共查询到20条相似文献,搜索用时 15 毫秒
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BackgroundOsteocalcin is the most abundant non-collagenous protein in bone and is specifically expressed in osteoblasts. Previous studies using osteocalcin-deficient (Ocn–/–) mice demonstrated that osteocalcin inhibits bone formation, and serum uncarboxylated osteocalcin functions as a hormone that improves glucose metabolism, induces testosterone synthesis in the testes, and maintains muscle mass. Furthermore, the relationship between serum osteocalcin and glucose metabolism or cardiovascular risk in humans has been reported. However, new Ocn–/– mice exhibited different phenotypes.HighlightBone volume, formation, and resorption were normal in the new Ocn–/– mice. The orientation of collagen fibers was parallel to the bone longitudinal direction and the size of apatite crystals was normal, but the c-axis of apatite crystals was random and bone strength was reduced in new Ocn–/– mice. Glucose metabolism, testosterone synthesis, and muscle mass were normal in new Ocn–/– mice. Exercise improved glucose metabolism and increased bone formation, leading to an increase in the serum osteocalcin level, which is a marker for bone formation.ConclusionContrary to previous findings, new Ocn–/– mice revealed that osteocalcin has no function in the regulation of bone quantity, but instead, functions to direct the parallel alignment of the c-axis of apatite crystals with collagen fibrils. Moreover, it has no physiological function as a hormone that regulates glucose metabolism, testosterone synthesis, or muscle mass. These controversial phenotypes require further investigation. The relationship of serum osteocalcin with glucose metabolism or cardiovascular risk suggests the importance of exercise for their improvement. 相似文献
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《口腔医学》2005,(5)
The Journal of Stomatologyis an academic joural inthe field of oral medicine,mainly coveringthe latest achievements andtrendsin bothbasic and clinical researches,aiming at providingthe up-to-dateinformationforthe clinicians,teachers,scientific researchers andstudents andpromotingthe academic exchanges for the development of stomatology.It has such columns as basic researches,clinical researches,treatises,outpatient management,surveys,preventive oral medicine,clinic forums,reviews,experiences,s… 相似文献
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《口腔医学》2007,(1)
The Journal of Stomatologyis an academic joural inthe field of oral medicine,mainly coveringthe latestachievements andtrends in both basic and clinical researches,aiming at providingthe up-to-date informationfor the clinicians,teachers,scientific researchers and students and promotingthe academic exchanges for thedevelopment of stomatology.It has such columns as basic researches,clinical researches,treatises,outpatientmanagement,surveys,preventive oral medicine,clinic forums,reviews,experience… 相似文献
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《口腔医学》2008,(3)
The Journal of Stomatology is an academic joural in the field of oral medicine,mainly covering the latest achievements and trends in both basic and clinical researches,aiming at providing the up-to-date information for the clinicians,teachers,scientific researchers and students and promoting the academic exchanges for the development of stomatology. 相似文献
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《口腔医学》2007,(4)
The Journal of Stomatologyis an academic joural inthe field of oral medicine,mainly coveringthe latestachievements andtrends in both basic and clinical researches,aiming at providingthe up-to-date informationfor the clinicians,teachers,scientific researchers and students and promotingthe academic exchanges for thedevelopment of stomatology.It has such columns as basic researches,clinical researches,treatises,outpatientmanagement,surveys,preventive oral medicine,clinic forums,reviews,experience… 相似文献
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《口腔医学》2008,28(1):I0002-I0003
<正>The Journal of Stomatology is an academic joural in the field of oral medicine, mainly covering the latest achievements and trends in both basic and clinical researches, aiming at providing the up-to-date information for the clinicians, teachers, scientific researchers and students and promoting the academic exchanges for the development of stomatology. It has such columns as basic 相似文献
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《口腔医学》2007,(12)
The Journal of Stomatology is an academic joural in the field of oral medicine,mainly covering the latest achievements and trends in both basic and clinical researches,aiming at providing the up-to-date information for the clinicians,teachers,scientific researchers and students and promoting the academic exchanges for the development of stomatology.It has such columns as basic researches,clinical researches,treatises,outpatient management,surveys,preventive oral medicine,clinic forums,reviews,… 相似文献
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《上海口腔医学》2003,12(3)
ShanghaiJournalofStomatology(SJS)ispublishedbimonthlyinChinesebySchoolofStomatology,ShanghaiSecondMedicalUniversi-ty,andisapeerreviewedgeneraldentaljournalforalldentists,researchersandhealthworkersregardlessoftheirdentalsub-specialtyortypesofemployment.Itwasfoundedin1992,andbecomesoneofthetopdentaljournalsinChina.ThejournalfunctionsasawindowintoChina'sdentalsciences,whichreflectstheuptodateadvancesandprogressesinthefieldofChineseStomatology.Itservesthepurposeofinternationalacademicexchan… 相似文献
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Vinckier F 《Revue belge de médecine dentaire》2000,55(1):41-50
Local anesthesia fails in 10% of cases of inferior alveolar nerve block and 7% of all cases of local anesthesia in general practice. Possible causes of failure are infection, wrong selection of local anesthetic solution, technical mistakes, anatomical variations with accessory innervation and anxiety of the patient. In this publication we discuss reasons for frequent failure in case of infection and in inferior alveolar nerve block. Understanding the mechanism of failure in local anesthesia, makes it possible to formulate guidelines to guarantee success. These measures are discussed in detail. 相似文献
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Christensen GJ 《Journal of the American Dental Association (1939)》2003,134(11):1517-1519
Dental specialties have an important, positive role in improving education and practice, stimulating research and defining quality expectations in their areas of expertise. However, it is well-known that general dental practitioners accomplish a significant portion of the dental therapy that commonly is classified as being within the scope of the respective recognized specialty areas. In this column, I have made suggestions about methods for improving the interaction between specialists and generalists and a call for better acceptance by each group of the capabilities of the other. 相似文献
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