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Five flavonoid glycosides were identified from flowers of Arnica montana, ten from A. CHAMISSONIS subsp. FOLIOSA var. INCANA. The structures were established on the basis of acid hydrolysis and spectral data (UV, NMR, MS) as the 7-beta-glucosides of pectolinarigenin, apigenin, and chrysoeriol; luteolin 3'- O-beta-glucoside; the 3-beta-glucuronides of kaempferol, isorhamnetin, and 6-methoxykaempferol; the 3,7-di-beta-glucosides of quercetin and patuletin; the 3-beta-glucosides of betuletol and quercetagetin 6,3',4'-trimethyl ether; and the 7-[6'- O-(2-methylbutyryl)]=glucosides of luteolin and eupafolin. The latter four are new natural compounds. Differences between these two ARNICA species are discussed. 相似文献
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Five flavonoid glycosides were identified from flowers of ARNICA MONTANA, four from A. CHAMISSONIS subsp. FOLIOSA var. INCANA. The structures were established on the basis of total acid hydrolysis and spectral data (UV, (1)H-NMR, (13)C-NMR, MS) as hispidulin 7- O-beta-glucoside, isorhamnetin 3- O-beta-glucoside, 3- O-beta- D-glucopyranosides of spinacetin, 6-methoxykaempferol and patuletin and querectin 3- O-(6'- O-acetyl)-beta- D-glucopyranoside. The latter compound can serve as distinctive marker between these two ARNICA species. The (1)H-NMR spectra in CD (3)OD are discussed. 相似文献
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Pei-Cheng Zhang Ying-Jun Zhou Sui-Xu Xu 《Journal of Asian natural products research》2013,15(1):77-82
Abstract Two novel natural products, namely pinnatifida C, pinnatifida D, were isolated from the leaves of Crataegus pinnatifida Bge.var.major N.E.Br. Their structures were elucidated by the spectroscopic analysis and chemical evidence. 相似文献
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Two Flavonoid Glycosides from Cassia occidentalis Pods 总被引:1,自引:0,他引:1
From the ethanolic extract of the pods of CASSIA OCCIDENTALIS, two flavonoid glycosides namely 3,5,3',4'-tetrahydroxy-7-methoxyflavone 3- O-(2'-rhamnosyl glucoside) and 5,7,4'-trihydroxy-3,6,3'-trimethoxy-flavone 7- O-(2'-rhamnosyl glucoside) have been isolated and their structures characterised. Both these aglycones (1, 2) are known but their glycosides are being reported for the first time. 相似文献
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《Pharmaceutical biology》2013,51(4):246-250
AbstractFrom the aerial parts of Satureia obovata, the previously known flavonoid compounds xantho microl, cirsimaritin, genkwanin, diosmetin, chrysoeriol, apigenin, luteolin, luteolin-7-0-β-D-gluco side, luteolin-7-0-β-D-rutinoside, vicenin-2 and the uncommon luteolin-3′-0-β-D-glucoside have been isolated and identified by UV, EIMS and chromatographic procedures. Previously, only xan-thomicrol has been reported from Satureia species. 相似文献
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The main flavonoid glycosides from BETULAE folium are separated with a RP-HPLC method. The mobile phase for the separation of the seven most important compounds (rutin, hyperin, quercetin-3-arabinofuranoside, quercetin-3-arabinopyranoside, quercetin-3-rhamnoside, quercetin-3-glucuronide, and myricetin-3-galactoside) was optimized with the "PRISMA" model, which is a multisolvent optimization system. The isocratic separations were finished within 30 minutes and the peak purity was controlled with diode-array detection. The method can be applied for quantitative determination, as was demonstrated for different samples of B. PENDULA and B. PUBESCENS. 相似文献
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Ten flavonoid glycosides were identified in flowers of HETEROTHECA INULOIDES ("Mexican Arnica"). Their structures were established by spectral data (UV, (1)H-NMR, (13)C-NMR, mass) and total acid hydrolysis as kaempferol 3-beta-glucoside, 3-beta-galactoside, 3-beta-rutinoside, 3-beta-robinobioside, quercetin 3-beta-glucoside, 3-beta-galactoside, 3-beta-glucuronide, 3-beta-glucuronide-6'-methylester, 3-alpha- L-arabinoside, and 3-beta-rutinoside. Additionally, caffeic, protocatechuic, and chlorogenic acid as well as umbelliferone were found. 相似文献
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Rheum ribes Linn (Polygonaceae) root is used traditionally to treat diabetes, hemorrhoids, ulcers, and diarrhea. Here, the hypoglycemic effect of R. ribes root extract in healthy mice was investigated. Fasted mice were given a single dose of 50?mg/kg of three extracts of different polarity from R. ribes by gastric feeding and the blood glucose was measured 0, 1, 2, 4, and 24?h later. The aqueous extract showed a significant hypoglycemic effect. In vitro, the aqueous extract stimulated insulin release from INS-1E cells at both stimulatory (20?mM) and non-stimulatory (1?mM) glucose concentrations, thus suggesting a mechanism for the in vivo effect. The hypoglycemic active fraction was found to contain anthraquinone glycosides of aloe emodin, emodin, physcion, and chrysophanol derivatives. 相似文献
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目的:研究聚酰胺柱色谱分离纯化野菊花中黄酮苷类-蒙花苷的工艺条件.方法:以野菊花中蒙花苷的解析率与纯度为指标,通过考察静态、动态吸附试验,优化聚酰胺分离纯化野菊花中蒙花苷的工艺条件.结果:聚酰胺对黄酮苷有良好的分离效果,其优化工艺为:最佳上柱样品溶液质量浓度2.0 mg· ml-1,吸附流速2 BV· h-1,10%乙醇除杂液和50%乙醇洗脱液分别以1 BV· h-1速度洗脱.蒙花苷动态饱和吸附量7.582 mg·g-1,蒙花苷动态解析率为91.27%,纯度达到12.63%.结论:聚酰胺对野菊花中蒙花苷分离纯化性能较高,纯度提高了5.2倍.可用于野菊花中黄酮苷类-蒙花苷的进一步分离与纯化. 相似文献
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目的:建立淫羊藿黄酮苷类指纹图谱和含量测定方法,对淫羊藿质量进行分析。方法:本文采用HPLC法,对来源于5个基原种(淫羊藿Epimedium brevicornu Maxim.、箭叶淫羊藿Epimedium sagittatum ( Sieb.et Zucc. ) Maxim.、柔毛淫羊藿Epimedium pubescens Maxim.、朝鲜淫羊藿Epimedium koreanum Nakai、巫山淫羊藿Epimedium wushanense T. S. Ying)的淫羊藿进行了黄酮类成分指纹图谱分析,并比较了5种基原样品中淫羊藿苷、朝藿定A、B、C和宝霍苷I的含量。结果:淫羊藿各基原种的指纹图谱及5种黄酮类成分的含量显示一定的差异。结论:本文建立的方法简便,数据可靠,可以为淫羊藿标准的修订提供有益参考。 相似文献
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Two new flavonoid glycosides sagittatins A and B were isolated from EPIMEDIUM SAGITTATUM and their structures were fully characterized by chemical and spectroscopic means. 相似文献
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秀山金银花、叶、茎中绿原酸的检测及其抑菌作用研究 总被引:1,自引:0,他引:1
目的测定金银花及其叶片、茎中绿原酸的含量,考察其抑菌效果。方法采用高效液相色谱法(HPLC法)和最低抑菌浓度(MIC)测定法。色谱柱为Phenomenex C18柱(250mm×4.6mm,5μm),流动相为乙腈-pH=2.04的0.4%磷酸(13:87,V/V),流速为0.5mL/min,检测波长为327nm。结果金银花及其叶片、茎中绿原酸的含量分别为6.1%,1.8%,0o金银花提取液和金银花叶片提取液对大肠杆菌的MIC分别为18.75mg/mL和150mg/mL,对金黄色葡萄球菌的MIC分别为4.6875mg/mL和37.5mg/mL。结论金银花及其叶片中绿原酸含量高,抑菌作用强。仝银花叶片具有较高的开发价值,药效可代替金银花。 相似文献
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目的 筛选黑沙蒿中有抗肥大细胞脱颗粒的二咖啡酰奎宁酸类化合物(dicaffeoylquinic acid,DCQAs),并结合网络药理学方法对活性化合物抗过敏性鼻炎作用机制进行探索。方法 通过检测细胞生存率、β-氨基己糖苷酶释放率及中性红染色建立C48/80诱导P815细胞脱颗粒的最佳方案;检测β-氨基己糖苷酶释放率筛选DCQAs;通过STITCH、Swiss、TCMID、TCMSP及GeneCards数据库收集活性化合物靶点、过敏性鼻炎和肥大细胞脱颗粒的相关靶点,获得共同有效靶点;应用String数据库和Cytoscape 3.7.2软件构建化合物-潜在有效靶点的网络图;利用DAVID数据库对有效靶点进行GO (Gene Ontology)功能富集分析和KEGG (Kyoto Encyclopedia of Genes and Genomes)通路富集分析。结果 6种DCQAs中,仅有3,5-DCQA和4,5-DCQA可显著减少肥大细胞脱颗粒;通过筛选发现18个潜在有效靶点,其中整合素β-1(integrin β-1,ITGB1)、中性粒细胞弹性蛋白酶(neutrophil elastase,ELANE)、72 kDa IV型胶原酶(72 kDa type IV collagenase,MMP2)、原癌基因酪氨酸蛋白激酶(proto-oncogene tyrosine-protein kinase Src,SRC)以及caspase-3可能是中心节点;GO和KEGG分析显示活性DCQAs通过白细胞跨内皮转移信号通路、GnRH信号通路和肿瘤信号通路等参与MAPK正向调节、细胞外基质分解和整合素介导的信号通路等生物学过程。结论 3,5-DCQA和4,5-DCQA为黑沙蒿提取物抗过敏性鼻炎的潜在活性化合物,通过多靶点-多途径发挥作用,为黑沙蒿提取物治疗过敏性鼻炎提供科学依据。 相似文献