广东省中小学教师心理卫生状况调查

Objective:To investigate mental health state of primary- middle school teachers in Guangdong. Methods :1321 pri-mary - middle school teachers in Guangdong were administered SCL- 90. Results:The mental health of Primary - middle school teachers was worse than that of Chinese norm, and 23.92 % of them was worse in at least one item. There was significant differ-ence between different teacher groups. The mental health of teachers from primary school, especially the male teachers and teaders with lower educational level was an important issue. Conclusion: Primary - middle school teachers need more help to improve their mental health.     

青少年罪犯人性观发展及相关因素

目的 了解青少年罪犯人性观发展特点及相关影响因素,为狱所心理健康工作和思想政治教育的开展提供科学依据.方法 采用人性的哲学修订量表(RPHN)和症状自评量表(SCL-90)对170名青少年罪犯进行测评.并选取相匹配的180名大、中、小学男生做对照.结果 青少年罪犯在值得信任因子上与对照组有非常显著差异(P<0.001),青少年罪犯人性观与罪犯受教育程度、入狱时间、父亲受教育程度呈显著相关性(P<0.05,P<0.01).青少年罪犯人性观的愤世嫉俗因子项与其心理健康中抑郁、敌对两因子项呈显著相关性(P<0.05).青少年罪犯人性观的值得信任因子项与其心理健康中偏执因子项呈显著负相关性(P<0.05).结论 青少年罪犯的人性观发展,与其本人的受教育程度、父亲的教育方式以及管教场所的心理、思想教育是分不开的.同时青少年罪犯人性观也影响着其心理健康.

Abstract：

Objeetive To learn characteristics of juvenile offender human nature and the related influence factors,which will supply a scientific basis for the prison's ideological and political education and mental health work. Methods A total of 170 juvenile offenders were investigated by Philosophies of Human Nature Scale(RPHN) and SCL--90; and 180 college students, middle school students and pupiles were choosen as normal controls. Results There were remarkable differences in trusted factor between juvenile offenders and the control group(P<0. 001). The juvenile offenders' human nature was significantly related to Level of their education, imprisonment, level of their father's education (P<0. 05, P<0. 01). The juvenile offenders' cynical factor were significantly related to depression factor and hostility factor of their mental health(P<0. 05). The juvenile offenders'trusted factor were significantly related to paranoid factor of their mental health(P<0. 05). Conclusion Level of education of juvenile offender-s,their father's educational Methods and psychological, ideological education in the prison has influence on human nature views, and juvenile offenders' human nature views has influence on their mental health.     

综合医院一线医务人员工作应激调查

Objective: To explore the job stress status of medical staffs in general hospital. Methods: A total of 201 medical staffs were sampled from a general hospital in Changsha City, Hunan Province, and their job stress levels were evaluated by the Medical Job Stress Invemory. Results:The subjects from internal medicine department showed silgnificantIy higher job stress level than those from surgical departmem;and the doctors group showed higher stress level in the interpersonal subscale than the nurses group. Condusion:It is important to pay attention to medical staff's job stress and job burnout in order to improve their mental health levels.     

Expression of NOD2 and NLRP3 in the articular cartilage of a rabbit model of osteoarthritis established by arthrorisis using plaster cast北大核心

BACKGROUND: Nucleotide-binding oligomerization domain (NOD)-like receptor plays an important role against inflammatory responses caused by pathogens and non-pathogens, as well as in the initial stage of autoimmune response. Meanwhile, NOD2 and NOD-like receptor protein 3 (NLRP3) are the representative proteins of NOD-like receptor family. OBJECTIVE: To detect the expression of NOD2 and NLRP3 in a rabbit model of osteoarthritis. METHODS: Thirty New Zealand rabbits were randomly divided into six groups (n=5 per group), including five experimental groups (2, 4, 6, 8 and 10 weeks) and one control group. The model of osteoarthritis was established by fixing the left knee joints using plaster cast, and were sacrificed at postoperative 2, 4, 6, 8 and 10 weeks. The controls received no intervention, and were killed at 10 weeks postoperatively. The left distal femur articular cartilage was taken for safranin-fast green staining. The pathological changes were evaluated by Mankin’s scores, and the expression levels of NOD2 and NLRP3 were detected by immunohistochemistry. RESULTS AND CONCLUSION: The Mankin’s scores in the experimental groups were significantly higher than those in the control group (P < 0.01). Moreover, the scores in the experimental groups were significantly increased with time (P < 0.01). The expression levels of NOD2 and NLRP3 in the chondrocytes were also increased with time (P < 0.01). These results indicate that the expresison of NOD2 and NLRP3 in the cartilage cells is positively correlated with the pathological changes of osteoarthritis, which may be through promoting apoptosis in cartilage cells, thus accelerating the development of osteoarthritis. © 2018, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.     

Electroacupuncture for chronic pain in a model of knee arthritis北大核心

BACKGROUND: Acupuncture has been found to be effective for alleviating low back pain and acute pain due to knee arthritis, but its effect on chronic pain is under discussion. OBJECTIVE: To investigate the mechanism underlying electroacupuncture (EA) alleviating chronic pain in a New Zealand rabbit model of knee arthritis. METHODS: (1) Thirty-two New Zealand rabbits were selected, and the knee osteoarthritis model was established by injecting 4% papain into the knee articular cavity of rabbit’s bilateral hind limbs. The model rabbits were randomly divided into four groups (n=8 per group): normal saline plus EA, normal saline plus sham EA, nor-Binaltorphimine (nor-BNI) plus EA, and nor-BNI plus sham EA groups. The dosage of nor-BNI was 1 mg/kg, once daily, for consecutive 3 days. 30-minute EA was given at 2 hours after administration, once daily, until the day the rabbits were killed. Sham EA indicated no given electric current. The behaviors of the lower limbs were evaluated by Basso, Beattie, Bresnahan scores. The rabbits were respectively killed at 1, 3, 5 and 7 days after administration, the spinal cord was separated, and then fixed with formaldehyde. The expression levels of interleukin-17, interleukin-17 receptor A and NR1 in the spinal cord tissues were detected by immunofluorescence. (2) The other 24 New Zealand rabbits were randomly divided into model and control groups (n=12 per group), and the knee osteoarthritis model was established in the former group. Afterwards, the two groups were randomized into two subgroups, followed by given the intrathecal administration of normal saline, or 2 μg interleukin-17 antibody serum dissolved in 10 μL normal saline, once daily, for consecutive 3 days. The behaviors of the lower limbs were evaluated by Basso, Beattie, Bresnahan scores, and the expression levels of p-NR1 and interleukin-17 receptor were detected by western blot assy. RESULTS AND CONCLUSION: The Basso, Beattie, Bresnahan scores in the nor-BNI plus EA group were significantly increased, while the expression levels of interleukin-17, interleukin-17 receptor A and NR1 in the spinal cord tissues were significantly decreased (P < 0.05). The expression level of NRI did not differ significantly between nor-BNI plus EA and nor-BNI plus sham EA groups (P > 0.05). After administration of interleukin-17 antibody serum, the Basso, Beattie, Bresnahan scores in the model group was significantly increased, and the expression levels of interleukin-17 and NR1 in the spinal cord tissues were significantly decreased, but still significantly higher than those in the control subgroups (P < 0.05). These results suggest that chronic pain in knee arthritis is the result of an increase in the expression level of NRI induced by interleukin-17. EA can remarkably improve the pain in the model rabbits of knee arthritis by downregulating interleukin-17 in the spinal cord tissues, rather than interleukin-17 receptor. © 2017, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.     

Effects of Transdermal Estrogen Therapy on Expressions of Estrogen Receptors and T-lymphocyte Apoptosis in Surgically Menopausal Women

Studies have demonstrated estrogen replacement therapy can improve the life quality of surgically menopausal women. However, the mechanisms in this process remain poorly defined. Here we show the effect of transdermal estrogen therapy on expressions of estrogen receptors and T-lymphocyte apoptosis in surgically postmenopausal women. Fifteen surgically menopausal women, 15 naturally menopausal women and 15 young women were chosen in our studies. Peripheral vein blood was collected and serum E2 and FSH levels were assessed using ACCESS. T-lymphocyte apoptosis and the expressions of Fas, FasL and ER subtypes α and β were determined. The serum E2 levels of surgically menopausal woman were significantly higher, and the ＂Improved Kupperman Index＂ and the scores of ＂Menopause Specific Quality of Life Questionnaire＂ in surgically menopausal women were significantly low after ERT. The rates of T-lymphocyte apoptosis and FasL expression in surgically menopausal women were decreased after ERT, but the difference was not significant. The expressions of ERa and ERβ in two menopausal groups were significantly lower than those of the young group. They were both significantly up-regulated after 3 months of ERT. Transdermal ERT could significantly upregulate the serum E2 level, could improve menopausal symptoms and life quality of surgically menopausal women and upregulate ERa and ERβ expressions on T lymphocytes, especially ERp. Thus, the low dose of transdermal ERT may have a protective effect on menopausal women＇s immune function and aging.     

Study on the Influencing Factors of Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

Objective:To investigate the influencing factors of the cervical lymph node metastasis in papillary thyroid microcarcinoma(PTMC) and to provide a theoretical basis for cervical lymph node dissection.Methods:A total of 80 PTMC patients treated in the Department of Breast and Thyroid Surgery of our Hospital from January 2017 to January 2018 were selected in the study.All the patients accepted the first surgical treatment and were confirmed by pathology.The clinical data of all PTMC patients were retrospectively analyzed,and the related factors such as gender,age,number of primary lesions,tumor diameter and extrathyroidal invasions were analyzed.The factors that actually affected the lymph node metastasis of PTMC patients were explored.Results:All patients underwent prophylactic central lymph node dissection.Lymph node metastasis occurred in 26 patients in the central region and in 13 patients in the lateral neck region.The rate of lymph node metastasis in the central region of men was 41.18%,and the rate of lymph node metastasis in the lateral neck region was 23.53%,which were significantly higher than that of women's 30.16% and 14.29%.The differences were statistically significant(P0.05).The regional metastasis rate of the patients of ≤45 years was 45.83%,and the lateral neck region metastasis rate was 20.83%,which were significantly higher than those of patients45 years old(12.50%,9.38%) and the differences were statistically significant(P0.05).The lymph node metastasis rate in the central region and in the lateral neck region of tumor diameter 0.5 cm were 27.27%and 9.09% respectively,which were significantly lower than those of the tumor diameter0.5-1.0 cm(38.89%,25.00%)(P0.05).The rate of lymph node metastasis in the central region of single focus was 20.37%,which was significantly lower than that of57.69% in the multifocal lesions;the rate of lymph node metastasis in the cervical region of the single lesion was 11.11%,which was significantly lower than 26.92% in the multifocal area;the differences were statistically significant(P0.05).The metastasis rate of the patients with extrathyroidal invasions in the central area was 60.00%,which is significantly higher than that without extrathyroidal invasions(30.67%).About the tumor neck invasion of the lateral neck region,the lymph node metastasis rate of the patients with extrathyroidal invasions was 40.00%,which was significantly higher than that without extrathyroidal invasions(14.67%).The differences were statistically significant(P0.05).Logistic regression analysis showed that gender and tumor size were independent influencing factors of lymph node metastasis in the central and lateral neck regions(P0.05).Conclusion:Young,male,multifocal,tumor diameter 0.5-1.0 cm and extrathyroidal invasions are risk factors for cervical lymph node metastasis in patients with PTMC.Gender and tumor size are independent factors affecting central/lateral cervical lymph node metastasis in PTMC patients.     

小学高年级学生心理健康相关因素统计分析

目的 了解4～6年级小学生的心理健康状况,对其相关因素进行分析.方法 采用心理健康诊断测验(MHT),同伴提名、班级戏剧量表对某小学228名4～6年级学生进行问卷潮试;同时收集教师的学业成绩等级评价结果 和教师接纳性结果 .结果 小学生心理健康问题总分检出率为1.6%;心理健康问题总分与学业成绩显著正相关,与同伴接纳性显著负相关;学业成绩对心理健康问题总分具有正向预测作用,社会行为的孤立/消极因子和年龄具有负向的预测作用.结论 小学高年级学生的心理健康水平与学业成绩高度相关.

Abstract：

Objective To study the mental health conditions of primary school students in Grade 4～6 and effects of its affected factors. Methods A total of 228 pupils in Grade 4～6 in primary school were examined by mental health tests (MHT), Peer Namination and Class Play Questionnarie, and their rating academic achievement by tescher and teacher acceptance were collected too. Results 1. 6%students suffered from mental health problems. Sum score of mental health problem correlated with academic achievement positively, and with peer acceptance negatively. Academic achievement could predict the sum score of mental health problem positively, and the factor "peasive/sclitary" of social behavior and age could predict negatively. Conclusion The mental health correlates highly with academic achievement.     

自体髂骨植骨联合自体骨髓干细胞移植治疗骨折术后骨不连

BACKGROUND: Bone nonunion is a common complication in the orthopedic treatment, and its morbidity reached 5%-10%, which results in the long-term functional disturbance of the limbs, and even disability. Autogenous iliac crest graft has been commonly used to treat bone nonunion, but some limitations still exist. OBJECTIVE: To investigate the treatment outcomes of autogenous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion after fracture surgery. METHODS: Clinical and follow-up data from 69 patients with bone nonunion were analyzed retrospectively. All patients were allotted to combination (n=37) and iliac (n=32) groups, followed by treated with autologous iliac crest graft combined with autologous bone marrow stem cell transplantation or  autologous crest graft, respectively. Afterwards, the hospitalization time, fracture healing time, bone mineral density and Fereadez-Esteve callus scores were detected and compared between groups. RESULTS AND CONCLUSION: The hospitalization time did not differ significantly between groups (P > 0.05). The fracture healing time in the combination group was significantly shortened compared with the iliac group (P < 0.05). The bone mineral density and Fereadez-Esteve callus scores in the combination group were significantly higher than those in the iliac group at 3 and 6 months after surgery (P < 0.05). The excellent and good rate of the affected limb function in the combination group was significantly higher than that in the iliac group (P < 0.05). These results suggest that autogenous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion can accelerate fracture healing, promote porosis and improve the functional recovery of affected limbs. 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程     

抑郁症患者抑郁症状、应付方式与人格关系的研究

Objective: To explore the relation among depression, coping styles and personality in major depression. Methods:87 major depression patients and 90 normal controls were assessed by Self- Rating Depression Scale (SDS), Eysenck Personality Questionnaire and Coping Styles Questionnaire. Results: The patients were found with higher scores in Neuroticism and Psychoti-cism, and lower in Extrovision and positive coping styles than normal controls. Significant relationship was found among depres-sion, extrovision, psychoticism and positive coping styles. The last three accounted for 36.8 % of the variance of depression in major depression. Conclusion: The patients scored high in neuroticism and psychoticism, and low in extorvision and positive cop-ing styles. The application of little positive coping styles may be a part of extrovision and/or psychoticism in major depression.