共查询到19条相似文献,搜索用时 62 毫秒
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报道了一条简便合成标题化合物的路线,单羟基化合物(6)直接用二异丁基铝氢还原为r-半缩醛,后者经Wittig反应直接转化为目标物和15-差向异构体。 相似文献
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报道了一条简便合成标题化合物的路线.单羟基化合物(6)直接¥用二异丁基铝氢还原为r-半缩醛,后者经Witig反应直接转化为目标物和15-差向异构体 相似文献
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以商业易得的(+)-内向3-溴莰酮-2为手性源合成了光学活性的(1’R,2S,2‘S)-2-(2-溴甲基-2-甲基-3-亚甲基)环戊基丙酸。 相似文献
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2—(E)—芳亚甲基—5—环戊烯(1)基—5—烃基环戊酮类化合物的合成… 总被引:1,自引:1,他引:0
设计合成了含有αβ-不饱和酮和环戊烯基结构的2-(E)-芳亚甲基-5-环戊烯(1)基-5-烃基环戊酮类11个未见文献报道的新化合物,初步药理结果显示。该类化合物EAC和HepA癌细胞具有较强的抑制作用,体内抑癌试验也显示一定活性,但抗炎活性较弱。 相似文献
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E L Shapiro L Weber H Harris C Miskowicz R Neri H L Herzog 《Journal of medicinal chemistry》1972,15(7):716-720
Synthesis and biological activity of 17-esters of 6-dehydro-16-methylene-17 alpha-hydroxyprogesterone are presented. A systematic study of the influence of the alteration of halogen at 6 and the acyl group at 17 on the progestational and antiandrogenic activities of the resulting structures is described. A convenient general method for synthesis of all of the members of the generic family from the precursors in common is described. It is believed that 6-chloro-16-methylene-17 alpha-hydroxy-4,6-pregnadiene 17-acetate, because of its structural similarity to chlormadinone acetate and its high progestational potency, will perform as a contraceptive at perhaps a lower dose than that of chlormadinone acetate. 相似文献
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The pharmacological profile of TX 066 (17 alpha-acetoxy-6-methyl-19-nor-4,6-pregna-diene-3,20-dione), a new oral progestative 总被引:1,自引:0,他引:1
17 alpha-Acetoxy-6-methyl-19-nor-4,6-pregna-diene-3,20-dione (TX 066) has the pharmacological profile of a pure progestogen with no side effect such as androgenic activity. Its pituitary suppressing effect is relatively weak, as is also its antiestrogenic activity. It possesses a powerful antiandrogenic effect, which, in addition to the classic uses for progestogens, may make TX 066 useful in the treatment of certain diseases such as prostatic hypertrophy or the Stein-Leventhal syndrome. 相似文献
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Sergeev PV Semeĭkin AV Smirnova ZS Rzheznikov VM Grinenko GS Fedosov AV Fedotcheva TA Shimanovskiĭ NL 《Eksperimental'naia i klinicheskaia farmakologiia》2004,67(4):54-56
Antitumor activity of a new highly active promising gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one (butagest) was studied in mice with model cervical carcinoma (RShM-5). The reference drug was medroxyprogesteron acetate (MPA, Depo Provera) used in clinics. The new preparation introduced perorally in a dose of 1 mg per mice inhibited the model tumor growth by 73%, which was 18% (p < 0.01) more effective than the action of the reference drug MPA. The effect of the new gestagen was also studied in vitro with respect to human breast carcinoma of the MCF-7 line and human cervical carcinoma HeLa. The viability of the tumor cells was studied during a 6-day incubation with the drug at a concentration of 10(-7)-10(-5) M (MTT test). The reference compounds were progesterone and MPA. These drugs suppressed the growth of both MCF-7 and, in higher concentrations, of HeLa. Butagest inhibited the growth of HeLa in all concentrations. Thus, the new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one is capable of suppressing the viability of human breast carcinoma and human cervical carcinoma, being comparable or even more effective than the reference drugs. 相似文献
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应用质子去偶及质子偶合INEPT方法测定药物合成中间体(Ⅱ)的结构。与宽带质子去偶及门控去偶方法比较,INEPT方法具有较高的灵敏度和选择性,节省实验时间。 相似文献