镜经鼻颅底外科技术大多数外科医生联想到的是其微创的特点和有限的适应证.如垂体腺瘤切除、视神经减压及脑脊液鼻漏修补等。尽管国内外众多文献屡屡列举内镜颅底外科与显微外科比较的优点有:①微侵袭;②视觉效果好;③方法简便;④可迅速到达手术区域;⑤手术时间短;⑥减少脑组织牵拉;⑦副损伤小。但其单手操作、不易控制出血、手术适应证选择范围较窄和复杂的内镜外科技术训练等缺点也无法回避。因此.内镜经鼻颅底外科的适应证一直是临床医生广泛关注和争议较大的问题。人们关注是因为希望了解内镜下能够观察和处理的颅底病变范围有多大?这项微创外科技术在颅底外科领域究竟能走多远?人们对内镜经鼻颅底外科适应证的争议源于这是一个新的领域.尚处于探索阶段。人们的直接和间接经验均不足。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=735FFE4E5DDA011B&language=0&ctl=13&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">15.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=B06B55C87406F159" target="_blank">颅鼻沟通肿瘤的显微外科手术及颅底重建</a>   <em><strong>总被引:3,自引:0,他引:3</strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%9c%b4%e6%b5%a9%e5%93%b2" target="_blank">朴浩哲</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%ad%99%e4%bd%a9%e6%ac%a3" target="_blank">孙佩欣</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e7%83%a8" target="_blank">张烨</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%a7%9a%e5%86%b0" target="_blank">姚冰</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%bd%a6%e4%b8%9c%e6%96%b9" target="_blank">车东方</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%99%88%e6%82%a6" target="_blank">陈悦</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%ad%94%e4%bb%a4%e6%9d%83" target="_blank">孔令权</a> <a class="a2" href="#">《中华神经外科杂志》</a>2006,22(6):370-371 </div> <div>作者于2003年1月至2004年11月采用经纵裂入路显微外科手术切除前颅底沟通瘤,“三明治”法颅底重建11例,疗效满意,报告如下。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=B06B55C87406F159&language=0&ctl=18&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">16.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=6322549ADAE3930F1DF942D0753118D2" target="_blank">游离鼻粘膜瓣在垂体腺瘤经鼻入路神经内镜手术鞍底重建中的应用</a>   <em><strong></strong></em>    <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=6322549ADAE3930F1DF942D0753118D2' target='_blank'><img src='/ch/ext_images/free.gif' valign='bottom' title='点击此处可从《中国临床神经外科杂志》网站下载免费的PDF全文' border='0'></a>   <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=6322549ADAE3930F1DF942D0753118D2' target='_blank'>下载免费PDF全文</a> </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%be%90%e4%bd%b3" target="_blank">徐佳</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e5%bd%ac%e5%bd%ac" target="_blank">王彬彬</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e5%8d%8f%e9%94%8b" target="_blank">王协锋</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%a8%8b%e5%88%9a" target="_blank">程刚</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%83%a1%e5%8d%ab%e6%98%9f" target="_blank">胡卫星</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%99%b6%e8%b6%85" target="_blank">陶超</a> <a class="a2" href="#">《中国临床神经外科杂志》</a>2022,27(12):1013-1015 </div> <div>目的 探讨游离鼻粘膜瓣在垂体腺瘤经鼻入路神经内镜手术鞍底重建中的应用效果。方法 回顾性分析2020年1月至2022年2月经鼻入路神经内镜手术治疗的80例垂体腺瘤的临床资料。术中应用游离鼻粘膜瓣进行鞍底重建。结果 肿瘤全切除63例,近全切除2例,次全切除9例,部分切除6例。出院后随访6~32个月,无脑脊液漏。结论 垂体腺瘤经鼻入路神经内镜切除术中,应用游离鼻粘膜瓣进行鞍底重建,效果良好。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=6322549ADAE3930F1DF942D0753118D2&language=0&ctl=29&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">17.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=9155585193D06292086ED3ABA19934EE" target="_blank">神经内镜下经鼻-扩大蝶窦入路术后颅底重建(附20例分析)</a>   <em><strong>总被引:1,自引:1,他引:1</strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e6%b8%85" target="_blank">王清</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%85%b0%e9%9d%92" target="_blank">兰青</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e9%b2%81%e6%99%93%e6%9d%b0" target="_blank">鲁晓杰</a> <a class="a2" href="#">《中国微侵袭神经外科杂志》</a>2008,13(12) </div> <div>目的探讨神经内镜下经鼻-扩大蝶窦入路术后的颅底重建技术。方法回顾性分析20例神经内镜下经鼻-扩大蝶窦入路术后的颅底重建经验。其中鞍结节脑膜瘤7例,颅咽管瘤3例,垂体腺瘤10例。在切除肿瘤后均采用人工硬脑膜-明胶海绵和生物胶-人工硬脑膜的"三明治"式方法,同时辅以球囊支持修补材料和持续腰池引流。结果1次手术修补成功15例,短暂性脑脊液鼻漏经保守治疗治愈3例,2例2次内镜下经鼻入路行颅底重建得以修复。术后随访6个月~4年,疗效满意。结论"三明治"式修补方法加球囊支撑和持续性腰池引流,可显著降低术后脑脊液鼻漏的发生,是神经内镜下经鼻-扩大蝶窦入路术后颅底重建的可靠技术。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=9155585193D06292086ED3ABA19934EE&language=2&ctl=28&etl=125" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">18.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=A701BEA26F6F1B6D19789A47CE4B016E" target="_blank">经鼻入路显露颅底中线区的内镜解剖研究</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%ae%8b%e6%98%8e" target="_blank">宋明</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%a3%b4%e5%82%b2" target="_blank">裴傲</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e8%b5%b5%e6%be%8e" target="_blank">赵澎</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%a1%82%e6%9d%be%e6%9f%8f" target="_blank">桂松柏</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e4%b8%a5%e8%80%80%e5%8d%8e" target="_blank">严耀华</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e5%bc%a0%e4%ba%9a%e5%8d%93" target="_blank">张亚卓</a> <a class="a2" href="#">《中华神经外科杂志》</a>2012,28(3) </div> <div>目的 确定内镜下采用经鼻入路至颅底中线区的显露范围,确定相关手术标志.方法 选用福尔马林固定灌注的成人尸头标本5具,在内镜下采用经鼻入路进行显露.结果 内镜下采用经鼻入路至颅底中线区,可显露从鸡冠至C2椎体上缘的广泛区域,显露双侧12对脑神经,颈内动脉和椎-基底动脉系统.结论 内镜下采用经鼻入路显露颅底中线区是安全可行的.采用内镜经鼻入路,可处理颅底中线区病变.  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=A701BEA26F6F1B6D19789A47CE4B016E&language=2&ctl=18&etl=68" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">19.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=64488958E8AA8ED38E0B2EDF5007D8D6" target="_blank">颅底重建材料与技术的发展</a>   <em><strong></strong></em>   </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e7%8e%8b%e5%bf%97%e5%bc%ba%e7%bb%bc%e8%bf%b0" target="_blank">王志强综述</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%bc%86%e6%9d%be%e6%b6%9b%e5%ae%a1%e6%a0%a1" target="_blank">漆松涛审校</a> <a class="a2" href="#">《国际神经病学神经外科学杂志》</a>2011,38(4):392-396 </div> <div>显微外科颅底重建和内镜外科颅底重建是紧密联系的两个方面,其材料技术交错互补。自体材料组织相容性好、修复能力强,但有二次创伤、且带血运自体组织操作难度大、技术要求高,异体材料种类繁多、取材方便、塑形良好、且无手术副损伤。以防治脑脊液漏等严重并发症为目的的多层重建技术被广泛认同和应用。  <a href="relate_search.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=F36852868DF483FE8E3377698C9D0C67&aid=64488958E8AA8ED38E0B2EDF5007D8D6&language=0&ctl=12&etl=0" target="_blank">相似文献</a>    </div> <div><br></div> <div class="clear"></div> </div> <div class="clear"></div> </div> <div class="search_article"> <div class="search_articleleft">20.</div> <div class="search_articleright"> <div> <a class="a1" href="https://yyws.alljournals.cn/view_abstract.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=6322549ADAE3930F6A0068376031C7BD" target="_blank">垂体腺瘤经鼻蝶入路神经内镜切除术后脑脊液鼻漏的危险因素</a>   <em><strong></strong></em>    <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=6322549ADAE3930F6A0068376031C7BD' target='_blank'><img src='/ch/ext_images/free.gif' valign='bottom' title='点击此处可从《中国临床神经外科杂志》网站下载免费的PDF全文' border='0'></a>   <a href='https://yyws.alljournals.cn/get_pdf_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&aid=6322549ADAE3930F6A0068376031C7BD' target='_blank'>下载免费PDF全文</a> </div> <div> <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%b1%aa%e4%b9%90%e7%94%9f" target="_blank">汪乐生</a>  <a href="search.aspx?subject=medicine_health&major=sjbxjsbx&field=author_name&encoding=utf-8&q=%e6%9d%a8%e9%82%a6%e5%9d%a4" target="_blank">杨邦坤</a> <a class="a2" href="#">《中国临床神经外科杂志》</a>2022,27(7):541-543 </div> <div>目的 探讨垂体腺瘤经鼻蝶入路神经内镜切除术后脑脊液鼻漏的危险因素。方法 回顾性分析2016年1月至2019年3月经鼻蝶入路神经内镜手术治疗的130例垂体腺瘤的临床资料。结果 130例中,术后发生脑脊液鼻漏15例,发生率为11.5%(15/130)。多因素logistic回归分析发现,体质指数>25.0 kg/m<sup>2</sup>、术中脑脊液漏、再次手术是垂体腺瘤经鼻蝶入路神经内镜术后发生脑脊液漏的独立危险因素(P<0.05)。10例采用腰大池外引流,5例采用药物脱水治疗;15例未发生颅内感染情况;出院后随访12~36个月,未再次发生脑脊液鼻漏。结论 脑脊液鼻漏是PA经鼻蝶入路神经内镜切除术后较为常见的并发症,预后良好。对于体质肥胖、术中脑脊液漏和再次手术的PA,术后应密切关注脑脊液鼻漏和颅内感染情况,可考虑二次手术。  <a 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