Sleep duration and the risk of future lipid profile abnormalities in middle-aged men: the Kansai Healthcare Study

BackgroundAlthough short sleep duration has been reported to be associated with future cardiometabolic diseases, it is not fully understood whether sleep duration is prospectively associated with the risk of each lipid profile abnormality.MethodsSubjects were nondiabetic Japanese, 40–55 years of age, who were not taking oral lipid-lowering medications: for the incidence of low high-density lipoprotein cholesterol (HDL-C), 7627 men with an HDL-C level ≥40 mg/dL; for high triglycerides, 6973 men with a triglyceride level <200 mg/dL; for high low-density lipoprotein cholesterol (LDL-C), 7273 men with an LDL-C level <160 mg/dL; for high non-HDL-C, 7415 men with a non-HDL-C level <190 mg/dL; and for high total cholesterol (TC), 7196 men with a TC level <240 mg/dL. Lipid profile abnormalities were defined according to the Adult Treatment Panel III guidelines of the National Cholesterol Education Program.ResultsDuring the 6-year observation period, there were 1022 cases of low HDL-C. Multiple-adjusted hazard ratios for low HDL-C were 0.79 (95% confidence interval, 0.64–0.97) for sleep durations of 5 to <7 h and 0.62 (0.46–0.83) for ≥7 h compared with <5 h. There were 1473 cases of high triglycerides. Multiple-adjusted hazard ratios for high triglycerides were 0.81 (0.68–0.98) for sleep durations of 5 to <7 h and 0.90 (0.72–1.13) for ≥7 h compared with <5 h. However, no association between sleep duration and the risk of future high LDL-C, non-HDL-C, or TC was observed.ConclusionsModerate and/or long sleep durations decreased the risk of future low HDL-C and high triglycerides.     

Sleep duration and abnormal serum lipids: the China Health and Nutrition Survey

ObjectiveTo examine the associations between sleep duration and total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), and lipoprotein (a) [Lp(a)].MethodsThe present study analyzed 8574 adults from the China Health and Nutrition Survey (2009). Sleep duration was classified into ⩽6, 7, 8, 9, and ⩾10 h. Age, education, occupation, current smoking, current drinking, physical activity, body mass index, hypertension, and diabetes were adjusted as confounders in gender-stratified multiple logistic regression models.ResultsCompared with women reporting 8 h sleep duration, the odds ratios (ORs) and 95% confidence intervals (CIs) of high TC for those with ⩽6, 7, 9, and ⩾10 h were 1.65 (1.32–2.06), 1.19 (1.00–1.43), 1.11 (0.89–1.39), and 1.27 (1.02–1.60) after adjusting for confounders. Likewise, the ORs (95% CIs) of high LDL-C were 1.71 (1.28–2.29), 1.36 (1.05–1.76), 1.04 (0.74–1.46), and 1.09 (0.78–1.53), whereas those of high ApoB were 1.80 (1.34–2.42), 1.15 (0.88–1.52), 0.95 (0.66–1.35), and 1.00 (0.70–1.43) for women with ⩽6, 7, 9, and ⩾10 h sleep duration, respectively. These associations were not statistically significant in men.ConclusionsBoth shorter and longer sleep durations were associated with higher risks of abnormal serum lipid profiles in women but not in men.     

胆红素和脂质对脑卒中发病影响的差异性探讨

目的探讨血清胆红素和脂质及其综合指数与脑出血(CH)、短暂性脑缺血发作(TIA)及脑梗死(CI)的关系。方法对128例CH、108例TIA及104例CI急性期患者血清胆红素、胆固醇等指标进行检测,并进行对比分析。结果CI组年龄显著高于CH组(P<0.05)。TIA、CI组患者血清总胆红素(TBIL)、间接胆红素(IBIL)、高密度脂蛋白胆固醇(HDL-C)显著低于CH组(P<0.05或P<0.01),血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、非高密度脂蛋白胆固醇(n-HDL-C)水平及LDL-C/HDL-C、TC/HDL-CTG/HDL-C比值显著高于CH组(P<0.05或P<0.01);CI组患者血清直接胆红素(DBIL)/IBIL比值显著高于CH组(P<0.01),血清IBIL、HDL-C水平显著低于TIA组(P<0.05),血清LDL-C、n-HDL-C水平及LDL-C/HDL-C、TC/HDL-C比值显著高于TIA组(P<0.05或P<0.01),各组间其它指标间差异无统计学意义(P>0.05)。结论血清胆红素和脂质及其综合指数不同程度的变化与脑卒中关系密切。     

绝经期女性脑梗死患者雌激素水平与血脂关系研究

目的 研究绝经期女性脑梗死患者血清中雌二醇(E2)、血脂含量变化,探讨雌激素对缺血性脑血管疾病的关系。方法 取78名绝经期女性脑梗死患者和62名对照组患者空腹静脉血,测定血清E2、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋门胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白-AI(Apo-AI)及载脂蛋白B100(Apo-B100)。结果脑梗死组E2水平(12.86pg/ml)低于对照组(25.59pg/ml),有显著差异(P<0.01)。脑梗死组TG、TC、LDL-C、Apo-B100显著高于对照组(P分别<0.01、0.01、0.01、0.05),脑梗死组HDL-C显著低于对照组(P<0.01),脑梗死组ApoA-I与对照组相比无显著性差异(P>0.05)。雌激素水平与TG、TC、LDL-C、Apo-B100呈显著负相关(r分别为-0.63、-0.44、-0.57、-0.30,P<0.01),与HDL-C呈显著正相关(r=0.53,P<0.01)。结论 雌激素水平降低可导致血脂谱异常改变,从而促进动脉粥样硬化,低雌激素水平可能是缺血性脑血管病发生的危险因素之一。     

Association between plasma lipid levels and migraine in subjects aged ≥50 years: preliminary data from the Zabùt Aging Project

We evaluated the association between lipid levels and migraine using cross-sectional, population-based data of 1809 subjects aged ≥50 years; 151 subjects with migraine and 1658 nonmigraineurs were included. Diagnosis of migraine was carried out using the criteria of the International Headache Society. The following plasma lipids were collected: total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Only TC (p<0.003) and LDL-C levels (p<0.004) were significantly higher in migraineurs than nonmigraineurs. After multiple adjustments, only elevated TC (≥220 mg/dl) was significantly associated with migraine (OR [95% CI]=1.6 [1.1–2.3]); this association increased in elderly males with migraine (OR [95% CI]=3.8 [1.4–9.9]). According to our results, TC plasma levels should be closely monitored in elderly males with migraine.

     

Lipid Levels and Short-Term Risk of Recurrent Brain Infarcts in Symptomatic Intracranial Stenosis

ObjectivesHyperlipidemia is a strong risk factor for intracranial atherosclerotic disease (ICAD) and clinical stroke recurrence. We explored the effect of serum lipid levels on subclinical infarct recurrence in the Mechanisms of earlY Recurrence in Intracranial Atherosclerotic Disease (MYRIAD) study.Materials and MethodsWe included enrolled MYRIAD patients with lipid measurements and brain MRI at baseline and brain MRI at 6-8 weeks. Infarct recurrence was defined as new infarcts in the territory of the symptomatic artery on brain MRI at 6-8 weeks compared to baseline brain MRI. We assessed the association between baseline total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels and recurrent infarct at 6-8 weeks using multivariable logistic regression.ResultsAmong 74 patients (mean age 64.2±12.9 years, 59.5% were white, 60.8% men), 20 (27.0%) had new or recurrent infarcts. Mean HDL-C (37.2 vs. 43.9 mg/dL, P=0.037) was lower and TG (113.5 vs. 91.3 mg/dL, P=0.008) was higher while TC (199.8 vs. 174.3 mg/dL, P=0.061) and LDL-C (124.3 vs. 101.2 mg/dL, P=0.053) were nominally higher among those with recurrent infarcts than those without. LDL-C (adj. OR 1.022, 95% CI 1.004-1.040, P=0.015) and TG (adj. OR 1.009, 95% CI 1.001-1.016, P=0.021) were predictors of recurrent infarct at 6-8 weeks adjusting for other clinical and imaging factors.ConclusionsBaseline cholesterol markers can predict early infarct recurrence in patients with symptomatic ICAD. More intensive and rapid lipid lowering drugs may be required to reduce risk of early recurrence.     

Both frequency and duration of rotating night shifts are associated with metabolic parameters: a cross-sectional study

BackgroundRotating night shift work contributes to the development of metabolic syndrome and relevant diseases. However, the contribution of different aspects of rotating night shift is rarely studied.AimThis study investigated the association of frequency and duration of rotating night shift with metabolic parameters.MethodsA cross-sectional study was conducted in nurses. Socio-demographic characteristics, duration and frequency of rotating night shifts, and metabolic parameters including body mass index (BMI), fasting blood glucose (FBG), blood pressure (BP), triglyceride, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), were collected. Sleep quality and perceived stress were assessed with Pittsburgh Sleep Quality Index (PSQI) and Perceived Stress Scale (PSS) respectively. Ratio of rotating night shift years to age (RRSYA) was calculated to present cumulative effect. Metabolic parameters were log-transformed and z-transformed in sequence. Multiple linear regressions were applied to explore the effect of frequency and RRSYA on metabolic parameters. Mediation analysis was used to estimate potential mediating effect of sleep quality and perceived stress.ResultsFrequency of rotating night shift work was significantly associated with elevated FBG and BMI, and decreased LDL-C. RRSYA was significantly associated with higher BMI, TC, LDL-C, BP and FBG. Sleep quality exhibited significant mediating effect between rotating night shift features and FBG and BMI.ConclusionsOur results suggest that frequency and RRSYA are associated with metabolic profile alterations, but the effects are different. Sleep quality appears to be an important mediator of the night shift's metabolic effect. Proper shift arrangement and sleep quality assurance may reduce the negative metabolic changes.     

Alexithymia,Suicide Ideation,C-Reactive Protein,and Serum Lipid Levels Among Outpatients with Generalized Anxiety Disorder

The aim of the present study was to investigate the relationships between alexithymia, suicide ideation, C-Reactive Protein (CRP), and serum lipid levels in adult outpatients with a DSM-IV diagnosis of Generalized Anxiety Disorder (GAD). Seventy consecutive patients with GAD were recruited and evaluated. Measures were the Hamilton Anxiety Scale, the Toronto Alexithymia Scale (TAS–20), the Scale of Suicide Ideation (SSI), and the Montgomery Åsberg Depression Rating Scale (MADRS). All patients were assessed for: CRP, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceridaemia (TG), and very-low-density lipoprotein cholesterol (VLDL-C). TC/HDL-C and LDL-C/HDL-C ratios were also evaluated. Alexithymic patients showed higher scores on almost all rating scales and altered serum CRP and lipid levels vs. non-alexithymics. In the hierarchical regression model, the presence of higher MADRS scores together with higher scores at the Difficulty in Identifying Feelings dimension of TAS-20 were associated with higher rates of suicide ideation. Although alexithymic subjects with GAD may show a CRP and cholesterol dysregulation, this latter seems independent on increased suicide ideation, rather to Difficulty in Identifying Feelings, and subthreshold depressive symptoms. Study limitations and future research implications are discussed.     

LDL-C/HDL-C ratio and risk of all-cause mortality in patients with intracerebral hemorrhage

Background: The low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio has been recognized as a strong risk predictor of cardiovascular diseases. However, the association between the LDL-C/HDL-C ratio and the prognosis of acute intracranial hemorrhage (ICH) is unclear. Thus, we prospectively investigated whether a low LDL-C/HDL-C ratio could predict all-cause mortality and whether LDL-C/HDL-C ratio is superior to traditional lipid profiles in predicting mortality among Chinese patients with acute ICH.

Methods: A prospective cohort study of 356 patients with acute ICH was conducted, and the mean follow-up time point was 80.4 days. Participants were divided into four categories based on LDL-C/HDL-C ratio quartiles. Three-month outcomes were evaluated by in-person or telephone interviews with patients or their family members. The end point was three-month mortality from all causes.

Results: Forty-seven deaths from all causes were documented. The multivariate analysis found that LDL-C/HDL-C ratio [hazard ratio (HR) = 0.49, p = 0.008] and LDL-C (HR = 0.27, p = 0.044) were significantly associated with all-cause mortality. The Kaplan–Meier curves show that patients in the lowest quartiles had the highest cumulative incidence rates (log-rank p = 0.027). After adjusting for covariates, a low LDL-C/HDL-C ratio was associated with a 3.55-fold increase in the risk of all-cause mortality (HR, 3.55 [95% confidence interval, 1.04–12.14]; P-trend = 0.011) when the highest and lowest quartiles were compared. The C-statistic of the LDL-C/HDL-C ratio was significantly larger than other traditional lipid profiles (all p < 0.05).

Conclusions: A low LDL-C/HDL-C ratio was independently associated with an increased risk of all-cause mortality at three months in patients with ICH. Moreover, the LDL-C/HDL-C ratio appeared to be a best lipid predictor of all-cause mortality than traditional lipid profiles.     

Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia

OBJECTIVE: To determine whether low low-density lipoprotein cholesterol (LDL-C) but not high-density lipoprotein cholesterol (HDL-C) and triglyceride concentrations are associated with worse outcome in a large cohort of ischemic stroke patients treated with IV thrombolysis. METHODS: Observational multicenter post hoc analysis of prospectively collected data in stroke thrombolysis registries. Because of collinearity between total cholesterol (TC) and LDL-C, we used 2 different models with TC (model 1) and with LDL-C (model 2). RESULTS: Of the 2,485 consecutive patients, 1,847 (74%) had detailed lipid profiles available. Independent predictors of 3-month mortality were lower serum HDL-C (adjusted odds ratio [(adj)OR] 0.531, 95% confidence interval [CI] 0.321-0.877 in model 1; (adj)OR 0.570, 95% CI 0.348-0.933 in model 2), lower serum triglyceride levels ((adj)OR 0.549, 95% CI 0.341-0.883 in model 1; (adj)OR 0.560, 95% CI 0.353-0.888 in model 2), symptomatic ICH, and increasing NIH Stroke Scale score, age, C-reactive protein, and serum creatinine. TC, LDL-C, HDL-C, and triglycerides were not independently associated with symptomatic ICH. Increased HDL-C was associated with an excellent outcome (modified Rankin Scale score 0-1) in model 1 ((adj)OR 1.390, 95% CI 1.040-1.860). CONCLUSION: Lower HDL-C and triglycerides were independently associated with mortality. These findings were not due to an association of lipid concentrations with symptomatic ICH and may reflect differences in baseline comorbidities, nutritional state, or a protective effect of triglycerides and HDL-C on mortality following acute ischemic stroke.     

Serum lipids and memory in a population based cohort of middle age women

OBJECTIVE: To assess the relation between serum lipids and memory in a healthy middle age cohort of women. METHODS: For 326 women in the Melbourne Women's Midlife Health Project aged 52-63 years, serum lipids were measured annually, and memory was assessed during the eighth annual visit. RESULTS: There was a small but significant association between current low density lipoprotein cholesterol (LDL-C) concentrations and memory; for total cholesterol (TC) the association approached significance. Better memory was associated with positive changes in TC and LDL-C based on lipid measurements three years, but not six years, earlier. Memory performance was lowest among women in the lowest quartile of current LDL-C values and among women whose LDL-C levels declined over the previous three years. High density lipoprotein cholesterol (HDL-C) and triglyceride concentrations were unassociated with memory. The association between memory and TC and LDL-C was primarily related to immediate recall and not delayed recall performance on the word list task. Low cholesterol has been linked with depression, but lipid measures and self-rated mood were unrelated. CONCLUSIONS: Higher serum concentrations of LDL-C, and relatively recent increases in TC and LDL-C concentrations, are associated with better memory in healthy middle age women. Possible cognitive effects of cholesterol reduction should be considered in future studies of lipid lowering agents.     

The effects on lipid and apolipoprotein serum levels of long-term carbamazepine, valproic acid and phenobarbital therapy in children with epilepsy

The aim of the present study was to assess the effect of long-term carbamazepine (CBZ), valproic acid (VPA) and phenobarbital (PB) treatment on serum lipids and apolipoproteins in epileptic children. Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and triglycerides (TGs) were measured and the LDL-C/HDL-C and TC/HDL-C ratios were calculated in 320 children and adolescents (129 receiving CBZ, 127 receiving VPA and 64 receiving PB) suffering from various types of epilepsy. Additionally, in a subgroup of 181 children (68 CBZ; 78 VPA; 35 PB) apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), HDL2-C and HDL3-C were measured and apoA-I/apoB and HDL2-C/HDL3-C ratios were calculated. Results of the measurements were compared with those of 169 age-and sex-matched healthy controls. None of the variables considered was significantly correlated with time elapsed since start of treatment or with drug concentration in serum. TC and LDL-C serum levels were high in children receiving CBZ or PB and low in those treated with VPA. Serum LDL-C level exceeded 130 mg/dl in 27.9% of CBZ-group, 31.8% of the subjects receiving PB, but only in 7% of those receiving VPA and in 11.8% of control group subjects. CBZ-treated children also showed high HDL-C and HDL3-C values. In the group receiving VPA, HDL2-C, HDL2-C/HDL3-C ratio and apo B were significantly lower than in the control group. Mean apoA-I levels were low in all treated groups: by contrast, in neither group did TGs, VLDL-C levels and TC/HDL-C or LDL-C/HDL-C ratios differ significantly from the corresponding control group. Our results suggest that the effects of long-term AED therapy on lipid profile and, particularly, on apolipoprotein serum levels increase risk of atherosclerosis-related disease. Moreover, these results confirm our previously reported increased risk in CBZ and PB-treated patients.     

The U-shaped association between self-reported sleep duration and visual impairment in Korean adults: a population-based study

ObjectiveThis study aimed to investigate the association between self-reported sleep duration and visual impairment (VI) in Korean adults.MethodsThis population-based, cross-sectional study examined ophthalmologic data of 16,374 Koreans aged 19 years and older from the 2010–2012 Korea National Health and Nutrition Examination Survey (KNHNES V). VI data (best-corrected distance visual acuity worse than 0.5 logMAR in the better-seeing eye) were obtained from direct ophthalmologic examinations, and data on self-reported sleep duration (≤5, 6, 7, 8, or ≥9 h/night) were obtained using questionnaires. Multiple logistic regression analysis was conducted to examine the association between self-reported sleep duration and VI, and we also adjusted for possible covariates.ResultsThe weighted VI prevalences (95% CIs) were 1.23% (0.70–1.76), 0.40% (0.10–0.70), 0.18% (0.04–0.31), 0.42% (0.26–0.58), and 0.66% (0.25–1.07) for participants who slept ≤5, 6, 7, 8, and ≥9 h/night, respectively. Even after adjusting for demographic factors (age and sex), lifestyle factors (household income, occupation, smoking status, regular exercise, and suicidal thoughts), and medical factors (diabetes, hypertension, stroke, and history of ocular surgery), greater risk of VI was found in the ≤5 h/night (OR = 3.23, 95% CI: 1.43–7.31) and ≥9 h/night (OR = 2.56, 95% CI: 1.03–6.41) groups, compared to the 7 h/night group.ConclusionsIn Korean adults, self-reported sleep duration and VI exhibited a U-shaped association. Both very short (≤5 h/night) and very long (≥9 h/night) sleep durations were significantly associated with increased VI.     

Latent Toxoplasma gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia

BackgroundPrevious studies suggested a complex association between Toxoplasma gondii (TG) infection and host lipid metabolism. Both TG infection and metabolic disturbances are very common in patients with schizophrenia, but this relationship is not clear.MethodsIn this cross-sectional study, we evaluated the association between TG seropositivity, serum lipid levels, body mass index (BMI) and metabolic syndrome (MetS) in 210 male inpatients with schizophrenia.ResultsIn our sample of schizophrenia patients, with the mean age of 43.90 ± 12.70 years, the rate of TG seropositivity was 52.38% and the prevalence of MetS was 17%. Patients with the TG antibodies had lower serum triglyceride levels and body weight compared to TG seronegative patients, despite having more frequently received antipsychotics (clozapine, olanzapine risperidone and quetiapine), which are well known to induce weight gain and metabolic abnormalities. However, the only significant change in metabolic parameters, observed in TG seropositive patients with schizophrenia, was decreased serum triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio. No associations were observed between TG seropositivity and serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose levels, waist circumference, BMI and the rate of MetS.ConclusionThis is the first report of the association between TG infection and decreased serum triglyceride to HDL-C ratio in a sample of carefully selected men with chronic schizophrenia.     

Risperidone and serum lipid profile changes in child and adolescent patients

Objectives

Atypical antipsychotics (AAPs) have been reported to cause metabolic dysregulation that can cause AAPs-related weight gain. The purpose of this study was to assess triglyceride, cholesterol, and weight changes among risperidone-treated children and youths.

Methods

Eighty-one subjects treated with risperidone for any psychiatric disturbances were included in the study. Fasting total low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG) levels were measured at the baseline and at the sixth month of treatment.

Results

TG, TC and LDL-C levels increased over time and reached statistical significance but there has been no change in HDL-C levels. Seven subjects (8.64%) crossed the threshold into clinically significant hypertriglyceridemia, four subjects (4.94%) crossed the threshold into clinically significant hypercholesterolemia, defined as going over the 95th percentile of published age normed plasma TG and TC levels, respectively. There was a positive correlation between TG and TC elevations and weight gain. There was no significant association with age, gender, diagnoses, risperidone dose and changes of serum TG, TC or LDL-C levels.

Conclusion

The present study identified significant associations between lipid dysregulation and risperidone treatment. Since there is little research available on long-term lipid profile follow-up with atypical antipsychotics treatment in children and youths, controlled studies in larger samples should be carried out to reveal the relationship between risperidone use and plasma lipid parameters in the pediatric population.     

Low serum lipid levels,use of statin and cerebral microbleeds: A systematic review and meta-analysis

IntroductionPrevious studies have shown that low serum lipids and statins may be related to cerebral hemorrhage. We made the meta-analysis to evaluate the associations between serum lipid levels or statins treatment and cerebral microbleeds (CMBs) to identify whether the similar correlation also existed.MethodWe comprehensively searched the Medline, Embase, Cochrane library, Web of Science, only included English journal articles, and systematically collected the observational studies and randomized controlled trials (RCTs) from September 1975 to August 2021. Random-effects model was used to pool data. Statistical heterogeneity was assessed by I² statistic and chi-square. 11 items checklists recommended by the Agency for Healthcare Research and Quality (AHRQ), Newcastle–Ottawa Scale (NOS), and Cochrane Risk of Bias tool (ROB) were used to evaluate the methodological quality of cross-sectional studies, cohort studies and randomized controlled trial, respectively.ResultsFive cohort studies, two RCTs, and ten cross-sectional studies, including 16,637 subjects and 2663 CMBs patients, were included in our quantitative synthesis. Our study found that after adjusting the covariates, total cholesterol (TC) was significantly inversely correlated with the prevalent CMBs in any location, while total triglycerides (TG) and High-density lipoprotein (HDL) were significantly inversely associated with prevalent deep CMBs. Low-density lipoprotein (LDL) was negatively associated with incident CMBs after adjusted confounders. We did not found statistical differences between statin and CMBs after adjusted covariates.ConclusionSerum major lipid (TC TG HDL LDL) levels may be inversely associated with CMBs. Currently, no sufficient evidence proves that statin therapy is the risk factor of CMBs.     

CardioChekPA便携式全血分析仪检测血脂性能及其在社区脑卒中高危人群血脂筛查中的应用

目的评价CardioChekPA便携式全血检测仪（便携式全血检测仪）检测血脂的可靠性,探讨其用于社区脑卒中高危人群血脂筛查的可行性及准确性。方法根据美国国家临床实验室标准化委员会制定的患者样本比对实验及偏差评价指南EP9-A文件标准,分别以ADVIA2400全自动生化分析仪和便携式全血检测仪为参考仪器（目标检测系统）和试验系统,检测受试者血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平,计算两种检测系统相关系数和直线回归方程,并对其预期偏差进行评估;在比对基础上应用便携式全血检测仪检测1263例社区年龄〉40岁的高危人群血脂水平。结果便携式全血检测仪检测血脂与ADVIA2400全自动生化分析仪具有良好的相关性（r〉0．975,P〈O．05）,不同医学决定水平可允许误差均位于预期偏差的95％CI内,提示两种仪器检测总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平相近,数据可接受。社区筛查共检测1263例受试者,异常检出率为总胆周醇347例（27．47％）、甘油三酯348例（27．55％）、高密度脂蛋白胆固醇62例（4．91％）、低密度脂蛋白胆固醇441例（34．92％）。结论CardioChekPA便携式全血检测仪测定胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆同醇的结果与实验室常规ADVIA2400全自动生化分析仪测定结果相近,结果准确可信,可用于社区流行病学调查。     

玉米黄质对高脂诱发鹌鹑模型血管脂质过氧化损伤的保护作用*

背景：大多数人工合成的抗氧化药物长期应用均有一定的毒副作用,玉米黄质作为天然药物有其独特的生理效应。 目的：观察玉米黄质对高脂诱发血管脂质过氧化损伤效应鹌鹑模型影响的量效关系。 方法：建立鹌鹑高脂模型,利用玉米黄质按30,60mg/kg灌胃7周后,取空腹血测定血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及丙二醛水平、血清超氧化物歧化酶、谷胱甘肽过氧化物酶及诱导型一氧化氮合酶活性;检测各组动物肝脏组织中总胆固醇、三酰甘油水平;并采用苏木精-伊红染色观察主动脉血管病理变化。 结果与结论：与高脂模型组相比,玉米黄质组血清三酰甘油、总胆固醇和低密度脂蛋白胆固醇浓度明显降低,而血清高密度脂蛋白胆固醇浓度明显增高;肝脏总三酰甘油及总胆固醇的合成也受到强烈抑制;玉米黄质组血清超氧化物歧化酶活性、谷胱甘肽过氧化物酶活性明显提高,而诱导型一氧化氮合酶活性下降、丙二醛水平减少。说明玉米黄质具有良好的降脂功效,对高脂诱导的血管脂质过氧化损伤有明显的抑制作用,且高剂量较低剂量作用效果更为理想。     

绝经后脑梗死患者性激素及血脂变化的研究

目的 观察绝经后动脉粥样硬化血栓性脑梗死(atherothrombotic cerebral infarction,ATCI)患者血清性激素变化及其对血脂的影响。方法 选择43例绝经1年以上患有ATCI的妇女(A组),平均年龄65.5岁,41名绝经1年以上的健康妇女(B组),平均年龄63岁,以及47名健康育龄行经妇女(C组),平均年龄38岁,进行血清雌二醇、促卵泡刺激素、促黄体生成素及血脂谱测定。结果 A组患者血清雌二醇、高密度脂蛋白胆固醇水平较低,而血清促卵泡刺激素、促黄体生成素、总胆固醇和低密度脂蛋白胆固醇水平则较高,与B组和C组相比差异有显著性意义(均P<0.01)。直线相关分析表明,血清雌二醇与促卵泡刺激素、促黄体生成素、总胆固醇和低密度脂蛋白胆固醇水平呈负相关,而与高密度脂蛋白胆固醇呈正相关。结论 绝经后动脉粥样硬化血栓性脑梗死患者存在严重的性激素失调及脂质代谢异常,其中血清雌二醇水平的降低可能是其发病原因之一。