慢性心力衰竭患者血清同型半胱氨酸、尿酸和血脂水平的变化及意义

目的观察慢性心力衰竭患者血清同型半胱氨酸(Hcy)、尿酸(UA)及总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白a[Lp(a)]等血脂相关指标水平的变化,并分析上述指标与患者心功能的关系,以探讨检测上述指标在慢性心力衰竭临床诊治中的应用价值。方法选取2013年2月-2016年8月我院心内科收治的慢性心力衰竭患者192例,作为观察组,并根据美国心脏病协会(NYHA)心功能分级分为Ⅱ级(n=46)、Ⅲ级(n=108)、Ⅳ级(n=38)3个亚组,另选取同期在我院进行健康体检的体检人员74例作为对照组。比较观察组与对照组及3个亚组间血清Hcy、UA、TC、TG、HDL-C、LDL-C、Lp(a)水平,采用Spearman等级相关分析观察组患者血清Hcy、UA、TC、TG、HDL-C、LDL-C、Lp(a)水平与NYHA分级的关系。结果与对照组体检人员比较,观察组患者血清Hcy、UA、Lp(a)水平升高,TC、TG、HDL-C水平降低,差异具有统计学意义(P0.05),而组间血清LDL-C水平比较,差异无统计学意义(P0.05);观察组心功能Ⅱ级、Ⅲ级、Ⅳ级3个亚组患者血清Hcy、UA、TC、TG、HDL-C、Lp(a)比较,差异具有统计学意义(P0.05),而组间血清LDL-C水平比较,差异无统计学意义(P0.05);Spearman等级相关分析显示,观察组患者血清Hcy、UA、Lp(a)与NYHA分级呈正相关(P0.05),TC、TG、HDL-C与NYHA分级呈负相关(P0.05),LDL-C与NYHA分级无显著相关(P0.05)。结论血清Hcy、UA、TC、TG、HDL-C、Lp(a)水平均随着慢性心力衰竭患者心功能的恶化而变化,可作为患者病情评估的参考指标,血清水平检测对指导早期干预治疗以降低远期心血管事件风险具有重要的意义。     

彰武县中学生血脂水平及异常分布特征调查

目的了解高血压及心脑血管疾病高发区中学生血脂水平及异常情况,以便采取干预措施。方法在彰武县农村随机抽取6所中学,对抽取的全部学生进行调查并测定血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及体格检查。结果(1)调查学生TC为(3.52±0.65)mmol/L,TG为(0.94±0.53)mmol/L,LDL-C为(1.71±0.49)mmol/L,HDL-C为(1.32±0.41)mmol/L。TC、TG和LDL-C女生均高于男生,差异有统计学意义。(2)各年龄组之间血脂呈交替高低变化。(3)肥胖组TC、TG水平均高于体重正常组,HDL-C水平则是肥胖组低于体重正常组,差异有统计学意义。(4)女生TC、TG和LDL-C的异常率略高于男生,而HDL-C异常率发生水平则男生略高于女生。(5)4种指标在不同年龄组中异常率的发生无随年龄增高而增高的趋势。(6)TG异常情况在肥胖组高于体重正常组,差异有统计学意义。结论该地区青少年空腹血TC、TG、LDL-C和HDL-C水平低于全国大部分地区城市健康青少年水平。     

老年高血压患者肾功能、血脂指标水平与血清同型半胱氨酸的关系研究

目的 探讨老年高血压患者的血清肌酐（Cr）、尿酸（UA）、尿素（Urea）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平变化情况,分析其与同型半胱氨酸（Hcy）水平的相关性。方法 回顾性分析盐城市第一人民医院2019年6月至2022年6月收治的80例老年高血压患者的基础资料,依据Hcy水平将其分为正常Hcy组（Hcy<15μmol/L,48例）、高Hcy组（Hcy≥15μmol/L,32例）。入院后检测所有患者血清Hcy、Cr、UA、Urea、TC、TG、HDL-C、LDL-C水平,比较两组患者上述指标的水平变化情况;分析肾功能、血脂指标与血清Hcy水平的相关性。结果 与正常Hcy组比较,高Hcy组患者血清Cr、UA、Urea、TG、TC、Hcy、LDL-C水平均更高,HDL-C水平更低;经Pearson相关性分析,高血压患者血清Cr、Urea、UA、TC、TG、LDL-C水平与Hcy水平均呈正相关（r=0.732、0.667、0.685、0.543、0.453、0.467）,血清HDL-C水平与Hcy水平呈负相关（r...     

H型高血压伴急性脑梗死患者血清SAA和脂蛋白水平变化意义

目的探讨H型高血压患者并发急性脑梗死血清淀粉样蛋白A(SAA)、载脂蛋白a[LP(a)]的变化及其相互关系。方法选取我院2016年1月-2018年2月收治的120例急性脑梗死患者,根据血清同型半胱氨酸(Hcy)的水平分为H型组56例(Hcy≥10.0μmol/L)、普通组64例(Hcy10.0μmol/L),比较两组的血清Hcy、血清SAA、Lp(a)、空腹血糖(FPG)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、颈动脉内膜中层厚度(IMT)、美国国立卫生研究院卒中量表(NIHSS)评分,并采用简单线性相关分析法探讨血清Hcy与SAA、IMT、NIHSS评分的关系。结果 H型组患者的FPG、SBP、DBP、TC、TG、HDL-C、LDL-C水平与普通组患者比较,差异均不具有统计学意义(P0.05); H型组患者的血清Hcy、血清SAA、Lp(a)、IMT水平高于普通组患者,差异均具有统计学意义(P0.05); H型组和普通组患者的NIHSS评分差异不具有统计学意义(P0.05); H型高血压伴急性脑梗死患者的血清SAA、Lp(a)与NIHSS评分、IMT测定值均呈正相关关系(P0.05)。结论 H型高血压伴急性脑梗死患者的血清SAA、Lp(a)升高较普通脑梗死患者明显,并且Hcy与患者SAA、Lp(a)、NIHSS评分及IMT的变化具有一定的关系。     

慢性三氯化镧暴露对大鼠血糖和血脂水平的影响

目的探讨稀土元素镧的慢性暴露对大鼠血糖、血脂的影响。方法分别以0.1、2和40 mg/kg剂量的三氯化镧(LaC l3)给大鼠经口灌胃,每天1次,90 d后处死;取全血测定糖化血红蛋白(HbA1 c),分离血清测定血糖(G lu)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。结果与对照组相比,3个LaC l3暴露剂量组大鼠HbA1C、血清G lu、TG和LDL-C水平无统计学意义;0.1和2 mg/kg剂量LaC l3暴露组大鼠血清TC水平分别为(1.38±0.14)mmol/L和(1.37±0.26)mmol/L,与对照组大鼠(1.57±0.14)mmol/L相比有明显降低;0.1 mg/kg剂量LaC l3暴露组大鼠血清HDL-C为(0.79±0.12)mmol/L,比对照组大鼠(0.93±0.10)mmol/L有明显降低。结论0.1~40 mg/kg LaC l3慢性暴露对大鼠血清G lu、TG和LDL-C水平无显著影响;低、中剂量LaC l3慢性暴露可使大鼠血清TC和HDL-C降低。     

基于VAP+血脂分型检测的肥胖孕妇血脂亚组分与新生儿不良出生结局的相关性研究

目的 研究基于VAP+血脂分型检测的肥胖孕妇血脂亚组分与新生儿不良出生结局的相关性。方法 选取2021年1—10月在温州市中心医院进行产前检查的136例肥胖孕妇作为研究组，同期进行产前检查的健康孕妇150例作为对照组。通过试剂盒直接测定法检测两组孕妇血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平，采用GPO-PAP法检测血清三酰甘油(TG)、总胆固醇(TC)水平，采用VAP+血脂分型技术检测血清脂蛋白(a)[LP(a)]、残粒脂蛋白胆固醇(RLP-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)水平。采用Pearson法分析肥胖孕妇血脂水平与新生儿不良出生结局的相关性。结果 对照组HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平分别为(3.74±0.46)mmol/L、(2.39±0.52)mmol/L、(3.08±0.41)mmol/L、(4.36±0.80)mmol/L、(139.15±11.84)mg/L、(0.18±0.14)mmol/L、(1.90±0.37)g/L、(0.79±0.12)g/L;研究组HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平分别为(2.96±0.35)mmol/L、(3.72±0.49)mmol/L、(4.10±0.39)mmol/L、(6.79±0.62)mmol/L、(220.83±50.61)mg/L、(0.30±0.16)mmol/L、(2.20±0.45)g/L、(0.96±0.20)g/L。研究组孕妇的血清LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平均高于对照组，HDL-C水平低于对照组，差异均有统计学意义(均P<0.05)。研究组早产儿、巨大儿、高胆红素血症发生率均高于对照组，差异均有统计学意义(均P<0.05)。Pearson相关性分析发现：肥胖孕妇的血清HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平与早产儿、新生儿窒息、巨大儿、高胆红素血症及低出生体质量儿发生率均呈正相关(均P<0.05)。结论 肥胖孕妇的血脂水平明显增高，且和新生儿不良出生结局存在相关性，临床需强化孕期血脂监测，并给予针对性预防干预措施。     

婴儿期体格发育与新生儿脐血血脂水平的关系

目的:探讨足月新生儿脐血血脂水平与婴儿期体格发育的关系。方法:选择501例自然经阴道分娩的足月健康新生儿,分别测定脐血总胆固醇(TCH)、甘油三酯(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的水平。追踪随访至婴儿12月龄时,根据营养状况分为肥胖组、标准组及营养不良组,分别评价各组间婴儿出生时的脐血血脂水平。结果:肥胖组TCH为(1.76±0.85)mmol/L,TG为(0.43±0.42)mmol/L,HDL-C为(1.15±0.53)mmol/L;标准组TCH为(1.56±0.71)mmol/L,TG为(0.38±0.38)mmol/L,LDL-C为(0.99±0.41)mmol/L,HDL-C为(1.07±0.38)mmol/L,营养不良组TCH为(1.66±0.50)mmol/L,TG为(0.49±0.44)mmol/L,LDL-C为(0.98±0.33)mmol/L,HDL-C为(1.19±0.55)mml/L。LDL-C为(0.88±0.42)三组婴儿出生时脐血血脂值均无明显差异(P>0.05)。结论:脐血血脂水平与婴儿期体格发育无明显关系。     

绝经过渡期女性血清抗苗勒管激素水平与心血管风险因子的相关性分析

目的分析绝经过渡期女性血清抗苗勒管激素(AMH)水平与心血管风险因子的相关性。方法选取2019年12月—2022年3月宁波市鄞州区鄞州第二医院收治的60例绝经过渡期妇女作为观察组,并选取同期于该院就诊的60例绝经过渡期前妇女作为对照组,比较两组血清AMH水平与心血管风险因子[体质指数(BMI)、空腹血糖(FBG)、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)、舒张压(DBP)、血尿酸(UA)、同型半胱氨酸(Hcy)、脂蛋白a(LPa)],并根据血清AMH水平将观察组患者分为低AMH组(28例)和高AMH组(32例),比较两组心血管风险因子,并采用多元线性回归分析血清AMH水平与心血管风险因子的相关性。结果观察组的年龄、BMI、FBG、TC、TG、LDL-C、SBP、DBP值及血清LPa水平均显著高于对照组,血清AMH水平低于对照组(P<0.05),两组HDL-C、UA、Hcy水平比较,差异均无统计学意义(均P>0.05)。低AMH组的年龄、BMI、FBG、TC、TG、LDL-C、SBP、DBP值及血清LPa水平均显著高于高AMH组,差异有统计学意义(P<0.05),两组HDL-C和血清UA、Hcy水平比较,差异均无统计学意义(均P>0.05)。多元线性回归分析显示,血清AMH水平与年龄、BMI、FBG、TC、TG、LDL-C、SBP、DBP值及血清LPa水平均存在线性相关(P<0.05),与HDL-C和血清UA、Hcy水平无明显相关性(P>0.05)。结论绝经过渡期女性血清AMH水平降低,可增加心血管疾病发生率,临床应对血清AMH水平进行监测,对预测绝经过渡期女性心血管疾病风险具有重要意义。     

冠心病患者血清同型半胱氨酸与血脂指标的相关性研究

目的探讨冠心病患者血清同型半胱氨酸(Hcy)水平与低密度脂蛋白胆固醇(LDL-C)/高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)/HDL-C、甘油三酯(TG)/HDL-C比值之间的相关性。方法选取60例CHD患者和60例健康对照者,采用全自动生化分析仪检测血清Hcy浓度与LDL-C、HDL-C、TC、TG水平,并分析Hcy与LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值之间的相关性。结果与正常对照组相比,CHD组血清Hcy、LDL-C、TC、TG水平升高,而HDL-C水平降低,差异有统计学意义(P0.01,P0.05)。CHD组血清LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值较正常对照组显著升高(P0.01),Hcy与LDL-C/HDL-C(r=0.267 3,P0.01)、TC/HDL-C(r=0.277 1,P0.01)、TG/HDL-C(r=0.236 3,P0.01)比值均呈正相关。结论血清Hcy浓度和LDL-C、HDL-C、TC、TG水平与CHD的发生发展密切相关,分析Hcy与LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值的相关性对于探讨CHD的发病机制及其检测具有重要价值。     

糖尿病患者血脂检验临床价值研究

目的分析糖尿病患者血脂异常原因,为临床治疗糖尿病血脂异常提供依据。方法取40例糖尿病患者作为实验组,40例血糖正常人作为对照组,取两组早晨空腹血(血清),测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)。结果实验组TC、TG、HDL-C、LDL-C分别为(5.37±1.13)mmol/L、(2.81±1.19)mmol/L、(1.39±0.61)mmol/L、(3.83±1.11)mmol/L,对照组分别为(4.10±0.75)mmol/L、(1.62±0.72)mmol/L、(1.48±0.83)mmol/L、(2.72±0.92)mmol/L。结论糖尿病患者血脂含量明显升高,其中TC、TG、LDL升高明显。提示糖尿病患者在控制血糖的同时,应进行相应的降脂治疗。     

Plasma testosterone,serum FSH,and serum LH levels in transvestism

Plasma testosterone, serum FSH, and serum LH levels of 26 members of a club established for heterosexual transvestites were assayed. Mean plasma testosterone, serum FSH, and serum LH levels of the transvestite subjects were not significantly different from the normal range. The implications of these findings are discussed.This work was supported by the National Health and Medical Research Council of Australia.     

Bone mineral density, serum albumin and serum magnesium

OBJECTIVES: This study explores clinical and laboratory abnormalities that contribute to the prevalence of bone fractures in frail and control elderly patients, to ascertain factors that relate to bone strength and fragility. METHODS: Patients were selected as free from renal failure and not taking supplements or medications that affect their magnesium status, and categorized according to their underlying diseases, sex and age, and evaluated by tests of bone strength. RESULTS: Findings, differentiating elderly patients on the basis of their magnesium, calcium, serum albumin, body mass, bone mineral density and their fracture occurrence were tabulated. CONCLUSION: Evidence is presented of low magnesium and albumin serum levels, especially in women with low bone density, as well as of low calcium and trace minerals.     

Effect of mercury toxicity on serum osmolality,plasma sodium and potassium,and serum proteins in the chicken

Juvenile male chickens were exposed continuously to 300g/ml of mercury (Hg) in the form of mercuric chloride (HgCl₂),via the drinking water, from hatching through six weeks of age. Serum osmolality and plasma potassium were increased significantly as a result of the Hg treatment. Plasma sodium was increased numerically in two of the three trials. Of the serum proteins, only albumin and the transferrins exhibited a consistent significant increase. It is concluded that alterations in serum ions and proteins account for the significant increase in plasma osmolality. The increase in transferrins may represent a mechanism to bind and detoxify Hg.Paper No. 5922 of the Journal Series of the North Carolina Agricultural Research Service, Raleigh, NC 27650.The use of trade names in the publication does not imply endorsement by the North Carolina Agricultural Research Service of the products named, nor criticism of similar ones not mentioned.     

A contraceptive vaginal ring releasing ethinyl estradiol and the progestin ST-1435: bleeding control, serum steroid concentrations, serum lipids and serum chemistry

Four women used vaginal rings releasing the synthetic progestin ST-1435 and ethinyl estradiol for at least three 21-day cycles with a 7-day treatment-free period between intervals of use. Patterns of bleeding were evaluated and serum concentrations of ST-1435, estradiol, progesterone and ethinyl estradiol were measured by radioimmunoassay. Total serum cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and serum chemistry were determined before ring use and during the first and third treatment cycles. The women experienced no difficulties in using the vaginal ring and all continued to use the ring after the first three cycles. Bleeding control was good and hormonal side effects were minimal. Serum steroid concentrations were: ST-1435, 289 +/- 117 pmol/l (mean +/- SD); ethinyl estradiol, 172 +/- 108 pmol/l; and estradiol, 184 +/- 107 pmol/l. Concentrations of serum progesterone were low, indicating complete suppression of ovulation during treatment. Total serum cholesterol increased slightly during use of ring. However, this increase could be accounted for by an increase in serum HDL-cholesterol. Liver function tests were in the normal range during ring use and values of serum chemistry showed no significant changes. This contraceptive vaginal ring presents a good method of contraception, showing good bleeding control and no harmful metabolic effects.     

Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis

Antioxidant micronutrients have been hypothesized to provide protection against rheumatoid arthritis. We investigated serum selenium and serum alpha-tocopherol for their prediction of subsequent development of rheumatoid arthritis in a case-control study nested within a Finnish cohort of 18,709 adult men and women who had neither arthritis nor a history of it at the baseline examination in 1973-1978; by late 1989, 122 had developed rheumatoid arthritis. Of the incident cases, 34 were rheumatoid factor-negative. Three controls per each incident case were individually matched for sex, age, and municipality. Serum selenium and alpha-tocopherol concentrations were measured from stored serum samples collected at baseline. Serum selenium was inversely related to subsequent occurrence of rheumatoid factor-negative but not rheumatoid factor-positive rheumatoid arthritis. The relative risks, adjusted for smoking and serum total cholesterol, for the highest relative to the lowest tertile of serum selenium, were 0.16 [95% confidence interval (CI) = 0.04-0.69] for rheumatoid factor-negative and 0.96 (CI = 0.49-1.90) for rheumatoid factor-positive rheumatoid arthritis. During the first 10 years of follow-up, the relative risk for rheumatoid arthritis for the highest compared with the lowest tertile of serum alpha-tocopherol was 0.44 (CI = 0.19-0.99). No association was found for longer follow-up periods. Low selenium status may be a risk factor for rheumatoid factor-negative rheumatoid arthritis, and low alpha-tocopherol status may be a risk factor for rheumatoid arthritis independently of rheumatoid factor status.     

Caffeine, blood pressure, and serum lipids

To study the effects of caffeine on serum lipids and blood pressure, we conducted a double-blind, randomized trial with two parallel groups in 69 young, healthy subjects. After a 3-wk run-in period, subjects were randomly assigned to one of two groups receiving either 4-6 140-mL cups filtered decaffeinated coffee per day and an equal number of pills containing 75 mg caffeine or 4-6 140-mL cups filtered decaffeinated coffee per day and an equal number of placebo pills, for 9 wk. In both groups caffeine intake from other sources was not allowed. The main finding of this study is that abstinence from caffeine for a period of 9 wk has no effect on either serum lipids or blood pressure.